Homo sapiens tumor protein p63 deltaN isoform delta (TP63)

mRNA, complete cds

GenBank: GQ202690.1
FASTA Graphics
LOCUS GQ202690 4435 bp mRNA linear PRI 13-SEP-2009
DEFINITION Homo sapiens tumor protein p63 deltaN isoform delta (TP63) mRNA,
complete cds.
ACCESSION GQ202690
VERSION GQ202690.1 GI:257449249
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4435)
AUTHORS Mangiulli,M., Valletti,A., Caratozzolo,M.F., Tullo,A., Sbisa,E.,
Pesole,G. and D'Erchia,A.M.
TITLE Identification and functional characterization of two new
transcriptional variants of the human p63 gene
JOURNAL Nucleic Acids Res. 37 (18), 6092-6104 (2009)
PUBMED 19700772
REFERENCE 2 (bases 1 to 4435)
AUTHORS Mangiulli,M., Valletti,A., Tullo,A., Caratozzolo,M., Sbisa',E.,
Pesole,G. and D'Erchia,A.M.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2009) Dipartimento di Biochimica e Biologia
Molecolare, University of Bari, via Orabona, 4, Bari 70125, Italy
FEATURES Location/Qualifiers
source 1..4435
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..4435
/gene="TP63"
CDS 140..1390
/gene="TP63"
/note="deltaNp63delta"
/codon_start=1
/product="tumor protein p63 deltaN isoform delta"
/protein_id="ACV53610.1"
/db_xref="GI:257449250"
/translation="MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDH
AQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYST
ELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN
 EGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSC
VGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKN
GDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLP
QHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQ
RNALTPTTIPDGMGANRSGKSENP"
ORIGIN
1 agagagaaag agagagaggg acttgagttc tgttatcttc ttaagtagat tcatattgta
61 agggtctcgg ggtggggggg ttggcaaaat cctggagcca gaagaaagga cagcagcatt
121 gatcaatctt acagctaaca tgttgtacct ggaaaacaat gcccagactc aatttagtga
181 gccacagtac acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc
241 ctcgtccacc agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc
301 ctacgcacag cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa
361 caccgactac ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa
421 gtcggccacc tggacgtatt ccactgaact gaagaaactc tactgccaaa ttgcaaagac
481 atgccccatc cagatcaagg tgatgacccc acctcctcag ggagctgtta tccgcgccat
541 gcctgtctac aaaaaagctg agcacgtcac ggaggtggtg aagcggtgcc ccaaccatga
601 gctgagccgt gaattcaacg agggacagat tgcccctcct agtcatttga ttcgagtaga
661 ggggaacagc catgcccagt atgtagaaga tcccatcaca ggaagacaga gtgtgctggt
721 accttatgag ccaccccagg ttggcactga attcacgaca gtcttgtaca atttcatgtg
781 taacagcagt tgtgttggag ggatgaaccg ccgtccaatt ttaatcattg ttactctgga
841 aaccagagat gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc
901 aggaagagac aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac
961 aaagaacggt gatggtacga agcgcccgtt tcgtcagaac acacatggta tccagatgac
1021 atccatcaag aaacgaagat ccccagatga tgaactgtta tacttaccag tgaggggccg
1081 tgagacttat gaaatgctgt tgaagatcaa agagtccctg gaactcatgc agtaccttcc
1141 tcagcacaca attgaaacgt acaggcaaca gcaacagcag cagcaccagc acttacttca
1201 gaaacagacc tcaatacagt ctccatcttc atatggtaac agctccccac ctctgaacaa
1261 aatgaacagc atgaacaagc tgccttctgt gagccagctt atcaaccctc agcagcgcaa
1321 cgccctcact cctacaacca ttcctgatgg catgggagcc aacagatctg gcaagtctga
1381 aaatccctga gcaatttcga catgcgatct ggaagggcat cctggaccac cggcagctcc
1441 acgaattctc ctccccttct catctcctgc ggaccccaag cagtgcctct acagtcagtg
1501 tgggctccag tgagacccgg ggtgagcgtg ttattgatgc tgtgcgattc accctccgcc
1561 agaccatctc tttcccaccc cgagatgagt ggaatgactt caactttgac atggatgctc
