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Maternal Morbidity Associated With Vaginal Versus

Cesarean Delivery
Lara J. Burrows, MD, Leslie A. Meyn, MS, and Anne M. Weber, MD, MS

OBJECTIVE: To describe postpartum maternal morbidity (Obstet Gynecol 2004;103:907–12. © 2004 by The Amer-
associated with mode of delivery in term, singleton ican College of Obstetricians and Gynecologists.)
pregnancies. LEVEL OF EVIDENCE: II-2
METHODS: The Magee Obstetric Medical and Infant data-
base was examined for the years 1995 to 2000. Patients were Recently interest has grown with idea that injury sus-
grouped into 6 types of delivery mode: spontaneous vagi- tained during childbirth might contribute to the subse-
nal delivery, operative vaginal delivery, primary cesarean quent development of pelvic floor disorders. This has
delivery without trial of labor, primary cesarean delivery prompted some clinicians to question the potential ben-
with trial of labor, repeat cesarean delivery without trial of efits of a “prophylactic” cesarean delivery. Concur-
labor, and repeat cesarean delivery with trial of labor.
rently, the debate over whether “elective” cesarean de-
Multivariable logistic regression provided odds ratios and
liveries should be performed on maternal request is
95% confidence intervals (CI) for morbidity by delivery
mode adjusted for demographic characteristics and comor-
escalating.
bidities. Spontaneous vaginal delivery was used as the Whether cesarean delivery is performed for medical
referent group (odds ratio ⴝ 1). indications or at the patient’s request, data regarding the
respective morbidities for vaginal and cesarean deliver-
RESULTS: Of 32,834 subjects, 27,178 had vaginal delivery
(operative ⴝ 4,908; spontaneous ⴝ 22,270) and 5,656 had
ies are poorly defined. There are few reports on morbid-
cesarean delivery. Third- or fourth-degree lacerations oc- ities associated with vaginal birth. Until recently, events
curred in 1,733 (7.8%) women who had spontaneous vagi- such as anal sphincter lacerations were not even consid-
nal delivery compared with 1,098 (22.3%) who had opera- ered significant sources of morbidity.
tive vaginal delivery. Overall, 523 women (1.6%) had The earliest reports on cesarean deliveries focused
endometritis. Compared with spontaneous vaginal deliv- mainly on mortality associated with the procedure.
ery, primary cesarean delivery with trial of labor conferred However, maternal mortality has become increasingly
a 21.2-fold increased risk of endometritis (95% CI 15.4, rare in developed countries. Many studies evaluating
29.1). Even without trial of labor, women after primary maternal morbidity associated with cesarean delivery
cesarean delivery were 10.3 times more likely to develop were performed in the 1970s and 1980s; since then,
endometritis (95% CI 5.9, 17.9) than after spontaneous obstetric practice has changed considerably. Therefore,
vaginal delivery. The risk of transfusion was highest in the goal of this study was to provide a current descrip-
women delivered by primary cesarean after labor, 4.2
tion of maternal morbidity for cesarean and vaginal
times higher (95% CI 1.8, 10.1) than spontaneous vaginal
deliveries.
delivery. The risk of pneumonia was 9.3 times higher (95%
CI 3.4, 25.6) after repeat cesarean delivery with labor. Deep
venous thromboses occurred in 15 (0.1%) after spontaneous
MATERIALS AND METHODS
vaginal delivery, 2 (0.04%) after operative vaginal delivery,
and 12 (0.2%) after cesarean delivery. This study was a review, which used the Magee Obstet-
CONCLUSION: Compared with spontaneous vaginal deliv- ric Medical and Infant database, of 32,834 women who
ery, cesarean delivery is associated with increased risks of delivered at Magee-Womens Hospital from 1995 to
endometritis, the need for transfusion, and pneumonia; 2000. This number included patients who were term (37
however, these rates are lower than reported previously. weeks of gestation or greater) with a singleton pregnancy
and who had only 1 delivery or their first delivery at this
From the Department of Obstetrics, Gynecology and Reproductive Sciences, Magee- institution. The data were captured as they passed
Womens Hospital, Pittsburgh, Pennsylvania. through medical records and electronically interfaced
This research was presented in abstract form in September 2003 at the Annual with the database. This interface contained all Interna-
Meeting of the American Urogynecologic Society, Hollywood, Florida. tional Classification of Diseases, 9th Revision, diagnosis

