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Biomedical
J o urnal o f Volume 2, Number 2 ) 2008
Chronic
Inflammation
• Biomodulation of Osteoarthritis
• Lumbosacral Pain Syndrome – A Case Study
)
Contents
I n Fo c u s
Biomodulation of Osteoarthritis . . . . . . . . . . . . . . . . . . . . . . . 4
W h a t E l s e I s N e w ? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Specialized Applications
Biopuncture Protocols for the Treatment
of Chronic Inflammatory Disorders . . . . . . . . . . . . . . . . . . . . . 10
Re f r e s h Yo u r H o m o t ox i c o l o g y
Movement and the Matrix: The Importance of
Biomechanical Signals in Matrix Remodeling . . . . . . . . . . . . . 13
M a r ke t i n g Yo u r P r a c t i c e
Getting Organized . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
N e w Pe r s p e c t i v e s
Sulfur in Health and Disease:
A Hypothesis on Sulfur Intoxication . . . . . . . . . . . . . . . . . . . . 20
Making of ...
Suis-Organ Products in Antihomotoxic Medicine . . . . . . . . . 26
Published by/Verlegt durch: International Academy for Homotoxicology GmbH, Bahnackerstraße 16,
) 2 76532 Baden-Baden, Germany, e-mail: journal@iah-online.com
Editor in charge/verantwortlicher Redakteur: Dr. Alta A. Smit
Print/Druck: VVA Konkordia GmbH, Dr.-Rudolf-Eberle-Straße 15, 76534 Baden-Baden, Germany
© 2008 International Academy for Homotoxicology GmbH, Baden-Baden, Germany
)
A Holistic Approach
to Chronic Inflammation
Reference:
) 3
Biomodulation of Osteoarthritis
By Martin Plotkin, MD, and Alta A. Smit, MD
Introduction From the homotoxicological per- the most abundant cells and proin-
spective, OA falls into the degenera- flammatory cytokines such as IL-1,
Osteoarthritis (OA) is a chronic, dis- tion phase on the Disease Evolution TNF-α, and IL-8 are the most
abling condition that affects synovial Table and shares many of the char- prominent. In contrast, chronic in-
joints. Its pathogenesis involves mul- acteristics of degenerative disease flammation develops over a longer
tiple etiologies, including mechani- processes, namely, chronic inflam- period of time and may persist for
cal, genetic, and biochemical factors. mation accompanied by the release weeks, months, or years. Markers of
OA is generally described as “nonin- of dangerous free radicals such as chronic inflammation such as C-re-
flammatory” arthritis in contrast to peroxynitrite, disturbance of the active protein (CRP) may be elevat-
rheumatoid arthritis, but this is in- normal cycle of degeneration and ed in patients with OA and may be
creasingly recognized as a misno- repair, and disturbance of angiogen- mediated by IL-6, which is the ma-
mer, since inflammation does indeed ic balance in the direction of inap- jor cytokine secreted by macrophag-
contribute to both the symptoms propriate vascularization. es. IL-6 may also play a role in an-
and the progression of OA.1 Morn- giogenesis, which is another factor
ing or inactivity stiffness is a com- Inflammation in osteoarthritis contributing to the pathology of OA
mon symptom in OA, but acute in- (see below).
flammatory flares with all the clinical The effects of subclinical chronic in- The outcome of acute inflammation
signs (redness, warmth, swelling, flammation in OA are now increas- is elimination of the irritation, fol-
and further loss of function) are also ingly being recognized.2 The onset lowed by restoration of the tissues
common in OA patients. of acute inflammation is generally to their original state. In chronic in-
sudden, with the above-mentioned flammation, on the other hand, in-
Figure 1: Degradation and repair in the symptoms developing in a matter of flammation and repair occur concur-
matrix. In osteoarthritis, the catabolic/ minutes or hours. Neutrophils are rently, and the joints remain
anabolic rhythm is disturbed.
Metalloproteinases Antimetalloproteinases
Angiogenesis
VEGF, FGF
abnormal even after the inflamma- (BMPs), which reciprocally inhibit portant to know whether these mo-
tion subsides. In chronic inflamma- the actions of the MMPs and there- lecular factors also contribute to cell
tion, the cells that predominate are fore induce tissue healing. This cata- death.
macrophages and often lymphocytic bolic/anabolic oscillation is of vital The cause of chronic synovitis in
infiltrates. Chronic inflammation can importance in normal tissue integri- OA is not well understood. Debris
therefore be seen as a misguided at- ty.3,4 When the process is disturbed or parts of cartilage may be found in
tempt on the part of chondrocytes (due to continuous tissue damage, the synovium, where they provoke
and other cells to eliminate damaged either by mechanical stressors or typical responses to foreign bodies.
tissue and to effect repair. toxins) or the body’s ability to trig- Mechanical injury can also lead to
ger repair reduced (due to either a the secretion of free radicals or reac-
Anabolic/catabolic imbalance deficiency of growth factors or an tive oxygen species (ROS).
inability to respond to them, as is
Oscillation between degradation seen in old age), an overactive cata- ROS and chronic cartilage
and repair is a normal occurrence in bolic/anabolic cycle results (see Fig- destruction
the matrix. Although the extracellu- ure 1).
lar matrix is the functional unit in To better understand cartilage de- The role of ROS in cartilage damage
this process, homeostasis is affected struction, at least inasmuch as it is remains controversial. Recently,
by chondrocytes. Matrix metallo- mediated by chondrocytes them- Green et al. added to the literature
proteinases (MMPs) are stimulated selves (sometimes called chondro- describing the role of ROS release
by inflammatory cytokines and ma- cytic chondrolysis), we must study after mechanical injury in the pro-
trix degradation products to induce the molecular mechanisms that dis- gression of cartilage destruction.5
degradation of older or damaged rupt the balance between chondro- Nitric oxide in particular is impli-
tissues and are counterbalanced by a cyte catabolic and anabolic activity. cated in this process and may com-
number of growth factors, notably Since chondrocytes are lost to cell bine with other ROS to form the
) 5
also members of the TGF-β family, death at some point in the process of highly toxic compound peroxyni-
Bone Morphogenetic Proteins cartilage destruction, it is also im- trite.
