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Deep vein thrombosis
CONTINUING
PROFESSIONAL
DEVELOPMENT
Page 61
Read Clio Badenhorst’s
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Guidelines on
multiple choice practice profile on how to write a
questionnaire late-stage dementia practice profile
Authors
Introduction
Lynda Bonner
Consultant nurse for thrombosis and anticoagulation, A DVT is a thrombus or blood clot that can
King’s College Hospital NHS Foundation Trust, London. occur in any of the deep veins in the body.
Jacqueline Johnson However, DVT most commonly occurs in the
Coagulation clinical nurse specialist, King’s College Hospital NHS deep veins of the leg or pelvis (National Institute
Foundation Trust, London. for Health and Care Excellence (NICE) 2012a)
Correspondence to: lynda.bonner@nhs.net (Figure 1). Although most DVTs start distally in
the veins of the calf, they can extend proximally
Keywords into the veins at knee level and above the
knee; from here, the thrombus can break off
Anticoagulants, deep vein thrombosis, post-thrombotic syndrome, and travel to the lungs, causing a pulmonary
pulmonary embolism, venous thromboembolism embolism (PE) (Kearon 2003). Silverstein
et al (1998) estimated that the incidence of
Review symptomatic DVT and PE was 145 and 69
All articles are subject to external double-blind peer review and checked respectively per 100,000 adults. The collective
for plagiarism using automated software. term venous thromboembolism (VTE) refers to
both DVT and PE (NICE 2012a).
Online VTE is associated with significant
morbidity and mortality. The most common
Guidelines on writing for publication are available at complication of DVT is post-thrombotic
www.nursing-standard.co.uk. For related articles visit the archive and syndrome (Roberts et al 2013). It can occur
search using the keywords above. in more than one third of patients with DVT
(Kahn 2009), and can significantly affect the
patient’s quality of life by causing pain, and The economic burden on the NHS of
heaviness and swelling in the leg (Kearon diagnosing and managing DVT is considerable.
2003). Severe post-thrombotic syndrome may The House of Commons Health Committee
develop in 5-10% of patients with a DVT (2005) reported that VTE associated with
and this may manifest in the development hospitalisation costs the NHS £640 million
of venous leg ulcers (Kahn 2009). Patients per year. Although prevention of VTE was
diagnosed with a DVT are also at risk of identified by the medical director of the NHS
developing a recurrent DVT or PE. If a patient as a clinical priority for improving quality and
develops a PE, it could be fatal if the embolus productivity in hospitals in recent years (West
is large enough to obstruct the arteries of the 2009), it is essential that nurses are familiar
lungs (Hirsh and Hoak 1996). An autopsy with ways to prevent VTE and how to support
study by Lindblad et al (1991) found that the and care for patients who develop signs and
incidence of fatal PE was approximately 40 symptoms of DVT or who require treatment
per 100,000 of the population. Non-fatal for a newly diagnosed DVT.
PE can also significantly affect the patient’s
quality of life. Shortness of breath, chest
pain and fatigue can result from pulmonary Signs and symptoms
hypertension because of increased pressure in DVT can occur without the patient showing
the pulmonary arteries caused by obstruction any signs or symptoms. Several factors
of blood flow by the PE (Ribeiro et al 1999). determine presentation of a DVT, including
1 A patient who has
Complete time out activity 1 the size of the thrombus, which can extend to
been recently diagnosed
occlude both proximal and distal veins, the
with a DVT tells you that
Because DVT is common and causes ability of collateral blood vessels to cope with
he has heard that DVTs
significant morbidity and mortality, NICE transporting blood to bypass the thrombus,
are invariably fatal.
(2010) has developed guidelines to assist and the severity of vascular occlusion
What would you say to
healthcare professionals in reducing risk (blockage) and inflammation caused by the
this patient to help him
associated with VTEs in hospitalised patients, thrombus (Kearon 2003). A DVT is more
achieve a more balanced
together with guidelines on the diagnosis and likely to cause symptoms when it obstructs
understanding of the
management of patients who are suspected of venous outflow, resulting in inflammation of
possible consequences
having VTE (NICE 2012a). the vein wall and surrounding tissue (Hirsh
of having a DVT?
and Hoak 1996). Common symptoms of a
FIGURE 1 DVT are warmth, redness, pain and swelling
2 Create a
in the affected limb. When a patient reports
presentation that you Veins of the right leg these symptoms, a clinician should undertake
could use to teach
a physical examination of the whole limb to
junior colleagues or Inferior
observe for signs suggestive of DVT. These
students about the vena cava
include tenderness on palpation, warmth,
signs and symptoms of
Common erythema, cyanosis, oedema and superficial
DVT. Include pictures
iliac vein venous dilation that can present as prominent
or diagrams of the
Proximal collateral veins (Kahn 1998).
typical appearance of Femoral vein
veins Complete time out activity 2
the affected limb in a
patient diagnosed with Great These signs and symptoms are not specific to
DVT. Ask the students saphenous DVT and can be present in numerous other
what sort of symptoms
Popliteal vein conditions. Therefore, clinical judgement about
they would expect the
the likelihood of DVT should also take into
patient to report and
account the patient’s individual risk factors
what they would expect Posterior tibial
for DVT, concurrent illnesses and medication,
to find on examination
medical and surgical history, and demographic
of the affected limb.
