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Boehringer Ingelheim Page 14 of 14

Trajenta
Linagliptin, 5 mg film coated tablet

Response Document
Proprietary confidential information © 2017 Boehringer Ingelheim International GmbH or one or more of its affiliated companies

antidiabetics. The potential side effects identified for linagliptin with insulin confirm prior
findings for linagliptin (nasopharyngitis, cough, hypersensitivity and pancreatitis) when used
as monotherapy or in combination with oral antidiabetics. Only constipation was identified as
an additional potential side effect in patients with T2DM taking linagliptin as an add-on to
insulin.

REPONSE TO COMMENTS dated 23 June 2014

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