ROS also will induce inflammatory Neoinnervation also follows angio- permitting a certain level of inflam-
mediators, such as NF-κB, IL-1, and genesis and may contribute to pain mation so that degradation of debris
IL-6. ROS have been implicated in in chronic synovitis (see Figure 2). can occur.
chondrocyte senescence.6 ROS may Targeting these aspects could lead Zeel has been used for degenerative
also have a direct influence on the to novel approaches to treating OA. arthritis for many years; empirical
production of Vascular Endothelial The fact that Zeel, a homeopathic evidence indicates that it is as effec-
Growth Factor (VEGF), a powerful combination medication, is formu- tive as Cox-1 and Cox-2 inhibitors
stimulator of angiogenesis and lated to address these aspects, along in treating OA.22 However, it may
chronic inflammation.7 with its excellent tolerability, makes have a special role to play with re-
it an ideal option for treating the gard to the pathophysiology of
Angiogenesis and chronic chronic inflammation seen in OA. chronic inflammation. Many of its
inflammation ingredients, such as Rhus tox, con-
Bioregulatory treatment of OA tain flavonoids, known for their an-
The formation of new blood vessels tioxidant effects.23 Rhus tox and Ar-
is essential during fetal development We have seen in the previous section nica also have been shown to have
but rarely occurs in adults except in that OA is characterized by chronic, effects on IL-6, which is secreted by
overzealous attempts at remodeling low grade inflammation with fre- macrophages and may play a central
and regeneration, as in OA. Inflam- quent flare-ups of acute inflamma- role in chronic inflammation and an-
matory mediators can stimulate an- tion. Conventional treatments giogenesis. In an animal study,
giogenesis either directly or indi- (NSAIDs, paracetamol/acetamino- Stančíková demonstrated that when
rectly. Inflammatory cells that phen, and/or intra-articular corti- rabbits with experimentally induced
produce this effect include mac- costeroids) act to suppress only cer- arthritis were treated with either
rophages and mast cells, which are tain aspects of the inflammation and Zeel or a solvent (reference sub-
present in the OA synovium. Mac- have significant side effects. stance), the Zeel group developed
rophages are generally found wher- Intra-articular administration of far fewer erosions and less hypertro-
ever abnormal angiogenesis occurs, hyaluronic acid attempts to supply phic cartilage than the solvent
as in synovitis and tumors. Angio- the cartilage with proteoglycan sup- group.24 Histochemical analysis also
genesis may be important in poten- port.9 Combinations of chondroitin revealed significant vascularization
tiating or perpetuating inflamma- sulfate and glucosamine have long of the deeper layers of cartilage in
tion, rather than initiating it. On the been used for this purpose in treat- the animals treated with the solvent,
other hand, angiogenesis may be in- ing OA, with variable evidence of whereas the Zeel group developed
directly self-perpetuating because it efficacy.10,11,12 Some promising new only a few capillaries. (In view of
increases inflammatory cell infiltra- treatments use autologous serum.13 the central role that angiogenesis
tion and thus increases the cells that The use of antioxidants in OA has appears to play in the pathophysiol-
secrete angiogenic factors such as not been proven to be beneficial and ogy of OA, this is a very important
VEGF and Fibroblast Growth Factor remains controversial.14 finding.) And finally, the arrange-
(FGF-1).8 In view of the pathogenesis outlined ment of chondrocytes was also much
Vascularization of normally avascu- above, the use of low-concentration more structured in the verum group.
lar cartilage and at the osteochon- antigens with a multi-target regula- It is interesting to note that the alka-
dral junction is a feature of OA. In tion such as is seen in the antihomo- loid sanguinarine, found in Sangui-
growing individuals, angiogenesis is toxic repertoire becomes interest- naria canadensis (one of Zeel’s in-
required for normal endochondral ing. gredients), has been shown to
ossification to close long bones. This inhibit VEGF.25,26
process is mediated by VEGF from Traumeel and Zeel as
hypertrophic chondrocytes. In OA, combination therapy in OA
however, growth through osteo- Conclusion
phytes at the joint margin also oc- Traumeel has been shown in studies
curs through osteochondral ossifica- to be both clinically efficacious and Ongoing research is clarifying the
tion. Cartilaginous extensions of the an immune-modulating medica- complex pathophysiology of OA.
) 6 articular surface become invaded by tion15-21 and should be considered Disruption of the catabolic/anabolic
blood vessels, and bone extends for its immune-regulating proper- cycle of the cartilaginous matrix ap-
from the subchondral structures. ties, which promote repair while pears paramount. New evidence
3. Aigner T, Soeder S, Haag J. IL-1ß and BMPs 15. Heine H, Schmolz M. Induction of the im-
suggests that both the generation of – interactive players of cartilage matrix deg- munological bystander reaction by plant ex-
ROS (through mechanical pressure) radation and regeneration. Eur Cell Mater tracts. Biomed Ther 1998;16(3):224-226.
and angiogenesis contribute signifi- 2006;12:49-56. 16. Porozov S, Cahalon L, Weiser M, Branski D,
4. Yasuda T, Poole AR. A fibronectin fragment Lider O, Oberbaum M. Inhibition of IL-1β
cantly to the development of chron- induces type II collagen degradation by col- and TNF-α secretion from resting and ac-
ic inflammation, tissue destruction, lagenase through an interleukin-1-mediated tivated human immunocytes by the homeo-
pathway. Arthritis Rheum 2002;46:138-148. pathic medication Traumeel® S. Clin Dev Im-
and pain. Standard treatment with 5. Green DM, Noble PC, Ahuero JS, Birdsall munol 2004;11(2):143-149.