VOL. 103, NO. 5, PART 1, MAY 2004


© 2004 by The American College of Obstetricians and Gynecologists. 0029-7844/04/$30.00 907
Published by Lippincott Williams & Wilkins. doi:10.1097/01.AOG.0000124568.71597.ce
Table 1. Demographic Characteristics of 32,834 Women With Term Singleton Deliveries in the Magee Obstetric Medical
Infant Database From 1995 to 2000
Spontaneous Operative Repeat cesarean Repeat cesarean with
vaginal vaginal without trial of labor trial of labor
(n ⫽ 22,270) (n ⫽ 4,908) (n ⫽ 865) (n ⫽ 768)
Race†
White 18,005 (81.2) 3,827 (78.2) 740 (85.7) 623 (81.4)
Black 3,444 (15.5) 865 (17.7) 104 (12.1) 123 (16.1)
Other 737 (3.3) 199 (4.1) 19 (2.2) 19 (2.5)
Mean age (y) 28.7 ⫾ 6.0 28.4 ⫾ 6.1 32.7 ⫾ 4.8 32.3 ⫾ 4.8
Median gestational age (wk) 39 (37–44) 39 (37–43) 39 (37–42) 39 (37–43)
Median gravidity 2 (1–18) 2 (1–18) 3 (2–10) 3 (2–15)
Primiparous 10,442 (46.9) 3,180 (64.8) 0 0
Median education (y)㛳 14 (8–22) 14 (8–21) 14 (9–24) 14 (9–23)
Smoked during pregnancy¶ 2,904 (13.1) 720 (14.7) 128 (14.8) 127 (16.6)
Marital status
Married 13,643 (61.3) 2,838 (57.8) 662 (76.5) 551 (71.7)
Single 6,617 (29.7) 1,649 (33.6) 109 (12.6) 155 (20.2)
Other 2,010 (9.0) 421 (8.6) 94 (10.9) 62 (8.1)
Maternal weight on admission 3,184 (16.6) 605 (13.9) 223 (29.2) 186 (26.8)
⬎ 91 kg#
Data are presented as n (%), mean ⫾ standard deviation, or median (overall range)
* P value from Pearson’s ␹2 test.

117 missing.

P-value from one-way analysis of variance.
§
P-value from Kruskal-Wallis test.

3,245 missing.

112 missing.
#
4,366 missing.

and procedure codes. In addition, trained chart abstrac- Patients were categorized as follows: spontaneous vag-
tors reviewed each medical record after every delivery inal delivery, operative vaginal delivery, primary cesar-
and coded the information into an electronic format for ean delivery without trial of labor, primary cesarean
demographic variables, such as maternal history of delivery with trial of labor, repeat cesarean delivery
smoking. Variables were validated later by manual re- without trial of labor, and repeat cesarean delivery with
view of 100 arbitrarily selected medical records. This trial of labor. A trial of labor was defined as an attempt to
study was approved by the Magee-Womens Hospital achieve a vaginal delivery in patients who had no mater-
Institutional Review Board. nal or fetal contraindications to such an attempt. This

Table 2. The Frequency of Comorbidities for 32,834 Women Stratified by Mode of Delivery
Spontaneous Operative Repeat cesarean Repeat cesarean with
vaginal vaginal without trial of labor trial of labor
Comorbidity (n ⫽ 22,270) (n ⫽ 4,908) (n ⫽ 865) (n ⫽ 768)
Preeclampsia 432 (1.9) 132 (2.7) 10 (1.2) 10 (1.3)
Pregestational diabetes 84 (0.4) 13 (0.3) 11 (1.3) 5 (0.7)
Systemic lupus erythematosus 24 (0.1) 10 (0.2) 0 0
Sickle cell disease 196 (0.9) 47 (1.0) 0 0
Chronic hypertension 230 (1.0) 66 (1.3) 0 0
Pregnancy-induced hypertension 1268 (5.7) 273 (5.6) 0 0
Chorioamnionitis 822 (3.7) 350 (7.1) 8 (0.9) 69 (9.0)
Episiotomy 11,603 (52.1) 3,316 (67.6) 0 1 (0.1)
3rd- or 4th-degree perineal laceration 1733 (7.8) 1098 (22.4) 0 1 (0.1)
Premature rupture of membranes 947 (4.3) 271 (5.5) 2 (0.2) 32 (4.2)
Prolonged rupture of membranes 501 (2.2) 154 (3.1) 2 (0.2) 22 (2.9)
Preterm spontaneous uterine contractions 140 (0.6) 24 (0.5) 3 (0.3) 5 (0.7)
Prolonged 2nd stage of labor 168 (0.8) 255 (5.2) 0 11 (1.4)
Data are presented as n (%).
* P value from Pearson’s ␹2 test.

