3/31/2018 APUD cell - Wikipedia

APUD cell
APUD  cells constitute a group of apparently
unrelated endocrine cells, which were named by the
scientist A.G.E. Pearse, who developed the APUD
concept in the early 1960s. These cells share the
common function of secreting a low molecular weight
polypeptide hormone. There are several different
types which secrete the hormones secretin,
cholecystokinin and several others. The name is
derived from an acronym, referring to the
following:[1][2]

Amine Precursor Uptake – for high uptake of

amine precursors including 5-hydroxytryptophan
(5-HTP) and dihydroxyphenylalanine (DOPA).[2] Actions of the major digestive hormones secreted by
Decarboxylase – for high content of the enzyme APUD cells
amino acid decarboxylase (for conversion of
precursors to amines).

See also
Apudoma
Enteroendocrine cell
Neuroendocrine cell

List of human cell types derived from the germ layers

References
1. Welbourn RB (January 1977). "Current status of the apudomas" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1
396259). Ann. Surg. 185 (1): 1–12. doi:10.1097/00000658-197701000-00001 (https://doi.org/10.1097%2F000006
58-197701000-00001). PMC 1396259 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1396259)  . PMID 12724 (h
ttps://www.ncbi.nlm.nih.gov/pubmed/12724).
2. Pearse, A.G. (1969). "The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD
series and the embryologic, physiologic and pathologic implications of the concept". J. Histochem. Cytochem. 17
(5): 303–13. doi:10.1177/17.5.303 (https://doi.org/10.1177%2F17.5.303). PMID 4143745 (https://www.ncbi.nlm.ni
h.gov/pubmed/4143745).

External links
APUD Cells (https://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=APUD+Cells) at the US National
Library of Medicine Medical Subject Headings (MeSH)

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This page was last edited on 17 March 2018, at 16:38.

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