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* Senior Lecturer, Department of Oral Pathology, Index Institute of Dental sciences, Indore, Madhya Pradesh, India
** Reader, Department of Prosthodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India
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ABSTRACT materials, immunological factors, dietary factors,
Denture stomatitis is the most prevalent and various medications and predisposing systemic
long standing problem in denture wearers. The pathologies.[4]
etiopathogenesis of denture stomatitis is CLASSIFICATION:[5]
multifactorial and complex to understand. The Different classifications have been proposed, but
placement of denture produces significant the reference classification for denture stomatitis
changes in the oral environment and adversely is the one suggested by Newton in 1962, based
affects the integrity of oral tissues. The exclusively on clinical criteria:
combination of entrapment of yeast cells in Type I: A localized simple inflammation or
irregularities in denture-base and denture- pinpoint hyperemia.
relining materials, poor oral hygiene and Type II: An erythematous or generalized simple
several systemic factors is the most probable type seen as more diffuse erythema involving a
cause for the onset of this infectious disease. part or the entire denture covered mucosa.
Hence colonization and growth on prostheses Type III: A granular type (inflammatory papillary
by Candida species are of clinical importance. hyperplasia) commonly involving the central part
This article gives a comprehensive review of of the hard palate and the alveolar ridges.
etiopathogenesis and management and current Type III often is seen in association with type
trends in management of denture stomatitis. I or type II.
KEYWORDS: Denture stomatitis; denture Type III denture stomatitis involves the
wearers; candida albicans epithelial response to chronic inflammatory
stimulation secondary to yeast colonization
INTRODUCTION and, possibly, low-grade local trauma
Denture stomatitis is a term used to indicate a resulting from an ill-fitting denture.
inflammatory response of the denture bearing ETIOPATHOGENESIS
mucosa. It is also known as denture sore mouth, Candida albicans has been shown to be the
denture induced stomatitis, inflammatory principal Candida strain responsible for
papillary hyperplasia, and chronic atrophic inflammatory pathology, though various species
candidiasis. It is more commonly seen in elderly of candida like C.dubliniensis, C. Parapsilosis, C.
patients wearing complete or partial dentures. It is Krusei; C. Tropicalis and above all C. glabarta
more commonly seen in palatal and gingival have been isolated from the inflammatory lesion6.
mucosa which is in direct contact with the denture The pathogenesis of candida – associated denture
base.[1] The prevalence of denture stomatitis in stomatitis is elaborate and multifactorial.
edentulous patients has been reported as 62%, C.albicans is a normal oral microorganism, and
39% and 23% respectively by different upto 67% of people carry this organism without
researchers.[2] No racial or sex predilection exists, clinical evidence of infection. Local and systemic
although some authors have described a higher factors can determine the transformation of
prevalence among women.[3] Denture stomatitis is C.albicans from a commensal to a pathogenic
recognized as having a multifactorial etiology organism. The line between its status as yeast and
including such causative factors as: Candida hyphae is very thin and as the host cell becomes
yeast infections, bacterial infections, poor oral immunocompromised, it becomes active and
and denture hygiene, unrelieved denture use, starts secreting several hydrolytic enzymes such
denture trauma, allergic reactions to denture as proteinases and phospholipases which help in
their adherence to host cells and digesting their used as adjuncts in the prosthodontic treatment
cell walls for nutrient supply to assist further and management of traumatized oral mucosa, and
invasion.[7] are most commonly used in association with the
PREDISPOSING FACTORS mandibular denture.[12] Recently materials which
The predisposing factors of denture induced are available are either silicone elastomers,
stomatitis included systemic and local factors plasticized higher methacrylate polymers,
such as microbial factors, denture cleaning hydrophilic polymethacrylates or
methods, wearing dentures through the night, ill fluoropolymers.[13] Even though these materials
fitting denture, poor oral hygiene and denture exhibit excellent tissue tolerance, one of the
hygiene, xerostomia, smoking, quality and problems is the colonization of Candida species
quantity of saliva, occlusion, parafunctional on and within the material. Fungal growth is
habits and carbohydrate rich diets, denture age known to destroy the surface properties of the
and possibly a defect in host’s defense liner and this may lead to irritation of the oral
mechanism. tissues. This is due to a combination of increased
LOCAL FACTORS surface roughness and high concentrations of
a) Micro organisms exotoxins and metabolic products produced by
The presence of the denture on the oral mucosa the fungal colonies.[14]
alone serves as a catalyst for the initiation of d) Denture plaque
denture stomatitis by altering the local Poor denture hygiene is considered to be one of
microenvironment by decreasing pH, saliva flow the etiologic factor for denture stomatitis. Various
and mechanical cleansing, serving as a reservoir factors stimulating yeast proliferation, such as
for harbouring microorganisms. Of these poor oral hygiene, high carbohydrate intake,
microorganisms, it is generally regarded that reduced salivary flow, composition of saliva,
Candida species, particularly Candida albicans, design of the prosthesis and continuous denture
is one of the most common causative agents of wearing can also enhance the pathogenicity of
denture stomatitis. In fact, they have been found denture plaque.[15]
to comprise approximately eighty percent of the e) Surface Texture and Permeability of
microorganisms recovered from the oral mucosa Denture Base
of denture wearers.[8] Certain bacterial species, The tissue surface of the dentures usually shows
like Staphylococcus species, Streptococcus micropits and microporosities. Such irregularities
species, species, Fusobacterium species or of surface make possible the yeasts to nest and
Bacteroides species has been identified in patients make difficult to eliminate bacteria by mechanics
with denture stomatitis. and chemical hygiene manoeuvres; therefore, in
b) Trauma presence of poor oral hygiene, Candida can
Denture trauma due to ill fitting dentures is penetrate, stick and aggregate with the bacterial
believed to be one of the etiological factors in communities. Substrate surface properties, as
denture stomatitis. Nyquist[9] considered that surface charge, surface free energy,
trauma caused by dentures was the dominant hydrophobicity, and roughness have all been
factor in the occurrence of denture stomatitis. reported to influence the initial adhesion of
Cawson[10] concluded that the trauma and microorganism.[16]
candidal infection are significant causes of f) Saliva
denture stomatitis. Immunohistochemical analysis The role of the saliva in the colonization of C.
of the mucosal tissue also has demonstrated a albicans is still controversial. Some studies have
possible role of trauma in denture stomatitis.[11] shown that it reduces the adhesion of C. albicans.
Trauma caused incorrect vertical dimension of In fact, the saliva possesses defensive molecules
occlusion, unstable dentures, occlusal alterations, as lysozyme, lactoferrine, calprotectin, IgA that
nocturnal wear of dentures are also considered as decrease the adhesion of Candida to the oral
risk factors for denture stomatitis. surfaces. The decrease or the complete absence of
c) Denture lining materials saliva in individuals with xerostomia induces the
Denture lining materials, which include tissue change and the imbalance of the normal microbial
conditioners and soft denture liners, are widely communities favouring the proliferation of