908 Burrows et al Maternal Morbidity for Different Modes of Delivery OBSTETRICS & GYNECOLOGY
deep venous thrombosis (DVT), pulmonary embolism,
urinary tract infection, intraoperative complications, and
Primary cesarean Primary cesarean pneumonia.
without trial of labor with trial of labor Morbidities were tabulated for each mode of delivery.
(n ⫽ 657) (n ⫽ 3,366) P* Patients were analyzed based on gravidity, parity, age,
race, level of education, marital status, history of smok-
572 (87.5) 2,743 (81.7) ⬍ .001 ing, maternal weight on admission, and the following
61 (9.3) 500 (14.9) maternal conditions: preeclampsia, pregestational diabe-
21 (3.2) 115 (3.4)
30.4 ⫾ 6.0 29.2 ⫾ 6.0 ⬍ .001‡ tes, systemic lupus erythematosus, sickle cell disease,
39 (37–42) 40 (37–44) ⬍ .001§ hypertensive disease, premature rupture of membranes,
1 (1–9) 1 (1–11) ⬍ .001§ prolonged rupture of membranes, preterm spontaneous
491 (74.7) 2,902 (86.2) ⬍ .001 uterine contractions, prolonged second stage of labor,
14 (8–20) 14 (8–23) ⬍ .001§ and chorioamnionitis in labor. Because maternal height
72 (11.0) 410 (12.2) ⬍ .001
⬍ .001 and prepregnancy weight were not recorded in the data-
435 (66.2) 2,001 (59.4) base, maternal weight on admission was dichotomized as
147 (22.4) 1,017 (30.2) less than or equal to 91 kg (200 lb) and greater than 91 kg
75 (11.4) 348 (10.3) (200 lb) as a proxy for obesity.
148 (25.6) 752 (25.7) ⬍ .001 By using a ␹2 test at the .05 significance level, this
study had greater than 99% power to detect a significant
difference in the rate of morbidities across all 6 delivery
groups based on the occurrence of these morbidities in
included both spontaneous and induced labor. In the the database. Except for DVT in the operative vaginal
database, the existing “labor” variable categorized pa- delivery group, which had a rate of 0.04%, all morbidi-
tients as those who had “spontaneous labor,” “induced ties occurred at a rate of 0.1% or more. All statistical
labor,” or “no labor.” Patients who were categorized as analyses were performed by using SPSS statistical soft-
“no labor” had undergone a scheduled cesarean deliv- ware 10.1.4 (SPSS Inc, Chicago, IL). Normality was
ery, either primary or repeat for a given indication. For defined by visually assessing the shape of the frequency
the purposes of our analysis, we combined the spontane- distributions. Normally distributed variables were pre-
ous and induced categories to represent patients who sented as mean ⫾ standard deviation. Data that were not
labored in any capacity. This is how we were able to normally distributed were presented as median values
group our cesarean delivery patients into those who did with overall ranges. The associations of delivery mode,
and did not have a trial of labor. International Classifi- demographic characteristics, and maternal conditions with
cation of Diseases, 9th Revision, codes were used to maternal morbidity were evaluated by using Pearson’s ␹2
identify patients with the following complications: post- or Fisher exact tests where appropriate. The associations of
partum hemorrhage, blood transfusion, endometritis, demographic characteristics and maternal conditions with
delivery mode were evaluated by using Pearson’s ␹2, one-
way analysis of variance, or Kruskal–Wallis tests where
Primary cesarean Primary cesarean appropriate. All statistical tests were evaluated at the .05
without trial of labor with trial of labor significance level. Separate multivariable logistic regression
(n ⫽ 657) (n ⫽ 3,366) P* models were developed to identify factors independently
23 (3.5) 200 (5.9) ⬍ .001 associated with each morbidity. Variables with P values less
6 (0.9) 27 (0.8) ⬍ .001 than .1 were considered for inclusion in the models. Models
0 0 .06 were developed by using forward stepwise regression
0 0 ⬍ .001 based on the likelihood ratio test statistic. Variables were
0 0 ⬍ .001
1 (0.2) 1 (0.03) ⬍ .001 retained in the model if the Wald ␹2 test statistic had a P
16 (2.4) 632 (18.8) ⬍ .001 value of .05 or less.1
0 8 (0.2) ⬍ .001
0 1 (0.03) ⬍ .001
13 (2.0) 231 (6.9) ⬍ .001 RESULTS
2 (0.3) 232 (6.9) ⬍ .001
3 (0.5) 19 (0.6) .8 Of 32,834 subjects, 27,178 had vaginal delivery (opera-
0 115 (3.4) ⬍ .001 tive ⫽ 4,908; spontaneous ⫽ 22,270) and 5,656 had
cesarean delivery. Third- or fourth-degree lacerations
occurred in 1,733 (7.8%) women who had spontaneous