NSAIDs aims primarily to reduce HH. Cellular events leading to chondrocyte 17. Lyss G, Knorre A, Schmidt TJ, Pahl HL, Mer-
inflammation and control pain. Sub- death after cartilage impact injury. Arthritis fort I. The anti-inflammatory sesquiterpene
Rheum 2006;54:1509-1517. lactone helenalin inhibits the transcription
stances that inhibit MMPs are cur- 6. Yudoh K, Nguyen T, Nakamura H, Hongo- factor NF-kappaB by directly targeting p65.
rently deemed too toxic to be of any Masuko K, Kato T, Nishioka K. Potential J Biol Chem 1998;273(50):33508-33516.
involvement of oxidative stress in cartilage 18. Zell J, Connert W-D, Mau J et al. Treat-
use in OA. Viscosupplements, chon- senescence and development of osteoar- ment of acute sprains of the ankle. Biol Ther
droitin sulfate and glucosamine, and thritis: oxidative stress induces chondrocyte 1989;7(1):1-6.
some other novel treatments are also telomere instability and downregulation 19. Schneider C, Klein P, Stolt P, Oberbaum M.
of chondrocyte function. Arthritis Res Ther A homeopathic ointment preparation com-
used, with variable evidence of effi- 2005;7(2):R380-R391. pared with 1% diclofenac gel for acute symp-
cacy. 7. Fay J, Varoga D, Wruck CJ, Kurz B, Gol- tomatic treatment of tendinopathy. Explore
dring MB, Pufe T. Reactive oxygen species 2005;1(6):446-452.
Due to the different effects of the induce expression of vascular endothelial 20. Birnesser H, Oberbaum M, Klein P, Weiser
two antihomotoxic medications growth factor in chondrocytes and human M. The homeopathic preparation Traumeel
Traumeel and Zeel on acute and articular cartilage explants. Arthritis Res Ther S compared with NSAIDs for symptomatic
2006;8(6):R189. treatment of epicondylitis. J Musculosekelet Res
chronic inflammation, it is feasible 8. Mentlein R, Pufe T. New functions of angio- 2004;8(2-3):119-128.
to administer these two products in genic peptides in osteoarthritic cartilage. Curr 21. Singer SR, Amit-Kohn M, Weiss S, Rosen-
Rheumatol Rev 2005;1:37-43. blum J, Lukasiewicz E, Itzchaki M, Oberbaum
combination: Zeel for long-term 9. Bellamy N, Campbell J, Robinson V, Gee M. Efficacy of a homeopathic preparation in
treatment, Traumeel at the begin- T, Bourne R, Wells G. Viscosupplementa- control of post-operative pain – A pilot clini-
tion for the treatment of osteoarthritis of cal trial. Acute Pain 2007;9(1):7-12.
ning of treatment and for acute
the knee. Cochrane Database Syst Rev 2006; 22. Birnesser H, Stolt P. The homeopathic an-
flare-ups. Both of these medications 19;(2):CD005321. tiarthritic preparation Zeel comp. N: a re-
have been shown to have excellent 10. Barnhill JG, Fye CL, Williams DW, Reda DJ, view of molecular and clinical data. Explore
Harris CL, Clegg DO. Chondroitin product 2007;3(1):16-22.
tolerability profiles. Further research selection for the glucosamine/chondroitin 23. Mersch-Sundermann V, Kassie F, Böhmer S,
is warranted to clarify the exact ef- arthritis intervention trial. J Am Pharm Assoc et al. Extract of Toxicodendron quercifolium
2006;46(1):14-24. caused genotoxicity and antigenotoxicity in
fect of Zeel on angiogenesis and the
11. Clegg DO, Reda DJ, Harris CL, et al. Glu- bone marrow cells of CD1 mice. Food Chem
effect of the medication on ROS in cosamine, chondroitin sulfate, and the two in Toxicol 2004;42(10):1611-1617.
chronic inflammation.| combination for painful knee osteoarthritis. 24. Stančíková M, Bély M, Metelmann HW, et
N Engl J Med 2006;354(8):795-808. al. Effects of Zeel comp. on experimental
12. Hochberg MC. Nutritional supplements osteoarthritis in rabbit knee. Rheumatologia
References for knee osteoarthritis – still no resolution. 1999;13:101-108.
N Engl J Med 2006;354:858-859. 25. Basini G, Bussolati S, Santini SE, Grasselli
1. Loeser RF. Molecular mechanisms of carti- 13. Wehling P, Moser C, Frisbie D, et al. Autolo- F. Sanguinarine inhibits VEGF-induced an-
lage destruction: mechanics, inflammatory gous conditioned serum in the treatment of giogenesis in a fibrin gel matrix. Biofactors
mediators, and aging collide. Arthritis Rheum orthopedic diseases: the orthokine therapy. 2007;29(1):11-18.
2006;54(5):1357-1360. BioDrugs 2007;21(5):323-332. 26. Basini G, Santini SE, Bussolati S, Gras-
2. Bonnet CS, Walsh DA. Osteoarthritis, an- 14. Henrotin Y, Kurz B. Antioxidant to treat os- selli F. Sanguinarine inhibits VEGF-induced
giogenesis and inflammation. Rheumatology teoarthritis: dream or reality? Curr Drug Tar- Akt phosphorylation. Ann N Y Acad Sci
)
2005;44:7-16. gets 2007;8(2):347-357. 2007;1095:371-376.
