Name of Drug Classification and Mechanism of Indication and Contraindication Side Effects or Adverse Nursing Responsibilities

(Dosage, Route, Frequency, Action Reactions

Timing)

Generic Name: Classification: Indication:  white patches or sores 14 rights of medication

Amoxicillin Penicillins
Brand Name:
Amoxil Mechanism of Action:
Description: Amoxicillin inhibits the
final transpeptidation step of
peptidoglycan synthesis in bacterial
Dosage: cell wall by binding to 1 or more of the
500mg 1cap penicillin-binding proteins (PBPs), thus better absorbed than Ampicillin.
inhibiting cell wall biosynthesis
resulting in bacterial lysis.
Pharmacokinetics:
Absorption: Rapidly and completely
Route: absorbed from the GI tract. Time to
Oral peak plasma concentration: 1-2 hr.
Distribution: Widely distributed into
body tissues and fluids. Crosses the
placenta and enters breast milk (small
amounts). Plasma protein binding:
Frequency: Approx 20%.
TID Metabolism: Undergoes partial hepatic
metabolism and converted to
penicilloic acid.
Excretion: Via urine (60% as
unchanged drug) and faeces. Plasma
Timing: half-life: 1-1.5 hr.
7, 1, 7
This drug is a semi-synthetic
broad spectrum penicillin closely
related to Ampicillin. It binds to
Penicillin-binding proteins in the
cytoplasmic membranes of
bacteria, thus inhibiting cell-wall
synthesis. It also inhibits cell
growth and cell division. It is
Contraindication:
Hypersensitivity to amoxicillin
and other penicillins.
inside your mouth or on
your lips;
 fever, swollen glands, rash
or itching, joint pain, or
general ill feeling;
 pale or yellowed skin,
yellowing of the eyes, dark
colored urine, fever,
confusion or weakness;
 severe tingling, numbness,
pain, muscle weakness;
 easy bruising, unusual
bleeding...
1. Right Drug/Medication
2. Right Client/Patient
3. Right Route
4. Right Dose
5. Right Frequency/Time
6. Right Assessment
7. Right Approach
8. Right Education
9. Right Evaluation
10. Right Documentation
11. Right to Refuse
12. Right Principle of Care
13. Right Prescription
14. Right Nurse Clinician
Assessment & Drug Effects
Determine previous hypersensitivity reactions
to penicillins, cephalosporins, and other
allergens prior to therapy.
Lab tests: Baseline C&S tests prior to
initiation of therapy, start drug pending
results; periodic assessments of renal, hepatic,
and hematologic functions should be made
during prolonged therapy.
Monitor for S&S of an urticarial rash (usually
occurring within a few days after start of
drug) suggestive of a hypersensitivity
reaction. If it occurs, look for other signs of
hypersensitivity (fever, wheezing, generalized
itching, dyspnea), and report to physician
immediately.
Report onset of generalized, erythematous,
maculopapular rash (ampicillin rash) to
physician. Ampicillin rash is not due to
hypersensitivity; however, hypersensitivity
should be ruled out.
Closely monitor diarrhea to rule out
pseudomembranous colitis.
Patient & Family Education

Take drug around the clock, do not miss a

dose, and continue therapy until all
medication is taken, unless otherwise directed
by physician.
Report onset of diarrhea and other possible
symptoms of superinfection to physician (see
Appendix F).