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MATERNITY BLUES: PHENOMENA

AND RELATIONSHIP TO LATER


POST PARTUM DEPRESSION
Catherine C. Hapgood, Gail S. Elkind, and James J. Wright
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As part of a prospective investigation of postnatal psychiatric disorder, 66


women, randomly selected antenatally, completed visual analogue scales
postpartum and rated their mood state daily for two weeks following childbirth.
They were then interviewed using the Goldberg Standardised Psychiatric In-
terview on four occasions up to 14 months postpartum. Dysphoric mood was
temporally related to childbirth. Emotional lability was the important affective
component of the puerperium. A significant correlation was found between the
blues and subsequent postnatal depression. Lability of mood in the puer-
For personal use only.

perium was related to psychiatric symptoms up to 14 months postpartum and


was the strongest predictor of later psychopathology. Maternity blues ratings
were not accounted for by labour variables.

Australian and New Zealand Journal of Psychiatry 1988; 22: 299-306

The affective disturbance which commonly occurs tum significantly more severely than in the non-puer-
in the first two weeks following childbirth (“the peral state has been shown by Knight and Thirkettle
blues”) is thought to be a normal transient part of the (71. They also demonstrated that the method of
early puerperium [ 1,2]. There is now increased recog- measuring postnatal mood change is vitally important
nition of, and interest in, the association between this and suggested that this is because the experience is one
mood disturbance and childbirth [3-61. Whether the of overall affective dysphoria rather than a depressive
blues is truly a minor transitory occurrence, or whether syndrome.
it is associated with more severe and clinically sig- The reported incidence of postnatal blues varies
nificant postpartum disorder remains unclear and is the from 34-79% [8,9].This is at least partly explained by
subject of this paper. the general lack of agreement about the definition of
Although mood change after childbirth is accepted the blues. Descriptive studies have yielded prevalence
as common, no clear definition of the blues exists and rates for individual symptoms occurring postpartum;
hence there are no widely accepted rating scales. That tearfulness, depression, anxiety, insomnia, headaches,
negative affective symptoms are experienced postpar- confusion and fatigue have all been commonly
reported [2,10]. However, no clear inclusion criteria
exist at this stage. Emotional lability was thought to be
Department of Psychiatry and Rehavioural Science, University an important component of the blues [ 11-13], but is
of Auckland, Private Bag, Auckland, New Zealand
not part of Pitt [ 2 ] or Stein’s [ 101 rating scales. The
Catherine C Hapgood FRANZCP, Research Fellow
blues are thought to be transient, but temporal limits
Gail S Elkind PhD, Associate Lecturer
remain arbitrarily defined. The expected level of emo-
James J Wright MD, FRACP. MRCPsych, FRANZCP, Associate
Professor and Head of Department.
tional intensity in a minimal case ranges from that of
Yalom who will accept an isolated episode of weep-
300 MATERNITY BLUES AND POST PARTUM DEPRESSION

ing in the postnatal period, to pre-determined scores using instruments similar to, or identical with, those in
on clinical rating scales [2,10]. earlier studies, in a prospective design. A factor
Literature which has addressed the question of analysis of the “blues” VAS was also carried out, to
whether the blues is related to maternal mental state in permit more precise definition of the mental
either pregnancy or postpartum is confounded by the phenomena involved in the concept of “blues”.
use of different instruments and time scales, making
direct comparisons difficult. Yalom et al’s [ I ] study Method
was essentially a descriptive account of mood change
postpartum - 22 of their initial sample of 39 women The sample consisted of women randomly selected
were telephoned at eight months postpartum, and only from six ante-natal clinics at the National Women’s
Aust NZ J Psychiatry Downloaded from informahealthcare.com by University of Auckland on 01/13/15

one reported prolonged mood change since the puer- Hospital, Auckland, and a nearby private obstetric
perium. Davidson [ 141 and subsequent workers practice. This was done to ensure a sample repre-
[ 15,16,10,17] all found an association between sentative of women delivering at the hospital. Ex-
lowered mood in late pregnancy and greater distress in clusion criteria initially applied were an inability to
the early puerperium. In addition, Handley [ 161 and speak English and a planned house move out of the
Stein [ 101 both found an association between depres- area in the next twelve months.
sion in the first 6 months and 3 months respectively The women were approached at 34 weeks of preg-
after childbirth, and antenatal distress with more nancy and asked whether they would take part in the
severe symptoms in the puerperium. In both these study. They were given verbal and written information
studies later depression requiring a visit to the general about the purpose of the study, and assured of con-
practitioner, and in Stein’s [ 101 study the Self Rating fidentiality. Two weeks later the initial research inter-
For personal use only.