Distal
Peroneal
characteristics. By taking this information
Emphasise that DVTs veins into account, the clinician should be able to
are often clinically
improve their accuracy in predicting whether
asymptomatic so even
Anterior tibial a DVT is present or not (Kahn 1998). NICE
in the absence of many
JOANNA CAMERON
the patient for the scan and assist with development of post-thrombotic syndrome in
repositioning. If the patient has a painful the leg (Kearon 2003).
leg then the nurse should discuss with the DVT treatment should take into
individual the use of analgesia before the scan consideration the patient’s needs and
to minimise further discomfort. preferences (NICE 2012a). Allowing patients
Complete time out activity 3 to have a role in decision making in agreeing
treatment plans is important to encourage
Results of diagnostic tests adherence to treatment (Horne et al 2005,
Venous ultrasonography is highly accurate for Department of Health 2012). The nurse needs
diagnosing proximal DVT; treatment can be to be a skilled communicator and to convey
initiated without the need for further diagnostic effectively to the patient the importance of
tests or treatment can be withheld if the scan is adhering to the agreed treatment plan (World
negative (Kearon et al 1998). However, NICE Health Organization 2003). Verbal information
(2012a) recommends that patients with a should be supported by written information
two-level DVT Wells score suggestive of DVT and should be tailored to accommodate the
and a positive D-dimer test should have repeat needs of patients who do not speak or read
venous ultrasonography six to eight days later, English or who may have learning disabilities
even if the initial proximal ultrasound scan was (NICE 2012a).
negative. This additional testing is necessary Treatment of proximal DVT consists of both
to check that there has been no extension of a pharmacological and mechanical interventions
distal DVT into the proximal veins, where a (NICE 2012a). This article focuses on the use
DVT is considered to be clinically significant. of anticoagulation and graduated compression
There has been much debate about the need to stockings because these are the most common
scan for distal DVTs, which are less clinically treatment options. Although it is beyond the
important than proximal DVTs because they scope of this article, it is worth acknowledging
are unlikely to break off and cause a PE. If that in special circumstances patients may be
the whole leg is scanned initially then a repeat considered for insertion of an inferior vena cava
ultrasound scan is not necessary (NICE 2012a). filter (University of Michigan 2013) or catheter-
If a repeat venous ultrasonography scan directed thrombolytic therapy (NICE 2012a).
is required, the nurse should explain the
importance of this additional scan to the Pharmacological interventions
patient in diagnosing or excluding DVT. Anticoagulation is the mainstay of treatment
Failure to diagnose DVT correctly could result for DVT (Scarvelis and Wells 2006). Patients
in a fatal PE (NICE 2012a). Even if diagnostic are usually offered dual therapy with a
testing has suggested it is unlikely that the parenteral and an oral anticoagulant such as
patient has a DVT, it is still important for the a vitamin K antagonist. Warfarin is the most
nurse to advise the patient about the signs commonly used vitamin K antagonist because
and symptoms of DVT and PE, and when there is a high level of evidence supporting
and where to seek medical help should these its efficacy (Khoo et al 2009, NICE 2012a).
3 You suspect a
symptoms occur (NICE 2012a). Low-molecular-weight heparin, unfractionated
patient may have a DVT.
Complete time out activity 4 heparin and fondaparinux are all parenteral
How would you explain
anticoagulants; the decision about which one is
to the patient what
best for the patient should take into account
investigations may be Treatment the person’s comorbidities (such as
necessary?
The aim of DVT treatment is to prevent the bleeding history and renal impairment),
extension of the DVT in the short term, and contraindications and preferences (NICE
4 Find out what DVT
to prevent recurrent DVT or a PE in the long 2012a). Low-molecular-weight heparin is
diagnostic pathway
term (Scarvelis and Wells 2006). Treatment porcine derived (Harenberg et al 1990) and
exists for outpatients
is also targeted at preventing complications some patients may object to its use on the basis
and inpatients in your
of DVT such as post-thrombotic syndrome of cultural or religious grounds.
organisation. If you
(NICE 2012a). Normally the valves in the Administration of an oral and parenteral
work in primary care,
veins promote blood flow return, aided by anticoagulant should be started as soon as
what steps would
contraction of the leg muscles. However, these possible after DVT diagnosis. The parenteral
you take to arrange a
valves can be damaged by a DVT, which results anticoagulant should be continued for
referral for a patient
in venous reflux and venous hypertension in at least five days, or until the patient has
with suspected DVT
the leg. Venous reflux and venous hypertension achieved therapeutic levels – international
for diagnostic tests?
are the main contributing factors for the normalised ratio (INR) of 2.0 or above for a
presence of active cancer, then anticoagulant apply and remove the stocking, especially if
treatment should continue for six months or they have problems with dexterity, and some
longer (NICE 2012a). Low-molecular-weight may find it difficult to tolerate wearing them.
heparin is preferred over vitamin K antagonists Patients who can tolerate wearing graduated
for DVT treatment in cancer patients. This compression stockings should be advised
patient group might have poor appetite, to wear them during the day and remove
require chemotherapy, or be prescribed them at night. Patients should ask the GP for
interacting medications and these are factors repeat prescriptions for their stockings, which
that could lead to erratic INRs in patients should be replaced regularly, according to
taking vitamin K antagonists, which could manufacturer’s recommendations. If patients
increase their risks of bleeding or developing experience any numbness or tingling in their
further VTE (Lee and Levine 2003). Treatment leg or notice any skin damage when wearing
with a low-molecular-weight heparin has been compression stockings, they should remove
shown to be an effective and safe alternative to them immediately and seek medical advice.
conventional vitamin K anagonists in cancer Complete time out activity 5
patients with VTE (Linkins 2008).
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