7
Even western medicine is not always Honey relieves coughs in children, It has long been known that regular
strictly rational, and little headway according to a randomized study in exercise has positive effects on
has been made against its unfounded which 105 children with upper re- health, but now a study conducted
myths and preconceptions. For ex- spiratory infections were given hon- at King’s College in London has
ample, the claim that only 10 per- ey, a cough suppressant, or no medi- shown that physically active people
cent of the human brain is utilized is cation at night before going to bed. also seem to be biologically younger
demonstrably false. There is also no The children who received honey than their nonathletic age peers.
scientific evidence to support the re- fared the best not only in terms of Scientists used leukocyte telomere
peatedly postulated health-promot- frequency and severity of coughing lengths to determine the biological
ing effects of drinking a daily mini- but also with regard to quality of age of more than 2,400 subjects
mum of eight glasses of water. Hair sleep (both their own and their par- ranging in age from 18 to 81. Te-
and fingernails do not continue to ents’). lomeres are the terminal sections of
grow after death, nor does shaving DNA that protect chromosomes
make hair grow back faster and Arch Pediatr Adolesc Med from destruction. Over the course of
thicker. Ophthalmologists agree that 2007;161(12):1140-1146 a lifetime, telomeres become shorter,
reading by flashlight under the cov- leaving the chromosomes more sus-
ers at night will not ruin your eyes, ceptible to damage and disease. Sci-
and eating turkey will not make you Mozart as medicine entists found that older but more
sleepy any faster than other, simi- active subjects had the same telo
larly fatty or heavy foods. Forbid- mere lengths as younger people who
ding the use of cell phones in hospi- Not only is Mozart’s music beauti- were inactive. It seems, therefore,
tals may be conducive to patients’ ful, it also has its uses in the ICU. In that lack of physical exercise accel-
recovery, but to date there is no one study, 10 patients on artificial erates the aging process.
proof that radiation emitted by the respiration listened to slow move- An active lifestyle that includes ade-
phones makes medical equipment ments from Mozart’s piano sonatas quate exercise is both “good medi-
malfunction. In tests, interference through earphones for one hour on cine” and a cost-effective anti-aging
has been noted only in rare instanc- the first day after surgery, with as- strategy. Science has now provided
es when mobile phones and medical tonishing effects. In comparison to couch potatoes with one more bit of
electronic devices were in very ex- the control group, the patients who motivation to become active.
tremely close proximity. received “Mozart therapy” experi-
enced decreases in heart rate and Arch Intern Med
BMJ 2007;335:1288-1289 blood pressure and required signifi- 2008;168(2):154-158
cantly less sedation.
Gender has no bearing on how Being afraid heightens your sense of There’s nothing new under the sun:
much a person talks, according to a smell. That was the admittedly over- Stuffed animals are now available in
study conducted by Texas scientists simplified conclusion of an Ameri- the shape of viruses, microbes, and
who recorded snippets of students’ can study that investigated the con- other germs. The selection of 15
conversations. They found that in nection between olfactory acuity cm-long “GIANTmicrobes,” as the
the course of a day, men talk just as and emotional stress in 12 young American manufacturer calls its cud-
much as women – roughly 16,000 adults. Subjects were asked to iden- dly bacilli, includes Helicobacter
words, on average, although there tify the non-matching substance in a pylori, the syphilis germ, and the
were significant variations within series of three chemicals that smelled AIDS virus (complete with its own
each gender. Taciturn men and very similar. Results improved sig- red AIDS ribbon) – to name just a
women alike got by on approxi- nificantly during the second round few. Prices for these monster mi-
mately 8,000 words per day, while of smell testing, when the partici- crobes begin at $7.95 US (7 euros).
chatterboxes of either sex let loose pants were exposed to stress in the The real items are usually free, but
24,000 words during the same time form of mild electric shocks. The in- they’re harder to get rid of than
period. vestigators interpreted this mecha- stuffed animals.
nism as a survival strategy that helps
New Scientist 2007;195(2612);18 humans sort out dangerous “mes- www.giantmicrobes.com
sages” from an overabundance of
sensory stimuli.
Science 2008;319(5871):1842-1845
F O R P RO F E S S I ONA L U S E ON LY
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) 9
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Table 3: Example of a standard step-by-step biopuncture treatment for chronic Clinical applications of
inflammatory disorders biopuncture in treating chronic
inflammatory disorders
tion (phase 2 product). At a later The step-by-step strategy is not set In cases of chronic inflammatory
stage, we can inject more specific, in stone but can be adapted to each disorders, we usually administer six
symptom-related medications such patient’s specific situation. Begin- weekly injections and then give the
as Spascupreel or a Homaccord am- ning with Lymphomyosot is espe- body six weeks to respond and
poule if available (phase 3 products). cially important for hyper-respond- achieve bioregulation and complete
Finally, we work on a deeper (cellu- ers (sensitive patients). The three healing. If necessary, the whole pro-
lar) level with injections of medica- steps and six weekly sessions shown cess (another series of 6 injections)
tions such as Coenzyme composi- in Table 3 are a typical example of may be repeated.
tum, Zeel, or Discus compositum step-by-step biopuncture treatment
(phase 4 products). (See table 2). of chronic inflammatory disorders.
In the first step, which combines
) 11
Here are three examples of chronic sion: subcutaneously in the shoulder generative joint disease) may be in-
disorders: in the shoulder, in the pain zone, into muscles or near ten- jected into the above-mentioned
knee, and in the Achilles tendon. dons, and/or into ligaments. sites.
