HAZOP Centrifuge and Dryer

HAZOP ANALYSIS
To manufacture of Ambroxol hcl
Hazop Study - Process – for Ambroxol Stage-1

Stages Process Operation Possible Hazards / Remedial Action
failures
Bottom valve Operational control - checkpoint shall be
included in the batch sheet to indicate
opened, or Leakage
whether the bottom valve has been closed
of Bottom Valve
prior to charging methanol & is not Leaking.
Charging of Methanol,
Methanol addition pipe is kept to the Bottom
Fire hazard due to of the reactor
static electricity Pipe lines are all SS and equipment motors are
Reaction of 2-Amino-3,5- flame proof.
Dibromo Benzaldehyde Charging of 2-amino 3,5 Instruction is Laid in the SOP , To Avoid
Stage-1 with Trans-4-amino- Dibromobenzaldehyde& Spillage out side the spillage outside the Equipment,Lay down the
Cyclohexanol,in methanol Trans-4-amino reactor, Poly Bags to Collect the spilled Material,&
with Sodium borohydride cycloHexanol Transfer to the reactor
Fire hazard due to SS scoops to avoid static electricity. The
static electricity reactor is earthed by conducting wires
Irritation to skin & Using hand gloves & goggles.
eyes
The temperature is raised by slow heating till
Refluxing the reaction reflux; the methanol Vapour Loss is due to
Loss of Methanol Excessive heat, Instruction is Given in SOP, To
mass Open the steam valve to Optimum so as to
maintain the reflux
The centrifuge is earthed by conducting wires.
The filtration is carried out through a centrifuge.
Centrifuges are high speed machines and sources of
hazard in a chemical plant. Ample precautions are
taken to carry out the centrifuging as hazard free as
possible. We are using a 48 inch dia SS316 centrifuge,
bottom driven and top discharge. this is a four point
Fire hazard due to static suspension machines which are put on special vibra
To separate the electricity, operator mount for smooth vibration free noiseless operation.
hazard if any loading / The speed is controlled by a variable frequency drive
Centrifuging Ist Stage From the unloading activity and the feeding of the centrifuge is done by
liquid carried out in a running pneumatically controlled valves at lower RPM under
centrifuge nitrogen purging. Even the bearing housing of the
centrifuge is provided with a nitrogen purging facility.
An interlocking system is provided for ensuring that
the lids cannot be opened while the centrifuge is
running and thereby preventing any operational
hazard by human error . All the limits switches and the
safety interlocking switches are flame proof including
the VFD controls.
Charging of Bottom valve opened, Operational control - checkpoint shall be included in
Purification of Ambroxol or Leakage of Bottom the batch sheet to indicate whether the bottom valve
acetone, has been closed prior to charging methanol & is not
Stage-2 Crude By Carbon Treatment Valve Leaking.
& Crystallization by Hcl, Instruction is Laid in the SOP , To Avoid spillage outside
centrifuging Charging of Spillage out side the the Equipment,Lay down the Poly Bags to Collect the
Ambroxol Crude reactor, spilled Material,& Transfer to the reactor
The Filtration Operation is Carried out in Closed SS
Filtration Spillage,Filter Cloth Line, Filter cloth cleaned for Every Batch & this
Block Cleaning of the Filter along with Cloth is Incorporated
In the BPR
Acetone Charging SS pipe is Fixed to the Bottom of
Fire hazard due to the reactor
static electricity Pipe lines are all SS and equipment motors are flame
proof.
The Addition of Hydrochloric acid is charged through
Hcl Addition Hydrochoric acid the Closed lines, without any Spillage,personnel
Spillage & Irritation Protective Equipments are Used to avoid the Exposure
& tackle the irritation
The filtration is carried out through a centrifuge.
Centrifuges are high speed machines and sources of
hazard in a chemical plant. Ample precautions are
taken to carry out the centrifuging as hazard free as
possible. We are using a 48 inch dia SS316 centrifuge,
Fire hazard due to bottom driven and top discharge. this is a four point
static electricity, suspension machines which are put on special vibra
operator hazard if any mount for smooth vibration free noiseless operation.
loading / unloading The speed is controlled by a variable frequency drive
activity carried out in a and the feeding of the centrifuge is done by
running centrifuge pneumatically controlled valves at lower RPM under
nitrogen purging. Even the bearing housing of the
centrifuge is provided with a nitrogen purging facility.
An interlocking system is provided for ensuring that
the lids cannot be opened while the centrifuge is
running and thereby preventing any operational
hazard by human error. All the limits switches and the
safety interlocking switches are flame proof including
the VFD controls
Solvent recovery Charging of MLR No specific hazard All charging is done by vacuum sucking to avoid
Hazardous waste spillages and through the closed SS pipe lines.
after distillation
Drying of the RCVD is fitted with flame proof motors. Unloading into
Drying Separation of solvents from product in No specific hazard the bins by actuated valve, Hence No- Less Exposure
operation the product Rotocone vacuum Hand gloves & goggles should be used.
Dryer
To manufacture of Anastrozole
Hazop Study - Process – for Anastrozole

