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ABSTRACT
Nanotechnology drug delivery system has been developed for delivery of pharmaceutical active
agents into the target sites of the body. The pharmaceutical active agent could be delivered into
the target site by using natural polysaccharide. Polysaccharide has the potential as
nanotechnology drug delivery system with the high potential benefits of passive/active targeting
and reduced undesirable side effects. The mucoadhesive, biodegradable, and biocompatible
properties of polysaccharides can be used for increasing the efficiency of drug delivery system.
This study reviews recent advances made in using three common natural polysaccharide;
cellulose, alginate and chitosan in nanodrug delivery.
(e.g. alginate), plant origin (e.g. pectin, guar Cellulose is the most abundant
gum), microbial origin (e.g. dextran, polysaccharide available worldwide and
xanthan gum), and animal origin (chitosan, exhibits attractive structure and single
40
chondroitin) . Due to the presence of properties, which are quite attractive for
various derivable groups on molecular both academic and industrial researchers21
chains, polysaccharides can be easily Cellulose based polymers has a positive
modified chemically and biochemically, characteristics such as safety,
resulting in many kinds of polysaccharide biodegradability, biocompatibility, and
derivatives. In addition, polysaccharides protein rejecting ability20. The hydrophilic
nature of the cellulose within paper structure USDA Forest Products Lab, Alberta
are very important for good fiber bonding26. Innovates-Technology Futures)18.
Chemical structure of the cellulose:
The current distribution of the
nanomaterials produced by type is
approximately 65% cellulose nanofibrils,
34% cellulose nanocrystals, and 1%
bacterial cellulose; however, this landscape
does not reflect the ease with which these
materials are produced and is likely to shift
21
due to the scale at which cellulose
nanocrystals can be produced and their
Cellulose represents ~ 1.5 x 1012 tons
numerous applications18.
of the total biomass produced yearly, and as
such is the most abundant structural polymer The amorphous nanoparticles (ANP)
in nature13. Cellulose has been used for are completely hydrolyzed by cellulolytic
millennia as a source of fuel, building enzymes with forming of glucose that can be
materials, paper products, and textile fibers. used further for biological, cosmetic or
Its widespread use is primarily due to the medical application. Low-acidic and soft
unique intrinsic physical, chemical, and nanoparticles can be used in cosmetic
mechanical properties that largely arise from formulation for gentle skin peeling. The
the hierarchical organization of natural ANP-TAS complexes can be applied in
cellulosic materials. For example, the tight remedies aimed for effective care and cure
packing of glucan chains contained in the of the skin10.
core of cellulose microfibrils gives plant cell
2. Alginate
walls the rigidity to withstand the
mechanical stresses of their environment18 Alginate, an anionic unbranched
biopolymer, is comprised of guluronic and
The appearance of the first pilot- and
mannuronic acid residues30. The most
industrial-scale producers of cellulose
common techniques used for the preparation
nanofibrils (e.g., Innventia, Borregard, Oji
of alginate nanoparticles are the reverse
Paper, VTT, Daicel) and cellulose
microemulsion, desolvation, cross-linking,
nanocrystals (e.g., CelluForce, Melodia,
and evaporation29. Alginate can interact with
the cationic components due to its anionic extensively applied as drug/gene delivery
nature. Therefore, it can be used for the systems23,37,43. The most common
preparation of delivery systems due to techniques used for the preparation of
incorporate positively charged drugs and alginate nanoparticles are the reverse
molecules. Calcium alginate is the most microemulsion43, evaporation38,
commonly used alginate matrix in the desolvation28, and cross-linking22. As a
engineering of drug/gene delivery systems37. polymeric acid alginate is negatively
charges in solution25.
Chemical structure of the alginate:
Alginate can interact with the
cationic components due to its anionic
nature. Therefore, it can be used for the
preparation of delivery systems due to
incorporate positively charged drugs and
molecules. Calcium alginate is the most
commonly used alginate matrix in the
34 engineering of drug/gene delivery systems37.