4/27/2018 Site-specific DNA-methyltransferase (cytosine-N4-specific) - Wikipedia

Site-specific DNA-methyltransferase
(cytosine-N4-specific)
Site-specific DNA-m ethy ltransferase (cy tosine-N4-specific) (EC
2.1.1.113 (https://enzy me.expasy .org/EC/2.1.1.113), modification
Site-specific DNA-
methylase, restriction-modification system, DNA[cytosine-
methyltransferase
N4]methyltransferase, m4C-forming MTase, S-adenosyl-L- (cytosine-N4-specific)
methionine:DNA-cytosine 4-N-methyltransferase) is an enzy me with Identifiers
sy stematic name S-adenosyl-L-methionine:DNA-cytosine N4- EC 2.1.1.113 (http://www.ch
methyltransferase. [1][2][3][4] This enzy me cataly ses the following number em.qmul.ac.uk/iubmb/e
chemical reaction nzyme/EC2/1/1/113.htm
l)
S-adenosyl-L-methionine + DNA cytosine S-
adenosyl-L-homocysteine + DNA N4-methylcytosine CAS 169592-50-1 (http://ww
number w.commonchemistry.or
This is a large group of enzy mes. [5] g/ChemicalDetail.aspx?
ref=169592-50-1&title=)
See also Databases

DNA methyltransferase
IntEnz IntEnz view (https://ww
w.ebi.ac.uk/intenz/quer
y?cmd=SearchEC&ec=
References 2.1.1.113)
1. Kessler, C.; Manta, V. (1990). "Specificity of restriction endonucleases BRENDA BRENDA entry (http://w
and DNA modification methyltransferases: a review". Gene. 92: 1–248. ww.brenda-enzymes.or
doi:10.1016/0378-1119(90)90486-B (https://doi.org/10.1016%2F0378-111
g/enzyme.php?ecno=2.
9%2890%2990486-B). PMID 2172084 (https://www.ncbi.nlm.nih.gov/pub
med/2172084). 1.1.113)
2. Klimasauskas, S.; Timinskas, A.; Menkevicius, S.; Butkiene, D.; Butkus, ExPASy NiceZyme view (http://w
V.; Janulaitis, A. (1989). "Sequence motifs characteristic of ww.expasy.org/enzyme/
DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-
2.1.1.113)
C5 DNA-methylases" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC335
216). Nucleic Acids Res. 17: 9823–9832. doi:10.1093/nar/17.23.9823 (htt KEGG KEGG entry (http://ww
ps://doi.org/10.1093%2Fnar%2F17.23.9823). PMC 335216 (https://www.n w.genome.ad.jp/dbget-b
cbi.nlm.nih.gov/pmc/articles/PMC335216)  . PMID 2690010 (https://www.
in/www_bget?enzyme+
ncbi.nlm.nih.gov/pubmed/2690010).
2.1.1.113)
3. Roberts, R.J. (1990). "Restriction enzymes and their isoschizomers" (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC331877). Nucleic Acids Res. MetaCyc metabolic pathway (http
18: 2331–2365. doi:10.1093/nar/18.suppl.2331 (https://doi.org/10.1093%2 s://biocyc.org/META/sub
Fnar%2F18.suppl.2331). PMC 331877 (https://www.ncbi.nlm.nih.gov/pm string-search?type=NIL
c/articles/PMC331877)  . PMID 2159140 (https://www.ncbi.nlm.nih.gov/p
&object=2.1.1.113)
ubmed/2159140).
PRIAM profile (http://priam.prab
i.fr/cgi-bin/PRIAM_profil

https://en.wikipedia.org/wiki/Site-specific_DNA-methyltransferase_(cytosine-N4-specific) 1/2
4/27/2018 Site-specific DNA-methyltransferase (cytosine-N4-specific) - Wikipedia

4. Yuan, R. (1981). "Structure and mechanism of multifunctional restriction es_CurrentRelease.pl?

endonucleases". Annu. Rev. Biochem. 50: 285–319. EC=2.1.1.113)
doi:10.1146/annurev.bi.50.070181.001441 (https://doi.org/10.1146%2Fann
urev.bi.50.070181.001441). PMID 6267988 (https://www.ncbi.nlm.nih.gov/ PDB RCSB PDB (http://www.rc
pubmed/6267988). structures sb.org/pdb/search/smartSu
5. R.J. Roberts. "A complete listing of all of these enzymes" (http://rebase.n bquery.do?smartSearchSu
eb.com/rebase/rebase.html). btype=EnzymeClassificati
onQuery&Enzyme_Classifi
External links cation=2.1.1.113) PDBe (h
ttps://www.ebi.ac.uk/pdbe/
Site-specific DNA-methyltransferase (cytosine-N4-specific) (https://www.n entry/search/index?ec_nu
lm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=Site-specific+DNA-meth
yltransferase+(cytosine-N4-specific)) at the US National Library of mber:2.1.1.113) PDBsum
Medicine Medical Subject Headings (MeSH) (https://www.ebi.ac.uk/thor
nton-srv/databases/cgi-bin/
enzymes/GetPage.pl?ec_n
umber=2.1.1.113)

Search
PMC articles (https://www.ncbi.nl
m.nih.gov/entrez/query.fcgi?
db=pubmed&term=2.1.1.11
3%5BEC/RN%20Number%5
D%20AND%20pubmed%20
pmc%20local%5Bsb%5D)
PubMed articles (https://www.ncbi.nl
m.nih.gov/entrez/query.fcgi?
db=pubmed&term=2.1.1.11
3%5BEC/RN%20Number%5
D)
NCBI proteins (https://www.ncbi.nl
m.nih.gov/protein?term=2.1.
1.113%5BEC/RN%20Numb
er%5D)

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