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Product Catalog
Peptide & Material Research and Development
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/ PRODUCTS
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 As a company of perseverance,
A&PEP has walked only one path that no one has stepped on.

With a spirit of challenge not being afraid of change and innovation, our company has grown into a
company specialized in peptide synthesis and solutions until today, since the separation from the
Central Research Center of Hyundai Pharm Co., Ltd. in 2001. We are always trying to be with you as a
beautiful companion of mankind under the slogan of changing the world with human beauty.
A&PEP has designed over 30,000 different peptides for 16 years and synthesized the peptides
according to the protocol. As a result of our focused research on peptide-related technology,
we developed NSC-amino acid, a novel amino-protecting group, which is currently protected as
an international patent. This technology enabled mass-production of peptides and gave us an
advantage in price competitiveness. Not only by developing peptide cosmetics materials but also
by introducing the traditional fermentation science of Korea, our company launched a global brand
strategy from 2015, and has been meeting with the world customers in earnest.
Now, A&PEP is aiming to be the best in every aspect in order to make a leap to the world. We will
offer various innovative products to meet the needs of customers around the world with human-
centered management.
 1996. 01. Central Research Center, Hyundai Pharm Co., Ltd. : Patent application for
Nsc-Amino acid/Production of prototypes for 20 items
2001. 03. Establishment of A&PEP Co., Ltd.
2001. 05. Venture business certification on
2002. 11. Certification of the company-affiliated research center
2004. 05. Development of Mass Production Technology of medical peptide Desmopressin
Start of supply it to Hyundai Pharm Co., Ltd. as a raw material for 'Uremin' Tab.,
which is a therapeutic drug for frequent urination
2012. 07. Development of new whitening peptides and patent registration
(Application No. 10-2011-0121135)
2014. 07. Release of an anti-inflammatory peptide (ApepAF-1)
2016. 06. Patent registration of fermented collagen
2017. 10. Company to be relocated (finalized to Oksan Industrial Complex)

4 I A&PEP COMPANY
PRODUCTS

A&PEP COMPANY I 5
 Finexell-T11
INCI Name :
Hexapeptide-9, Tripeptide-29, Tripeptide-1,
Acetyl hexapeptide-8, Lactobacillus / Collagen Ferment Filtrate

- A complex consisting of peptides and extracts with excellent efficacy for improvement of wrinkles
and prevention of skin aging
- All of the components exerts their effects through different mechanisms, so it is thought that
there is a strong anti-aging effect due to the combination of the fundamental approach and
improvement for wrinkles.
- Hexapeptide-9 is effective for skin regeneration, Tripeptide-29 improves wrinkles by collagen
production,Tripeptide-1 and Acetyl hexapeptide-8 improves wrinkles and Lactobacillus/Collagen
Ferment Filtrate promotes collagen biosynthesis in vivo, which all lead to an anti-aging effect.

Component Contents Component Contents

Hexapeptide-9 800ppm Tripeptide-29 100ppm

Acetyl Hexapeptide-8 100ppm Tripeptide-1 100ppm

Lactobacillus/
5% - -
Collagen Ferment Filtrate

NATURAL / ARTIFICIAL SOURCES OF LIGHT

UVB, UVA, Blue light & INFRA-RED

Irritation-relief
(Lactobacillus/Collagen
Ferment Filtrate)
Anti-oxidant
↘ ROS & Free ardicals
↗ Antioxidant defenses
Anti-inflammatory (Lactobacillus/
Collagen Ferment Filtrate)

Cellular protection CELLULAR DEFENCE Anti-INFLAMMATION

(Tripeptide-1)
↗ Lipid Antioxidant ↗ Lipid Antioxidant
↗ DNA Repair ↗ DNA Repair
↘ Apoptosis of cells ↘ Apoptosis of cells

the corium barrier improvement EXTRACELLULAR MATRIX

(Hexapeptide-9, Tripeptide-29,
Acetyl hexapeptide-8) ↘ MMP-1,3,6,9
↗ Elastin, collagens contents

6 I A&PEP COMPANY
 Finexell-T11
Skin regeneration assay
200 200

180 180

160 160

140 140

120 120

100 100

80 80

60 60

40 40

20 20

0 0
CTL 20.0% 10.0% 5.0% 2.5% CTL 20.0% 10.0% 5.0% 2.5%

[HACAT cells] [HDF cells]

