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JADXXX10.1177/1087054715595697Journal of Attention DisordersHult et al.

Article
Journal of Attention Disorders

ADHD and the QbTest: Diagnostic Validity


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DOI: 10.1177/1087054715595697
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Nicklas Hult1, Josefin Kadesjö1, Björn Kadesjö1, Christopher Gillberg1,


and Eva Billstedt1

Abstract
Objective: We assess the diagnostic accuracy of the QbTest, which measures the cardinal symptoms of ADHD. Method:
The study group comprised 182 children (mean age about 10 years), of whom 124 had ADHD and 58 had other clinical
diagnosis of which 81% had ASD. Results: Only QbTest parameters for inattention and hyperactivity differentiated between
ADHD and other clinical diagnoses at the p ≤ .01 level, not for measures of impulsivity. Sensitivity ranged from 47% to
67% and specificity from 72% to 84%. Positive predictive value ranged from 41% to 86%, and negative predictive value from
43% to 86%. Area under the curve varied from .70 to .80. Conclusion: The ability of the individual QbTest parameters
to identify ADHD was moderate. The test’s ability to discriminate between ADHD subtypes was unsatisfactory. (J. of Att.
Dis. XXXX; XX(X) XX-XX)

Keywords
QbTest, inattention, hyperactivity, impulsivity, attention deficit/hyperactive disorder, ASD, diagnosis

Introduction CPTs have been widely used as an objective measure of


attention in children with ADHD. As the name implies,
Over the past 20 years, many millions of children globally CPTs require the participant to pay attention over a rela-
have been identified, diagnosed, and treated because of tively long period of time by monitoring a sequence of audi-
ADHD. It is recommended (National Collaborating Centre tory and/or visually presented stimuli and to respond
for Mental Health (UK) [NCCMH], 2009) that the diagno- whenever a previously designated target stimulus appears.
sis (Diagnostic and Statistical Manual of Mental Disorders As it is impossible to compensate once the stimulus presen-
[4th ed.; DSM-IV]; American Psychiatric Association, tation is over and as the stimuli are presented rather rapidly
1994) be made on the basis of a full clinical and psychoso- and over an extended period of time, even brief periods of
cial assessment, a full developmental and psychiatric his- inattention can be assessed. There are several CPTs on the
tory, and independent observer reports and that the market with reliable psychometric qualities. For example, a
diagnostic criteria of the DSM-IV (ADHD) or International study by Soreni, Crosbie, Ickowicz, and Schachar (2009)
Statistical Classification of Diseases and Related Health showed that Conner’s CPT (CCPT) demonstrated higher
Problems (10th rev. [ICD-10]; hyperkinetic disorder, World test–retest reliability than more subjective instruments such
Health Organization, 1992) be met. Many subjective instru- as behavioral questionnaires. Halperin, Sharma, Greenblatt,
ments with the purpose of “guiding” the diagnostic work-up and Schwartz (1991) showed that CPTs had adequate split-
have been developed over the years, particularly self-rating half and test–retest reliability.
scales or informant rating scales, for example, the Swanson, Meta-analyses of validity have shown that children with
Nolan and Pelham-IV (SNAP) (Bussing et al., 2008), and ADHD generally perform poorly on CPTs compared with
the Conners parent and teacher rating scales (Conners, those without ADHD (Losier, McGrath, & Klein, 1996).
Parker, Sitarenios, & Epstein, 1998; Conners, Sitarenios, However, McGee, Clark, and Symons (2000) showed that
Parker, & Epstein, 1997). Clinical instruments and neuro-
psychological tests such as Continuous Performance Tests
(CPTs), proposing to objectively measure the “endopheno- 1
University of Gothenburg, Sweden
types” of ADHD (e.g., “inattention,” “hyperactivity,” and
Corresponding Author:
“impulsivity”), have entered the arena in the last decades.
Nicklas Hult, Gillberg Neuropsychiatry Centre, Sahlgrenska Academy,
The idea is appealing to clinicians who struggle with inter- University of Gothenburg, Kungsgatan 12, SE-411 19 Gothenburg,
rater disagreement or contradictions found in information Sweden.
from parents and teachers. Email: nicklas.hult@kan.nu
2 Journal of Attention Disorders 

Table 1.  Demographical and Clinical Descriptive of the Sample.