1621 gccgcaataa gcaacagcgc atcaaagagg agggggagtg agcctcacca tgtgagctct
1681 tcctatccct ctcctaactg ccagccccct aaaagcactc ctgcttaatc ttcaaagcct
1741 tctccctagc tcctcccctt cctcttgtct gatttcttag gggaaggaga agtaagaggc
1801 tacctcttac ctaacatctg acctggcatc taattctgat tctggcttta agccttcaaa
1861 actatagctt gcagaactgt agctgccatg gctaggtaga agtgagcaaa aaagagttgg
1921 gtgtctcctt aagctgcaga gatttctcat tgacttttat aaagcatgtt cacccttata
1981 gtctaagact atatatataa atgtataaat atacagtata gatttttggg tggggggcat
2041 tgagtattgt ttaaaatgta atttaaatga aagaaaattg agttgcactt attgaccatt
2101 ttttaattta cttgttttgg atggcttgtc tatactcctt cccttaaggg gtatcatgta
2161 tggtgatagg tatctagagc ttaatgctac atgtgagtga cgatgatgta cagattcttt
2221 cagttctttg gattctaaat acatgccaca tcaaaccttt gagtagatcc atttccattg
2281 cttattatgt aggtaagact gtagatatgt attcttttct cagtgttggt atattttata
2341 ttactgacat ttcttctagt gatgatggtt cacgttgggg tgatttaatc cagttataag
 2401 aagaagttca tgtccaaacg tcctctttag tttttggttg ggaatgagga aaattcttaa
2461 aaggcccata gcagccagtt caaaaacacc cgacgtcatg tatttgagca tatcagtaac
2521 ccccttaaat ttaataccag ataccttatc ttacaatatt gattgggaaa acatttgctg
2581 ccattacaga ggtattaaaa ctaaatttca ctactagatt gactaactca aatacacatt
2641 tgctactgtt gtaagaattc tgattgattt gattgggatg aatgccatct atctagttct
2701 aacagtgaag ttttactgtc tattaatatt cagggtaaat aggaatcatt cagaaatgtt
2761 gagtctgtac taaacagtaa gatatctcaa tgaaccataa attcaacttt gtaaaaatct
2821 tttgaagcat agataatatt gtttggtaaa tgtttctttt gtttggtaaa tgtttctttt
2881 aaagaccctc ctattctata aaactctgca tgtagaggct tgtttacctt tctctctcta
2941 aggtttacaa taggagtggt gatttgaaaa atataaaatt atgagattgg ttttcctgtg
3001 gcataaattg catcactgta tcattttctt ttttaaccgg taagagtttc agtttgttgg
3061 aaagtaactg tgagaaccca gtttcccgtc catctccctt agggactacc catagacatg
3121 aaaggtcccc acagagcaag agataagtct ttcatggctg ctgttgctta aaccacttaa
3181 acgaagagtt cccttgaaac tttgggaaaa catgttaatg acaatattcc agatctttca
3241 gaaatataac acattttttt gcatgcatgc aaatgagctc tgaaatcttc ccatgcattc
3301 tggtcaaggg ctgtcattgc acataagctt ccattttaat tttaaagtgc aaaagggcca
3361 gcgtggctct aaaaggtaat gtgtggattg cctctgaaaa gtgtgtatat attttgtgtg
3421 aaattgcata ctttgtattt tgattatttt ttttttcttc ttgggatagt gggatttcca
3481 gaaccacact tgaaaccttt ttttatcgtt tttgtatttt catgaaaata ccatttagta
3541 agaataccac atcaaataag aaataatgct acaattttaa gaggggaggg aagggaaagt
3601 ttttttttat tattttttta aaattttgta tgttaaagag aatgagtcct tgatttcaaa
3661 gttttgttgt acttaaatgg taataagcac tgtaaacttc tgcaacaagc atgcagcttt
3721 gcaaacccat taaggggaag aatgaaagct gttccttggt cctagtaaga agacaaactg
3781 cttcccttac tttgctgagg gtttgaataa acctaggact tccgagctat gtcagtacta
3841 ttcaggtaac actagggcct tggaaattcc tgtactgtgt ctcatggatt tggcactagc
3901 caaagcgagg cacccttact ggcttacctc ctcatggcag cctactctcc ttgagtgtat
3961 gagtagccag ggtaaggggt aaaaggatag taagcataga aaccactaga aagtgggctt
4021 aatggagttc ttgtggcctc agctcaatgc agttagctga agaattgaaa agtttttgtt
4081 tggagacgtt tataaacaga aatggaaagc agagttttca ttaaatcctt ttaccttttt
4141 tttttcttgg taatccccta aaataacagt atgtgggata ttgaatgtta aagggatatt
4201 tttttctatt atttttataa ttgtacaaaa ttaagcaaat gttaaaagtt ttatatgctt
4261 tattaatgtt ttcaaaaggt attatacatg tgatacattt tttaagcttc agttgcttgt
4321 cttctggtac tttctgttat gggcttttgg ggagccagaa gccaatctac aatctctttt
4381 tgtttgccag gacatgcaat aaaatttaaa aaataaataa aaactaatta agaaa
//
Rattus norvegicus tumor protein p63 (Tp63), transcript variant 6,
mRNA
NCBI Reference Sequence: NM_001127344.1
FASTA Graphics
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LOCUS NM_001127344 1182 bp mRNA linear ROD 10-AUG-2014