failures
Instruction is Laid in the SOP , To Avoid
Charging of , , , ,- Spillage out side the spillage outside the Equipment,Lay down the
reactor, Poly Bags to Collect the spilled Material,&
tetramethyl-5-(
Transfer to the reactor
methyl)-1,3- benzene
diacetonitrile
Reaction of , , , ,- static electricity reactor is earthed by conducting wires
tetramethyl-5-( methyl)-
eyes
1,3- benzene diacetonitrile
Operational control - checkpoint shall be
with Acetonitrile, n-bromo
Bottom valve included in the batch sheet to indicate
succinamide, Ethyl acetate
opened, or Leakage whether the bottom valve has been closed
and Water then separate
Stage-1 of Bottom Valve prior to charging Acetonitrile & is not
the organic layer and
Acetonitrile Leaking.
distillation organic layer
Acetonitrile addition pipe is kept to the
and added cyclohexane
Fire hazard due to Bottom of the reactor
static electricity Pipe lines are all SS and equipment motors
are flame proof.
Spillage out side the spillage outside the Equipment,Lay down the
n-bromo succinamide Transfer to the reactor
eyes
of Bottom Valve prior to charging Ethyl acetate & is not
Ethyl acetate Leaking.
Ethyl acetate addition pipe is kept to the
are flame proof.
The temperature is raised by slow heating
Distillation of the till Distillation; the Acetonitrile
Loss of Acetonitrile Vapour Loss is due to Excessive heat,
organic layer
Instruction is Given in SOP, To Open the
steam valve to Optimum so as to maintain
the Distillation.
of Bottom Valve prior to charging Cyclohexane & is not
Cyclohexane Leaking.
Cyclohexane addition pipe is kept to the
are flame proof.
Fire hazard due to The centrifuge is earthed by conducting
wires.
static electricity,
The filtration is carried out through a
Centrifuging To separate the liquid operator hazard if
centrifuge. Centrifuges are high speed
any loading /
machines and sources of hazard in a chemical
unloading activity
plant. Ample precautions are taken to carry
carried out in a out the centrifuging as hazard free as
running centrifuge possible. We are using a 48 inch dia SS316
centrifuge, bottom driven and top discharge.
this is a four point suspension machines
which are put on special vibra mount for
smooth vibration free noiseless operation.
The speed is controlled by a variable
frequency drive and the feeding of the
centrifuge is done by pneumatically
controlled valves at lower RPM under
nitrogen purging. Even the bearing housing
of the centrifuge is provided with a nitrogen
purging facility. An interlocking system is
provided for ensuring that the lids cannot be
opened while the centrifuge is running and
thereby preventing any operational hazard
by human error . All the limits switches and
the safety interlocking switches are flame
proof including the VFD controls.
Charging of MLR All charging is done by vacuum sucking to
Solvent recovery Hazardous waste after No specific hazard avoid spillages and through the closed SS
distillation pipe lines.
VTD is fitted with flame proof motors.
Drying Separation of solvents from Drying of the product in No specific hazard Unloading into the bins by actuated valve,
operation the product VTD Hence No- Less Exposure
Hand gloves & goggles should be used.
Reaction of Stage – I Bottom valve Operational control - checkpoint shall be
material, with Acetone, included in the batch sheet to indicate
Stage-2 Potassium carbonate and Charging Acetone opened, or Leakage whether the bottom valve has been closed
1,2,4-Triazole then filtrated of Bottom Valve prior to charging Acetone & is not Leaking.
and added Ethyl acetate Acetone addition pipe is kept to the Bottom
and Hydrochloric acid Fire hazard due to of the reactor
are flame proof.
Potassium carbonate Transfer to the reactor
eyes
1,2,4-Triazole Transfer to the reactor
eyes
The Filtration Operation is Carried out in
Spillage,Filter Cloth Closed SS Line, Filter cloth cleaned for Every
Block Batch & this Cleaning of the Filter along with
Filtration Cloth is Incorporated In the BPR
Acetone Charging SS pipe is Fixed to the
are flame proof.
of Bottom Valve prior to charging Ethyl acetate & is not
are flame proof.
of Bottom Valve prior to charging Hydrochloric acid & is not
Hydrochloric acid Leaking.
Hydrochloric acid addition pipe is kept to the
are flame proof.
Distillation of the till Distillation; the Acetone and ethyl
Loss of Acetone acetate Vapour Loss is due to Excessive
organic layer
and ethyl acetate heat, Instruction is Given in SOP, To Open
the steam valve to Optimum so as to
maintain the Distillation.
wires.
static electricity,
The filtration is carried out through a
Centrifuging To separate the liquid operator hazard if
centrifuge. Centrifuges are high speed
any loading /
machines and sources of hazard in a chemical
unloading activity
plant. Ample precautions are taken to carry
carried out in a out the centrifuging as hazard free as
running centrifuge possible. We are using a 48 inch dia SS316
Reaction of stage –II Instruction is Laid in the SOP , To Avoid
material, Sodium Spillage out side the spillage outside the Equipment,Lay down the
carbonate and Ethyl reactor, Poly Bags to Collect the spilled Material,&
Stage-3 acetate with water then Sodium carbonate Transfer to the reactor
separated the layer and Fire hazard due to SS scoops to avoid static electricity. The
added Ethyl acetate and reactor is earthed by conducting wires
cyclohexane tnen static electricity Using hand gloves & goggles.
centrifuge the reaction Irritation to skin &
mass eyes

of Bottom Valve prior to charging Hydrochloric acid & is not
Hydrochloric acid addition pipe is kept to the
are flame proof.
Distillation of the Loss of Ethyl till Distillation; the Ethyl acetate Vapour Loss
organic layer is due to Excessive heat, Instruction is Given
acetate
in SOP, To Open the steam valve to
Optimum so as to maintain the Distillation.
of Bottom Valve prior to charging Cyclohexane & is not
Cyclohexane Leaking.
Cyclohexane addition pipe is kept to the
are flame proof.
Centrifuging To separate the liquid static electricity, wires.
operator hazard if The filtration is carried out through a
any loading / centrifuge. Centrifuges are high speed
unloading activity machines and sources of hazard in a chemical
carried out in a plant. Ample precautions are taken to carry
running centrifuge out the centrifuging as hazard free as
possible. We are using a 48 inch dia SS316
Charging of MLR All charging is done by vacuum sucking to
Solvent recovery Hazardous waste after No specific hazard avoid spillages and through the closed SS
distillation pipe lines.
To manufacture of Bendamustin
Hazop Study - Process – for Bendamustin
failures
Stage I Reaction of Ethyl-4-(5- Addition of Ethyl-4-(5- Instruction is Laid in the SOP , To Avoid
(bis(2-hydroxy ethyl) (bis(2-hydroxy ethyl) Spillage out side the spillage outside the Equipment,Lay down
amino)-1-methyl-1H- amino)-1-methyl-1H- reactor, the Poly Bags to Collect the spilled
benzoid) imidazol-2- benzoid) imidazol-2- Material,& Transfer to the reactor
yl)butanoate in presence yl)butanoate Fire hazard due to SS scoops to avoid static electricity. The
of thionyl chloride. static electricity reactor is earthed by conducting wires
Irritation to skin & eyes Using hand gloves & goggles.
Charging of Thionyl Operational control - checkpoint shall be
chloride Bottom valve opened, included in the batch sheet to indicate
or Leakage of Bottom whether the bottom valve has been closed
Valve prior to charging thionyl chloride & is not
Leaking.
Thionyl chloride addition pipe is kept to
Fire hazard due to the Bottom of the reactor
are flame proof.
The centrifuge is earthed by conducting
wires.
Fire hazard due to The filtration is carried out through a
static electricity, centrifuge. Centrifuges are high speed
Centrifuging To separate the Ist operator hazard if any machines and sources of hazard in a
Stage From the liquid loading / unloading chemical plant. Ample precautions are
activity carried out in a taken to carry out the centrifuging as
running centrifuge hazard free as possible. We are using a 48
inch dia SS316 centrifuge, bottom driven
and top discharge. this is a four point
suspension machines which are put on
special vibra mount for smooth vibration
free noiseless operation. The speed is
controlled by a variable frequency drive
and the feeding of the centrifuge is done
by pneumatically controlled valves at
lower RPM under nitrogen purging. Even
the bearing housing of the centrifuge is
provided with a nitrogen purging facility.
An interlocking system is provided for
ensuring that the lids cannot be opened
while the centrifuge is running and
thereby preventing any operational
hazard by human error. All the limits
switches and the safety interlocking
switches are flame proof including the VFD
controls.
Charging of MLR
Solvent recovery Hazardous waste after No specific hazard All charging is done by vacuum sucking to
Distillation distillation avoid spillages and through the closed SS
pipe lines.
To manufacture bicalutamide
Hazop Study - Process – for BICALUTAMIDE

Process Operation Possible Hazards / Remedial Action
failures
Reaction of 10 N-[4- Charging of 10 Spillage out side Instruction is Laid in the SOP , To Avoid spillage outside the
cyano-3-trifluoromethyl N-[4-cyano-3- the reactor, Equipment, Lay down the Poly Bags to Collect the spilled
phenyl]-3-[4-fluorophenyl trifluoromethyl Material,& Transfer to the reactor
thio]-2-hydroxy-2-methyl phenyl]-3-[4- Fire hazard due to SS scoops to avoid static electricity. The reactor is earthed by
propanamide and fluorophenyl static electricity conducting wires
Potassium permanganate thio]-2- Irritation to skin & Using hand gloves & goggles.
in Acetonitrile. hydroxy-2- eyes
methyl
propanamide
Charging of Bottom valve Operational control - checkpoint shall be included in the batch
Potassium opened, or sheet to indicate whether the bottom valve has been closed prior
permanganate Leakage of Bottom to charging Potassium permanganate & is not Leaking.
Valve
Fire hazard due to Potassium permanganate addition pipe is kept to the Bottom of
static electricity the reactor. Pipe lines are all SS and equipment motors are flame
proof.
Charging of Bottom valve Operational control - checkpoint shall be included in the batch
Acetonitrile opened, or sheet to indicate whether the bottom valve has been closed prior
Leakage of Bottom to charging Acetonitrile & is not Leaking.
Valve
Fire hazard due to Acetonitrile addition pipe is kept to the Bottom of the reactor.
static electricity Pipe lines are all SS and equipment motors are flame proof.
Filtration Spillage, Filter The Filtration Operation is Carried out in Closed SS Line, Filter cloth
Cloth Block cleaned for Every Batch & this Cleaning of the Filter along with
Cloth is Incorporated In the BPR
Hazop Study - Process – for BICALUTAMIDE