ADHD n = 124 CC n = 58

  n (%) n (%) p
M age (SD) 10.3 (1.7) 10.8 (1.8) n.s.
Mean full scale IQ (SD) 89.5 (13.2) 92.2 (14.6) n.s.
Male/female 97/27 (78/22) 53/5 (91/9) .001
Autism spectrum disorders 35 (28) 47 (81) .001
Tic disorders 5 (4) 7 (12) n.s.
DCD 39 (32) 4 (7) .001
Borderline intellectual functioning 12 (10) 9 (16) n.s.
Dyslexia 38 (31) 6 (10) <.01
Language disorder 11 (9) 6 (10) n.s.
Depression/anxiety disorder 6 (5) 4 (7) n.s.

Note. CC = clinical comparison; DCD = developmental coordination disorder.

CCPT did not differentiate between children with ADHD were all given the QbTests as part of a neuropsychiatric
from clinical controls. Zelnik, Bennett-Back, Miari, Goez, assessment. All the children were comprehensively evalu-
and Fattal-Valevski (2012) examined conditional probabili- ated including examination by a child psychiatrist/pediatric
ties for the Test of Variables of Attention (TOVA) finding a neurologist, and a neuropsychologist. The diagnosis of
sensitivity of .91 and specificity of .21, that is, 79% false ADHD and other neurodevelopmental disorders was per-
positives when used as a diagnostic instrument. Edwards formed according to “gold standard” in clinical setting
et al. (2007) evaluated CCPT regarding validity and utility in including assessment by a multi-professional team using
assessment of ADHD in a study of 104 children 6 to 12 years LEAD procedure (Longitudinal, Experts, All, Data; Spitzer,
of age. The CCPT performed better than a random test in 1983). The diagnosis was based on behavioral criteria
classifying ADHD, but the receiver operating characteristic according to the DSM-IV on the basis of all available infor-
(ROC) analysis showed the accuracy of the CCPT to be low. mation except that collected from the QbTest. The diagnos-
The CPTs mentioned above measure many of the core tic decision was not made on the basis of results obtained at
symptoms in ADHD, but “hyperactivity” is not included. A the QbTest. Different rating scales were used as guidelines
CPT test measuring aspects of motor activity is the QbTest. in the diagnostic work-up, but the clinician’s judgment was
Sharma and Singh (2009) reported that the results of the decisive. Exclusionary criteria were as follows: (a) ongoing
QbTest agreed with ADHD diagnosis in 90% of cases. They medication with central stimulants at the time of the assess-
estimated sensitivity at .96 and specificity at .81, respec- ment (n = 85), (b) not valid QbTest (e.g., computer failure,
tively. Vogt and Shameli (2011) evaluated the clinical utility noncompliance; n = 32), (c) Wechsler Intelligence Scale for
of the QbTest and found that it provided an increased Children-IV (WISC-IV) or Wechsler Preschool and Primary
robustness of the clinical diagnosis. There is a clear need to Scale of Intelligence-III (WPPSI-III) full scale IQ at or
further evaluate the diagnostic accuracy of the QbTest in the below 70 (n = 18), and (d) syndromal medical disorder diag-
assessment of ADHD and to (a) study QbTest’s ability to nosis including 22q11 deletion syndrome (n = 4) or Ehler
identify ADHD in clinical groups, and (b) assess its power Danlos syndrome (n = 1). This means that 182 children were
to separate ADHD subtypes from each other. The present left for inclusion in the study. Retrieval of data was made by
study was launched with these two objectives. one of the authors (J.K.) who examined all CNC-files and
registered diagnoses, IQ, comorbidity, QbTest scores, and
ongoing medication at the time of the assessment.
Method
Procedure Participants
The study was conducted between 2005 and 2009 at the As already mentioned, 182 children met criteria for inclusion
Child Neuropsychiatry Clinic (CNC), a statewide regional in the study; these including the ADHD group (n = 124), with
and specialized clinic for the assessment of ADHD, autism, a mean age of 10.3 ± 1.7 years and the non-ADHD clinical
and other neurodevelopmental disorders, in Gothenburg, comparison (CC) group (n = 58) with a mean age of 10.8 ± 1.8
Sweden. A total of 322 children between 6 and 12 years of years (Table 1). The boy:girl ratios were 3:1 in the ADHD
age were referred to CNC with suspected ADHD, autism, or group and 9:1 in the CC group. In the ADHD group, 88 chil-
another neurodevelopmental disorder during this period and dren were diagnosed with ADHD combined subtype, 30 with
Hult et al. 3