We begin by injecting Traumeel and We usually begin with two sessions Step 1 consists of two sessions of
Lymphomyosot subcutaneously into of subcutaneous injections of injections of Traumeel plus Lym-
the pain zone (step 1). If the biceps Traumeel and Lymphomyosot in the phomyosot administered s.c. and
tendon is tender upon clinical ex- pain zone (step 1). If the patellar around the tendon (Figure 3). In the
amination, we also administer an- tendon is tender, the same combina- third and fourth sessions, Traumeel
other injection near the tendon. This tion is also injected near the tendon. may be injected into soft tissue clos-
treatment is repeated one week later. In the third and fourth sessions (step er to the tendon while Lymphomyo-
In the third and fourth sessions (step 2), Lymphomyosot plus Traumeel or sot plus Traumeel (or Spascupreel) is
2), Lymphomyosot and Traumeel Spascupreel may be injected i.m. injected into the calf muscle (step 2).
(or Spascupreel) may be injected (e.g., into the quadriceps) and/or In the fifth and sixth sessions, Coen-
into several different muscles (e.g., Traumeel and dextrose may be in- zyme compositum may be injected
pectoral, trapezius, infraspinatus: see jected into the collateral ligaments near the tendon and into the calf
Figure 1, deltoid) and/or Traumeel or the pes anserinus (see Figure 2). muscle (step 3).|
and dextrose may be injected into In the fifth and sixth sessions (step
the shoulder ligaments (e.g., AC lig- 3), Coenzyme compositum (or Zeel
ament, coraco-clavicular ligament) in elderly patients or in cases of de-
or into the joint capsule. In the fifth
and sixth sessions (step 3), injections
of Coenzyme compositum (or Zeel,
in the case of degeneration of the
shoulder joint) may be administered
on several different levels per ses- References
)
I, Küstermann K. Introduction to Bioregulatory trial. Anesth Analg 2000;91(2):408-409.
12 Medicine. Stuttgart, Germany: Thieme Pub-
lishers; in press.
Microscopic view of
the extracellular matrix
Data suggest that constant applica- enzymes stimulated by tissue dam- rhythm, and normal angiogenic bal-
tion of cyclic tensile strain (CTS) age or inflammatory mediators are ance. The three pillars of antihomo-
blocks IL-1β-induced proinflamma- counteracted by antiproteases acti- toxic therapy (detoxification and
tory genes at the transcriptional vated by substances such as TGF-β.12 drainage, immunomodulation, and
level. The signals generated by CTS To date, these effects had been not- organ regulation) are essential to en-
are sustained after its removal, with ed only in specialized connective sure matrix health.
their persistence dependent on the tissue. The possibility that they will It can be postulated that many envi-
length of CTS exposure. Further- also be found in loose connective ronmental toxins carry electrical or
more, the sustained effects of me- tissue suggests an overall plasticity chemical charges that may disrupt
chanical signals are also reflected in reflecting an individual’s overall subtle piezoelectric signals and af-
their ability to induce aggrecan syn- movement patterns and would also fect transcription of mediators, thus
thesis. These effects were seen on explain the effect of local inflamma- affecting plasticity. The example of
transcription factors of inflammato- tory foci on the entire body, known the zebra fish tail, which regener-
ry mediators on chondrocyte stretch empirically to practitioners of bio- ates completely after being severed,
in vivo. These findings, extrapolated logical medicine. Oschman also ex- shows that adult zebra fish have the
to human chondrocytes, may pro- amines this phenomenon in an arti- capacity to regenerate the caudal fin,
vide the insight needed to achieve cle reviewing the role of free a process that is inhibited by expo-
optimal sustained effects of physical electrons and their antioxidant ac- sure to the ubiquitous environmen-
therapies in the management of ar- tivity.13 tal contaminant 2,3,7,8-tetrachloro
thritic joints.11 In conclusion, movement of the ma- dibenzo-p-dioxin (TCDD). Fin
trix plays an important role in its regeneration is a complex process re-
3. Plasticity signals remodeling and regeneration. We quiring precise regulation of several
would do well to include stretching processes including wound healing,
Structural change of an organism is or even aerobic exercise as part of ECM production, revascularization,
closely related to the cell’s ability to our patients’ treatment.14 The need innervation, and bone formation.
modulate its pericellular environ- is especially great in cases of tissue TCDD, a persistent organic pesti-
ment, whether in the normal process damage that require remodeling, as cide, directly inhibits this process.15
of growth, in maintaining homeo- in fractures, osteoporosis, and even The practice of advanced supportive
stasis, or as part of a disease process. tendon injury. detoxification with subsequent
This response of connective tissue to drainage is thus recommended for
mechanical stress is well-known. Supportive bioregulation matrix health. Antihomotoxic medi-
According to Langevin, it takes cine combined with proper nutrition
place over days or weeks following As mentioned above, matrix remod- can support this process. Medica-
a change in posture or a new activi- eling is a complex process relying tions such as Thyreoidea composi-
ty. It follows remodeling of the ECM on multiple factors: the immune sys- tum and Pulsatilla compositum are
with changes in the collagen matrix tem for controlled inflammation and especially suitable for supporting
as well as viscoelasticity. Matrix re- repair, the action of amino acid-de- the matrix biorhythm. Immune
) 14 modeling is an example of a cata- pendent proteases and metallopro- modulation that down-regulates in-
bolic/anabolic cycle: Proteolytic teinases, normal cortisol diurnal flammatory mediators and secretion
Submandibular_Gland.JPG
) 15
Evidence-Based Homeopathy
More Than Results of Double-Blind Studies!
