Rong et al 

Meta-analysis of Genetic Association with PACG

Footnotes and Financial Disclosures

Originally received: July 7, 2015. Obtained funding: Not applicable
Final revision: December 1, 2015. Overall responsibility: Rong, Chu, Ma, Yam, Young, Tham, Pang, Chen
Accepted: December 16, 2015.
Abbreviations and Acronyms:
Available online: February 4, 2016. Manuscript no. 2015-1133.
1 AACG ¼ acute angle-closure glaucoma; ACG ¼ angle-closure glaucoma;
Department of Ophthalmology and Visual Sciences, The Chinese Uni- CI ¼ confidence interval; GWAS ¼ genome-wide association study;
versity of Hong Kong, Hong Kong, China.
HSP70 ¼ heat shock protein 70; HWE ¼ HardyeWeinberg equilibrium;
2
Department of Ophthalmology and Visual Sciences, Prince of Wales IOP ¼ intraocular pressure; ITC ¼ irido-trabecular contact;
Hospital, Hong Kong, China. NOS ¼ Newcastle Ottawa Scale; NOS3 ¼ nitric oxide synthase 3;
3
Hong Kong Eye Hospital, Kowloon, Hong Kong, China. OR ¼ odds ratio; PAC ¼ primary angle-closure; PACD ¼ primary angle-
Financial Disclosure(s): closure disease; PACG ¼ primary angle-closure glaucoma;
The author(s) have no proprietary or commercial interest in any materials PACS ¼ primary angle-closure suspect; PAS ¼ peripheral anterior syn-
discussed in this article. echiae; SE ¼ standard error; SNP ¼ single nucleotide polymorphism.
Author Contributions: Correspondence:
Conception and design: Rong, Chen Li Jia Chen, PhD, Department of Ophthalmology and Visual Sciences, The
Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New
Data collection: Rong, FY Tang, Ma, Yam, SM Tang, Li, Gu, Chen
Territory, Hong Kong. E-mail: lijia_chen@cuhk.edu.hk.
Analysis and interpretation: Rong, FY Tang, Chu, SM Tang, Li, Gu,
Young, Tham, Pang, Chen

Pictures & Perspectives

An Unusual Presentation of a Vitreous Hemorrhage

A 38-year-old woman with poorly controlled diabetes
presented with gradually decreasing vision to hand motion in
the right eye. Slit lamp dilated exam revealed a crescentic
boat-shaped hemorrhage in Berger’s or Erggelet’s space (Fig
1). This retrolental vitreous hemorrhage was characterized by
an acute bleed topped by a layer of dehemoglobinized blood.
Moderate diffuse vitreous hemorrhage prevented elucidation
of fine retinal details on ophthalmoscopy, allowing only the
observation of panretinal photocoagulation scars; no large
retinal tears were evident. Dilated fundus examination of the
left eye revealed neovascularization of the optic disc with
clinically significant macular edema and neovascularization of
vessels along the inferior arcade. The ophthalmologic findings
were consistent with vitreous hemorrhage as a complication of
proliferative diabetic retinopathy.
JAMES LIN, MD
NAILYN RASOOL, MD
JASON HOROWITZ, MD
Department of Ophthalmology, Harkness Eye Institute, Columbia
University College of Physicians and Surgeons, New York, New
York

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