inattentive subtype, 2 with hyperactive/impulsive subtype, the central parts of Sweden. The sample was representative
and 4 were diagnosed as ADHD-NOS (ADHD–not otherwise of Swedish demographics in terms of parent ethnicity, par-
specified). As shown in Table 1, the most frequent comorbidi- ent marital status, possession of car in the household, and
ties in the ADHD group were developmental coordination the free-time activities that the child took part in.
disorder (DCD; 32%), dyslexia (31%), and autism spectrum
disorder (ASD; 28%). In the CC group, the majority of the Cardinal parameters
participants had ASD (81%). Borderline intellectual level
QbInattention provides an index of inattention based on
(IQ = 70-84), language disorder, tics, and depression/anxiety
Omission Errors, Reaction Time, and Reaction Time
disorder were found in small subgroups in both the ADHD
Variation (see Points 1-3 below).
and CC groups. No significant differences were found
QbActivity provides an index of the patient’s ability to
between groups regarding age or full scale IQ. Number of
regulate motor activity. It is based on Time active,
comorbid diagnosis averaged 2.4 (SD = 1.4) in the ADHD
Distance, Area, and Micro Events (see Points 4-7 below).
group and 1.4 (SD = 0.6) in the CC group. For assessment of
QbImpulsivity provides an index of impulsivity based on
effects of ASD comorbidity on QbTest performance, we
Commission Errors, Normalized Commission Errors,
divided the ADHD group (n = 124) in two subgroups: ADHD
and Anticipatory Responses (see Points 8-10 below).
+ ASD (n = 35) and ADHD−no ASD (n = 89).
Attention parameters
Instrument
1.  Reaction Time, measured in milliseconds, is the
The QbTest is a computerized CPT including measures of average time between stimulus presentation and
inattention/impulsivity combined with a motion tracking correct button press.
device recording activity measures. The QbTest measures 2.  Reaction Time Variation is the standard deviation of
the three cardinal symptoms of ADHD; inattention, hyperac- the Reaction Time and reflects Reaction Time
tivity, and impulsivity presented in the test report as cardinal consistency
parameters—QbInattention, QbActivity, and QbImpulsivity. 3.  Omission Errors is a measure of registered omitted
The test report is calculated by the QbTest software. There is responses to the targets.
no total ADHD score provided in the QbTest report.
The test developer assumed that some parameters mea- Activity parameters
sure the same underlying construct. By using statistical pro-
4.  Time active is a measure of the test participant’s
cedure of factor analysis (principal–component analysis) to
movement during the test period and is calculated
identify parameters that are strongly correlated with each
on a second to second basis. Each second with
other, three cardinal parameters were created to aid in the
movement more than 1 cm is counted.
test result interpretation. Each parameter included in the
5.  Distance indicates the amount of total activity for
cardinal parameters is weighted differently depending on
the test period and is measured as the distance in
their correlation (factor loading) to the cardinal parameter
meters that the marker on the headband has
(Knagenhjelm & Ulberstad, 2010). QbActivity includes
traveled.
data from the parameters Time Active, Distance, Area, and
6.  Area reflects how vivid the movements are during
Micro Events registered during the second half of the test.
the test, measured as the surface covered by the
QbInattention include the parameters Omission Errors,
marker on the headband reflector.
Reaction Time, and Reaction Time Variation during the sec-
7.  Micro Events reflect the degree of activity during
ond half of the test. QbImpulsivity is computed from
the test period, which is measured by quantifying a
Commission Errors, Normalized Commission Errors, and
change in position greater than 1 mm since the last
also includes Anticipatory responses. The cardinal parame-
micro event.
ters are weighted by a component score coefficient. During
the attention task test, a high-resolution infrared camera
Impulsivity parameters
monitors the head movements of the participant responding
to stimuli appearing on the computer screen. The results are 8.  Commission Errors occur when a response is regis-
compared with a norm group of the same age and gender. tered on a nontarget stimulus.
The raw score is transformed and presented as Q-score, 9.  Normalized Commission Errors is measured by
equivalent to Z-score, and percentiles in the test report examining the percentage of Commission Error
(Knagenhjelm & Ulberstad, 2010). The norm sample, rates relative to the percentage of correct responses
according to the QbTest manual, comprised 426 children to target.
aged between 6 and 12 years from six different schools situ- 10.  Anticipatory is a response detected just before or
ated in cities of different sizes and level of urbanization in just after a stimulus is presented (“guesses”).
4 Journal of Attention Disorders 

