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9th semester
Lecture 10
Fundamentals
Forensic toxicology refers to the use toxicology for the purpose of law
The most common application is to identify any chemical that may serve as
causative agent in inflicting death or injury on humans or causing damage
to the property
2- Interpretation of the results regarding to physiological effect of the detected chemicals on the
deceased at the time of death
Sample under
investigation may
only contain
micrograms or
nanograms
Example :
-Detection of ethanol in victims or industrial accidents not due to postmortem changes
- Intoxication of CO in fire victims to determine weather the death is before or after the fire started
Investigation of toxicity –related death / injury
The basic phases in conducting an investigation of a suspected toxicant-induced /
related death or in living victims of criminal poisoning
High concentration of drug toxicant GIT and liver indicates oral digestion
Compounds located in tissues surrounding an injection sites indicates a
fresh IM Or Iv injection
Detection of drug combustion breakdown products within fluids / tissues reveal
that smoking was the route of drug administration ( product of crack pyrolysis ; is
unhydroecgonine methylester , high conc.of the product Indicates that smoking is the route of cocaine
administration )
Laboratory analysis :
Sorbitol :
It increases the gut motility to improve excretion of the poison – charcoal complex
Because of the diarrhea induced by this agent ( and other cathartics) careful
monitoring of fluid and electrolytes is necessary
Contraindications :
2- Enzymatic detoxification :
i- Sodium thiosulphate : Increase the conversion of
cyanide to thiocyanate by rhodanase enzyme
thus being easily excreted by the kidney
C- Functional antidotes :