Questionnaire used to assess the blues was also used view was conducted. Demographic data were
to measure depression at 3 months postpartum. obtained, followed by a clinical interview. History of
Paykel [ 181 found an association between postnatal psychiatric illness, family psychiatric history, past his-
depression at 6 months postpartum and a history of the tory of postnatal depression, whether the pregnancy
blues, in cases in which there was an absence of un- was planned, past history of abortions (both spon-
desirable life events. The clinical account of the blues taneous and induced) and whether breast feeding was
was gained retrospectively in this study at the time of planned, were recorded.
the single assessment interview. The woman’s attitudes to her mother were assessed
Kendell et al [ 191 used daily visual analogue scales using visual analogue scales for dependency, close-
(VAS) to assess mood change in the first 3 weeks ness, identification with, feelings of fondness for and
postpartum, and then used a standardised psychiatric mixed feelings about mother. These five scales were
interview (Goldberg et al. 1970) between 3 and 5 chosen on the basis of their face validity, in the absence
months postpartum to diagnose depression. Higher of established standard instruments.
depression and lability ratings together with a more Whether or not the woman’s own parents were alive,
pronounced 5 day peak on the daily ratings, were living close by, and any separations from them in
found in those women who were depressed postpar- childhood were also recorded.
tum. This was followed by a standardised psychiatric in-
However, Kumar and Robson [21] used the same terview [20]. The rater (CCH) was a psychiatrically
psychiatric interview [20] at 3 months postpartum in a trained interviewer who had received formal training
prospective design, but failed to show an association in the use of the instrument (as requested by the desig-
between depression post-natally and either General ners). (Control studies for inter-rater reliability have
Health Questionnaire (GHQ) scores at I week postpar- been performed on an independent sample of subjects
tum or a retrospective account of the blues. Their together with a proportion of the main sample and will
sample consisted of middle class primiparous women be reported elsewhere. Ratings obtained by two
of higher social class than those of Kendell et al‘s [ 191 qualified psychiatrist raters were similar.) The
randomly selected sample, and they did not use daily Goldberg interview was then re-administered at 6
rating scales in the immediate postpartum period. weeks 3 months 6 months and 14 months postpartum.
The present study aimed to clarify the association Following delivery, details about the spontaneity of
between “the blues” and post-partum depression by onset of labour and the length of Stage I and Stage I1
CATHERINE C. HAPGOOD, GAIL S. ELKIND & JAMES J. WRIGHT 30 I

were extracted from the obstetric record. Type of Results


anaesthetic, type of delivery, and any complications
were noted. Two days after delivery the women were The mean age of women in this sample was 28 years
asked about their labour, including whether it had been (SD 5.6 years; range 17 to 43). At the time of initial
as they had expected, and how they felt about it over- interview 74% of the sample were legally married and
all. The women recorded their mood for the first 2 26% were in de facto relationships with the father of
weeks following childbirth using VAS which were the baby. Racial origins were Caucasian (7 1 %),
filled in daily for 14 days, starting on the first postpar- Polynesian (non-Maori) (16%), Maori (1 1%) and
tum day. other, Chinese and Indian (2%).
The VAS used six mood scales (happiness, depres- The social class of the sample did not differ from
sion, tears, anxiety, irritability, and lability) which that of the New Zealand general population [23].
Aust NZ J Psychiatry Downloaded from informahealthcare.com by University of Auckland on 01/13/15

were the same VAS as used by Kendell et al [19]. Using the woman’s occupation, the social class dis-
Knight & Thirkettle [7] found VAS ratings to be the tribution was 2 1 % in Classes 1 and 2,41% in 3 and 4,
most sensitive method of measuring puerperal mood 19% in 5 and 6; 19% had never held jobs in the paid
state. The VAS were provided in a booklet for the sub- work force. Using the partner’s occupation, the social
jects. No titles for the scales were given. The women class distribution was: 31% in 1 and 2, 49% in 3 and
were given instructions to fill in their booklet at the 4, and 16% in 5 and 6. Four percent of the partners
same time each day (early evening) and asked to be as were not working. (The Revised SE index distribution
honest as they could in rating how they had felt in for New Zealand male work force is 1 & 2=2 1 c/o, 3 &
general on each scale over the past 24 hours. If they 4=5 1%, 5 & 6=20%). At the time of the initial research
missed a day they were asked to leave the page blank interview 52% of the sample were employed and 48%
For personal use only.

