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Parkinson’s Disease
Transers: RXmen
PARKINSON
DISEASE
neurocognitive disorder
characterized by a syndrome
composed of combinations of
bradykinesia, rigidity, tremor
and postural instability
PARKINSON
DISEASE
first described in 1817 by James
Parkinson as the “shaking palsy”
second most prevalent neurodegenerative
disorder after Alzheimer’s disease
typical age of onset is between 50-70 y/o
Diagnosis
1. Presence of at least two of the three
cardinal features of parkinsonism:
- tremor
- rigidity
- bradykinesia
2. Presence of at least two of the following:
- marked response to levodopa
- asymmetry of signs
- asymmetry at onset
3. Evidence of disease progression
4. Absence of clinical features of alternative
diagnosis
5. Absence of etiology known to cause
similar features
PARKINSON
DISEASE
No Functional Impairment
Pharmacological treatment is not
needed
Non-pharmacologic interventions may
be initiated during this time, which
include:
Education
Support services,
Management of emotional needs of the
patient and caregiver
Exercise
Nutrition
Physical therapy
Levodopa
• a precursor of dopamine
• Most effective antiparkinsonian drug
• Gold standard of treating PD
• Absorption is interfered by dietary
amino acids coming from foods rich in
protein taken on an empty stomach
• For patients older than 60 years old
LEVODOPA + CARBIDOPA
(Sinemet)
100/25mg, tablet
# 30 tablets
Refill: 0
LEVODOPA + CARBIDOPA
(Sinemet CR)
Refill: 0
200/50mg, tablet
# 30 tablets
100/25mg, capsule
# 30 tablets
LEVODOPA + CARBIDOPA +
ENTACAPONE
(Stalev)
Refill: 0
PRAMIPEXOLE HCl
(Ramipex)
Warning:
Watch out for the following: nausea,
vomiting, dizziness, hypotension, and
syncope.
Medication for
Parkinson Disease
PRIBEDIL
(Trivastal Retard)
50 mg, tablet
# 30 tablets
Refill: 0
BIPERIDEN HCl
(Akineton/Akidin)
2 mg, tablet
# 30 tablets
Refill: 0
AMANTADINE SULFATE
(PK-MERZ)
Refill: 0