VOL. 103, NO. 5, PART 1, MAY 2004 Burrows et al Maternal Morbidity for Different Modes of Delivery 909
Table 3. Postpartum Morbidities in 32,834 Women From 1995 to 2000 Stratified by Mode of Delivery

Endometritis, Pneumonia,
Delivery group n Endometritis adjusted* Pneumonia adjusted†
Spontaneous vaginal 22,270 97 (0.4) 1.0 (Referent) 17 (0.1) 1.0 (Referent)
Operative vaginal 4,908 33 (0.7) 0.9 (0.6, 1.5) 9 (0.2) 2.3 (1.0, 5.4)
Repeat cesarean without trial of labor 865 23 (2.7) 9.9 (5.8, 16.9) 4 (0.5) 5.2 (1.5, 18.1)
Repeat cesarean with trial of labor 768 35 (4.6) 14.6 (9.2, 23.1) 5 (0.7) 9.3 (3.4, 25.6)
Primary cesarean without trial of labor 657 20 (3.0) 10.3 (5.9, 17.9) 2 (0.3) 4.7 (1.1, 20.4)
Primary cesarean with trial of labor 3,366 315 (9.4) 21.2 (15.4, 29.1) 4 (0.1) 1.7 (0.6, 5.2)
Total 32,834 523 (1.6) 41 (0.1)
Data are presented as n (%) or odds ratio (95% confidence interval).
* Adjusted for age, race, smoking, admission weight ⬎ 91 kg (200 lb), chorioamnionitis, prolonged rupture of membranes, and vaginal
lacerations.

Adjusted for education and smoking.

Adjusted for episiotomy, pregnancy-induced hypertension, age, preeclampsia, chorioamnionitis, and prolonged second stage of labor.
§
Adjusted for preeclampsia, chorioamnionitis, and sickle cell disease.

Adjusted for prolonged second stage of labor.