DEFINITION Rattus norvegicus tumor protein p63 (Tp63), transcript variant 6,
mRNA.
ACCESSION NM_001127344
VERSION NM_001127344.1 GI:189083862
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1182)
AUTHORS Tuna B, Unlu M, Aslan G, Secil M and Yorukoglu K.
TITLE Diagnostic and prognostic impact of p63 immunoreactivity in renal
malignancies
JOURNAL Anal. Quant. Cytol. Histol. 31 (2), 118-122 (2009)
PUBMED 19402389
REFERENCE 2 (bases 1 to 1182)
AUTHORS Stepan A, Margaritescu C, Simionescu C and Ciurea R.
TITLE E-cadherin and p63 immunoexpression in dysplastic lesions and
urothelial carcinomas of the bladder
JOURNAL Rom J Morphol Embryol 50 (3), 461-465 (2009)
PUBMED 19690775
REFERENCE 3 (bases 1 to 1182)
AUTHORS Bui T, Sequeira J, Wen TC, Sola A, Higashi Y, Kondoh H and Genetta
T.
TITLE ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly
induced in response to cortical ischemia
JOURNAL PLoS ONE 4 (2), E4373 (2009)
PUBMED 19194497
REMARK GeneRIF: The pro-survival response of neurons, initiated through
the rapid induction of p63, is mediated ultimately by the
transcriptional repression of a pro-apoptotic isoform of p73 by
ZEB1.
REFERENCE 4 (bases 1 to 1182)
AUTHORS He Y, Wu X, Tang W, Tian D, Luo C, Yin Z and Du H.
TITLE Impaired delta NP63 expression is associated with poor tumor
development in transitional cell carcinoma of the bladder
JOURNAL J. Korean Med. Sci. 23 (5), 825-832 (2008)
PUBMED 18955789
REFERENCE 5 (bases 1 to 1182)
AUTHORS Hayashi T, Yoshinaga A, Ohno R, Ishii N, Kamata S and Yamada T.
TITLE Expression of the p63 and Notch signaling systems in rat testes
during postnatal development: comparison with their expression
levels in the epididymis and vas deferens
JOURNAL J. Androl. 25 (5), 692-698 (2004)
PUBMED 15292098
REFERENCE 6 (bases 1 to 1182)
AUTHORS Djelloul S, Tarunina M, Barnouin K, Mackay A and Jat PS.
TITLE Differential protein expression, DNA binding and interaction with
SV40 large tumour antigen implicate the p63-family of proteins in
replicative senescence
JOURNAL Oncogene 21 (7), 981-989 (2002)
PUBMED 11850815
REFERENCE 7 (bases 1 to 1182)
AUTHORS Dellavalle RP, Egbert TB, Marchbank A, Su LJ, Lee LA and Walsh P.
TITLE CUSP/p63 expression in rat and human tissues
JOURNAL J. Dermatol. Sci. 27 (2), 82-87 (2001)
PUBMED 11532371
REFERENCE 8 (bases 1 to 1182)
AUTHORS Bamberger C and Schmale H.
TITLE Identification and tissue distribution of novel KET/p63 splice
variants
JOURNAL FEBS Lett. 501 (2-3), 121-126 (2001)
PUBMED 11470269
REFERENCE 9 (bases 1 to 1182)
AUTHORS Celli J, Duijf P, Hamel BC, Bamshad M, Kramer B, Smits AP,
Newbury-Ecob R, Hennekam RC, Van Buggenhout G, van Haeringen A,
Woods CG, van Essen AJ, de Waal R, Vriend G, Haber DA, Yang A,
McKeon F, Brunner HG and van Bokhoven H.
TITLE Heterozygous germline mutations in the p53 homolog p63 are the
cause of EEC syndrome
JOURNAL Cell 99 (2), 143-153 (1999)
PUBMED 10535733
REFERENCE 10 (bases 1 to 1182)
AUTHORS Schmale H and Bamberger C.
TITLE A novel protein with strong homology to the tumor suppressor p53
JOURNAL Oncogene 15 (11), 1363-1367 (1997)
PUBMED 9315105
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AJ277450.1.