and fill in the next days page. They were asked not to described their normal occupation as household
compare their previous ratings. At the same times as duties.
the VAS ratings they were also asked to rate the quan- The DSM-111 axis I diagnoses made in the postpar-
tity and quality of their sleep the previous night and tum period were major depressive disorder, adjust-
whether the baby had been predominantly restless or ment disorder with depressed mood, and adjustment
settled in the past 24 hours. All women were seen on disorder with mixed emotional features (depression
the 2nd-3rd day postpartum to check that they had and anxiety). There were 2 cases of adjustment disor-
remembered to take the booklet to hospital with them der with anxious mood at 6 weeks postpartum.
and to check again that they fully understood the in- Eighteen women were diagnosed as having major
structions. Ninety five women returned completed depressive disorder at some stage, 10 of whom had no
questionnaires at the 6 weeks postpartum interview. diagnosis in the antenatal period and were therefore
On each occasion when the Goldberg Standardised new cases. The total score on the Goldberg, i.e. the
Psychiatric Interview was administered, a DSM-111 symptom score plus twice the mental state rating,
Axis I diagnosis was made (again by CCH), and therefore essentially represented the severity of affec-
Research Diagnostic Criteria (Spitzer et a1 [ 2 2 ] were tive disorder postpartum.
applied. The verbatim transcripts of a proportion of in-
terviews where a diagnosis had been made were dis- Strategy for Overall Data Analysis
cussed with two other psychiatrists (JMK & JJW) and
agreement on diagnosis was reached with that of CCH 66 subjects completed all of the VAS on all 14 days
in all instances examined.A total Goldberg score was postpartum. Some summarising of the daily data items
also calculated for each interview using Goldberg’s was necessary to make a factor analysis feasible. This
method, i.e. the sum of all the symptom scores, plus was done by adding together the scores over several
twice the mental state rating. A further overall rating days (1-5) (6-9) (10-14) for each mood scale. This
was also made which gave an indication of severity of resulted in minimal distortion of the raw data, in the
disorder on a 5 point scale (0 = No symptoms, 1 = sense that this data smoothing accounted for more of
symptoms of minor significance for which no treat- the total variance after factor analysis than other
ment is necessary 2 = symptoms requiring intervention methods of collapsing the data across time. It also
by a general practitioner, 3 = psychiatric intervention produced the most clinically meaningful factors. The
required. 4 = inpatient psychiatric treatment needed). resulting 18 items were subjected to a principal com-
302 MATERNITY BLUES AND POST PARTUM DEPRESSION

Table I . Maternity blues factors and item loadings

Items Factors
Early Mlddie Late Happiness Lability
Unhapplness Unhappiness Unhapplness
Days 1-5:
-Depression .83
-Tearfulness .a0
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-Anxiety .88
-Irritability .68

Days 6-9:
-Depression .76
-Tearfulness .79
-Anxiety .62
-Irritability .87

Days 10-14:
-Depression .83
-Tearfulness .82
-Anxiety .58
-Irritability .75
For personal use only.

Happiness:
-Days 1-5 .71
-Days 6-9 .91
-Days 10-14 .90

Lability:
-Days 1-5 .82
-Days 6-9 .82
-Days 10-14 .87

ponents analysis with varimax rotation. Five factors 2, table 2). Thus, the predictive usefulness of the col-
were identified. These factors were tentatively lective factor scores was measured after controlling for
labelled early unhappiness, middle unhappiness, late the effects of immediate pre-natal state.
unhappiness, happiness and lability. Items were as- Heading 3, table 2, shows the unique predictive value
signed only to the factor on which they had the highest of each factor after the other four factors have been
loading; the lowest of these loadings was .58 (see partialled out first.
Table 1). Five “blues factor scores” subsequently A critical assessment was then applied to the results
created for each subject each consisted of the sum of to exclude alternate logical associations, namely:
the unweighted item scores divided by the numbers of (a) Mann-Whitney U tests were used to compare
items on that factor [24]. primigravidae with multigravidae on each blues fac-
A two-stage general linear modelling procedure was tor. They did not differ significantly on any of the 5
then used to establish predictive relations between factor scores by Mann-Whitney U tests. Prediction of
these “blues” factor scores and outcome measures of T scores from blues factors was repeated using two
depression. First, the outcome measures were separate groups i.e., primiparae vs multiparae and very
predicted from the Goldberg scores at the 36th week little difference was found. Parity did not therefore
of pregnancy (heading 1, table 2). Then the remain- seem to be important.
ing variance in each of the later Goldberg scores was (b) A history of family and personal psychiatric his-
predicted from the five “blues” factor scores (heading tory was added to the linear model to see if the predic-
CATHERINE C. HAPGOOD, GAIL S. ELKIND & JAMES J. WRIGHT 303