Results : It was confirmed that Finexell-T11 helped two kinds of skin cells proliferate, which led
to an excellent effect on skin regeneration.
Note.
HACAT cells: Human epidermal cells (human keratinocyte)
HDF cells: Human fibroblast cells)
Tested by Anpep laboratory

Wound healing assay

Before CTL Complex 350ppm 175ppm

- 75ppm 30ppm 15ppm

Results : Finexell-T11 showed a cell regenerating effect when treated in skin cells at different
concentrations, which helped wound-healing
Note.
The cell recovery capacity was examined through growth of skin cells by performing wound healing assay.
Tested by Anpep laboratory

A&PEP COMPANY I 7
 Finexell-T11
Collagen synthesis assay
150
Finexell-T11 Hydrolysis collagen

100

50

0
CTL 20.0% 10.0% 5.0% 2.5%

Results : Finexell-T11 induced collagen production in a concentration-dependent manner in

dermal cells and it was effective for prevention and improvement of wrinkles
Note.
Collagen is synthesized as a procollagen form in the cell, and the propeptide is cleaved while it is secreted out of the
cell, forming extracellular collagen fibrils. Therefore, the amount of free propetides reflects the amount of collagen
synthesized in the cells. The amount of the carboxy-terminal peptide of the Procollagen type I, which is a free
propeptide, was measured by EIA method to evaluate the degree of intracellular collagen production
HDF -a cell : Human dermal fibroblast
Tested by Anpep laboratory

MMP-1 Inhibition assay

150
Finexell-T11 Retinol

100

50

0
CTL 20.0% 10.0% 5.0% 2.5%

Results : Finexell-T11 showed an excellent MMP-1 inhibitory effect in a concentration-dependent

manner and it was greatly effective for wrinkle improvement
Note
UV-irradiation promotes expressions of various substrate protein degrading enzymes (matrix metalloproteinase,
MMP). These collagen-degrading enzymes are various in type, among which collagenase (MMP-1) is most widely
known and degrades collagen type 1. By examining the degree of inhibition of this MMP-1, the wrinkle-reducing effect
can be determined
HDF -a cell: Human dermal fibroblast
Tested by Anpep laboratory

8 I A&PEP COMPANY
 Finexell-T11
Clinical test

Before After 4 weeks later

A&PEP COMPANY I 9
 TRANEXELL-V10
INCI Name :
Nicotinoyl Dipeptide-22, Tranexamoyl Dipeptide-22,
Lactobacillus/Citrus medica Limonum Peel Ferment extract, Citrus urantinum dulcis
(Orange) Peel Extract, Bifida Ferment Lysate
- A complex formulation consisting of various peptide combinations which have been screened
through numerous experiments to find the whitening effect
- Nicotinoyl dipeptide-22 and Tranexamoyl Dipeptide-22 are effective for whitening through
different mechanisms and they are effective for preventing melanocyte deposition through a
combined mechanism
-  Lactobacillus/Citrus medica Limonum Peel Ferment extract and Citrus urantinum dulcis (Orange)
Peel Extract have antioxidant and whitening effects, whereas Bifida Ferment Lysate has an anti-
aging effect by protecting against UV-induced damage and by preventing aging of cells.
- All raw materials are proprietary to A&Pep with our own unique concept, of which efficacies have
been proved through clinical studies and various experiments
- Application : Whitening

Component Contents Component Contents

Nicotionoyl dipeptide-22 500ppm Tranexamoyl Dipeptide-22 500ppm

Lactobacillus/Citrus medica
Limonum Peel Ferment
Tranexamic acid 1,000ppm 1.5%
extract, Citrus urantinum
dulcis (Orange) Peel Extract

Bifida Ferment Lysate 1.5% - -

Mechanism

Irritation-relief Inhibition of Melanin

(Bifida ferment Lysate) migration
(V-peptide)

Inhibition of Tyrosinase
(TranEX-peptide
Anti-inflammatory
Ferment Citrus)
(anti-inflammatory,
antioxidant)
Ferment Citrus, Bifida
ferment Lysate)

Inhibition of Tyrosinase
biosynthesis
(V-peptide, TranEX-peptide)

10 I A&PEP COMPANY
 TRANEXELL-V10
L-DOPA Inhibition assay

150
Tranxell-V10 TXA NA

100

50

0
CTL 20.0% 10.0% 5.0% 2.5%

Results : Tranexell-V10 showed a high L-DOPA-inhibitory effect and helped skin whitening
Note.
DOPA : An abbreviation for 3,4-Dihydroxyphenylalanine, an α-amino acid.
In skin melanin-containing cells, dopa is made from tyrosine by tyrosinase, which is further oxidized to dopaquinone
and melanin in sequence. Thus, the efficacy of the whitening component can be evaluated by measuring the
inhibition of DOPA oxidation activity.
Tested by Anpep laboratory

