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Platelet rich plasma (PRP) is an autologous solution comprised of a high concentration of platelets and WBC’s suspended in plasma. Platelets, or Thrombocytes, are a natural source of growth factors. When activated, these platelets release a large variety of known growth factors that accelerate the body’s natural healing process. Platelet rich plasma (PRP) application is a successful catalyst in the healing process for wide varieties of conditions. PRP was first developed in the 1970s and first used in an open heart surgery procedure. PRP therapy began gaining popularity in the mid 1990s. Methods of harvesting and using platelet rich plasma are becoming widely practiced in the fields of sports medicine, orthopedics, traumatology, general surgery, dentistry, dermatology and cosmetology and ophthalmology. Their main function is hemostasis by attaching to any breach in vessel where platelets aggregate, activate and release granules. The platelets organelle zone is rich in platelet granules. Alpha granules contain clotting mediators such as factor V, factor VIII, fibrinogen, fibronectin, platelet-derived growth factors, and chemotactic agents. Delta granules, or dense bodies, contain ADP, calcium, serotonin, which are platelet-activating mediators. Activated platelets release granules by exocytosis which contain not only clotting factors but more than sixty different biologically active substances that are involved in processes of tissue regeneration, angiogenesis, epithelialization, proliferation and differentiation of osteoblasts, and in synthesis of collagen and extracellular matrix of connective tissue.

Dry Eye Syndrome :

Dry eye is a chronic condition that decreases function and affect visual function with severe discapacity until now treatments are based in artificial eye drops. Platelet rich plasma has emerged as a strategy for cellular restoration, the purpose of this study is to evaluate their effects in lacrimal

production and safety of this intervention in patients with severe dry eye.


The patients who have been unable to obtain relief through other methods may have success with this treatment. The treatment is very safe and effective for the treatment of chronic and symptomatic Dry Eye Syndrome. Other indications for the use of Autologous PRP Eye Drops may include Ulcers and Ocular Surface Syndrome Post LASIK. Autologus E-PRP eye drops are prepared from patient’s own blood and takes 2-3 hours to prepare activated E-PRP. Finally it is combined in the antibiotic or lubricant drops and should be stored in refrigerator and used within 7 days.


Accelerated and enhanced healing Reduced inflammation Symptomatic improvement of Dry Eye Syndrome Effective in treating ulcers Reduction in pain May restore the corneal epithelial surface in patients with corneal ulcers The known contraindications for Autologous PRP eye drops:

Platelet Dysfunction Syndrome Critical Thrombocytopenia Hypofibrinogenemia Ongoing Dry Eye Infection


Alio J, Colecha J, et al. Symptomatic Dry Eye Treatment with Autologous Platelet-Rich Plasma. Ophthalmic Res 2007; 39: 124-129. Alio J, Pastor S, et al. Treatment of Ocular Surface Syndrome after LASIK with Autologous Platelet-rich Plasma. Journal of Refractive Surgery 2007; 23: 617-619. Alio J, Abad M, et al. Use of Autologous Platelet-Rich Plasma in the Treatment of Dormant Corneal Ulcers. Ophthalmology 2007; 114: 1286-1293. Koffler B. Autologous Serum Therapy of the Ocular Surface with Novel Delivery by Platelet Concentrate Gel. The Ocular Surface 2006; 4(4): 188-195. Marquez-de-Arecena R, Montero-de-Espinosa I, et al. Subconjunctival Application of Platelet Rich Plasma Concentrate in the Treatment of Ocular Burns: Preliminary Results. Arch Soc Esp Oftalmol 2007; 82: 475-482.

Please contact Dr. S K Hayatnagarkar, Cryobank Fertility Research Centre, Kamgar Chowk, N-2, CIDCO Aurangabad Cell and whatsapp: 9422725000,