Table 2. Prediction of Goldberg scores at 6,13,26 and 60 weeks postpartum from antenatal Goldberg score
and blues factor scores, as measured by F-ratios

Postpartum Goldberg scores

6 weeks 13 weeks 26 weeks 60 weeks


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(n=62) (n=60) (n=58) (n=56)


1. Antenatal Goldberg score
(36th week of pregnancy) 2.5V 1.71 8.90** 0.64

2. Combined perinatal blues factors


(After removing effect of antenatal Goldberg score) 2.94‘ 6.30’*’ 2.40’ 3.32*

3. Unique predictive value of each blues factor score


(After removing effects of antenatal Goldberg score
and the other four blues factor scores)
-early unhappiness 0.29 0.20 1.01 0.20
-middle unhappiness 0.21’ 0.23 2.58 1.26
-late unhappiness 2.08 0.04 1.13 7.17’*
For personal use only.

-happiness 0.34 0.62 0.25 0.49


-lability 2.36 9.15” 5.97” 7.56“

* = p<0.05 ** = p<O.Ol *‘* = p<O.OOl

tion of later depression was improved. However, these (c) Further tests were undertaken to test for inde-
two new variables accounted for very little of the pendence of “blues” factor scores from demographic
variance. The one exception was history of psychiatric variables. The relationship of maternity blues factor
disorder which by itself was a unique predictor for scores to other variables which might logically or
depression at fourteen months post partum (F = 4.28, theoretically be related to later depression was as-
p<O.OS) even when the S blues factors and family sessed, to check the independence of the factors per
psychiatric history were all co-varied out first. se. General linear models attempting to predict the fac-
tor scores from the following groups of independent
However, when two-way interactions were added to variables were used in this exercise: (1) Labour vari-
the above model then there was some improvement in ables, length of stages I and 11, type of anaesthetic, and
prediction. There were significant interactive effects type of delivery did not predict “blues” factors. (2)
between family psychiatric history, middle unhappiness, Planned pregnancy, previous abortion, pre-menstrual
and Goldberg scores at weeks 6, 13 and 60; between tension (PMT) whether or not breastfeeding at 6 weeks
family psychiatric history, late unhappiness and postnatally, number of feeds in 24 hours at 6 weeks
subsequent Goldberg scores; and between family postnatally and degree of difficulty breastfeeding at 6
psychiatric history, liability and Goldberg scores at weeks postnatally. None of these variables alone or in
weeks 13 and 60. None of these two-way interactions combination predicted “blues” factors with the single
was significant at more than two of the four time periods exception of middle unhappiness which was predicted
tested, however. by PMT alone (F = 4.08, p<O.OS).
304 MATERNITY BLUES AND POST PARTUM DEPRESSION

(3) Subject’s relationship with her own mother, with gested that the phenomena so loosely described as
respect to mother alive, mother in Auckland, “blues” are quite complex. The method used here,
childhood separation from mother, history of (rotation to orthogonality of principle component fac-
childhood physical abuse, closeness to mother, being tors, then naming the factors by their high weighted
like mother, dependence on mother, fondness of VAS components) enables us only approximately to
mother and ambivalent feelings about mother. None describe the independent subjective components, but
of the “blues” factors was predicted by the overall this appears a useful approximation.
model. However, ambivalent feelings about mothers, Firstly, while dysphoria is a necessary aspect of the
for the set of mothers of first babies only, predicted “blues” almost by definition, and has been widely
late unhappiness [F(I , 15)=4.84,p<O.O5] and early un- reported in the puerperium [2,7,10,19] the presence of
happiness [F(I , 15)=5.74, p<O.O5] uniquely, after all
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nearly independent temporal components has not been


other variables in the model had been co-varied out widely recognised.
first. Happiness might have been expected to be inverse-
(4) Help from subject’s mother after delivery. A ly related to dysphoria but was in fact uncorrelated
number of variables on availability of help from this with it, suggesting that some women experience them-
source were considered, but are not given here. None selves to be both happy and miserable at this time. The
of these variables predicted any maternity blues fac- assumption is that women are happy at having a baby
tors, singly or in combination. at this time, but are also experiencing more negative
Finally, the results were also analysed using diag- and fluctuating affects which may or may not be due
nostic categories for comparison, rather than Goldberg to identifiableexternal stressors. It may also be that the
scores. The average scores for each blues rating (not
social expectation of being happy at this time influen-
For personal use only.