vaginal delivery compared with 1,098 (22.3%) who had after trial of labor were 9.3 times more likely to have
operative vaginal delivery. There was a total of 12,602 pneumonia than women after spontaneous vaginal deliv-
episiotomies performed. ery. Smokers had an adjusted 2-fold increased risk of
The demographics for patients in the database strati- developing pneumonia.
fied by delivery mode are provided in Table 1. The Regarding postpartum hemorrhage, the spontaneous
method of delivery differed significantly by age and vaginal delivery and operative vaginal delivery groups
racial group (P ⱕ .001). White women were more likely had the highest rates, which were 5.0% and 4.7%, respec-
than black women to undergo cesarean delivery without tively. Independent risk factors for postpartum hemor-
a trial of labor. Women who underwent repeat cesarean rhage were episiotomy (OR 1.3; 95% confidence interval
delivery were older. The frequencies of comorbidities 关CI兴 1.1, 1.4), pregnancy-induced hypertension (OR 1.7;
stratified by delivery mode are shown in Table 2. Table
95% CI 1.4, 2.1), preeclampsia (OR 2.3; 95% CI 1.8,
3 shows the adjusted odds ratios (OR) stratified by
2.9), chorioamnionitis (OR 1.9; 95% CI 1.6, 2.3), and
delivery type for endometritis, pneumonia, postpartum
prolonged second stage of labor (OR 2.1; 95% CI 1.5,
hemorrhage, transfusion, and DVT.
2.8).
Endometritis, the most frequent morbidity, was most
strongly associated with cesarean delivery. Compared Of the 5,656 patients who underwent cesarean deliv-
with spontaneous vaginal delivery, cesarean delivery ery, 49 (0.86%) received blood transfusions compared
after trial of labor was associated with a 14.6-fold in- with 61 of 27,178 patients after vaginal delivery (0.22%).
creased risk of endometritis for repeat procedures and a Patients who had cesarean delivery with trial of labor
21.2-fold increased risk after primary procedures. sustained the highest risk, more than a 4-fold increase.
Women with chorioamnionitis were 3.2 times more Compared with spontaneous vaginal delivery, patients
likely to have endometritis when adjusted for delivery had an adjusted 5-fold increased risk of being transfused
mode, age, race, smoking, admission weight, prolonged if they had preeclampsia or sickle cell disease. The
rupture of membranes, and vaginal laceration. Those presence of chorioamnionitis increased the risk (ad-
who sustained an anal sphincter laceration were 2.9 to justed) of transfusion 3-fold.
4.5 times more likely to develop endometritis compared Of the 29 patients who had DVT, 15 (0.1%) had
with those who did not have a laceration when adjusted spontaneous vaginal delivery, 2 (0.04%) had operative
for delivery mode, age, race, smoking, admission weight, vaginal delivery, and 12 had cesarean delivery (0.2%). A
prolonged rupture of membranes, and chorioamnionitis. prolonged second stage of labor conferred a 6.1-fold
Prolonged rupture of membranes conferred a 2-fold increased risk of DVT. When stratified by delivery
increased risk of endometritis. Patients whose weight on mode, primary cesarean delivery with trial of labor
admission was greater than 200 pounds were 30% more imposed the highest risk of DVT, which was 3.9 times
likely to develop endometritis. higher than spontaneous vaginal delivery. Four patients
Of the 41 patients (0.1%) who developed pneumonia, had pulmonary emboli, 2 after spontaneous vaginal de-
those who underwent cesarean delivery incurred the livery (0.007%) and 2 after primary cesarean delivery
greatest risk. Women who had repeat cesarean delivery (0.04%), 1 with trial of labor and 1 without.

910 Burrows et al Maternal Morbidity for Different Modes of Delivery OBSTETRICS & GYNECOLOGY
Postpartum Deep venous
Postpartum hemorrhage, Transfusion, Deep venous thrombosis,
hemorrhage adjusted‡ Transfusion adjusted§ thrombosis adjusted㛳
1,105 (5.0) 1.0 (Referent) 40 (0.2) 1.0 (Referent) 15 (0.1) 1.0 (Referent)
231 (4.7) 0.8 (0.7, 0.97) 21 (0.4) 2.2 (1.3, 3.7) 2 (0.04) 0.5 (0.1, 2.2)
28 (3.2) 0.8 (0.6, 1.2) 4 (0.5) 3.0 (1.1, 8.3) 0 Not applicable
20 (2.6) 0.6 (0.4, 0.96) 6 (0.8) 4.2 (1.8, 10.1) 1 (0.1) 1.9 (0.2, 14.2)
18 (2.7) 0.7 (0.4, 1.1) 3 (0.3) 2.6 (0.8, 8.5) 1 (0.2) 2.3 (0.3, 17.8)
131 (3.9) 0.8 (0.6, 0.9) 36 (1.1) 4.4 (2.7, 7.1) 10 (0.3) 3.9 (1.7, 8.9)
1,533 (4.7) 110 (0.3) 29 (0.1)

