NEW RESEARCH POSTERS
6.29 — 6.31
response scores of WCST, the digit span scores (P < 0.05), and coding and
symbol search scores (P < 0.01) of WISC-IV; their scores in SWM, total
interval errors, and SWM strategy were reduced significantly (P < 0.05). In
the PSQ questionnaire, the scores of behavior problems, learning prob-
lems, hyperactivity impulsivity, hyperactivity index, and anxiety (P < 0.05)
were decreased significantly.
Conclusions: Through the exploratory research, we found that computer-
based training could improve the executive function performance on
response inhibition, working memory, processing speed, cognitive flexibility,
and plan-monitoring fields in children with ADHD, as well as the core symp-
toms of ADHD.
ADHD, COMP, NEPSYC
Supported by Natural Science Foundation of China Grant 81271510
http://dx.doi.org/10.1016/j.jaac.2017.09.373
6.29 ATYPICAL FUNCTIONAL CONNECTIVITY IN
ADOLESCENTS AND ADULTS WITH PERSISTENT
AND REMITTED ATTENTION-DEFICIT/
HYPERACTIVITY DISORDER (ADHD)
Giorgia Michelini, MSC, King’s College London, giorgia.
michelini@kcl.ac.uk; Joseph Jurgiel, BS, University of
California, Los Angeles, jajurgiel@gmail.com;
Ioannis Bakolis, PhD, King’s College London, ioannis.
bakolis@kcl.ac.uk; Celeste H.M. Cheung, PhD, King’s College
London, celeste.cheung@kcl.ac.uk;
Philip Asherson, MRCPsych, King’s College London, philip.
asherson@kcl.ac.uk; Sandra K. Loo, PhD, University of
California, Los Angeles, sloo@mednet.ucla.edu;
Jonna Kuntsi, PhD, King’s College London, jonna.kuntsi@kcl.
ac.uk; Iman Mohammad-Rezazadeh, PhD, University of
California, Los Angeles, irezazadeh@mednet.ucla.edu
Objectives: ADHD diagnosed in childhood often persists into adolescence
and adulthood, but the neural mechanisms underlying ADHD persistence/
remission are poorly understood. In a follow-up study, we aimed to examine
whether brain functional connectivity, measuring the interdependency of
brain oscillations between brain regions, reflects enduring deficits unrelated
to ADHD outcome or is a marker of ADHD remission, improving concurrently
with clinical profiles.
Methods: On average, six years after assessments in childhood, high-density
EEG was recorded in 110 adolescents and young adults with childhood ADHD
(87 persisters, 23 remitters) and 169 typically developing control subjects
during an arrow-flanker task-eliciting cognitive control. Functional connectivity
was quantified by applying a network-based (graph-theory) approach. Groups
were compared on connectivity metrics in theta, alpha, and beta frequency
bands in incongruent (high-conflict) trials before target onset (prestimulus),
during target processing (poststimulus), and in the degree of change from
prestimulus to poststimulus. ADHD outcome was examined with clinical
diagnosis (persistent/remitted ADHD) and with ADHD severity indicated by
continuous measures of symptoms and functional impairment.
Results: ADHD persisters showed increased prestimulus connectivity in theta,
alpha, and beta oscillations; increased poststimulus beta connectivity; and
reduced prestimulus/post-stimulus change in theta connectivity compared with
control subjects (all P < 0.01). In most measures showing ADHD persister-
control differences, ADHD remitters differed from control subjects (all P < 0.05)
but not from persisters. Likewise, no association emerged between connectivity
measures and ADHD severity in participants with childhood ADHD.
Conclusions: Adolescents and young adults with persistent and remitted
ADHD shared atypical connectivity profiles (hyperconnectivity and reduced
ability to modulate connectivity patterns with task demands), compared with
control subjects. These results indicate that these connectivity impairments
may represent enduring deficits in individuals with childhood ADHD, irre-
spective of current diagnostic status in adolescence/young adulthood.