63rd Congress of the Liga Medicorum Homeopathica Internationalis
(LMHI). The overall theme of this years’ conference was Liga president Dr. Ulrich Fischer
“Evidence-based homeopathy – more than results of gave the opening remarks, followed
by a moving tribute by David Owen
double-blind studies.”
to the many great British homeo-
paths and administrators who died
in a plane crash in 1972 on the way
Some highlights of To the surprise and delight of the Dr. Ulrike Keim’s satellite sympo-
the conference participants, Queen Paola of Bel- sium, “Is there a synergy between
gium paid an unannounced visit to classical homeopathy and homeo-
Among the many highlights of this the conference, sitting in the audi- pathic combination preparations?”
conference, here are a few of special ence and listening intently to an in- was well attended. Dr. Keim, known
interest: The first plenary session, on teresting presentation by her ho- to BT readers as a specialist on met-
the “Politics, History and Econom- meopathic physician, Dr. Maurice abolic syndrome (see BT issue
ics of Homeopathy,” included Ton Jenaer, on microimmunotherapy. A 1/2008), skillfully interwove the
Nicolai’s talk on the current status report of her visit aired on local principles of classical homeopathy,
of complementary and alternative television that evening. What a won- such as miasmatic theory, with the
medicine (CAM) in the European derful show of support for home- practical applications of antihomo-
healthcare system and Christian opathy! toxic combination medicines.
Boiron’s “Homeopathy is a lan- A variety of intriguing workshops Dr. Robbert van Haselen, Head of
guage.” dealt with different clinical methods Research at Biologische Heilmittel
In another plenary session on “Re- such as the Masi method, Sankaran’s Heel GmbH, Baden-Baden, gave an
search – from proving to double- “Bombay method,” the Vithoulkas interesting talk entitled “Detoxifica-
blind,” Prof. Claudia Witt presented method, etc., while others looked at tion and drainage – historical per-
an important paper on the treatment actual provings of a broad range of spectives and the current scientific
of atopic eczema in children. Dr. new (and old) substances. Jan Schol- state of the art,” which was well re-
Witt is the first person to hold the ten led a number of sessions on his ceived by the audience.
Chair for Research in Complemen- work with the Lanthanide remedies. Although the Liga is predominantly
tary/Alternative Medicine, recently The provings of this series of 15 a classical homeopathic organiza-
endowed by the Karl and Veronica “rare earth” elements appear to show tion, presentations dealing with ho-
Carstens Foundation, at the Charité affinity for the immune system. motoxicology were well received by
University Medical Center in Ber- the delegates. The next congress will
lin. be held in Warsaw, Poland, in Sep-
tember 2009.|
Dr. Michel Van Wassenhoven,
chairman of the 63rd Liga congress,
received the “Globular Politics Award.”
) 17
Getting Organized
Professional file management and
returning phone calls
By Marc Deschler
Marketing specialist
3. On each piece of mail, note what ing the information will take enough The solution? Institute an efficient
action it requires: Do you need time to allow you to think about system for returning calls. Your of-
to make an appointment, place your indecision. If you then go fice staff notes all incoming calls and
an order, discuss it in a team through the file at regular intervals, pulls those patients’ charts so they
meeting, file it for future refer- you’ll find that most of these materi- are immediately available when you
ence? als can simply be thrown out. have fifteen minutes free to return
4. Starting right now, make all such calls. If you don’t have to search for
decisions immediately. I’ll call you back! missing information, you’ll spend
less of your precious time on the
Organized decision-making requires Many practitioners accept calls from phone. Another plus: You get to de-
an appropriate filing system. Estab- patients even during office visits. cide whom you talk to, what you
lish folders for interesting topics This practice has at least three dis- talk about, and when.
you want to be sure not to forget, tinct disadvantages: Here are some general rules:
such as: • To avoid scheduling conflicts,
• items for your next team meeting 1. You may need to interrupt the make a habit of returning calls at
(for example, discuss this col- patient you’re with in the middle certain set times. Note these
umn!) of a very personal conversation. times in your daily calendar.
• tax tips to bring up at your next 2. The patient you’re with may • Make sure your employees tell
meeting with your tax advisor overhear confidential informa- patients when your call-back
• patients’ complaints that you tion about the patient on the time is so they will be available
need to address phone. when you call.
Set deadlines for dealing with the 3. Your work flow is disrupted. • Your office staff should make a
contents of these folders so nothing list that includes each caller’s
gets forgotten. As a general rule, do not allow your- name and phone number and the
Of course there are some decisions self to be interrupted by patient time and subject of the call.
that cannot be made on the spot. phone calls during office hours. This • If no one is available to answer
For example, you receive informa- is especially important during ap- the phone during office hours,
tion about some very interesting pointments because an interrupted record an appropriate message
new electroacupuncture technology, conversation is much less satisfying on your answering machine.
but there’s no place for it in your in- to the patient than even a brief con- If you follow these guidelines,
vestment plan at the moment. Make sultation in which he or she can you will always be able to give
a habit of saving such materials in a count on your undivided attention. each patient the attention they de-
file cabinet that is located as far from Furthermore, privacy of information serve, whether in person or on the
your desk as possible and that only is very high on most patients’ prior- phone. |
you use, so simply filing or retriev- ity list, so it should be preserved at
all costs.