factors) were compared across 14 days for two


ces ratings. The emergence of lability as a separate fac-
categories tor was of interest and importance and seems to
(a) women who developed major depressive disor- indicate that women distinguish the phenomena of
der in the first six months following childbirth (n=10);
“spirits going up and down” as an independent
(b) women who had no psychiatric diagnosis at any
phenomenon from intensity of mood.
stage during the study and were seen at all research in-
terviews (n=47) using Mann Whitney U tests. It has been suggested by Robin [ 1 11 and Ballinger
The detailed results of this analysis have been [ 121that lability is an essential component of the blues,
reported elsewhere (251.Of significance to the present and these results appear to support that belief. Kenner-
study was the fact that an association was ley el a1 [ 131 described lability of mood as an essen-
demonstrated between “blues” with post-partum tial component of primary blues and these results
depression of sufficient severity to be diagnosed as provide further confirmation.
DSM-I11 major depressive disorder. This association The phenomenon of lability is not measured by con-
was also most marked using the lability scales as the ventional mental state scales such as the General
index of “blues”. Health Questionnaire used by Kumar and Robson,
which may be why no linkage between the blues and
Discussion later depression was found in their study. Knight and
Thirkettle suggest that mood change in the puerperium
These results confirm an association between early is not accompanied by symptoms typical of a depres-
postpartum affective disturbance (blues) and late sive or anxiety disorder, but more one of strong nega-
postpartum disorder severe enough to be diagnosed as tive affective feelings. Our results indicate that lability
major depression using DSM-I11 criteria. Specifically, of affect may also be an essential feature of the blues
the findings of Kendell et a1 [ 191 are confirmed in all without any very close parallel to affects experienced
respects except the presence of a “day 5” peak of sig- in psychopathological states. Separate pheno-
nificant affective “blues” symptoms. The present menological conceptions to those applied in rating
results are compatible with the findings of other psychopathology may therefore be needed when the
authors, although close comparison can only be made “blues”are described. This has implications for the ap-
to that of Kendell. plication of conventional mood rating scales to the
The factor analysis of the “blues” VAS data sug- “blues”, which might be wholly misleading.
CATHERINE C. HAPGOOD, GAIL S. ELKIND & JAMES J. WRIGHT 305

Total scores on the Coldberg semi-structured psychiatric ment of “the blues” in the puerperium in the same way
interview were predicted by maternity blues factor scores as physical state is assessed, since this may be one of
at each time interval postpartum, including 14 months. the few predictors of the most common complication
Emotional lability was the most important predictor of of the postnatal period, postnatal deptession.
later psychiatric symptoms. Middle unhappiness was The results of this study together with those of Ken-
related to depression at 6 weeks post partum. An nerley confirm that the experience of “spirits going up
unexpected finding was a strong relationship between and down” is a critical phenomenon of “the blues”.
late unhappiness and depression at 14 months post Severe lability in the puerperium may be predictive of
partum. depression in later months. It is therefore essential to
The results of the analyses using extrinsic variables use a scale (or clinical evaluation) in which this chang-
ing mood is directly assessed, or the predominant fea-
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reasonably exclude a number of more trivial inter-


pretations of the predictive relations found. Ante natal ture of the blues may be unintentionally missed.
mood alone did not predict the “blues”. The interac-
tive effect of both past psychiatric history and positive
Acknowledgements
family history of psychiatric illness improved the
power of the blues factors to predict later mental state The authors are grateful to the Auckland Medical
marginally, but was not a major explanatory com- Research Foundation and the Ruth Spencer Trust
ponent. The blues factors themselves could not be which supported this work.
predicted by any demographic data. The only positive We wish to thank the obstetricians and nursing staff
findings were that a history of psychiatric disorder at National Women’s Hospital for their cooperation
either alone or in combination with family psychiatric and help with this study, and Mrs Josie McCallion for
For personal use only.

history was predictive of dysphoria early in the puer- secretarial assistance.