Tyrosinase Inhibition assay

150
Tranxell-V10 TXA Niacinamide

100

50

0
CTL 20.0% 10.0% 5.0% 2.5%

Results : Tranexell-V10 showed a tyrosinase-inhibitory effect in a concentration-dependent

manner and it was effective for whitening improvement
Note
Tyrosinase: An enzyme that reacts with an amino acid (tyrosine) to form melanin.
In skin melanin-containing cells, dopa is made from tyrosine by tyrosinase, which is further oxidized to dopaquinone
and melanin in sequence. Thus, the efficacy of the whitening component can be evaluated by measuring the
inhibition of melanin production through the inhibition of Tyrosinease activity.
Tested by Anpep laboratory

A&PEP COMPANY I 11
 TRANEXELL-V10
Melanogenesis inhibition assay

150
Tranxell-V10 Niacinamide

100

50

0
CTL 20.0% 10.0% 5.0% 2.5% -aMSH

Results : Tranexell-V10 showed a Melanin-inhibitory effect in a concentration-dependent manner

and it was effective for whitening improvement
Tested by Anpep laboratory

CTL 2.5% 5.0% 10.0% 20.0% -aMSH CTL 2.5% 5.0% 10.0% 20.0% -aMSH

[Apep Tranexell-V10] [Niacinamide]

12 I A&PEP COMPANY
 TRANEXELL-V10
Clinical test

Before After

- Ages : 40 years old

- Subjects : whitening
- Periods : 4 weeks
- Concentration : Apep Tranexell-V10 - 10%
- Methods :
1) It is used more than 5 times a week for 4 weeks.
2) It is used 7 times a week depending on the age range of the skin and pigments deposition range.

A&PEP COMPANY I 13
 TRANEX
INCI Name : Tranexamoyl Dipeptide-23
- A vitamin-peptide, which was created by introducing Tinexamic acid with a whitening effect to
the N-terminus of a Dipeptide through a chemical synthesis process.
- Tranexamic acid is a medical substance with anti-inflammatory/anti-allergic and hemostatic
effects, and has excellent anti-pigmentation properties for skin, which is effective for
improvement of skin tone.
- The Peptide plays a role in doubling the whitening effect

Component 1000ppm (0.1%) pH 4.0 ~ 6.0

Appearance Clear to Slightly Hazy Liquid Specific Gravity 0.98 - 1.10

Odor Characteristic Odor Preservative Free

Purity By HPLC > 95 % Recommended use level 3-7%

Mechanism

Fibrinolysis Activation Fibrinolysis Inhibition

I-PA I-PA

Plasminogen Plasminogen

Tranexamic acid

Fibrin

Fibrin

I-PA Plasminogen I-PA Plasminogen

Fibrin

Fibrin

14 I A&PEP COMPANY
 TRANEX
Efficacy evaluation(qRT - PCR)
Cycle 20 Cycle 30 Cycle 40
100
90
80
70
60
50
40
30
20
10
0
(+)Control (+)Control 0.1 0.05 0.1 0.05

TRANEX -1 TRANEX -2
Note.
qRT PCR (quantitative Real time PCR): A rapid and simple method for accurate quantitation by monitoring the
increase of the PCR amplification product in real time.
GAPDH (Glyceraldehyde 3-phosphate dehydrogenase): A protein that is used as a control to correct the result in the
experiment.

Clinical test

Ex. 1 Ex. 2

Change % of melanin index

a

0 week 2 week 4 week 6 week 8 week

TRANEX -2 0 8.1 13.2 19 26.9

TXA 0 6.5 8.2 9.8 11.4

Control 0 0.7 2.8 4.8 6.6

a[(M0-Mw)/M0] × 100
M0: Melanin index of 0 week, before using test cream
Mw: Melanin index of W(2~8 week respectively)

A&PEP COMPANY I 15
 Apep AF-1(0.1%)
INCI Name : Tetrapeptide-44
- An anti-inflammatory peptide (7 kinds of peptides were separated) from fast-fermented bean
paste (Chungkukjang)
- Naturally derived peptide (no skin toxicity)
- It reduces inflammation and irritation and inhibits skin troubles
- Domestic patent registration in 2014 (2014)
- One paper was published in The Journal of Nutrition 2013/183533 Version 1