) 19
• in various roles in the immune • in cellular apoptosis (caspase the basic biological rule which states
system (immunoglobulins, enzymes) that the physiological action of a
cytokines) • S-adenosylmethionine, synthesis cell increases or decreases in relation
• in adhesion molecules of epinephrine, creatinine, to the intensity of the stimulus:
(cellular = CAM and melatonin Weak stimuli stimulate the life func-
intercellular = ICAM) • hepatic metabolism of cyto- tions, moderately strong stimuli ac-
• in membrane receptors, chromes and action on xeno celerate them, strong stimuli act as
such as insulin biotics inhibitors, and the strongest stimuli
• in leukotrienes, such as LTD4 • in gastric fluid and pancreatic suspend the life functions.
and LTE4 fluid The high consumption of sulfur en-
• in the structure of growth • vitamins, such as thiamine, tering the body is probably trans-
hormone, calcitonin, dehydro biotin formed into an intense stimulus that
epiandrosterone, insulin, prolac • Shigella toxin, diphtheria toxin, displaces the equilibrium of the ma-
tin, somatomedin, somatostatin, immunotoxin trix and the membrane receptors, a
synthesis of T3 and T4 • in the pharmaceutical and food phenomenon leading to modifica-
• in the peptides activin, inhibins, industry and in agriculture tions in the network of information
atrial natriuretic peptide, brain The sources of the sulfur entering received and transported through
natriuretic peptide, C peptide, the body are diverse, and the ab- the matrix in the intranuclear, intra-
relaxin, arginine-vasopressin, sorption occurs via a number of car- cytoplasmic, and extracellular spac-
oxytocin riers, including food and the envi- es.
• epidermal growth factor, nerve ronment. Indirectly, we ingest sulfur A cascade effect then ensues that
growth factor, platelet-derived in the form of toxic by-products of leads to a change in biochemical,
growth factor, erythropoietin fuels derived from coal and petro- immunological, and hormonal re-
• leptin, cholecystokinin leum, which on combustion produce sponses. This also destabilizes the
• in the structure of collagen sulfur dioxide. Direct ingestion of three-dimensional structure of pro-
fibers, desmosine, elastin, sulfur occurs primarily in our daily teins, which, as we have already
fibrillin, fibronectin, integrin, diet with the consumption of foods seen, need the presence of the disul-
laminin, osteonectin, keratin rich in the sulfites used in the food fide bonds to maintain their stereo-
• in the structure of articular industry as preservatives and color- chemical presentation and recogni-
cartilage and glycosaminogly- ing agents to improve shelf life and tion at the cell membrane.
cans, chondroitin 4-sulfate color fixation, or with the ingestion Similarly, changes are produced in
and 6-sulfate, keratan sulfate I of refined sugar, which is found in a the assembly of collagen and elastin
and II, heparin, heparan sulfate, high percentage of the food and fibers. Destabilization of the proteo-
dermatan sulfate drink that we consume each day, or and aminoglycans that form the hy-
• constituent of the structure of with foods contaminated with pesti- drated fibrous framework for the
the vascular wall, endothelins cides. extracellular matrix results in com-
• in the coagulation cascade, The principles of Rudolf Arndt and petition between the H+ ions of the
structure of fibrinogen Hugo Schulz, which demonstrate weak acid of H2O and the hydrogen
) 21
• as a catalyst in the respiratory the linear pharmacological relation ions of the strong acids SO42- of sul-
chain of the citric acid cycle between dose and effect, give rise to furic acid H2SO4 and HPO42- of
References
phosphoric acid H3PO4. Proteogly- Contrast this with the pharmaco-
cans and aminoglycans are substanc- logical viewpoint and therapeutic 1. Cooper GM, Hausman RE. La Célula. 4th ed.
Madrid, Spain: Marbán; 2008.
es that readily undergo electrolytic indication of allopathic medicine, in 2. Esteller M. Epigenetics in cancer. N Engl J
exchange. Their alteration destroys which the damage caused by an ex- Med 2008;358(11):1148-1159.
3. Etezad-Razavi M, Mahmoudi M, Hefazi M,
their capacity to retain water in the cess of sulfur is treated with sulfur- Balali-Mood M. Delayed ocular complica-
cartilage and extracellular matrix, based drugs that the patient takes in tions of mustard gas poisoning and the re-
changing their state of fluidity to a high doses, causing a high degree of lationship with respiratory and cutaneous
complications. Clin Experiment Ophthalmol
state of desiccation or gel formation; intoxication and consequent wors- 2006;34(4):342-346.
the end result of this alteration is a ening of the disease. Although there 4. Fessenden R, Fessenden J. Química Orgánica.
2nd ed. Mexico City, Mexico: Grupo Edito-
loss of the ability of the body to ex- may be a relative improvement due rial Iberoamericana; 1984.
change information between differ- to an initial mechanism, what is seen 5. Foye WO. Principios de Química farmacéutica.
ent compartments, leading to loss of long-term is a worsening of symp- Barcelona, Spain: Reverté; 1984.
6. Ganong WF. Fisiología médica. 19th ed. Mexi-
the state of systemic equilibrium. toms and a chronification of the ini- co City, Mexico: Manual Moderno; 2004.
These alterations predispose the pa- tial disease process, each time neces- 7. Goldsby RA, Kindt TJ, Osborne BA, Kuby J.
Inmunología. 5th ed. McGraw Hill; 2004.
tient to chronic conditions such as sitating more combinations of 8. Lodish H, Berk A, Matsudaira P, et al. Biolo-
diabetes, rheumatic disease, osteo- medicines. We can take as an exam- gia Celular Y Molecular. 5th ed. México City,
porosis, and arthritis. ple the profile and timescale of a Mexico: Editorial Medica Panamericana;
2005.
What happens in this information chronic condition such as diabetes. 9. Meyers F, Jawetz E, Goldfien A. Farmacología
exchange? We do not know exactly, For chronic diabetic illness, treat- Clínica. 3rd ed. Mexico City, Mexico: Manual
Moderno; 1977.
but can postulate one of the follow- ment is commenced with sulfonyl 10. Murray RK, Granner DK, Mayes PA, Rodwell
ing: ureas, which are briefly effective. VW. Bioquímica de Harper. 15th ed. Mexico
• A change in body pH alters the However, in time the body ceases to City, Mexico: Manual Moderno; 2001.