Statistical Analysis  Table 2.  Comparisons of ADHD Group (n = 124) With CC


(n = 58) in QbTest Parameters Using Mann–Whitney U Test.
The Mann–Whitney U test was used for group comparison.
The Pearson two-tailed test was used to correlate number of ADHD total CC
comorbidities and QbTest cardinal parameters. The level of
n = 124 n = 58
significance was set at p ≤ .01. For evaluation of the diag-
nostic utility of QbTest cardinal parameters, we used ROC QbTest parameter Q-score (SD) Q-score (SD)
curves and computed the area under the curve (AUC). We
also calculated sensitivity (Se), specificity (Sp), positive QbActivity 1.7 (1.2)* 0.5 (1.2)
QbInAttention 1.2 (1.1)* 0.2 (0.9)
predictive value (PPV), and negative predictive value
QbImpulsivity 1.1 (1.6) 0.4 (1.3)
(NPV)—with a 68% prevalence of ADHD in this clinical
Activity
sample. This required both the use of a reference standard,
  Time active 1.1 (0.8)* 0.6 (1.1)
“gold standard” for diagnosis and a cutoff score for the
 Distance 1.8 (1.5)* 0.6 (1.3)
QbTest. Our “gold standard” was the clinical diagnosis of  Area 1.9 (1.5)* 0.8 (1.5)
ADHD and the QbTest cutoff was a q-score of 1.25 as rec-   Micro Events 1.5 (1.0)* 0.6 (1.1)
ommended by the test developer. For all statistical analyses, Inattention
we used SPSS statistical package system version 20.   Reaction time 0.6 (1.3)* 0.1 (1.1)
  Reaction time variation 2.0 (2.0)* 0.1 (1.8)
Ethics   Omission error 1.5 (1.0)* 0.6 (1.3)
Impulsivity
The study was approved by the Ethics Committee at the   Commission error 0.8 (1.1) 0.0 (1.0)
University of Gothenburg.   Normalized commission 0.8 (1.4) 0.1 (1.4)
 Anticipatory 0.9 (1.1)* 0.2 (1.0)
Results Note. CC = clinical comparison.
*p = .01.
QbTest Cardinal Parameters in ADHD Total
Group and CC Group .66 and specificity between .72 and .83. PPVs ranged from
.76 to .86 and NPVs from .37 to .50.
The cardinal parameters QbActivity and QbInattention
median scores were significantly higher, indicating more
deficits, in the ADHD total group than in the CC group Diagnostic Accuracy of Cardinal Parameters in
(Table 2). No difference was found between the ADHD ADHD Subtypes
total group and CC group regarding QbImpulsivity. In the ADHD combined group (n = 88), QbInattention and
QbActivity showed a moderate overall capacity (AUCs =
QbTest Standard Parameters in ADHD Total .77 and .74, respectively) to identify true positives.
Group and CC Group QbImpulsivity was found to have a slight overall capacity
(AUC = .62). Sensitivity ranged between .44 and .67 and
Group medians were significantly higher in the ADHD total specificity between .72 and .83. PPVs ranged from .71 to
group in 8 out of 10 ordinary test parameters (Table 2). No .82 and NPVs from .46 to .53 (Table 3).
differences were found between ADHD total and CC group Regarding predominantly inattentive subtype (n = 30),
regarding Commission Error and Normalized Commission. AUCs for QbInattention and QbActivity was moderate
All ordinary test parameters measuring activity were sig- (AUCs = .73 and .76), whereas QbImpulsivity was slight
nificantly different between ADHD group and CC group. (AUC = .62). Sensitivity ranges were between .37 and .60
and specificity between .72 and .83. PPVs ranged from .41
Diagnostic Accuracy of Cardinal Parameters in to .58 and NPVs from .69 to .78.
ADHD Total Group Due to small sample size in the hyperactive/impulsive
group (n = 2), analysis of diagnostic accuracy was not carried
The cardinal parameters ability to correctly classify those out in this group as well as in the ADHD-NOS group (n = 4).
with and without ADHD is presented as AUC in Table 3. In
the ADHD total group (n = 124) QbInattention and
Comorbidity and QbTest Results
QbActivity showed a moderate overall capacity (AUCs =
.76 and .74, respectively) to identify true positives. We found a positive correlation between number of comor-
QbImpulsivity was found to have a relatively weak overall bid diagnosis and QbActivity (r = .195, p = .05) but not
capacity (AUC = .62). Sensitivity ranged between .42 and regarding QbInattention and QbImpulsivity.
Hult et al. 5