Nine patients underwent hysterectomy at the time of ity that clinicians are more likely to transfuse if a patient
delivery: 2 after spontaneous vaginal delivery, 2 after has had surgery. As with the other morbidities, parity
primary cesarean without trial of labor, 3 after primary was a not a significant predictor of postpartum hemor-
cesarean with trial of labor, and 2 after repeat cesarean rhage.
with trial of labor. These patients were too few in num- Regarding postpartum hemorrhage, the OR for pri-
ber to undergo statistical modeling. The median age of mary cesarean deliveries without trial of labor was de-
these 9 patients was 28 years, 3 were primiparous, 5 had creased. The ORs for other cesarean delivery types were
chorioamnionitis, and 1 had preeclampsia. also decreased but not to a statistically significant level.
Of the 5,656 cesarean deliveries, 22 intraoperative Interestingly, a recent study examining maternal mor-
injuries were reported (0.38%) in the database, 11 of bidity associated with cesarean delivery without labor
which were cystotomies. Six occurred during primary found that women who underwent primary cesarean
and 5 during repeat cesarean delivery. Other injuries delivery without labor were less likely to have postpar-
included broad ligament and bladder flap hematomas, tum hemorrhage compared with those who had sponta-
lacerations of the uterine artery or urethra, and injury to neous onset of labor.7
the mesosalpinx. Previous reports of blood transfusions with cesarean
delivery range from 1.2% to 6.3%,5,8 which is higher
DISCUSSION than the rates found in this study (0.3–1.1%). This may
The most important finding of this study is that, al- reflect improvements in surgical technique or the in-
though overall rates of morbidity for cesarean deliveries creasing reluctance of practitioners to transfuse patients.
are higher than for vaginal births, they are not as high as Patients who had cesarean delivery after trial of labor
reported previously. The most common postoperative had a 4-fold higher transfusion rate compared with spon-
morbidity attributable to cesarean delivery across stud- taneous vaginal delivery. This may be the result of the
ies are infectious; endometritis has been reported to fact that performing cesarean delivery after substantial
occur in 6 –18% of procedures.2–5 The overall rate of descent of the fetus increases the chance of uterine,
6.9% after cesarean delivery in our study is on the low cervical, and vaginal lacerations. Furthermore, this
end of that range. Primary cesarean deliveries after labor group inclues patients who had urgent and emergent
carry a higher risk of infection than repeat procedures deliveries. The need for blood transfusions is more com-
without labor and our findings are consistent with this.6 mon with emergency surgery.5
Postpartum hemorrhage occurred most commonly in The occurrence of DVTs in the cesarean groups
the vaginal delivery groups. This was an unexpected (0.21%) was lower than the 0.6 –1.8% reported to date
finding and may reflect underestimation of the blood loss and highlights the rarity of this condition.6,9 Pulmonary
at cesarean delivery. Alternatively, this may reflect in- emboli have been reported in 0.1– 0.2% of cesarean
creased blood loss related to episiotomy use or other deliveries.5,10 In our series, the rate was even lower at
perineal or vaginal trauma. Although patients after spon- 0.04%. Given that this was such a rare occurrence re-
taneous vaginal delivery had the highest rate of postpar- gardless of delivery type, one cannot draw any meaning-
tum hemorrhage in this study, patients who had cesar- ful conclusions regarding risk by mode of delivery.
ean delivery had a higher transfusion rate. Perhaps this It is interesting that white women were more likely to
discrepancy is the result of inaccuracies in estimating undergo cesarean delivery without trial of labor. This
blood loss, different definitions of postpartum hemor- may reflect different practice patterns among private
rhage for vaginal and cesarean deliveries, or the possibil- practitioners and resident staff, especially regarding vag-

VOL. 103, NO. 5, PART 1, MAY 2004 Burrows et al Maternal Morbidity for Different Modes of Delivery 911
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Address reprint requests to: Dr. Lara J. Burrows, Department
increased risk of various other problems at three months
of Obstetrics, Gynecology and Reproductive Sciences, Magee-
postpartum. We were unable to assess the aforemen- Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213;
tioned morbidities because they were not recorded in the e-mail: lburrows@mail.magee.edu.
database or they primarily occurred in the outpatient
setting. Prospective studies taking these measures into
account are needed to fully characterize maternal mor- Received October 24, 2003. Received in revised form January 7, 2004.
bidity by delivery type. Accepted January 23, 2004.

912 Burrows et al Maternal Morbidity for Different Modes of Delivery OBSTETRICS & GYNECOLOGY

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