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17) Agranulocytosis(2)
18) Dohle bodies(2)
19) Pseduo Pelger Huet cells (2); Pelger Huet anomaly(2x2)
20) Dorfman Chanarin Syndrome (2)
21) Classify non neoplastic lesions of leukocytes. Discuss in detail the granulocytic non
neoplastic lesions.(10)
22) Chediak Higashi syndrome(2)
23) Downy cell(5)
24) Absolute eosinophil count(2,5)
25) Reticular hyperplasia(2)
26) Kimura’s disease(2)
27) Inflammatory pseudotumour of lymph node(2)
28) Lymphotropic viruses(2)
53) Discuss the recent concepts in diagnosis, classification and pathology of Hodgkin’s
Disease(10)
54) Morphological features of sub types of Hodgkin’s Lymphoma.(2)
55) RS cell(2)
56) Differences in presentation between Hodgkin and non-Hodgkin lymphomas(2)
57) Role of immunity in Hodgkins disease.(5)
58) Features of non classical variant of Hodgkin lymphoma (2)
59) Discuss the role of immunohistochemistry and molecular biology in the classification
of lymphomas and leukemia.(10)
60) Laboratory diagnosis of acute leukemias.(5)
61) Usefulness of karyotyping in the diagnosis and management of leukemia(5)
62) Cytochemical stains in acute leukemia(5)
63) FAB classification (5x2)
64) What are the technical advances in bone marrow pathology? Discuss the implication
of WHO classification in the marrow diagnosis of myeloid neoplasia.(10); Latest
classification of myeloid neoplasms(5)
65) WHO classification of AML(5); Recent advances in classification of AML (5); Describe
the subtypes of acute myeloid leukemia defined by the WHO classification. What are
the features that have an impact on prognosis.(10)
66) Prognostic factors in AML(2)
67) Ph chromosome(2)
68) Promyelocytic leukemia(5)
69) 5q syndrome(2)
70) Cytochemistry of megakaryocytic leukemia.(2)
8) G6PD deficiency(5)
9) Heinz body preparation and its application (2)
10) Discuss the pathogenesis, morphology and complications of sickle cell disease.(10)
11) Sickle cell trait(2)
12) Hb-F(5,2)
13) Hb electrophoresis(5x2)
14) Functional classification of haemoglobin variants and describe about HbE(10)
15) Thalassemia(5); Mutations in thalassemia(2); Discuss molecular basis and diagnosis
of thalassemia.(5)
16) Alpha thalassemia(5)
17) Beta thalassemia-molecular biology and lab diagnosis(5)
18) Hemoglobinopathies in India(5)
19) Lab diagnosis of hemoglobinopathies(10)
22) Classify haemolytic anaemias. Discuss the etiopathogenesis, clinical features and
laboratory findings in immune haemolytic anaemia.(10)
23) Immune mediated haemolytic anaemias.(5x2); Cold agglutinin haemolytic
anemia.(2); Cold acting antibodies(2)
24) Coomb’s test(5)
25) Hemolytic uremic syndrome(5)
26) Classify anemias. Discuss the etiopathogenesis, morphology and lab diagnosis of
pernicious anemia.(10)
27) What is the Peripheral smear appearance in Megaloblastic anemia. (2)
28) DD for microcytic hypochromic anaemia(2)
29) Sideroblastic anaemia(5x2)
30) Sideroblastemia(5)
31) Classify anemias. Discuss the etiopathogenesis, clinical features and laboratory
findings in Aplastic anemia.(10,5x2)
32) Pure red cell aplasia(2x2, 5x2)
33) Congenital anaemia(2)
34) Transient erythroblastopenia of childhood(2)
35) Enumerate the Hypo proliferative anemias.(2)
36) Refractory anemia(5)
37) Congenital dyserythropoitic anemias.(5)
40) Discuss in detail about the causes, differential diagnosis and investigations of
patients with pancytopenia(10); List causes of pancytopenia(2)
41) Pathology of bone marrow failure(5)
42) Leucoerythroblastic blood picture(5)
43) Porphyrias(5)
E. Coagulation and bleeding
1) Write about platelet STR receptors and ligand interaction.(5)
2) Procoagulant properties of Intima.(2)
3) Proteins of Fibrinolytic pathway.(2)
4) Structure of platelet(5)
5) Represent diagrammatically the molecular basis of platelet adhesion and
aggregation (2)
6) Thrombopoietin(2)
7) Von Willebrand factor(2);
8) G Proteins in platelet and their functions.(2)
9) Protein C(2)
10) Protein S(2x2)
11) Laboratory evaluation of hemostasis(10)
12) PT-INR(2); INR(2)
13) Partial thromboplastin time.(2)
14) Clot retraction time(2)
15) Bleeding time(2)
16) Platelet function tests.(5)
17) Aggregometer(5)
18) Laboratory detection and types of von Willebrand disease.(5x5)
19) Write briefly about Congenital Coagulopathies.(5)
20) Glanzmann’s thrombasthenia (2,5)
21) Hemophilia A(5)
22) Idiopathic thrombocytopenia(5x2)
23) Thrombotic microangiopathies(5)
24) Discuss the screening and specific tests used in the diagnosis of bleeding
disorders(10)
25) Classify haemorrhagic disorders and discuss the laboratory diagnosis of Von
Willebrand’s disease(10x2); Discuss and classify bleeding disorder. Discuss the role
of platelet and its abnormalities in hemostasis(10)
26) DIC(5x3); Define disseminated intravascular coagulation. Describe the
etiopathogenesis and laboratory diagnosis.(10)
F. Tranfusion Medicine
1) Autologous blood transfusion(2,5x2)
2) Storage of platelets in blood bank(2)
3) Cryoprecipitate(5)
4) Bombay blood group(2)
5) Kleihauer test.(2)
6) Tests done using cord blood in a setting of Rh incompatibility(2)
7) Discuss briefly transfusion reactions(5)
8) What are the factors that can cause increased destruction of circulating Platelets?(2)
9) P blood group(2)
10) What are blood components? Describe the preparation, storage and uses of blood
components.(10x3)
11) Platelet therapy and apheresis(5)
12) Discuss organization and legal concerns of blood banking.(5)
13) Blood transfusion reactions (10)
14) Blood component therapy(5)
G. Clinical Pathology
1) Urinary sediments(2,5x3)
2) Telescoped urinary sediment(2)
3) Automation in urine analysis.(5)
4) Analysis and importance of analysis of urinary calculi(5)
5) Instrumentation in urine analysisand its principle(5)
6) Hemoglobinuria(5)
7) Test for microalbuminuria(2)
8) Discuss creatinine clearance tests.(5)
9) ESR(2); Automation in ESR(5); Utility and accuracy of zeta sedimentation.(5)
10) CSF examination in meningitis
11) Pleocytosis(5)
12) PCV(2)
13) Red cell distribution width(2)
14) Recent advances in investigation of malaria.(5x2); Latest tests for malaria (2)
15) Semen analysis(5)