Table 3.  Clinical Utility of QbTest for Identifying ADHD and ADHD Subtypes With Cutoff Set at Recommended 1.25 Q-Score.

95% Confidence interval

  AUC Se Sp PPV NPV


ADHD total (n = 124)
 QbActivity .74 [.66, .82] .63 [.56, .73] .74 [.61, .84] .84 [.75, .91] .50 [.39, .61]
 QbInAttention .76 [.69, .84] .48 [.39, .57] .83 [70, .91] .86 [.75, .93] .43 [.34, .53]
 QbImpulsivity .62 [.53, .70] .42 [.33, .51] .72 [.59, .83] .76 [.64, .86] .37 [.28, .46]
ADHD-Combined (n = 88)
 QbActivity .74 [.66, .83] .67 [.56, .76] .74 [.61, .84] .80 [.68, .88] .60 [.47, .71]
 QbInAttention .77 [.69, .85] .51 [.40, .62] .83 [.70, .91] .82 [.69, .90] .53 [.42, .63]
 QbImpulsivity .62 [.53, .71] .44 [34, 55] .72 [59, 83] .71 [57, 82] .46 [36, 57]
ADHD-Inattentive (n = 30)
 QbActivity .73 [.63, .84] .60 [.41, .77] .74 [.61, .84] .55 [.37, .71] .78 [.65, .88]
 QbInAttention .76 [.66, .86] .47 [.29, .65] .83 [.70, .91] .58 [.37, .77] .75 [.62, .85]
 QbImpulsivity .62 [.50, .74] .37 [.21, .56] .72 [.59, .83] .41 [.23, .61] .69 [.56, .80]

Note. AUC = area under the curve; Se = sensitivity; Sp = specificity; PPV = positive predictive value; NPV = negative predictive value.

Table 4.  Comparison of CC Group (n = 58) With ADHD−No ASD (n = 89) and ADHD + ASD (n = 35) Groups in QbTest Cardinal
Parameters Using Mann–Whitney U Test.

ADHD total n = 124

ADHD–no ASD (n = 89) ADHD + ASD (n = 35) CC (n = 58)

Cardinal parameter Q-score (SD) Q-score (SD) Q-score (SD)


QbActivity 1.6 (1.2)* 1.7 (1.2)* 0.5 (1.2)
QbInAttention 1.5 (1.1)* 0.9 (0.9)* 0.2 (0.9)
QbImpulsivity 0.8 (1.5) 1.6 (1.9)* 0.4 (1.3)

Note. CC = clinical comparison; ASD = autism spectrum disorder.


*p = .01.