Component 1000ppm (0.1%) pH 4.0 ~ 6.0

Appearance Clear to Slightly Hazy Liquid Specific Gravity 0.98 - 1.10

Odor Characteristic Odor Preservative Free

Purity By HPLC > 95 % Recommended use level 3-7%

AF-1 concentration (PPM)

Mechanism (AF-1)
150

100
inhibition rate (%)

50

0
5000 2500 1250 625 313 156 78 36 0 LPS

Results : Anti-inflammatory peptides (ApepAF-1) inhibit LPS-induced NO expressions in Raw264.7

cells.
Note.
NO : A carrier involved in signal transduction in human body (involved in inflammatory reaction)
Tested by Anpep laboratory

16 I A&PEP COMPANY
 Apep AF-1(0.1%)
LPS

50
LPS LPS
40

Relative iNOS mRNA level

Con - 0.03 0.1 0.3 Con - 0.03 0.1 0.3

iNOS iNOS 30

20
β-actin β-actin
10
#1 peptide(mg/ml) #2 peptide(mg/ml)
0
Con - #1 #2
peptide(0.3mg/ml)

Results : anti-inflamatory peptide (ApepAF1(OP#1) and ApepAF-2 (OP #2) ) controls guided
iNOS's revelation augmentation by LPS in Raw264.7 cells.

Note.
NO : receptor that concern in transduction of human body(In inflammatory reaction participation
iNOS : NO creation kind of enzyme that do catalyst
b-actin : To control group which correct result in an experiment by protein kind use
Reference - Journals (The Journal of Nutrition 2013/183533 Version 1)

Clinical test (Chronic Inflammatory Disease - Acne)

Before After (4 weeks later)

- Age of subjects : 20 years old

- Subject number : 20
- Test target : Improvement of acne
- Test period : 4 weeks (duplicate tests)
- Testing dose : ApepAF-1 (0.1%) - 7%
- Test method :
1) It is used more than 5 times a week for 4 weeks.
2) It is used 7 times a week depending on the age range of the skin and pigments deposition range.

A&PEP COMPANY I 17
 V-peptide-2(0.1%)
INCI Name : Nicotinoyl Dipeptide-23
- A vitamin-peptide in which a vitamin (niacinamide) is chemically synthesized and introduced at
the N-terminus of the peptide
- Niacinamide is a known whitening ingredient, and the peptide plays a role in doubling the
whitening effect
- Domestic patent registration in 2012, PCT application in 2012, entry into individual countries (USA,
China, etc.)
- Function : whitening
- Application : Whitening, skin tone improvement

Component 20,000, 5000, 1000, 500ppm pH 3.5 ~ 6.5

Appearance Clear to Slightly Hazy Liquid Specific Gravity 0.98 - 1.10

Odor Characteristic Odor Preservative Free

Purity By HPLC > 93 % Recommended use level 30ppm

Mechanism
- V-peptide inhibits the activities of tyrosinase 1, 2 to directly suppress synthesis of melanin
- V-peptide inhibits production of tyrosinase-1,2, which involve in melanin production by
suppressing production of MITF in the nucleus
- V-peptide inhibits migration of melanosome by suppressing MITF production

Note.
Tyrosinase 1,2 : Enzymes involved in the most important initial rate determining step in the melanin biosynthesis
pathway
MITF (Microphthalmia-associated transcription Factor) : A transcriptional regulator which is important in the melanin
synthesis process and it promotes tyrosinase production

18 I A&PEP COMPANY
 V-peptide-2(0.1%)
Efficacy evaluation(qRT - PCR)
Tyrp1/GARPH Tyrp2/GARPH MITF/GARPH
1.4 7
Relative absorbance(420mm)

1.2 AA2G 6
5
1.0 Dipep
4
0.8
3
0.6
2
V-peptide
0.4 1

0.2 0
(+)Control

0
10
0
l

SH

10

0
ro

10

25
25
10
nt

p
M

p
p

pe
p
pe
a-
Co

pe

pe
pe
pe

Di
Di

Di

Di
Di
Di

T-

T-

T-
VI

VI

VI
Results : It was found that Tyrosinase 1,2 and MITF, which are involved melanin production,
were all inhibited

Clinical test

Before After (4 weeks later)

[Subject information | Gender : Female, Age : 33]

