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CAS Number: 79-46-9 RTK Substance number: 1392

DOT Number: UN 2608 Date: December 1995 Revision: July 2001
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* 2-Nitropropane can affect you when breathed in. * Exposure to hazardous substances should be routinely
* 2-Nitropropane should be handled as a CARCINOGEN-- evaluated. This may include collecting personal and area
WITH EXTREME CAUTION. air samples. You can obtain copies of sampling results
* Contact can irritate the skin and eyes. from your employer. You have a legal right to this
* Breathing 2-Nitropropane can irritate the nose and throat. information under OSHA 1910.1020.
* Breathing 2-Nitropropane can irritate the lungs causing * If you think you are experiencing any work-related health
coughing and/or shortness of breath. Higher exposures problems, see a doctor trained to recognize occupational
can cause a build-up of fluid in the lungs (pulmonary diseases. Take this Fact Sheet with you.
edema), a medical emergency, with severe shortness of
* High levels can interfere with the ability of the blood to OSHA: The legal airborne permissible exposure limit
carry Oxygen causing headache, fatigue, dizziness, and a (PEL) is 25 ppm averaged over an 8-hour
blue color to the skin and lips (methemoglobinemia). workshift.
Higher levels can cause trouble breathing, collapse and
even death. NIOSH: Recommends that exposure to occupational
* 2-Nitropropane may damage the kidneys, liver and carcinogens be limited to the lowest feasible
nervous system. concentration.
* 2-Nitropropane is a FLAMMABLE and REACTIVE
chemical and a FIRE and EXPLOSION HAZARD. ACGIH: The recommended airborne exposure limit is
10 ppm averaged over an 8-hour workshift.
2-Nitropropane is a colorless liquid with a fruity odor. It is * 2-Nitropropane may be a CARCINOGEN in humans.
used as a solvent, rocket fuel, gasoline additive, and in the There may be no safe level of exposure to a carcinogen, so
production of other chemicals. all contact should be reduced to the lowest possible level.


* 2-Nitropropane is on the Hazardous Substance List * Enclose operations and use local exhaust ventilation at the
because it is regulated by OSHA and cited by ACGIH, site of chemical release. If local exhaust ventilation or
DOT, NIOSH, NTP, DEP, IARC, HHAG, NFPA and enclosure is not used, respirators should be worn.
EPA. * Wear protective work clothing.
* This chemical is on the Special Health Hazard Substance * Wash thoroughly immediately after exposure to
List because it is a CARCINOGEN, and is 2-Nitropropane and at the end of the workshift.
FLAMMABLE and REACTIVE. * Post hazard and warning information in the work area. In
* Definitions are provided on page 5. addition, as part of an ongoing education and training
effort, communicate all information on the health and
HOW TO DETERMINE IF YOU ARE BEING safety hazards of 2-Nitropropane to potentially exposed
EXPOSED workers.
The New Jersey Right to Know Act requires most employers
to label chemicals in the workplace and requires public
employers to provide their employees with information and
training concerning chemical hazards and controls. The
federal OSHA Hazard Communication Standard, 1910.1200,
requires private employers to provide similar training and
information to their employees.
2-NITROPROPANE page 2 of 6

This Fact Sheet is a summary source of information of all Any evaluation should include a careful history of past and
potential and most severe health hazards that may result from present symptoms with an exam. Medical tests that look for
exposure. Duration of exposure, concentration of the substance damage already done are not a substitute for controlling
and other factors will affect your susceptibility to any of the exposure.
potential effects described below.
--------------------------------------------------------------------------- Request copies of your medical testing. You have a legal right
to this information under OSHA 1910.1020.
Mixed Exposures
Acute Health Effects * Because smoking can cause heart disease, as well as lung
The following acute (short-term) health effects may occur cancer, emphysema, and other respiratory problems, it may
immediately or shortly after exposure to 2-Nitropropane: worsen respiratory conditions caused by chemical exposure.
Even if you have smoked for a long time, stopping now will
* Contact can irritate the skin and eyes. reduce your risk of developing health problems.
* Breathing 2-Nitropropane can irritate the nose and throat. * Because more than light alcohol consumption can cause
* Breathing 2-Nitropropane can irritate the lungs causing liver damage, drinking alcohol can increase the liver
coughing and/or shortness of breath. Higher exposures can damage caused by 2-Nitropropane.
cause a build-up of fluid in the lungs (pulmonary edema), a
medical emergency, with severe shortness of breath. WORKPLACE CONTROLS AND PRACTICES
* High levels can interfere with the ability of the blood to
carry Oxygen causing headache, fatigue, dizziness, and a Unless a less toxic chemical can be substituted for a hazardous
blue color to the skin and lips (methemoglobinemia). substance, ENGINEERING CONTROLS are the most
Higher levels can cause trouble breathing, collapse and effective way of reducing exposure. The best protection is to
even death. enclose operations and/or provide local exhaust ventilation at
the site of chemical release. Isolating operations can also
Chronic Health Effects reduce exposure. Using respirators or protective equipment is
The following chronic (long-term) health effects can occur at less effective than the controls mentioned above, but is
some time after exposure to 2-Nitropropane and can last for sometimes necessary.
months or years:
In evaluating the controls present in your workplace, consider:
Cancer Hazard (1) how hazardous the substance is, (2) how much of the
* 2-Nitropropane may be a CARCINOGEN in humans since substance is released into the workplace and (3) whether
it has been shown to cause liver cancer in animals. harmful skin or eye contact could occur. Special controls
should be in place for highly toxic chemicals or when
Reproductive Hazard significant skin, eye, or breathing exposures are possible.
* There is limited evidence that 2-Nitropropane may damage
the developing fetus. In addition, the following controls are recommended:

Other Long-Term Effects * Where possible, automatically pump liquid 2-

* 2-Nitropropane may damage the kidneys, liver and Nitropropane from drums or other storage containers to
nervous system. process containers.
* Before entering a confined space where 2-Nitropropane
may be present, check to make sure that an explosive
MEDICAL concentration does not exist.

Medical Testing Good WORK PRACTICES can help to reduce hazardous

For those with frequent or potentially high exposure (half the exposures. The following work practices are recommended:
TLV or greater), the following are recommended before
beginning work and at regular times after that: * Workers whose clothing has been contaminated by
2-Nitropropane should change into clean clothing
* Liver function tests. promptly.
* Contaminated work clothes should be laundered by
If symptoms develop or overexposure is suspected, the individuals who have been informed of the hazards of
following are recommended: exposure to 2-Nitropropane.
* Eye wash fountains should be provided in the immediate
* Consider chest x-ray after acute overexposure. work area for emergency use.
* Kidney function tests. * If there is the possibility of skin exposure, emergency
* Blood methemoglobin level. shower facilities should be provided.
* Exam of the nervous system.
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* On skin contact with 2-Nitropropane, immediately wash or HANDLING AND STORAGE

shower to remove the chemical. At the end of the
workshift, wash any areas of the body that may have * Prior to working with 2-Nitropropane you should be
contacted 2-Nitropropane, whether or not known trained on its proper handling and storage.
skin contact has occurred. * 2-Nitropropane may explode when heated or if exposed to
* Do not eat, smoke, or drink where 2-Nitropropane is STRONG ACIDS (such as HYDROCHLORIC,
handled, processed, or stored, since the chemical can be SULFURIC and NITRIC).
swallowed. Wash hands carefully before eating, drinking, * 2-Nitropropane is not compatible with OXIDIZING
smoking, or using the toilet. AGENTS (such as PERCHLORATES, PEROXIDES,
some jobs (such as outside work, confined space entry, jobs ACID.
done only once in a while, or jobs done while workplace * Store in tightly closed containers in a cool, well-ventilated
controls are being installed), personal protective equipment area away from COMBUSTIBLES.
may be appropriate. * Protect storage containers from physical damage.
* Sources of ignition, such as smoking and open flames, are
OSHA 1910.132 requires employers to determine the prohibited where 2-Nitropropane is used, handled, or
appropriate personal protective equipment for each hazard and stored.
to train employees on how and when to use protective
* Metal containers involving the transfer of 2-Nitropropane
should be grounded and bonded.
* Use only non-sparking tools and equipment, especially
The following recommendations are only guidelines and may
when opening and closing containers of 2-Nitropropane.
not apply to every situation.
* Wherever 2-Nitropropane is used, handled, manufactured,
or stored, use explosion-proof electrical equipment and
Clothing fittings.
* Avoid skin contact with 2-Nitropropane. Wear solvent-
resistant gloves and clothing. Safety equipment suppliers/ QUESTIONS AND ANSWERS
manufacturers can provide recommendations on the most
protective glove/clothing material for your operation. Q: If I have acute health effects, will I later get chronic
* All protective clothing (suits, gloves, footwear, headgear)
health effects?
should be clean, available each day, and put on before
A: Not always. Most chronic (long-term) effects result from
repeated exposures to a chemical.
* ACGIH recommends Butyl Rubber and Silvershield as
protective materials.
Q: Can I get long-term effects without ever having short-
term effects?
Eye Protection A: Yes, because long-term effects can occur from repeated
* Wear indirect-vent, impact and splash resistant goggles exposures to a chemical at levels not high enough to make
when working with liquids. you immediately sick.
* Wear a face shield along with goggles when working with
corrosive, highly irritating or toxic substances.
Q: What are my chances of getting sick when I have been
exposed to chemicals?
Respiratory Protection A: The likelihood of becoming sick from chemicals is
increased as the amount of exposure increases. This is
Such equipment should only be used if the employer has a
determined by the length of time and the amount of
written program that takes into account workplace conditions,
requirements for worker training, respirator fit testing and material to which someone is exposed.
medical exams, as described in OSHA 1910.134.
Q: When are higher exposures more likely?
* Where the potential exists for exposure over 10 ppm, use a A: Conditions which increase risk of exposure include
MSHA/NIOSH approved supplied-air respirator with a full physical and mechanical processes (heating, pouring,
facepiece operated in a pressure-demand or other positive- spraying, spills and evaporation from large surface areas
pressure mode. For increased protection use in combination such as open containers), and "confined space" exposures
with an auxiliary self-contained breathing apparatus (working inside vats, reactors, boilers, small rooms, etc.).
operated in a pressure-demand or other positive-pressure
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Q: Is the risk of getting sick higher for workers than for ------------------------------------------------------------------------
community residents? The following information is available from:
A: Yes. Exposures in the community, except possibly in
cases of fires or spills, are usually much lower than those New Jersey Department of Health and Senior Services
found in the workplace. However, people in the Occupational Health Service
community may be exposed to contaminated water as PO Box 360
well as to chemicals in the air over long periods. This Trenton, NJ 08625-0360
may be a problem for children or people who are already (609) 984-1863
ill. (609) 292-5677 (fax)

