Preeclampsia sFlt-1/PlGF ratio

A new biomarker to aid in the diagnosis of preeclampsia

Determination of the sFlt-1/PlGF ratio from gestational week 20+0
Suggested patient profile

1 Investigation OR 2 Pathological OR 3 One of the following risk factors

of suspected uterine artery • Preeclampsia in a previous pregnancy
preeclampsia Doppler • Preexisting hypertension
• Preexisting kidney disease
• Diabetes

Sample materials: Serum

sFlt-1/PlGF ratio – Aid in diagnosis of preeclampsia

Early-onset preeclampsia Late-onset preeclampsia Gestational

20 34 weeks
sFlt-1/PlGF Rule-in sFlt-1/PlGF
Rule-in specificity: 95.5 %
specificity: 99.5 % sensitivity: 58.2 %
110
sensitivity: 88.0 %
85 *

33 33
Rule-out Rule-out
specificity: 94.0 % specificity: 73.1 %
sensitivity: 95.0 % sensitivity: 89.5 %

* At a cut-off of 85 for the whole gestational period (from week 20+0 to delivery) the sensitivity was calculated at 82 % and the specificity at 95 %.

References
Verlohren, S., Galindo, A., Schlembach, D., Zeisler, H., Herraiz, I., Moertl, M. G., et al. (2010). An automated method for the determination
of the sFlt-1/PIGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol. 202(2):161.e1-161.e11.
Study report: Diagnosis of Preeclampsia by means of the Elecsys® assays sFlt-1 and PlGF (2012); Data on file.

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