Comparison Between the CC Group and The overall capacity for the different QbTest parameters
ADHD–No ASD and ADHD + ASD on Cardinal to accurately identify individual cases of ADHD in the clin-
ical sample was only moderate. The AUC was similar for
Parameters Using Mann–Whitney U Test
the ADHD-Combined and ADHD-Inattentive subgroups
The CC group performed significantly better than both the indicating that the test has similar capacity independent of
ADHD + ASD and ADHD−no ASD groups regarding two of ADHD subtype. This is in line with previous studies that
the cardinal parameters, QbInattention and QbActivity (p = have shown that behavior ratings of inattentive symptoms
.01; Table 4). However, only the ADHD + ASD group are more related to objective measures of hyperactivity than
showed significantly higher results regarding QbImpulsitivity to those of inattention (Günther, Kahraman-Lanzerath,
than the CC group (p = .01). Compared with the ADHD−no Knospe, Herpertz-Dahlmann, & Konrad, 2012). Thus, the
ASD group, the ADHD + ASD performed better regarding individual test parameters could not discriminate between
QbInattention. ADHD subtypes. With cutoff set to 1.25 Q-score, as recom-
mended by the manufactor, sensitivity ranged from .47 to
.67, and specificity from .72 to .84. Results which replies
Discussion
findings from Sharma and Singh (2009).
The QbTest differentiated between clinical groups with and When analyzing the effect of comorbidity as expressed by
without ADHD at a group level. Three quarters of all the number of comorbid disorders on Qb results, we found that
activity, inattention, and impulsivity parameters clearly sepa- activity was influenced by the load of comorbidity. This result
rated ADHD from non-ADHD on a group-wise basis. highlights the role of motor control problems as a signal that
However, the cardinal parameter QbImpulsivity only showed should lead to a comprehensive assessment including not only
a trend toward separation of the two groups (p < .05). attentional deficits but also other comorbid disorders.
6 Journal of Attention Disorders 