Q: Don't all chemicals cause cancer? Web address:

A: No. Most chemicals tested by scientists are not cancer-
causing. Industrial Hygiene Information
Industrial hygienists are available to answer your questions
Q: Should I be concerned if a chemical causes cancer in regarding the control of chemical exposures using exhaust
animals? ventilation, special work practices, good housekeeping, good
A: Yes. Most scientists agree that a chemical that causes hygiene practices, and personal protective equipment including
cancer in animals should be treated as a suspected human respirators. In addition, they can help to interpret the results of
carcinogen unless proven otherwise. industrial hygiene survey data.

Q: But don't they test animals using much higher levels of a Medical Evaluation
chemical than people usually are exposed to? If you think you are becoming sick because of exposure to
A: Yes. That's so effects can be seen more clearly using chemicals at your workplace, you may call personnel at the
fewer animals. But high doses alone don't cause cancer Department of Health and Senior Services, Occupational
unless it's a cancer agent. In fact, a chemical that causes Health Service, who can help you find the information you
cancer in animals at high doses could cause cancer in need.
humans exposed to low doses.
Public Presentations
Q: Can men as well as women be affected by chemicals that Presentations and educational programs on occupational health
cause reproductive system damage? or the Right to Know Act can be organized for labor unions,
A: Yes. Some chemicals reduce potency or fertility in both trade associations and other groups.
men and women. Some damage sperm and eggs, possibly
Right to Know Information Resources
leading to birth defects.
The Right to Know Infoline (609) 984-2202 can answer
questions about the identity and potential health effects of
Q: Who is at the greatest risk from reproductive hazards?
chemicals, list of educational materials in occupational health,
A: Pregnant women are at greatest risk from chemicals that
references used to prepare the Fact Sheets, preparation of the
harm the developing fetus. However, chemicals may Right to Know Survey, education and training programs,
affect the ability to have children, so both men and labeling requirements, and general information regarding the
women of childbearing age are at high risk. Right to Know Act. Violations of the law should be reported to
(609) 984-2202.
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ACGIH is the American Conference of Governmental NAERG is the North American Emergency Response
Industrial Hygienists. It recommends upper limits (called Guidebook. It was jointly developed by Transport Canada, the
TLVs) for exposure to workplace chemicals. United States Department of Transportation and the Secretariat
of Communications and Transportation of Mexico. It is a
A carcinogen is a substance that causes cancer. guide for first responders to quickly identify the specific or
generic hazards of material involved in a transportation
The CAS number is assigned by the Chemical Abstracts incident, and to protect themselves and the general public
Service to identify a specific chemical. during the initial response phase of the incident.

A combustible substance is a solid, liquid or gas that will burn. NCI is the National Cancer Institute, a federal agency that
determines the cancer-causing potential of chemicals.
A corrosive substance is a gas, liquid or solid that causes
irreversible damage to human tissue or containers. NFPA is the National Fire Protection Association. It classifies
substances according to their fire and explosion hazard.
DEP is the New Jersey Department of Environmental
Protection. NIOSH is the National Institute for Occupational Safety and
Health. It tests equipment, evaluates and approves respirators,
DOT is the Department of Transportation, the federal agency conducts studies of workplace hazards, and proposes standards
that regulates the transportation of chemicals. to OSHA.

EPA is the Environmental Protection Agency, the federal NTP is the National Toxicology Program which tests
agency responsible for regulating environmental hazards. chemicals and reviews evidence for cancer.

A fetus is an unborn human or animal. OSHA is the Occupational Safety and Health Administration,
which adopts and enforces health and safety standards.
A flammable substance is a solid, liquid, vapor or gas that will
ignite easily and burn rapidly. PEOSHA is the Public Employees Occupational Safety and
Health Act, a state law which sets PELs for New Jersey public
The flash point is the temperature at which a liquid or solid
gives off vapor that can form a flammable mixture with air.
PIH is a DOT designation for chemicals which are Poison
Inhalation Hazards.
HHAG is the Human Health Assessment Group of the federal
ppm means parts of a substance per million parts of air. It is a
measure of concentration by volume in air.
IARC is the International Agency for Research on Cancer, a
scientific group that classifies chemicals according to their
cancer-causing potential. A reactive substance is a solid, liquid or gas that releases
energy under certain conditions.
A miscible substance is a liquid or gas that will evenly dissolve
in another. A teratogen is a substance that causes birth defects by
damaging the fetus.
mg/m3 means milligrams of a chemical in a cubic meter of air.
It is a measure of concentration (weight/volume). TLV is the Threshold Limit Value, the workplace exposure
limit recommended by ACGIH.
MSHA is the Mine Safety and Health Administration, the
federal agency that regulates mining. It also evaluates and The vapor pressure is a measure of how readily a liquid or a
approves respirators. solid mixes with air at its surface. A higher vapor pressure
indicates a higher concentration of the substance in air and
therefore increases the likelihood of breathing it in.
A mutagen is a substance that causes mutations. A mutation is
a change in the genetic material in a body cell. Mutations can
lead to birth defects, miscarriages, or cancer.
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>>>>>>>>>>>>>>>>> E M E R G E N C Y I N F O R M A T I O N <<<<<<<<<<<<<<<<<
Common Name: 2-NITROPROPANE ============================================
DOT Number: UN 2608 FOR LARGE SPILLS AND FIRES immediately call your fire
NAERG Code: 129 department. You can request emergency information from the
CAS Number: 79-46-9 following:

CHEMTREC: (800) 424-9300

FLAMMABILITY - 3 ============================================
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; Eye Contact
3=serious; 4=severe * Immediately flush with large amounts of water for at least
15 minutes, occasionally lifting upper and lower lids.
Skin Contact
* 2-Nitropropane is a FLAMMABLE and REACTIVE * Remove contaminated clothing. Wash contaminated skin
LIQUID. with soap and water.
* Use dry chemical, CO2, water spray, alcohol or polymer
foam extinguishers. Breathing
* POISONOUS GASES ARE PRODUCED IN FIRE, * Remove the person from exposure.
including Nitrogen Oxides. * Begin rescue breathing (using universal precautions) if
* CONTAINERS MAY EXPLODE IN FIRE. breathing has stopped and CPR if heart action has stopped.
* Use water spray to keep fire-exposed containers cool. * Transfer promptly to a medical facility.
* Vapors form explosive mixtures with air. * Medical observation is recommended for 24 to 48 hours
* 2-Nitropropane may ignite combustibles (wood, paper and after breathing overexposure, as pulmonary edema may be
oil). delayed.
* If employees are expected to fight fires, they must be
trained and equipped as stated in OSHA 1910.156. PHYSICAL DATA
SPILLS AND EMERGENCIES Vapor Pressure: 12.9 mm Hg at 68oF (20oC)
If 2-Nitropropane is spilled or leaked, take the following Flash Point: 75oF (24oC)
steps: Water Solubility: Slightly soluble

* Evacuate persons not wearing protective equipment from OTHER COMMONLY USED NAMES
area of spill or leak until clean-up is complete.
* Remove all ignition sources. Chemical Name:
* Absorb liquids in vermiculite, dry sand, earth, or a similar Propane, 2-Nitro-
material and deposit in sealed containers. Other Names:
* Ventilate and wash area after clean-up is complete. 2-NP; Dimethylnitromethane; Isonitropropane;
* Keep 2-Nitropropane out of a confined space, such as a Nitroisopropane
sewer, because of the possibility of an explosion, unless the
sewer is designed to prevent the build-up of explosive ---------------------------------------------------------------------------
Not intended to be copied and sold for commercial
* It may be necessary to contain and dispose of
2-Nitropropane as a HAZARDOUS WASTE. Contact purposes.
your state Department of Environmental Protection (DEP) ---------------------------------------------------------------------------
or your regional office of the federal Environmental
Protection Agency (EPA) for specific recommendations.
Right to Know Program
* If employees are required to clean-up spills, they must be
PO Box 368, Trenton, NJ 08625-0368
properly trained and equipped. OSHA 1910.120(q) may be (609) 984-2202
applicable. ---------------------------------------------------------------------------