MATERIAL SAFETY DATA SHEET SECTION 1 MANUFACTURE 3-15 EDOBOR!, 1-CHOME NISHI-KU, OSAKA HEAL EMERGENCY TELEPHONE Chemical Name and Synonyms Trade Name and Synonyms ISHIHARA SANGYO, KAISHA, LTD. PRODUCT LDENTIFICATION U.S, DISTRIBUTOR USHIHARA CORPORATION (U.S. A.) 601 CALIFORNIA ST... STE 1700 SAN FRANCISCO, CA 94108 (415) 421-8207 NUWEER (@00) 424-9300 (CHENTREC) Titanium Dioxide, Titanium White, Titania TIPAQUE OR-S7 [ons wo 13463-67-7 , Chemical Fani ly Inorganic Oxide | Formula Tide SECTION 2: HAZARDOUS INGREDIENTS UauveriaL ov covpovewr | cas. no % | PEL costa) TU IACSIH) : | i TEne/ou.n. total) Titaniun Dioxide jin. 90.0]. Sng/cu.m. 10ng/cu. m | espirable) | Avuminum Hydroxide 21645-51-2 | Wax. 3.0 | Non estebl ished | 2mg(AI)/cu. [aire oxide | 11628-4 Jane 1.0 [ton estabtited | Non estab tished (Titanium Dioxide is Tisted in Group 28 (Possibly Carcinogente to human) by (ARC PAGE (1) oR-57SECTION 3: PHYSICAL DATA ‘Appearance (Sol id, Liquid, Gas) | Powder Boi ling Point Not applicable Color White Specific Gravity 39 ~ 42 Solubility in Water Insoluble Bulk Density 02 ~ 12 Volatile by Volume Not applicable | Vapor Density (Air=1) | Not applicable SECTION 4: FIRE AND EXPLOSION HAZARD DATA Flash Point Inconbust ible Flammable Limits Inconbustible Extinguishing Media Not required Special Fire Fighting Procedures Not required Unusual Fire and Explosion Hazards None SECTION 5: HEALTH HAZARD DATA Effects of Overexposure Irritating to respiratory system Eye: Wash gently with water Energency and First Aid | Skin: Wash with water and soap Inhalation: Remove Person fron dust contaninated area Procedures Ingestion: In case of excessive ingestion, drink a quart or more of water, followed by glass of milk and caf! physician SECTION 6: TOXICOLOGICAL INFORMATION (1) Skin Corrosion _; No specific records avai lable. 2 Irritants Derma Very stight irritation to the skin could occur. 1) Respiratory Gross overexposure by inhalation may include mild and temporary upper respiratory irritation, 2) PAGE ( 2) oR-87@) Acute Toxicity Oral Adninistration LDso >12000ng/Kg in rats. 3,4) Intramuscular Injection : TDLo 360ng/Kg/2 years in rats. 5) TD 260ng/Ke/B4weeks in rats. 6) Inhalation No evidence of lung disease in humans and animals under long-term exposure to respirable Ti02. 7) TCLo 250ng/m=/6Hrs/2years in rats. 8) (@) Chronic Toxicity No specific signs of toxicity were observed in dogs, cats. rabbits and pigs after ingestion of Ti02 over 990 days. 4). (8) Carcinogenicity IARC: Group 28 (Possibly carcinogenic to hunans) 7) (6) Mutagenic Activity No literature avai lable. SECTION 7: SPECIAL PROTECTION INFORMATION tJ Respiratory Protection If exposure limits may be exceeded, use OSHA ( Specify Type) pernissible respirator Optional = May be worn to protect ekin If there is any drying effect from dust Safety glasses or goggles are suggested if dust is present Protective Gloves Eye Protection Other Protective Equipment | Not required SECTION 8: REACTIVITY DATA Inert to most chemicals, reagents, Stable Stebi lity under al conditions Tnoonpatibi Vity | later ials to Avoid) Hazardous decomposition or byproducts YWazardous Polymerization Will not occur conditions to avoid | None None None ( No Deconpos tion products) PAGE ( 3) R57SECTION 9: PRECAUTIONS FOR SAFE HANDLING AND USE Steps to be taken in case material is released or spilled Use any feasible mechanical neans to renove ‘spilled” material such as broom, brush, scoop, vacuum, or wet absorbent materials, but avoid spreading dust during clean up. Wisste disposal method Comply with Federal, State and local regulations Precautions to be taken in handling and storing ‘Store in cleen, dry place. Keep work area free of spill ‘Avoid ingestion as a comon sense measure. SECTION 10: SPECIAL PRECAUTIONS Hills Rating Health 1 Flanmabi lity ° Reactivity ° Naximum Personal Protection Ee SECTION 11: REGURATORY INFORMATION _ TSCA All component are listed on TSCA inventory. TSCA 12b(Export) Notification not reauired Cenadian DSL All component are listed on DSL inventory. SARATI Section 311 No Section 312 No jection 318 _Ne Calif. Proposition 65 None listed [ CERCLA RO None IATA Not regulated a bor Not regulated PAGE (4 ) cR-57REFERENCES Cutaneous Toxicity V.A.Dril! and P. lasar. eds. ,New York, Academic Press p127(1977) 2 TITANIUM DIOXIDE (Japan Titanium Dioxide Industry Association) P. 1 No62(1988) 3) FRAGRANCE JOURNAL P. 4 NoB0 (1986) 4) IPOS Environmental Health Criteria 24. Titanium(1982) 5) Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by the Institute of Chemical Biology, University of San Francisco. . AUG(1968) 8) Progress Report for Contract No. PH-43-64-886, Submitted ta the National Cancer Institute by the Institute of Chemical Biology, University of San Francisoo, , AUG(1969) 7) IARC RECENTLY EVALUATED TITANIUM DIOXIDE) 5, SUMMERY OF DATA REPORTED POSTED 27 FEBRUARY 2006 8) Toxicology and Appl ied Phanacol ogy, 79, p179 (1985) Although the information contained herein was believed to be accurate at the ‘time of preparation, ISHIHARA SANGYO KAISYA makes no guarantees and assume no responsibility for how this information is used. Users af this product should independently research data that nay be pertinent to their application, Date of latest revision : May 12, 2008 Prepared by: Qual ity Assurance Group ual ity Assurance Division (Telephone Number : 81-59-345-6148 Japan) Person Responsible for MSDS: Global Environmental Division (Telephone Nunber : 81~6-6444-5813 Japan) PAGE (5) R57