Our results are representative of a clinical sample with a impulsivity score seen in the ADHD + ASD group might be
high prevalence of ADHD and other neurodevelopmental a double effect of inhibitory deficit due both to ASD and
disorders and have implications for specialized clinics for ADHD. The difference in inattention might be explained by
ADHD assessments. It is not necessarily representative of different attentive styles, for example, that individuals with
clinics in primary care as it is heavily weighted with ASD. ASD may exhibit selective inattention to social stimuli or to
In clinical settings, high rates of PPV, presumably above unmotivated activities, whereas sustaining focus on activi-
85% to 90%, are desired for instruments chosen for guid- ties with limited connection to social stimuli (as in a com-
ance in the diagnostic processes as diagnostic tests are puterized test) is easier.
meant to provide the clinician with some surety that an ill- To sum up, the individual QbTest parameter ability to dif-
ness/condition is present. The individual QbTest parameters ferentiate between ADHD and CC group was good, but the
do not appear to have these characteristics in this clinical ability to identify ADHD in a clinical sample was moderate
study. In our study, the PPV for the cardinal parameters and the ability to discriminate between ADHD subtypes was
ranged from .76 to .86 and for the NPV from .37 to .50. In unsatisfactory. However, analyzing QbTest performances in
other words, among those who had a positive test result, the different clinical groups (including ADHD) might give valu-
probability of having ADHD was 76% to 86% (depending able information on clinical presentation that might explain
on which cardinal parameter is analyzed), and for those more than the broad diagnostic categories.
who had a negative test result, the probability of not having
ADHD was 37% to 50%. This emphasizes that ADHD
assessment needs to be performed by experienced clinical Strengths and Limitations
practitioners, that interpretation of the QbTest result should The strengths of the study is that the study group is repre-
be made with caution, and that the clinical evaluation should sentative of patients who will receive the test in practice and
still remain the gold standard for diagnosis. The QbTest that both the study group and the comparison group had
captures the core symptoms of ADHD at a group level and received the same reference test, a clinical diagnostic work-
also includes objective activity measures, which no other up using ADHD criteria according to DSM-IV.
test does. Like other neuropsychological tests, it provides a A limitation in the study is that although the ADHD
setting for relevant clinical observation. This indicates that diagnosis was not based on results from the QbTest, the
the administration of the test and evaluation of test results results were known to some of the clinicians, whose infor-
should be in the hands of experienced clinicians. Although mation could have contributed to the final diagnosis.
this study showed moderate validity for the individual Another limitation is that no interrater reliability tests
QbTest parameters, the intended use of the test is to comple- regarding diagnoses were carried out.
ment the clinical interview and validated symptom rating
scales to improve assessment precision in ADHD. Declaration of Conflicting Interests
Further on, the clinician needs to pay attention to comor-
The author(s) declared no potential conflicts of interest with
bid ASD. It is well known that almost half the children with
respect to the research, authorship, and/or publication of this
ASD suffer from hyperactivity, inattention, and impulsivity article.
(Murray, 2010; Sturm, Fernell, & Gillberg, 2004; Yoshida
& Uchiyama, 2004). This study highlights the similarities Funding
of CPT profiles in children with ADHD and children with
ASD, with or without coexisting ADHD. However, when The author(s) received no financial support for the research,
authorship, and/or publication of this article.
comparing children with ADHD (and no ASD) to those
with ADHD combined with ASD or to the CC group (where
a majority had ASD but no ADHD), we found interesting References
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of Child and Adolescent Psychopharmacology, 22, 131-138. symptoms in children with high-functioning pervasive devel-
doi:10.1089/cap.2010.0146 opmental disorder (PDD). European Child & Adolescent
Halperin, J. M., Sharma, V., Greenblatt, E., & Schwartz, S. T. Psychiatry, 13, 307-314.
(1991). Assessment of the Continuous Performance Test: Zelnik, N., Bennett-Back, O., Miari, W., Goez, H. R., & Fattal-
Reliability and validity in a nonreferred sample. Psychological Valevski, A. (2012). Is the test of variables of attention
Assessment: A Journal of Consulting and Clinical Psychology, reliable for the diagnosis of attention-deficit hyperactivity
3, 603-608. disorder (ADHD)? Journal of Child Neurology, 27, 703-707.
Knagenhjelm, P., & Ulberstad, F. (2010). QbTest technical man- doi:10.1177/0883073811423821
ual. Stockholm, Sweden: Qbtech AB.
Losier, B. J., McGrath, P. J., & Klein, R. M. (1996). Error pat- Author Biographies
terns on the Continuous Performance Test in non-medicated
and medicated samples of children with and without ADHD: Nicklas Hult is a clinical psychologist, working as a neuropsy-
A meta-analytic review. Journal of Child Psychology and chologist at a child and adolescent clinic in Gothenburg and is also
Psychiatry, 37, 971-987. a PhD student at the Gillberg Neuropsychiatry Centre, at the
McGee, R. A., Clark, S. E., & Symons, D. K. (2000). Does University of Gothenburg.
the Conners’ Continuous Performance Test aid in ADHD Josefin Kadesjö is a clinical psychologist working both as a
diagnosis? Journal of Abnormal Child Psychology, 28, school psychologist and a clinical psychologist at a child and ado-
415-424. lescent clinic in Gothenburg.
Murray, M. J. (2010). Attention-deficit/hyperactivity disor-
der in the context of autism spectrum disorders. Current Björn Kadesjö is a paediatrician at the Child Neuropsychiatric
Psychiatry Reports, 12, 382-388. doi:10.1007/s11920-010- Clinic at Queen Silvias Children´s Hospital, Gothenburg.
0145-3
Christopher Gillberg is professor Gillberg Neuropsychiatry
National Collaborating Centre for Mental Health (NCCMH).
Centre at the University of Gothenburg and child psychiatrist at
(2009). Attention deficit hyperactivity disorder: Diagnosis
the Child Neuropsychiatric Clinic at Queen Silvias Children´s
and management of ADHD in children, young people and
Hospital, Gothenburg.
adults. Leicester and London: The British Psychological
Society and the Royal College of Psychiatrists. Eva Billstedt is an associate professor at Gillberg Neuropsychiatry
Sharma, A., & Singh, B. (2009). Evaluation of the role of Qb test- Centre, University of Gothenburg and clinical psychologist at the
ing in attention deficit hyperactivity disorder. Archives of Child Neuropsychiatric Clinic at Queen Silvias Children´s
Disease in Childhood, 94(Suppl. 1), A72. Hospital, Gothenburg.

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