11. Nussey SS, Whitehead SA. Endocrinology: an
behavior of the disulfide bonds, respond to these drugs, making it integrated approach. Oxford, UK: BIOS Scien-
making them more rigid, the re- necessary to add another oral antidi- tific Publishers Ltd; 2001.
12. Reckeweg H-H. Materia Medica – Homoeo-
sult being that the protein chain abetic such as metformin or rosigli- pathia Antihomotoxica. 4th ed. Baden-Baden,
loses its capacity to adjust to the tazone, with the patient ultimately Germany: Aurelia; 2002.
membrane receptor. becoming dependent on insulin in 13. Schmid F, Rimpler M, Wemmer U. Medicina
antihomotóxica. Vol. I – Principios – clinica –
• An increase in these bonds causes order to manage symptoms and práctica. Baden-Baden, Germany: Aurelia;
changes in the three-dimensional without this curing the disease. We 2004:51-88.
14. Scientific opinion of the Panel on Food Ad-
structure of the protein chain. return then to the patient as a chron- ditives, Flavourings, Processing Aids and
• A loss of the capacity to form ic consumer of pharmacological Food Contact Materials (AFC) on a request
disulfide bonds causes the pro- substances that provide no cure from the Commission on the results of the
study by McCann et al. (2007) on the ef-
tein chains to break. but continually exacerbate fect of some colours and sodium benzoate
• A loss of cohesive strength of the the disease course and on children’s behaviour. The EFSA Journal
2008;660:1-54.
disulfide bonds makes them the permanent sulfur 15. Vannier L. Compendio de Materia Médica Ho-
cleave easily. intoxication. | meopática. 4th ed. México City, Mexico: Por-
We do not know exactly how this rúa, 1998.
16. World Cancer Research Fund/American In-
destructive process occurs, but we stitute for Cancer Research. Food, Nutrition,
are familiar with the catastrophic ef- Physical Activity, and the Prevention of Cancer:
A Global Perspective. Washington, DC: AICR;
fect of sulfur consumption on the 2007:35-37.
body. Within a few years, research
will surely reveal to us in detail how
the destructive effect of excessive in-
take of sulfur on bodily metabolism
occurs.
) 22
Free of charge
www.iah-online.com
) From the Practice
Treatment regimen
Whiplash is a term used to describe an injury to the soft
tissues – the muscles, ligaments, and nerves – of the neck. Treatment required a combination
of chiropractic (to restore normal
Many people fail to relate their symptoms to a car joint mobility and range of motion)
accident because the symptoms often begin days, months, and physical therapy (to restore
muscle flexibility and movement). In
or even years after the accident. addition, several antihomotoxic
medications were administered:
• Spascupreel and Zeel were inject-
Lumbosacral Pain
Syndrome
Suis-Organ Products in
Antihomotoxic Medicine
Part 2: Production and Quality Control
By Wilfried Stock, PhD
T he manufacturing of suis-organ
preparations is strictly regulat-
ed to ensure their safety. Before pro-
Homeopathic extracts
extracts are then further processed Viral and bacterial safety Because the animal tissues used in
into antihomotoxic medications in the manufacture of suis-organ medi-
accordance with the relevant manu- The special conditions under which cations are derived exclusively from
facturing guideline of the HAB. donor animals are raised (see Part 1: hogs, which have no known suscep-
Breeding and Raising the Donor tibility to spongiform encephalopa-
Quality assurance Pigs,“ BT 1/2008, pp. 24-25) and thy (BSE), there is no danger of
extensive testing of the animal tis- transmitting the disease. Thus the
In addition to the above-mentioned sues for zoonoses ensures that the suis-organ preparations manufac-
microscopic histological examina- quality of the suis-organ extracts tured and marketed by Heel meet all
tion of the animal raw material, ad- meets modern standards of safety. the requirements of the law and the
ditional analytical testing of finished The European Pharmacopoeia’s pharmacopoeia with regard to bio-
mother tinctures takes place in Heel’s general monograph on homeopathic logical materials of this type.|
quality control lab. In particular, the preparations requires that animal in-
References
identity of the mother tincture is gredients be free of viral and bac
confirmed through “isoelectric fo- terial agents to avoid infecting 1. Homöopathisches Arzneibuch 2007. Stuttgart,
cusing,” a specialized electrophore- patients. An assessment report, re Germany: Deutscher Apotheker Verlag,
2007.
sis technique applied in accordance gularly updated, evaluates the viral 2. European Pharmacopoeia. 6th ed. Strasbourg,
with the European Pharmacopoeia.2 safety of the hog tissue. France: Council of Europe, 2007.
Isoelectric focusing makes it possible
to identify the various components
of a biological material as shown on
an electropherogram. Comparison
to previous production runs then
ensures the uniformity of the current
batch of mother tincture.
Other physical characteristics (color,
opalescence, relative density) of the
mother tincture are also tested.
The prize will be awarded for results arising from research carried out in a registered practice or
in a laboratory. In either case the results have to be new, not published before and convincing.
Homotoxicology is one of medicine‘s great success stories. Originally conceived as a model to explain
the outstanding efficacy of a distinct class of homeopathic medications, homotoxicology has grown
into a comprehensive theory of disease.
The deadline for submissions is May 31. An independent panel of reviewers will allocate the awards.
The review panel maintains the right to allocate either of the awards to any of the entries. The review
panel‘s decision is final.
Interested parties are welcome to ask for entry details and conditions: