Anterior To inhibit (to

Will stimulate Target cell/ Hormone Increased /

Releasing Hormone Pituitary Feedback decrease)/stimulate (to
the ______ of Target organ target cell secreted/ Decreased/ To send signal to AP to
Hypothalamus Hormone to mechanism increase) the
the receptor result Excesss
release ____ hypothalamus by

FSH
Follicle Stimulating Sertoli cells Inhibin ↑ Inhibin negative Decreasing of GnRH decrease FSH
Hormone
Testis
LH Interstitial
Testosterone ↑ Testosterone negative Decreasing GnRH decrease LH
Luteinizing Hormone Leydig cell
GnRH Gonadotropes Mod ↑Estrogen negative Decreasing GnRH
Decrease FSH
Gonadotropin Releasing Slightly decrease LH
Hormone
FSH Follicular cell
Follicle Stimulating Estrogen Increase FSH, very High LH
ovarian Follicle Excessive
Hormone Ovary ↑Estrogen
Positive Increasing GnRH (LH Surge/ Preovulatory
Surge
LH Corpus Luteum Progesterone ↑Progesterone Negative Decreasing GnRH Decrease mainly LH
Luteinizing Hormone

TRH Thyrotropes TSH

Thyroid
Follicular cell T3 and T4 Excess T3 and T4 Negative Decreasing TRH Decreasing in T3 and T4
Thyrotropin Releasing gland
Hormone

Adrenal Cortex: Decreasing

a. Zona Glomerulosa Cortisol increase negative Decreasing CRH
ACTH/ ACTH/Cortocotropin
CRH Corticotropes Corticotropin
Adrenal (ACTH independent)
b. Zona Faciculata and
Corticotropin Releasing Adenocorticotropic Gland Androgen NO NEGATIVE FEEDBACK BECAUSE THE ANDROGENS PRODUCE BY THE
Zona reticularis (ACTH
Hormone Hormone DO NOT INCREASE
dependent)- secretio of (WEAK) ADRENAL CORTEX ARE WEAK
Cortisol and Androgen

Cell membrane ↑ milk production

PRH /plasma
Prolactin Releasing Hormone Breast in breastfeeding
membrane Increasing PRH, decreasing
Inhibited by Lactotropes Prolactin/PRL Mammary MILK when the baby suck Positive Increasing Prolactin
Janus kinase ll PIH/ Dopamine
PIH/Dopamine gland STAT (Signal Transducer
and Activator of
the mother’s nipple,
Prolactin Inhibitory Hormone Neural Reflex
Transcriptor

GHRH All cells in the Cell membrane

Growth Hormone body capable of /plasma Excess Somatomedin
Releasing Hormone growing ( Bones,
Growth membrane C, IGF 1( insulin-like Negative
inhibited by Somatotropes adipose, muscle, Growth Decreasing GHRH Decreasing Growth hormone
Hormone and Important
Janus kinase ll Growth Factor 1) I feedback
GHIH/Somatostatin Targer Organ
STAT (Signal Transducer
and Activator of the liver,
Growth Hormone LIVER Transcriptor
Inhibitory Hormone