A&PEP COMPANY I 19
 Apep Colla-5(0.05%)
INCI Name : Tripeptide-29
- A high-purity Tripeptide combined with 3 amino acids, which are key components of collagen
- It was confirmed that it was effectively penetrated to the horny layer, skin layer and hair follicles
at a high concentration due to its low molecular weight
- It is effective for collagen production, enhanced skin elasticity, wrinkle improvement and
prevention of wrinkle formation
- Application : Anti-aging, Reduce pores

Component 500ppm (0.05%) pH 4.0 ~ 6.0

Appearance Clear to Slightly Hazy Liquid Specific Gravity 0.98 - 1.10

Odor Characteristic Odor Preservative Free

Purity By HPLC > 95 % Recommended use level 3-7%

Mechanism

20 I A&PEP COMPANY
 Apep Colla-5(0.05%)
Clinical test

Test 0 Test 4 Weeks later

[Subject information | Gender : Male, Age : 69]

Test 0 Test 4 Weeks later

[Subject information | Gender : Male, Age : 40]

A&PEP COMPANY I 21
 Concentration
Application Product name INCI name (ppm) dossage(%) Remarks

Nicotinoyl Dipeptide-22,
Tranexamoyl Dipeptide-22,
Whitening Tranexell-V10 Lactobacillus/Citrus medica Limonum Peel 1,000 - New product
Ferment extract, Citrus urantinum dulcis
(Orange) Peel Extract, Bifida Ferment Lysate

Hexapeptide-9, Tripeptide-29,
Anti-Wrinkle Finexell-T11 Tripeptide-1, Acetyl hexapeptide-8 1,100 - New product
Lactobacillus/Collagen Ferment Filtrate
New product/
Whitening TRANEX -1,2 Tranexamoyl Dipeptide-23 1,000 - Patent
New product/
Whitening V-Peptide-2 Nicotinoyl Dipeptide-23 1,000 3-5 Patent
New product/
Anti-inflammation ApepAF-1 Tetrapeptide - 44 1,000 3-5 Patent

Anti-aging ApepColla-5 Tripetide-29 500 3-7 -

Poly Glutamic Acid,

Moisturizing effect Apep Ca-PGA - 3-10 New product
Calcium Chloride

Anti-aging ApepAHP-5 Acetyl Hexapeptide-8 500 3-5 -

Anti-aging ApepPPP-5 Palmitoyl Pentapeptide-4 500 3-5 -

Hair-care ApepCTP-10 Copper Tripeptide-1 1,000 3-5 -

Palmitoyl Oligopeptide
Lip-Care ApepPoly-3 500 3 -
(Palmitoyl Tripeptide-1)

Anti-aging ApepBiosix-5 Hexapeptide-9 500 5-10 -

Anti-aging ApepDegine Palmitoyl Tetapeptide-7 500 3-5 -

Anti-aging ApepGHK Tripetide-1 1,000 3-5 -

Anti-aging NA-GHK Nicotinoyl Tripetide 500 3-5 -

Anti-aging ApepAGES Carnosine & Glutathione 1,000 3-5 -

Hair-care ApepActigrowth-10 Copper Tripeptide-34 HCl 1,000 10 -

Anti-glycation ApepAGES Carnosine & Glutathione 1,000 3-5 -

Anti-Wrinkle ApepIHP-5 Hexapeptide-12 500 3-7 -

Whitening ApepNonapep-5 Nonapeptide-1 500 3-7 -

Wound Healing Apep L-9 Nonapeptide-7 500 3-7 -

Citrus urantinum dulcis

(Orange) Peel Extract
Anti-Oxidant Apep Ferment Citrus 10% - -
Lactobacillus/Citrus medica Limonum
Peel Ferment extract

Arctium Lappa Seed Extract/Glutathione/ - 3-5 -

Anti-Oxidant ApepFS-2 Forsythia Suspenasa Fruit Extract

Anti-aging Apep Bifida Repair System Bifida Ferment Lysate - 3-7 New product

Lactobacillus Ferment Lysate

Whitening ApepW-10 Filtrate (pentapeptide-13) 1,000 3 -

Lactobacillus/ New product/

Anti-aging Apep Ferment collagen - 3-7
Collagen Ferment Filtrate Patent

22 I A&PEP COMPANY
(316-1 Songdae-ri), 128, Yangcheongsongdae-gil, Ochang-
eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do
Tel. +82 043 241 3360 | Fax. +82 043 241 3365
E-mail : jingwenh@anpep.com
danielkim@anpep.com
http://www.anpep.com
http://www.anpep.com