Prevalence of coronary artery disease and plaque morphology assessed b... http://heart.bmj.

com/cgi/content/abstract/94/3/290

Published Online First: 23 July 2007. doi:10.1136/hrt.2007.121921

Heart 2008;94:290-295
Copyright © 2008 BMJ Publishing Group Ltd & British Cardiovascular Society

DIABETES, LIPIDS AND METABOLISM

Prevalence of coronary artery disease and plaque morphology assessed by

multi-slice computed tomography coronary angiography and calcium scoring in
asymptomatic patients with type 2 diabetes
A J H A Scholte 1, J D Schuijf1, A V Kharagjitsingh2, J W Jukema1,3, G Pundziute 1, E E van der Wall1, J J Bax 1

1
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
2
Department of Internal Medicine, Medisch Centrum Haaglanden, The Hague, The Netherlands
3
The Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands

Correspondence to:
Arthur J H A Scholte, MD, Leiden University Medical Center, Department of Cardiology, Albinusdreef 2, PO Box 9600,
2300 RC Leiden, The Netherlands; a.j.h.a.scholte@lumc.nl

Objective: The purpose of the study was to evaluate the prevalence of CAD as well as plaque morphology in asymptomatic patients
with type 2 diabetes using multi-slice computed tomography (MSCT). In addition, the relation between calcium score and MSCT
findings was explored.

Design: In 70 patients, coronary calcium scoring and non-invasive coronary angiography were performed. Angiograms showing
atherosclerosis were further classified as obstructive ( 50% luminal narrowing) CAD or not. Plaque type (non-calcified, mixed and
calcified) was determined. Finally, the relation between calcium score and MSCT findings was explored.

Results: A calcium score <10 was observed in 31 (44%) patients. A calcium score of 10–100 was observed in 14 (20%) patients while
a score of 101–400 or >400 was identified in 12 (17%) and 13 (19%) patients respectively. Non-invasive coronary angiography showed
CAD in 56 (80%) patients. 322 coronary segments with plaque were identified, of which 132 (41%) contained non-calcified plaques, 65
(20%) mixed plaques and 125 (39%) calcified plaques. The percentage of patients with obstructive CAD paralleled increasing calcium
score. The presence of CAD was noted in 17 (55%) patients with no or minimal calcium (score <10).

Conclusions: MSCT angiography detected a high prevalence of CAD in asymptomatic patients with type 2 diabetes. A relatively high
proportion of plaques were non-calcified (41%). Importantly, a calcium score <10 did not exclude CAD in these patients. MSCT might
be a useful technique to identify CAD in asymptomatic patients with type 2 diabetes with incremental value over calcium scoring.

Keywords: coronary artery disease; type 2 diabetes mellitus

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