Summary: This gene encodes tumor protein p63, a member of the p53
family of transcription factors involved in cellular responses to
stress and development. The family members include p53, p63, and
p73, which have high sequence similarity to one another. This
 similarity allows p63 and p73 to transactivate p53-responsive genes
causing cell cycle arrest and apoptosis. The family members can
interact with each other in many ways, including direct and
indirect protein interactions. This results in mutual regulation of
target gene promoters. Both alternative splicing and the use of
alternative promoters result in multiple transcript variants
encoding different protein isoforms.[provided by RefSeq, Dec 2009].

Transcript Variant: This variant (6) is an alternate promoter

product; it lacks several 5' and 3' exons, but has alternate 5' and
3' exons, as compared to variant 1. The resulting isoform (f, also
known as deltaNKETgamma) has shorter and different N- and
C-termini, as compared to isoform a.

Publication Note: This RefSeq record includes a subset of the

publications that are available for this gene. Please see the Gene
record to access additional publications.

##Evidence-Data-START##
Transcript exon combination :: AJ277450.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1182 AJ277450.1 1-1182
FEATURES Location/Qualifiers
source 1..1182
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="W"
/db_xref="taxon:10116"
/chromosome="11"
/map="11q23"
gene 1..1182
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/note="tumor protein p63"
/db_xref="GeneID:246334"
/db_xref="RGD:620863"
CDS 1..1182
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/note="isoform f is encoded by transcript variant 6; tumor
protein 63 kDa; transformation related protein 63;
keratinocyte transcription factor KET"
/codon_start=1
/product="tumor protein 63 isoform f"
/protein_id="NP_001120816.1"
 /db_xref="GI:189083863"
/db_xref="GeneID:246334"
/db_xref="RGD:620863"
/translation="MLYLESNAQTQFSEPQYTNLGLLNGMDQQIQNGSSSTSPYNTDH
AQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYST
ELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFN
EGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSC
VGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKN
GDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLP
QHTIETYRQQQQQQHQHLLQKHLLSACFRNELVESRREAPTQSDVFFRHSNPPNHSVY
P"
STS 4..251
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/standard_name="Trp63"
/db_xref="UniSTS:256990"
STS 11..82
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/standard_name="Trp63"
/db_xref="UniSTS:526812"
STS 282..483
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/standard_name="Trp63"
/db_xref="UniSTS:499117"
STS 599..683
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/standard_name="PMC25851P2"
/db_xref="UniSTS:272289"
STS 864..1031
/gene="Tp63"
/gene_synonym="Ket; P73l; Tp73l; Trp63"
/standard_name="Trp63"
/db_xref="UniSTS:144677"
ORIGIN
1 atgttgtacc tggaaagcaa tgcccagact caatttagtg agccacagta cacgaacctg
61 gggctcctga acggcatgga ccagcagatt cagaacggct cctcatctac cagcccctat
121 aacacagacc atgcacagaa cagcgtgacg gcaccctcgc cctatgcaca gcccagctca
181 accttcgatg ccctttctcc atcccctgcc attccctcca acacagatta cccaggccca
241 cacagcttcg atgtgtcctt ccagcagtca agcaccgcca agtcagctac ctggacgtat
301 tccaccgaac tgaagaaact ctactgccag attgcaaaga cctgccccat ccagatcaag
361 gtgatgaccc cacccccaca gggcgccgtc attcgtgcca tgcctgtcta caagaaagcc
421 gagcatgtca ccgaggttgt gaaacgatgt cctaaccacg agctgagccg cgagttcaat
481 gagggacaga ttgcccctcc cagtcatctg attcgagtag aagggaacag ccatgcccag
 541 tatgtagaag atcctatcac aggaaggcag agcgtgctgg tcccttatga gccaccacag
601 gttggcactg aattcacaac agtcctgtac aatttcatgt gcaacagcag ctgtgtcgga
661 ggaatgaacc gccgtccaat tttaatcatc gttactctgg aaaccagaga tgggcaagtc
721 ctgggccgac gttgctttga ggcccggatc tgcgcttgcc caggaagaga ccggaaggcc
781 gatgaagaca gcatcagaaa gcagcaagta tcagacagcg caaagaacgg cgatggtacg
841 aagcgccctt tccgtcagaa tacccacgga atccagatga cttccatcaa gaaacggaga
901 tccccagatg atgagctgct gtacctacca gtgagaggcc gtgagactta tgaaatgctg
961 ctcaagatca aggagtcgct cgagctcatg cagtatctcc ctcagcacac gatcgagacg
1021 tacaggcagc agcagcagca gcagcaccaa cacctacttc agaaacatct cctttcagcc
1081 tgcttcagga atgagcttgt ggagtcccgg agagaagctc cgacacagtc tgacgtcttc
1141 tttagacatt ccaacccccc aaaccactca gtgtacccat ag
//