perium (early unhappiness). A past history of
premenstrual tension was related to middle unhappi-
ness. A weak association was demonstrated between References
ambivalent feelings towards the woman’s own
mother, and early and late dysphoria. Lability was not 1. Yalom ID, Lunde, DT, Moos, RH, & Hamburg, DA. “Postpartum
Blucs” syndrome: a description and related variables. Archives of
predicted by past psychiatric history, family history of General Psychiatry 1968;68:16-27.
psychiatric disorder or a history of premenstrual ten- 2. Pill B. Maternity blues. British Journal of Psychiatry 1973;22:43I -
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whether or not the pregnancy was planned, labour vari- 3. Hamilton. JA. Postpartum psychiatric problems. The C.V. Mosby
Co. St. Louis 1962.
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therapeutic) or whether or not the mother was cal review. Psychological Bulletin 1984;95:498-5 15.
breastfeeding. Marital status, parity, total number of 5 . O’Hara MW, Neunaber, DJ, Zekoskie M. A prospective study of
postparturn depression, prevalence, cause and predictive factors.
pregnancies, social class and race did not appear to be
Journal of Abnormal Psychology 1984;93:158-171.
related to puerperal affective experience. 6.Thirkettle JA, & Knight RG. The psychological precipitants of tran-
These data indicate that those women who ex- sient postpartum depression: a review. Current Psychological
perience marked lability of mood during the first two Research Reviews 1985;4:143-66.
weeks postpartum may be at risk of later depression, 7. Knight RG, & Thirkettle JA. Anxiety and depression in the im-
mediate postpartum period: A controlled investigation of a
and yet will report themselves as being no less happy primiparous sample. Australia & New Zealand Journal of Psychiatry
than other women at this time. In clinical practice it 1986;20:430-436.
can appear a reasonable course of action to discharge 8. Dalton K . Prospective study into puerperal depression. British Jour-
women from hospital if they display severe dysphoria nal ofpsychiatry 1971;118:689-92.
9. Oakley A. Women Confined. Martin Robertson 1980; Oxford.
and lability postpartum in order that they might be in 10. Stein G S . The pattern of mental change and body weight change in
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taken by other health care workers. However, this 1980;24:165-71.
mood change may well herald the onset of later depres- 1 1 . Robin AA. The psychological changes of normal parturition.
Psychiatric Quarterly 1962;36:139-150.
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history and family psychiatric history. There would al disturbance lollowing childbirth and the excretion of cyclic AMP.
seem therefore to be a strong case for careful assess- Psychological Medicine 1979;9:293-3OO.
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13. Kennerley H, & Gath D. Maternity blues reassessed. Psychiatric the first three weeks after childbirth. Journal of Affective Disorders
Developments 1986;1: 1-17. I981 ;3:3 17-326.
14. Davidson J. Postpartum mood changes in Jamaican women: A 20. Goldberg D, Cooper B, Eastwood MR, Kedward HB, Shepherd M.
description and discussion of its significance. British Journal of A standardised psychiatric interview for use in community surveys.
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15. Nott PN, Franklin M, Armitage C, & Gelder MG. Hormone chan- 21. Kumar R, Robson KM. A prospective study of psychiatric disor-
ges and mood in the puerperium. British Journal of Psychiatry ders i n childbearing women. British Journal of Psychiatry
1976;128:379-83. 1984;144:35-47.
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17. Harris B. Prospective trial of I-tryptophan in the maternity blues. 23. Johnson R. A revision of socio-economic indices for New Zealand,
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18. Paykel ES, Emms EM, Fletcher J. Rassaby ES. Life events and so- 24. Wainer H. Estimating coefficients in linear models: It don’t make
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For personal use only.

REBECCA L. COOPER MEDICAL RESEARCH FOUNDATION


Applications are invited for grants available in 1989 in the fields of DIABETES, ARTHRITIS a
SCHIZOPHRENIA.
The Rebecca L. Cooper Medical Research Foundation was founded in 1984 with the purposg
of funding medical research throughout Australia.
In 1989 grants will be given for research in the above fields, and it is expected that the value
each grant will be between $5,000 and $10,000, and is preferably for specific equipment. Co
mitments for continued support cannot be given.
Application forms will be sent on request, either by phone or letter; the completed application
be received no later than Friday 11th November 1988. Results will be sent out by the seconc
week of December.
All enquiries should be addressed to :
The Rebecca L. Cooper Medical
Research Foundation
P.O. Box 257
Bondi Road
BOND1 N.S.W. 2026.
Telephone number (02) 30 3378.

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