Waktu (jamKadar Obat (mccg/mL) 1.

Durasi Obat adalah 3 jam bisa dilihat d

1 3.5
2 6.7 2 Ka = 2.303 x (-0.15) = 0.34545
3 4.9 Ke = 2.303 x (-0.45143) = 1.039
4 3.6 t1/2abs = 0.693/Ka = 2.006079
5 2.6 t1/2elim = 0.693/Ka = 0.66657
6 1.8
(𝐷𝑂 𝑥 𝐹 𝑥 𝐾𝑎)/(𝐶�° (𝐾𝑎−𝐾𝑒))
7 1.2 Vd =
8 0.8
9 0.5 (3 𝑥 0.8 𝑥 −0.34545)/(3.6 (0.34545
10 0.3
0.82908/2.4990
95844

Vd = 0.331751982218
AUC = 1/2 x A x T = 1/2 x 10 x 6
Cltot = Vd x Ke = 16 x -1.039643
Obat adalah 3 jam bisa dilihat dari awal kurva naik tepat saat MEC 4 mcg/mL pada jam pertama dan sampai jam ke-4

Ka = 2.303 x (-0.15) = 0.34545 Cara Berbeda

Ke = 2.303 x (-0.45143) = 1.03964329 F = f x (1-ER)
t1/2abs = 0.693/Ka = 2.0060790 f = seberapa diabsorbsi, absorbsi penuh dianggap 1
t1/2elim = 0.693/Ka = 0.6665747825872 0.8 = 1 x (1-ER)
ER = 0.2
(𝐷𝑂 𝑥 𝐹 𝑥 𝐾𝑎)/(𝐶�° (𝐾𝑎−𝐾𝑒))
Vd =
ER = CL/Q
0.8 𝑥 −0.34545)/(3.6 (0.34545 −1.039643290)) Dianggap clearance hanya pada hepar,
jadi Q adalah liver blood flow yaiut 90 L/h
0.2 = CL/90
0.82908/2.4990
95844 CL = 18
t1/2 = 0.7 x VD/CL
Vd = 0.331751982218 t1/2 = 0.7 x 16/18
AUC = 1/2 x A x T = 1/2 x 10 x 6.7 = 33.5 t1/2 = 0.67
Cltot = Vd x Ke = 16 x -1.03964329 = 16.63429264
SUMMARY OUTPUT

Regression Statistics
Multiple R 0.129701
R Square 0.016822
Adjusted R -0.47477
Standard E 1.813146
Observatio 4

ANOVA
df SS MS F Significance F
Regression 1 0.1125 0.1125 0.034221 0.870299
Residual 2 6.575 3.2875
Total 3 6.6875

Coefficients
Standard Error t Stat P-value Lower 95%Upper 95%
Lower 95.0%
Upper 95.0%
Intercept 5.05 2.220642 2.274117 0.150811 -4.50465 14.60465 -4.50465 14.60465
X Variable -0.15 0.810864 -0.18499 0.870299 -3.63887 3.338865 -3.63887 3.338865
SUMMARY OUTPUT

Regression Statistics
Multiple R 0.97132
R Square 0.943462
Adjusted R 0.929327
Standard E 0.231146
Observatio 6

ANOVA
df SS MS F Significance F
Regression 1 3.566286 3.566286 66.74866 0.001222
Residual 4 0.213714 0.053429
Total 5 3.78

Coefficients
Standard Error t Stat P-value Lower 95%Upper 95%
Lower 95.0%
Upper 95.0%
Intercept 4.585714 0.425017 10.78948 0.000418 3.405678 5.765751 3.405678 5.765751
X Variable -0.45143 0.055255 -8.16999 0.001222 -0.60484 -0.29802 -0.60484 -0.29802