failures
Fire hazard due to Acetone Charging SS pipe is Fixed to the Bottom of the reactor
Centrifuging To separate the Fire hazard due to The centrifuge is earthed by conducting wires.
bicalutamide static electricity, The filtration is carried out through a centrifuge. Centrifuges are
from the liquid operator hazard if high speed machines and sources of hazard in a chemical plant.
any loading / Ample precautions are taken to carry out the centrifuging as
unloading activity hazard free as possible. We are using a 48 inch dia SS316
carried out in a centrifuge, bottom driven and top discharge. This is a four point
running centrifuge suspension machines which are put on special vibra mount for
smooth vibration free noiseless operation. The speed is controlled
by a variable frequency drive and the feeding of the centrifuge is
done by pneumatically controlled valves at lower RPM under
nitrogen purging. Even the bearing housing of the centrifuge is
provided with a nitrogen purging facility. An interlocking system is
provided for ensuring that the lids cannot be opened while the
centrifuge is running and thereby preventing any operational
hazard by human error. All the limits switches and the safety
interlocking switches are flame proof including the VFD controls.
Solvent recovery Distillation of No specific hazard All charging is done by vacuum sucking to avoid spillages and
Acetonitrile through the closed SS pipe lines.
and hexane
into reaction
mass
Drying Separation of solvents Drying of the No specific hazard VTD is fitted with flame proof motors. Unloading into the bins by
operation from the product product in actuated valve, Hence No- Less Exposure
Vacuum tray Hand gloves & goggles should be used.
Dryer
To manufacture Bortizomib
Hazop Study - Process – for Bortizomib

failures
Stage I Reaction of 3- phenyl - Addition of Reaction of 3- Instruction is Laid in the SOP , To Avoid
2-[(pyrazine-2- phenyl -2-[(pyrazine-2- Spillage out side the spillage outside the Equipment, Lay down the
carbonyl)-amino] carbonyl)-amino] reactor, Poly Bags to Collect the spilled Material,&
propionic acid with R- propionic acid Transfer to the reactor
Borolex-(+)-pinanediol Fire hazard due to static SS scoops to avoid static electricity. The
trifluoro acetic acid electricity reactor is earthed by conducting wires
Charging of MDC Operational control - checkpoint shall be
Bottom valve opened, or included in the batch sheet to indicate
Leakage of Bottom Valve whether the bottom valve has been closed
prior to charging MDC & is not Leaking.
MDC addition pipe is kept to the Bottom of
Fire hazard due to static the reactor
electricity Pipe lines are all SS and equipment motors
are flame proof.
Hydroxy succinamide Spillage out side the Instruction is Laid in the SOP , To Avoid
reactor, spillage outside the Equipment, Lay down the
Poly Bags to Collect the spilled Material,&
Fire hazard due to static SS scoops to avoid static electricity. The
electricity reactor is earthed by conducting wires
Filtration Spillage Filter Cloth Block Closed SS Line, Filter cloth cleaned for Every
Batch & this Cleaning of the Filter along with
Charging of MLR
distillation avoid spillages and through the closed SS pipe
lines.
Filtration Spillage, Filter Cloth Block Closed SS Line, Filter cloth cleaned for Every
Batch & this Cleaning of the Filter along with
Stage II Addition of stage I Instruction is Laid in the SOP , To Avoid
product Spillage out side the spillage outside the Equipment, Lay down the
The Addition of Hydrochloric acid is charged
HCl Addition Hydrochoric acid Spillage through the Closed lines, without any
& Irritation Spillage, personnel Protective Equipments
are Used to avoid the Exposure & tackle the
irritation
Charging of N-Heptane Operational control - checkpoint shall be
prior to charging n-heptane & is not Leaking.
n-heptane addition pipe is kept to the Bottom
Fire hazard due to static of the reactor
are flame proof.
Saturated sodium Instruction is Laid in the SOP , To Avoid

bicarbonate Spillage out side the spillage outside the Equipment, Lay down the
Charging of MLR
lines.
Charging Ethyl acetate Operational control - checkpoint shall be
whether the bottom valve has been closed
Leakage of Bottom Valve
prior to charging ethyl acetate & is not
Leaking.
Fire hazard due to static Bottom of the reactor
are flame proof.
Charging methanol Operational control - checkpoint shall be
prior to charging methanol & is not Leaking.
Methanol addition pipe is kept to the Bottom
are flame proof.

Closed SS Line, Filter cloth cleaned for Every
Filtration Spillage, Filter Cloth Block Batch & this Cleaning of the Filter along with
Charging of MLR
lines.
Stage III Operational control - checkpoint shall be
Charging of methanol prior to charging methanol & is not Leaking.
methanol addition pipe is kept to the Bottom
are flame proof.
Addition of stage II Spillage out side the Instruction is Laid in the SOP , To Avoid
product reactor, spillage outside the Equipment, Lay down the
Poly Bags to Collect the spilled Material,&
Closed SS Line, Filter cloth cleaned for Every
Filtration Spillage, Filter Cloth Block Batch & this Cleaning of the Filter along with
Charging of MLR
distillation avoid spillages and through the closed SS
pipe lines.
RCVD is fitted with flame proof motors.
Drying Separation of solvents Drying of the product in No specific hazard Unloading into the bins by actuated valve,
operation from the product Rotocone vacuum Dryer Hence No- Less Exposure
To manufacture of Capecitabine
Hazop Study - Process – for CAPECITABINE
Stages Process Operation Possible Hazards / failures Remedial Action
Charging 5- Spillage out side the Instruction is Laid in the SOP , To Avoid spillage outside
the Equipment, Lay down the Poly Bags to Collect the
methyl reactor,
spilled Material,& Transfer to the reactor
tetrahydrofuran- Fire hazard due to static SS scoops to avoid static electricity. The reactor is
Reaction of 5-methyl 2,3,4-
tetrahydrofuran-2,3,4- electricity earthed by conducting wires
triyltriacetate
triyltriacetate, Irritation to skin & eyes Using hand gloves & goggles.
5-Fluorocytosine, Spillage out side the Instruction is Laid in the SOP , To Avoid spillage outside
Stannic chloride, the Equipment, Lay down the Poly Bags to Collect the
reactor,
TMSC, HMDS and Sodium Charging of 5- spilled Material,& Transfer to the reactor
bicarbonate into MDC Fluorocytosine Fire hazard due to static SS scoops to avoid static electricity. The reactor is
Stage -1 and toluene. electricity earthed by conducting wires
Irritation to skin & eyes. Using hand gloves & goggles.
Spillage out side the Instruction is Laid in the SOP , To Avoid spillage outside
reactor,
Charging of spilled Material,& Transfer to the reactor
TMSC Fire hazard due to static SS scoops to avoid static electricity. The reactor is
electricity earthed by conducting wires
Spillage out side the Instruction is Laid in the SOP , To Avoid spillage outside
reactor,
Charging of spilled Material,& Transfer to the reactor
HMDS Fire hazard due to static SS scoops to avoid static electricity. The reactor is
electricity earthed by conducting wires
Bottom valve Operational control - checkpoint shall be included in the batch
Charging of opened, or sheet to indicate whether the bottom valve has been closed prior
Leakage of Bottom to charging Stannic chloride & is not Leaking.
Stannic
Valve
chloride
Fire hazard due to Stannic chloride addition pipe is kept to the Bottom of the reactor.
opened, or sheet to indicate whether the bottom valve has been closed prior
Charging of Leakage of Bottom to charging MDC & is not Leaking.
MDC Valve
Fire hazard due to MDC addition pipe is kept to the Bottom of the reactor. Pipe lines
static electricity are all SS and equipment motors are flame proof.
Charging of Leakage of Bottom to charging toluene & is not Leaking.
toluene Valve
Fire hazard due to toluene addition pipe is kept to the Bottom of the reactor. Pipe
static electricity lines are all SS and equipment motors are flame proof.
Spillage, Filter The Filtration Operation is Carried out in Closed SS Line, Filter cloth
Cloth Block cleaned for Every Batch & this Cleaning of the Filter along with
Filtration
Fire hazard due to Tri methylamine and Sodium bicarbonate Charging SS pipe is
Fixed to the Bottom of the reactor. Pipe lines are all SS and
static electricity equipment motors are flame proof.
Distillation of Loss of ethyl The temperature is raised by slow heating till reflux; the methanol
Solvent recovery MDC and acetate and Vapour Loss is due to Excessive heat, Instruction is Given in SOP,
Toluene acetonitrile To Open the steam valve to Optimum so as to maintain the reflux
Charge IPA into reaction Charging of Leakage of Bottom to charging IPA & is not Leaking.
mass. Valve
IPA
Fire hazard due to IPA addition pipe is kept to the Bottom of the reactor. Pipe lines
static electricity are all SS and equipment motors are flame proof.