ADHD, NEURODEV
Supported by Action Medical Research and the Peter Sowerby Charitable
Foundation Grant GN1777, UK Medical Research Council (MRC) Grant
J OURNAL
S286 www.jaacap.org
G0300189, NIMH Grant R01MH062873, MRC Social, Genetic and Develop-
mental Psychiatry Centre, Institute of Psychiatry, Psychology and Neurosci-
ence, King’s College London Grant G9817803, and the National Institute for
Health Research Biomedical Research Centre for Mental Health at King’s
College London, Institute of Psychiatry, Psychology and Neuroscience and
South London and Maudsley National Health Service Foundation Trust
http://dx.doi.org/10.1016/j.jaac.2017.09.374
6.30 AN INVESTIGATION INTO THE UTILITY AND
SENSITIVITY OF THE SNAP-IV PARENT- AND
TEACHER-RATED QUESTIONNAIRE IN THE
ASSESSMENT OF ATTENTION-DEFICIT/
HYPERACTIVITY DISORDER (ADHD)
Cristal J. Oxley, MA, MBBS, MRCPsych, South London and
Maudsley NHS Foundation Trust, cristal.oxley@nhs.net;
Jenny Phillips, King’s College London, k1207269@kcl.ac.uk;
Omer S. Moghraby, BSc, MBBS, MRPsych, The Maudsley
Hospital, omermoghraby@nhs.net
Objectives: The purpose of this study is to establish the utility and sensitivity
of the Swanson, Nolan and Pelham Teacher and Parent Rating Scale (SNAP-IV)
in assessing ADHD in a clinical sample.
Methods: This study consisted of a retrospective review of medical records
from a clinical patient sample (N ¼ 65), aged seven to 17 years. Sensitivity of
SNAP-IV scores to medication changes were assessed using a two-tailed
paired t-test while Cohen’s kappa coefficient was used to assess concurrent
validity between SNAP-IV and Strengths and Difficulties Questionnaire (SDQ)
scores and interrater reliability (parents and teachers). Internal consistency was
measured using Cronbach’s alpha coefficient. Statistical analysis was per-
formed on the total SNAP-IV scores, both inclusive (items 1 - 26) and exclusive
(items 1 - 18) of the ODD items, and across the respective subdomains of
inattention, hyperactivity/impulsivity, and ODD.
Results: Total SNAP-IV scores showed no significant change following a
medication increase. Significant changes were observed in SNAP-IV scores in
the inattentive domain in patients who had no history of medication resis-
tance. SNAP-IV demonstrated acceptable test-retest reliability (a ¼ 0.781) and
moderate correlation between parent and teacher ratings (l ¼ 0.626). Cor-
relation between SDQ and SNAP-IV reports was fair for parents (l ¼ 0.256)
and teachers (l ¼ 0.286).
Conclusions: This study provides evidence that SNAP-IV can be a reliable
and valid screening tool as a component in assessment of ADHD behav-
iors within a clinical sample. Further research with a larger sample size is
required to further test the sensitivity of SNAP-IV to changes in medica-
tion dose.
ADHD, RI, TREAT
http://dx.doi.org/10.1016/j.jaac.2017.09.375
6.31 ASTHMA AND ATTENTION-DEFICIT/
HYPERACTIVITY DISORDER (ADHD): A
COMORBIDITY STUDY BASED ON MEDICATION
TREATMENT
Murat Pakyurek, MD, University of California, Davis,
mpakyurek@ucdavis.edu; Anca B. Luminare, MD, University of
California, Davis School of Medicine, abluminare@ucdavis.
edu; Ana-Maria Iosif, PhD, University of California, Davis,
aiosif@ucdavis.edu; Atoosa Azarang, MD, University of
California, Davis Medical Center, atoazarang@ucdavis.edu;
Thomas E. Nordahl, MD, PhD, University of California, Davis
School of Medicine, tenordahl@ucdavis.edu
Objectives: Previous cross-sectional studies have suggested an association
between asthma and ADHD. Our study aimed at evaluating the comorbidity
of asthma and ADHD based on how frequently drugs used to treat those
disorders are prescribed to the same patients. This study is stimulated by the
work of Ole Bernt Fasmer in Bergen, Norway.
OF THE AMERICAN A CADEMY OF CHILD & ADOLESCENT P SYCHIATRY
VOLUME 56 NUMBER 10S OCTOBER 2017