The filtration is carried out through a centrifuge. Centrifuges are high speed
machines and sources of hazard in a chemical plant. Ample precautions are
taken to carry out the centrifuging as hazard free as possible. We are using a 48
Fire hazard due to inch dia SS316 centrifuge, bottom driven and top discharge. This is a four point
static electricity, suspension machines which are put on special vibra mount for smooth vibration
Centrifuging To separate the Docetaxel operator hazard if any free noiseless operation. The speed is controlled by a variable frequency drive
Trihydrate stage-II from the liquid loading / unloading and the feeding of the centrifuge is done by pneumatically controlled valves at
activity carried out in a lower RPM under nitrogen purging. Even the bearing housing of the centrifuge
running centrifuge is provided with a nitrogen purging facility. An interlocking system is provided
for ensuring that the lids cannot be opened while the centrifuge is running and
thereby preventing any operational hazard by human error. All the limits
switches and the safety interlocking switches are flame proof including the VFD
controls.
Solvent Charging of ML’s Hazardous waste No specific hazard All charging is done by vacuum sucking to avoid spillages and through the closed
recovery after centrifuging
SS pipe lines.
Drying Separation of Drying of the product in vacuum VTD is fitted with flame proof motors. Unloading into the bins by actuated
solvents from No specific hazard valve, Hence No- Less Exposure
operation tray dryer Hand gloves & goggles should be used.
the product
Charge Bottom valve opened, Operational control - checkpoint shall be included in the batch sheet to indicate
capecitabine or Leakage of Bottom whether the bottom valve has been closed prior to charging Pyriddine & is
Stage-II stage-I, Charging of Pyriddine Valve not Leaking.
Pyriddine and n- Fire hazard due to Pyriddine addition pipe is kept to the Bottom of the reactor. Pipe lines are all
pentyl static electricity SS and equipment motors are flame proof.
chloroformate Bottom valve opened, Operational control - checkpoint shall be included in the batch sheet to indicate
into MDC. Charging of n-pentyl or Leakage of Bottom whether the bottom valve has been closed prior to charging n-pentyl
Valve chloroformate & is not Leaking.
chloroformate
Fire hazard due to N-pentyl chloroformate addition pipe is kept to the Bottom of the reactor.
Bottom valve opened, Operational control - checkpoint shall be included in the batch sheet to indicate
or Leakage of Bottom whether the bottom valve has been closed prior to charging MDC & is not
Charging of MDC Valve Leaking.
Fire hazard due to MDC addition pipe is kept to the Bottom of the reactor. Pipe lines are all SS and
Spillage, Filter Cloth The Filtration Operation is Carried out in Closed SS Line, Filter cloth cleaned for
Every Batch & this Cleaning of the Filter along with Cloth is Incorporated In the
Block
Filtration BPR
Fire hazard due to Pyridine Charging SS pipe is Fixed to the Bottom of the reactor. Pipe lines are
static electricity all SS and equipment motors are flame proof.
or Leakage of Bottom whether the bottom valve has been closed prior to charging Heptane &
Charge Heptane into organic Charging of Valve is not Leaking.
layer Heptane
Fire hazard due to Heptane addition pipe is kept to the Bottom of the reactor. Pipe lines are all SS
static electricity. and equipment motors are flame proof.
The temperature is raised by slow heating till reflux; the methanol Vapour Loss
Solvent recovery Distillation of MDC Loss of MDC is due to Excessive heat, Instruction is Given in SOP, To Open the steam valve to
Optimum so as to maintain the reflux
Fire hazard due to The filtration is carried out through a centrifuge. Centrifuges are high speed
machines and sources of hazard in a chemical plant. Ample precautions are
To separate the static electricity,
taken to carry out the centrifuging as hazard free as possible. We are using a 48
Capecitabine operator hazard if any
Centrifuging inch dia SS316 centrifuge, bottom driven and top discharge. This is a four point
stage-II from the loading / unloading
suspension machines which are put on special vibra mount for smooth vibration
liquid activity carried out in a
free noiseless operation. The speed is controlled by a variable frequency drive
running centrifuge
and the feeding of the centrifuge is done by pneumatically controlled valves at
lower RPM under nitrogen purging. Even the bearing housing of the centrifuge
is provided with a nitrogen purging facility. An interlocking system is provided
for ensuring that the lids cannot be opened while the centrifuge is running and
thereby preventing any operational hazard by human error. All the limits
switches and the safety interlocking switches are flame proof including the VFD
controls.
Charging of ML’s All charging is done by vacuum sucking to avoid spillages and through the closed
Solvent recovery Hazardous waste No specific hazard
after centrifuging SS pipe lines.
Drying Separation of solvents from the Drying of the VTD is fitted with flame proof motors. Unloading into the bins by actuated
product in No specific hazard valve, Hence No- Less Exposure
operation product
Vacuum tray dryer Hand gloves & goggles should be used.
or Leakage of Bottom whether the bottom valve has been closed prior to charging MDC & is not
Charging of MDC Valve Leaking.
Fire hazard due to MDC addition pipe is kept to the Bottom of the reactor. Pipe lines are all SS and
Charge capecitabine stage-II, Bottom valve opened, Operational control - checkpoint shall be included in the batch sheet to indicate
or Leakage of Bottom whether the bottom valve has been closed prior to charging methanol &
MDC, sodium hydroxide and Charging of
Valve is not Leaking.
hydrochloric acid into methanol
methanol. Fire hazard due to Methanol addition pipe is kept to the Bottom of the reactor. Pipe lines are all
static electricity SS and equipment motors are flame proof.
Stage-III Hydrochoric acid The Addition of Hydrochloric acid is charged through the Closed lines, without
HCl Addition any Spillage, personnel Protective Equipments are Used to avoid the Exposure
Spillage & Irritation
& tackle the irritation
Charging of Corrosive nature Use properly personnel protective equipment.
sodium hydroxide
Distillation of MDC Loss of MDC and The temperature is raised by slow heating till reflux; the methanol Vapour Loss
Solvent recovery is due to Excessive heat, Instruction is Given in SOP, To Open the steam valve
and methanol. methanol. to Optimum so as to maintain the reflux
Charge toluene into reaction Charging of Bottom valve opened, Operational control - checkpoint shall be included in the batch sheet to indicate
or Leakage of Bottom whether the bottom valve has been closed prior to charging toluene & is not
mass toluene Leaking.
Valve
Fire hazard due to Toluene addition pipe is kept to the Bottom of the reactor. Pipe lines are all SS
static electricity and equipment motors are flame proof.

The filtration is carried out through a centrifuge. Centrifuges are
high speed machines and sources of hazard in a chemical plant.
Ample precautions are taken to carry out the centrifuging as
Fire hazard due to hazard free as possible. We are using a 48 inch dia SS316
centrifuge, bottom driven and top discharge. This is a four point
To separate the static electricity, suspension machines which are put on special vibra mount for
operator hazard if
Centrifuging Capecitabine any loading / smooth vibration free noiseless operation. The speed is controlled
stage-III from unloading activity by a variable frequency drive and the feeding of the centrifuge is
the liquid carried out in a done by pneumatically controlled valves at lower RPM under
running centrifuge nitrogen purging. Even the bearing housing of the centrifuge is
provided with a nitrogen purging facility. An interlocking system is
provided for ensuring that the lids cannot be opened while the
centrifuge is running and thereby preventing any operational
hazard by human error. All the limits switches and the safety
interlocking switches are flame proof including the VFD controls.
Charging of
ML’s All charging is done by vacuum sucking to avoid spillages and
Solvent recovery Hazardous No specific hazard through the closed SS pipe lines.
waste after
centrifuging
Drying of the VTD is fitted with flame proof motors. Unloading into the bins by
Drying Separation of solvents product in No specific hazard actuated valve, Hence No- Less Exposure
operation from the product Vacuum tray Hand gloves & goggles should be used.
dryer
S.No Discription Yearly Data
2010 2011 2012 2013 2014 2015 2016
No.of minor 29 31 32 27 31 28 26
1 incident/accidents from
No.of major 0 0 0 0 0 0 1
2 incident/accidents from
No.of occupational health 0 0 0 0 0 0 0
diseases reported
3
4 No.of hot work permits 145 178 222 382
5 No.of height work permits 27 32 45 165
No.of vessel/confined space 58 82 103 197

entry work permits
6
No.of training programs 85 110 102 95 160 145 158
7 conducted on OH&S
No.of persons under gone 175 225 245 265 375 380 430
8 training
No.of competitions
conducted for creating 5 5 5 5 5 5 5
awareness on safety among
9 employees
10 Emergency response team 12 12 12 15 15 20 17
11 First aid trainings conducted 0 0 0 1 0 1 0
12 Plantations done 1850 2385 3885 4380 4682 4830 4950

13 Emergency control system 1 1 1 1
SHILPA MEDICARE LIMITED, UNIT-II
MEDICAL CHECKUP FOR EMPLOYEES, MAY-2016
Blood Analysis Urine Analysis

Blood VISION RESPIRA CARDIO CENTRAL ELECTRO CHEST X- RBC WBC Appearan PUS Sputum Remarks/Health Status
S.NO EMPLOYEE NAME DEPT. TORY VASCULAR NERVOUS CARDIO HB RBC TC DLC (%) AEC VDRL RBS Reaction Albumin Sugar RBC EP Cell
Group SYSTEM SYSTEM SYSTEM GRAM RAY Smear Smear ce Cells for AFB
Right Left Eye

Eye
Healthy & Free from Occupational health &
1 Y.Ramana G-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
2 K. Jindappa G-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
3 G. Timma Reddy G-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
4 S. Nagaraj G-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
5 K. Ramakrishna G-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
6 Suresh Shivamurthy G-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
7 B.Nageswara Rao E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
8 S.Venkata Ramana E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
9 T.Uday Kumar E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
10 V.V.China Bheema Raju E-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
11 Anjleya E-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
12 Anjeneya E-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
13 Marlingappa E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
14 M.Praveen Kumar E-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
15 A.Sasidhar C-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
16 Anil Gangadhar C-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
17 D.Madhava C-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
18 P.Nageswara Rao C-Block B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
19 Veera Subhramanyeswara Rao C-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
20 Prasanna Dhanshetti C-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
21 A.Suresh Reddy H-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
22 P.V.Shankar QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
23 K.Anantayya QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
24 Jyothi Prasad Reddy QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
25 B.Ganesh Kumar QC B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
26 Srinivasulu Lingam QC A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
27 Mukesh Balothiya AR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
28 Radha Satya Narayana AR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
29 Sambaji Shivaji Koli AR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
30 Meera masood Ali PD B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
31 Veerendra Kumar PD B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
32 Ganganna DM plant O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
33 Khajasab DM Plant B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
34 A.Suresh Safety B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
35 Gopal Reddy P R&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
36 D.Mallikarjuna Reddy R&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
37 Murali Krishna QA A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
38 Srinivasa Rao ENGG A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
39 Sandeep VG ENGG A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
40 Rama Prakash Sulakhe ENGG O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
41 Mohd Mustafa ENGG B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
42 Krishna ENGG B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
43 Sri Vallabha Mane ENGG O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
44 Yogesh Patil ENGG B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
45 Shaik Baji ENGG O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
46 Meenappa M ENGG B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
47 Aasish Goswami IT O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
48 S.Mohan Babu HR AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
49 Erranna Swamy Civil Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
50 Jindappa Civil B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
51 Jasvendra Kumar Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
52 Nageswar G Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
53 Suresh Goud B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
54 A.Ashok Kumar B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
55 Rama Mahendra Giri O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
56 Goindas Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
57 V.Bala Veeraiah AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
58 P.Bharat Kumar A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
59 Anupam Kapoor ERP B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
60 G.Arun Kumar Prod A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
61 M.Suman Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
62 Prabhu SS Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
63 DDN Srinivasa Rao Prod A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
64 Vereshappa Prod AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
65 G.Nageswara Rao Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
66 G.Praveen Kumar Prod AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
67 Sridhar Prod A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
68 Siddheswara Kumbhar Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
69 Umesh Jalkote Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
70 G.Srinivasa Rao Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
71 DP Singh Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
72 Kanaka Rao Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
73 Arun Kumar Prod A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
74 Gangadhar Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
75 Siva Yogi Shankar Kognure Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
76 G.Nagarjuna Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
77 P.Govinda Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
78 Amare Gouda Prod B- Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
79 K.Prasanna Kumar Prod A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
80 Chenna Reddy WH O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
81 Ahmed Pasha WH O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
82 Li.nga Reddy WH B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
83 Krishnam Naidu WH O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
84 Narasimhulu WH AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
85 M.Panduranga Naidu QA A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
86 N.Prasad Achanta QA AB- Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
87 K.Sathish Babu QA B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
88 BK Manga Raj QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
89 Devaraj Patil QC B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
90 B.Bharmannashivaraya QC AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
91 K.Surender Reddy QC A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
Contagious
92 Krishna QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative
diseases.
93 G.Sredhar QC A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
94 S.Jayadev Goranta QC A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
95 G.Ananathasena Reddy QC B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
96 Suresh Goud QC B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
97 N.Nagesh QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
98 B.Rajesh QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
99 D.Harnath Reddy QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
100 P.Jalandhar QC A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
101 Aasish Bedmutha QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
102 E.Kajan gouda QC O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
103 K.Anwar basha QC B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
104 Dr.U.Sheshachalam RA O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
105 Dr.Rafiuddin CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
106 Dr.Sanjay Hirpara CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
107 V.Arun Reddy CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
108 N.Jaganmohan Reddy CR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
109 Chandresh kumar tripati CR&D B- Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
110 arvind mishra CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
111 B.Yuva Teja CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
112 G.Venkata Reddy CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
113 U.Sridhar Babu CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
114 N.Ranjith CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
115 P.Satish CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
116 Vijay Kumar HP CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
117 T.Srinivas CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
118 Ajith Karpe CR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
119 Ramesh babu CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
120 Vishnu Vardhan reddy CR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
121 Ch.Raama Theerda CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
122 Ashok Kumar Addanki CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
123 Md.Azhar Hussain CR&D AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
124 Satya Narayana Danda CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
125 G.A.N.K.Reddy CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
126 Y.Veera Reddy CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
127 Rajavardhan Goud CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
128 Gangadhara Rao CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
129 G.Badraiah CR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
130 Dr.Vinod Kumar Singh AR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
131 Gopal Boblade AR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
132 Chandra Prakash AR&D AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
133 G.V.Pavan Kumar AR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
134 K.Narsappa Naidu AR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
135 Balaji kisanro kadam AR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
136 Dilip Kumar AR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
137 Sunil Shinde AR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
138 P.Srinivas Sarma P&A A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
139 Kuldeep Nagar Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
140 Munish Verma Prod B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
141 B.Eswara Rao Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
142 Aftab Ahmed Prod A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
143 S.Ashok Kumar Prod O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
144 Sanjay CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
145 karunakar CH AR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
146 K.Mangalagiri CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
147 N.Srinivasa Rao RA A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
148 Girisha CR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
149 Balaji Chandra CR&D AB+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
150 Narasimha Rao CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
151 Veera papaiah CR&D B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
152 Purandhar IPM O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
153 Nagesh IPM A- Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
154 M.Prasant Purohit CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
155 B.Poorna Chander Rao RA B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
156 B.Satish Kumar RA O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
157 M.Naresh Kumar CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
158 Dyaneswar vagare CR&D O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
159 Nanda Kumar Thegil AR&D A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
160 Paramanand G-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
161 C.Venkateswarulu G-Block O- Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
162 Raghunandan Gouda G-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
163 C.Sudhakar AJ-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
164 Ch.NagaBabu E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
165 M.Venkata Subba Rao E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
166 M.Praveen E-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
167 C.Srinivasulu E-Block O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
168 Sukadev Mahanti C-Block A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
169 B.Kasi Naidu ERP A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
170 P.Shiva Prasada Rao ENGG B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
171 N.Naga Raja ENGG A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
172 P.Rama Chandra Rao ENGG B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
173 Lav Kumar IT O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
IT
174 Vijay Kumar B+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
175 Kapil Khandelwal HR Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
176 Uma Kanth HR O+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
177 Sharanappa Admin A+ Normal Normal Nil Nil Nil Nil Nil Normal Normal Normal Normal Normal Normal Normal Normal Normal Clear Acidic Nil Nil Normal Nil Normal Negative Contagious diseases.
(l)
'F.No. J-11011/71,2007'lA[
Government
Forests
of lndla
Ministry of Environment and
(l'A'Division)
Paryavaran Bhawan
CGO ComPlex, Lodhi Road
New Delhi - 110 003
plahuiarai@vahoo.com
Telefax: 011 - 2436 3973
Dated: March 1r'2008
To,
-r4atsshilpa Medicare Limited

Gunj
10/80, Rajendra
102
Raichur-584
Karnataka
Karnataka by M/s
Subject: Expansion Proiect of Bulk Drug Unit at Raichur'
Shilpa regarding'
Medicare Limited- Environmental Clearance
Sir,
KindlyrefertoyourletterNo.SMU24/06.07dated?4bMarch2007seeking
proiec't'
environment clearance for the above mentioned
2.TheMinistryofEnvironmentandForestshasexaminedtheproposal.ltisnoted
thattheproposaliSforexpansionoftheexistingBulkDrugUnitatSurveyNo.33'334. aO, +t-li, itrict<sugur village in
capacity of the projest,
Raichur Districi of Karnataka. The
pro.iect is Rs. 21.83 crore3
after expansion wi[re tzo-.zs rpe. Total cost of the existing out of
protection and recuning cost for the
which 0.g6 C/ores will be for environment
samewillbeRs.o.24crores.Thetotallandarearequiredfortheprojectis0S.3Sha.The
SitedoesnotinvolveanyReserveForestsorEco-sensitivearea.NoR&RiSrequired'
expansion projecl-
The following 13 Produc{s shall be produced under the
Name of Products
9 lrinotecan HCI Trihydrate 0.1
10 Oxaliplatin 0.05
{1 Paclitaxel 0.1
12 Temozolomide 0.1
13 3a, 7B-Dihydroxy Cholanic Acid 60
Total 126.8
Power
3. Consumption will be 500 t(\,/A which will be met from KpTCL. DG Sets of
provided
500 KVA shall be as back up. Water requirement for the project shall be 13200
LTD. generation
Waste water will be 8000-9000 LTD which will be treated in the ETp and
used for gardening and landscaping.
4. The project activity is listed at S (0 and is of ,8, Category in the Schedule of EIA
Notification, 2006. The Project was considered as per para 2.1.1 (i) of the lnterim
operational
Guidelines dated 13s oc'tober2006 issued by the Ministry as the pubtic
Hearing for the proiect was held on 07.08.2006.
Based
5. on the information submitted by you, the Ministry of Environment and
Forests
hereby accords environmental clearance to the above project under the
provisions
of EIA Notification dated 14h september 2006 subject to compliance of the
following Specific and General conditions:
A. SPECIFICCONDITIONS:
Emissions
from the process vents shall be water/ alkali scrubbed & scrubbed
water shall
be treated in ETP. Scrubber efficiency shall be minimum g5o/o.
cyclone separator/EsP
with a minimum stack height of 30 m sha[ be instafled for
dispersion
of Particulate matter. Cyclone separator efiiciency shall be minimum
90%.
There shall be
l[. no odour nurbance from products & matErial used. odour shafl be
controlled as per the Guidelines of CpCB.
Regular yOC
monitoring of HC and shall be carried out at various probable
locations in
the ambient air in and around the plant and in the wort< zone area,
Water
withdrawal shall not exceed l3,2OO LTD which shall be sourced from rhe
Municipal supply.
The waste generation g00o the
water shall not exceed LTD which shafi be treated in
ETP up to tertiary
treatment and shall be used lor gardening and landscaping,
after meeting
the discharge norms. Domestic water wifi be sent to septic tank followed by
soak pil
/
(vi) Dedicated scrubbers and stacks of appropriate height as per the CentrEit
Pollution Control Board guidelines shall be provided to control the emissions
from
various vents. The scrubbed water shall be sent to ETp for further
treatment.
(vii) All the storage tanks will be under negative pressure to avoid ariy leakages.
Breather system
valves, N, blanketing and secondary condensers with brine chilling
provided All liquid
shall be for all the storage tanks to minimize vapour losses. raw
handling systems for
material shall be stored in storage Tanks and Drums. Closec
will be provided for
chemicals and solvents will be provided. Magnetic seals
pumps/agitators
for reactors for reduction of frrgitive emissions. Solvent traps
'be generating
shall installed wherever necessary. Reaclor solvent vapors will be
connected to condensers with receivers.
All other
(viii) venting equipment shall have vapour recovery system. All the pumjs anc
equipment's provided
where there is a likelihood of HC leakages shall be with
Leak Detection and Repair (LDAR) system and LEL indicators and Hydrocarbon
provision
detectors. for immediate isolation of such
equipment, in case a
of a leakage will also be made. Ttie company shall provide well defined Leak
Detection and Repair (LDAR) programme for
quantification and control
of fugitive emissions. The detectors sensitivity will
be in ppm levels.
The company
(ix) shall undertake following Waste Minimization measures.
Metering and control quantities

of of active ingredients to minimize waste.
Reuse of by-products
from the process as raw materials or as raw material
substitutes in other processes.
Use
of automated ,illing lo minimize spillage.
Use of
"Close Feed. system into batch reactors.
Venling
equipment through vapour recovery s)rslem. .
Use of high pressure
hoses for equipment cleaning to reduce waslewater
generation.
Fugitive emissions in
(x) lhe work zone environment, product, and raw materials
storage area shall be
regularly monitored. The emissions shall conform lo the
limits pollution
imposed by tbe State Control Boardycentral pollution Control Board.
The project
(xi) authorities shalr strictry compry with the rures and guiderines under
Manufacture, Stoiage
and lmport of Hazardous Chemicalshules, 1989 as
amended in October,
1994 and January, 2000 and Hazardous Waste
(Management and
Handling) Rules, 19g9, as amended from time lo time.
Aulhorization from the
obtained for collection, treatment,
storage, and disposal of AII T
packeo
Process waste, efe stuOge and Organic residue shall Le collected and in
proof
HOPE bags and stored temporarily in a separate leachate covered shed till
disposal into TSDF. 2oo kg of CoalAsh shall be sold to Brick manufac{urers'
vm. Spent solvents shall be recovered as faras possible I recovery shall not be less
than 98 percent. Solvent vapours emitted during purification process from
purification tanks as fugitive emissions shall be reduced as far as Possible. All
venting equipment shall have vapour recovery system.
The Company shall implement various commitments made during the Public
Hearing.
GENERAL CONDITIONS :
0 The piojec{ authorities shall strictly adhere to the stipulations made by the State
Pollution Control Board.
(iD No further expansion or modifications in the plant shall be carried out without
prior approval of the Ministry of Environment and Forests. ln case of deviations or
alterations in the .project proposal from those submitted to this Ministry {or
clearance, a fresh reference shall be made to the Ministry to assess the
adequacy of conditions imposed and to add additional environmental protection
measures required, if any.
(ii0 At no time, the emissions shall exceed the prescribed iiritr. tn the event of
failure of any pollution control system adopted by the unit, the unit shall be
immediately put out of operatien ,pnd shall not be restarted until the desifed
efficiency has been achieved.
(iv) The gaseous emissions (SO2, NOx, CO, VOC and HC) and Particulate matter
along. with ..RSPM .levels from . various process units shall conform to the
standards piescribed by the concemed authorities from time to time. At no time,
the emission levels shall go beyond the stipulated standards. ln the event of
failure of pollution control system(s) adopted by the unit, the respective unit shall
not be restarted until the coritrol measures are rectified to achieve the desired
efficiency. .
(v) The locations of ambient air quality monitoring stations shall be reviewed in
consultation with the State Pollution Control Board (SPCB) and additional
stations.shall be installed, if required, in the downwind direction as \nell as where
maximum ground level concentrations are anticipated.
(xxiii) r::t to
The project autt imprem ent the
conditio n s iT'li',r!ni','",":,i[?
",r,n [JX""T::: tr
iiil"?t'T:ffJ,;l"J?,Hl'1""trI#1il#*1l1l:Sitiii:xffisafl
purpose. not be diverted for any other
(xxiv) ._,
The implementation of rha
monitored by the ^.^;^- vis-a-vis envirot aclion plans
"i^:1!: nusio"j#;;;;:lmental
f;:l
monthlv shall b€
.l'ffiyJil3i:,ffi
comprianollf-"4
"r,no"o""ilo"ffjiil";Titriffi f:":i",T;
(xxv)
The project propon(
,#*#i
^;y",m
rff^H:fl:l{;'=ffiII j:y:lf i$#ilffi ,+ljiT
concerned Regional
The project
(xxvi) authorities shrI i^{^*
jT"rr]:?;
1'*::*.[:l;}*,,i#.m1:fi:1T1,,nT,r,r[,,,;
,?" rhe crearance, ir impremenration
"oJ:"#ffg.T:ffi::,,:fi:uspend or any or ,
7.
The Ministry reserves
necessary.r*-ii,"*"1,"*};J,:j.,:",":,:fi
lin;*xH:.:T1:;r;..,,,o,n.
g;*il5,,s#ttri*.x***istl.i*i?,
-r.,
;,!a*1a *-F.-.-nb.
(xii) The overall noise levels in and ardund the plant area shall be kept well within the
acoustic hoods'
standards by providing noise control measures lncluding
generation'The ambient noise
silencers, enclosures etc'on alt sources of noise levels shall
(Protection)
conform to the standards prescribed under Environment
(night time)'
Act, 1986 Rules, 1989 viz. 75 dBA (day time) and 70 dBA
green belt as per the CPCB
(xiii) 25% of the total area shall be developed as
guidelines.
shall be canied out on a
(xiv) Occupational health surveillance ofthe workers
regular per Factories Act'
basis and records shall be maintained as the
(xv) Training shall be imparted to all employees on safety and health aspec-ts of
periodicat medical
chemicals handling. Pre-employment and routine
examinations basis'
for all employees shall be undertaken on regular
shall be ensured'
(xvi) Usage of PPEs by allemployees/workers
mentioned in the
(xvii) The company shall strictly follow all the recommendations
(CREP)'
Charter on Corporate Responsibility for Environmental Proteclion
from rooftops of the
(xviii) The company shall harvest surfac,e as well as rainwater the
buildingsproposedintheexpansionprojectandstormwaterdrainstorecharge
thegroundwaterandusethesamewaterforthevariousactivitiesofthepoect
to conserve fresh water. .
(xix) The project proponent shall also comply with all the environmental protection
the
measures and safeguards proposed in the EINEMP report'All
recommendationsmadeinrespectofenvironmentalmanagementandrisk
mitigation measures relating to the project shall be implemented'
(xx) The company witt undeilafe i[ rbli;vant measures, as indicated dwing the Public
sunounding area'
Hearing for improving the Socio-economic conditions of the csR
administration
activities will be undertal(en by involving local villages and
(xx0 The company shall undertake ecodevelopmental measutes including community
the
welfare measures in the project area for the overall improvement of
environment. The ecodevelopment plan should be submitted to the SPCB within
three months of receipt of this letter for approval.
fledged
(xxii) A separate Environmental Management Cell equipped with full
Management
taboratory facilities shall be set up to carry out the Environmental and
Monitoring functions.
Copyb.
The Principal Secretary Department of Forests, Ecology & Envirorment

Govemment of Kamataka, room No. 404, 4s Floor, ll Stage, Multi Storeyec
Building, Eangaloie'560 001
Z The Chief Conservator of Forests, Regional Offic€ ( Southem Zone) , Ministry oF
Environment & Forests, lGndriya Sadan,4h Floor, C& F \Mrg, 17 Main Red, ll
Block , Kormangla, Banglore- 560 034; Kamataka .
parivesh
3. The Chairman, Central PdMion Control Board Bhavan. CBD-cumOfiice
Complex, East Arjun Nagar, New Dethi - 110 032.
paryavaran \
The Chairman, A.P.Pollulion Control Board, Bhavan, A-3, lndrstrial
Estate, SanathlGltr, Hyderbad- 5OO OlB, A.p.
Monitoring Cell, Ministry d Environment and Forests, paryavaran Bhavan, C6O

Complex, New Delhi.
6. Guard File.
7. Monitoring File .i.!:

Record File.
I
I
(Dr.P.L Ahuianil'
Director
RAICHUR
II,I..l
Fu;{, i Fax : 080-25586321 ar essera83,25589112
de*eef i E-mail :ho@kspcb.gov.in
E3arldJstr / Website : http:/lkspcb.gov.in 255881 51, 25588270
25588142,25586520
Smr*xd
ffi% M#e##* frffi*m;#,rx ffi**ffiS
ffimrsamtmkm pqlHH#efimxa
s€m*m ffilrxx6rm6 ffiwsard
"doddqld$", 1 00d sse
$daddr, do.49, rjucrsfls, tiorlcadr - 560 001, irnrud, ryadd
"Parisara Bhavana", 1st to Sth Floor,
# 49, church street, Bengaluru - 560 001, Karnataka, INDIA
F()ntuI-2
lsEE RULE s(4)l
IZATION
No.
PCBA4i MC/SE0/Ireg.No.S0480/20r:-l+t $ I L,, Daretl:
I i," ji I i, .:lt r*
l' The Vice Presidenr of M/s. shilpa
Industrial Grou,rh Medir:are Ltd - tinir II, plot
No. 33, 33A, 40 ro +1, nr"il,i,.J
Chicksugar._ Sg4l34, Raichui.,
!e1te-r", *arnaral<a, is hereby grarrred arr
-5(a) Hazirclous^\\zaste
authorizatiort u,der Rule of (i\,ranag.,r",,i. Handling arrd rr.ansbourrdar.\,
Move,re,1) Rules.200B as.arnended
upto.20l0lbr handliig;nrrraous wasfe in rlre rriarrer
indicated belou, rvhile carrying
orr tlre acrivitl, crf rrratrufacture of bulk clrLrus.
-
*::*', ",.,,-
t'' .":*"-'{cs iru:x-r$ir*#:ffini$ri
, ; I KL/A ; R;;,;;r;;,l"p,o.,iaeo rtre oil ,rcers rtre
L'scd
' oil ,
I i i i statrdards as pril' pan o ., ii,"

Sciredute 5" '
i 20.2 I Spenr sotverrr , 89 KL/A ; Shall be-*ro,ecl iiiitei*iiii-i,ii,i;";;ij-iliil l

i 20,3 i Distillatiorr Residue ,, I M-rtn 1 Shall be str:red irr a securid n*rii.,:iiii-fiarij I
j Shalt o:.*"^l:g
i 28.1 i Residue arrd Waste j t narr,+ iu isi.r=a ,,*l.*,,0
r,*ra i
i
| 28,2 i Sp.nr car.borr j q s jvre j llTl,.o::::;d ,aJ;*",J ,,rar*l ;;J il,",

i-'-----'-----.''---i r I Oveft( auth*r iz-ed 'fSDF.
: DiscaldedUlscal'{led/-rro. .i^^r i iShallI Gur ai;;:ils(c),eq ill i} Secttred
ChenricatLltenriCal j .,^^,,
, -^- jiDiqca,.,- ..r rrla'rShattI
over
il;ie.#d ;ir;ii,ie,:iiilttlannet'artdiiiiiiirartd
: Contairrers r i600 NoVA j
J3,3
; -"'" to KSPCB autliorizecl Recycler. afler

' 3{.3 , Sluclg,efi'cur\48.8I
i ;,:,ra1,1 jiSt,iriu"iior".i,;;;c;,;A;lr,,,,", i,iariii.,,t
* *--i-- i nr;e" t.- EDrD r rz\^,-
* * __ _, over ro KSICB aurlrorizerJ^.,-r^-.----- TSDF
t1
I
This
authorizatiorr is issued r'r'itht'etelence
cratecr: zg.0s.20rJ
ro the appricatiorr
fcrrce for
a periocl frrlrr 01.07.2013 t':o.oa.zoig arrcl u,iil be in
authorizarion rnt*rr.,,,.,."11ed
is *alid if the co,sents are'alid or suspe,clecl. (..Ttris
others,ise ir is nof a
'lhe to 'aliclautlror.izatio,.,).
Iire corrditions
l- authorizatirrrr is subjected
$tatecl belr:r,v ancl such condirions as rrra.r,tre

specifiedintheRulesfol'titetinrebeinginfcrrceunclerthel;i.virourrrent(protection)Act,
19g6.
FOR
& ON BEI-]AL,F OF'KSPCB
sd/-
N{EMBER
SEC]RET,,TRY
"ry&,frS *dd *.9,*" trt*d{: mse A\r*X) trli[ ,Sfl{},trry1p;ftge

{}i:] i:,'t-,q,$i*ilS" {:$f I of 2
#&&,

HAZOP Centrifuge and Dryer

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HAZOP ANALYSIS

To manufacture of Ambroxol hcl

Hazop Study - Process – for Ambroxol Stage-1

Hazop Study - Process – for Anastrozole

Operational control - checkpoint shall be

Hazop Study - Process – for BICALUTAMIDE

Hazop Study - Process – for BICALUTAMIDE

Hazop Study - Process – for Bortizomib

Saturated sodium Instruction is Laid in the SOP , To Avoid

The Filtration Operation is Carried out in

The centrifuge is earthed by conducting wires.

The centrifuge is earthed by conducting wires.

No.of vessel/confined space 58 82 103 197

11 First aid trainings conducted 0 0 0 1 0 1 0

12 Plantations done 1850 2385 3885 4380 4682 4830 4950

Blood Analysis Urine Analysis

Right Left Eye

-r4atsshilpa Medicare Limited

Metering and control quantities

The Principal Secretary Department of Forests, Ecology & Envirorment

Monitoring Cell, Ministry d Environment and Forests, paryavaran Bhavan, C6O

7. Monitoring File .i.!:

I i i i statrdards as pril' pan o ., ii,"

i 20.2 I Spenr sotverrr , 89 KL/A ; Shall be-*ro,ecl iiiitei*iiii-i,ii,i;";;ij-iliil l

| 28,2 i Sp.nr car.borr j q s jvre j llTl,.o::::;d ,aJ;*",J ,,rar*l ;;J il,",

; -"'" to KSPCB autliorizecl Recycler. afler

$tatecl belr:r,v ancl such condirions as rrra.r,tre

"ry&,frS *dd *.9,*" trt*d{: mse A\r*X) trli[ ,Sfl{},trry1p;ftge

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i 20.2 I Spenr sotverrr , 89 KL/A ; Shall be-ro,ecl iiiiteiiiii-i,ii,i;";;ij-iliil l

| 28,2 i Sp.nr car.borr j q s jvre j llTl,.o::::;d ,aJ;",J ,,rarl ;;J il,",

"ry&,frS dd .9," trtd{: mse A\r*X) trli[ ,Sfl{},trry1p;ftge