EXPERIMENT 9

HOMOGENEITY TEST

In process quality control (IPQC) tests means controlling the procedures involved
in manufacturing of dosage form from the starting materials to the distribution of the
finished products. In suspensions, one of the IPQC tests performed is the homogeneity
test using the sedimentation volume. Sedimentation volume is defined as is the ratio
between ultimate volume of sediment to the initial volume of the suspension. The value
is between the limits 0 to 1. The higher the sedimentation volume the better is the
physical stability.

OBJECTIVE: To check the homogeneity of suspension using in-process quality control

test.

APPARATUS/ GLASSWARE: 100ml graduated cylinder

MATERIALS/ SAMPLES: 10 bottles (or total volume of 300ml) of liquid product in

suspension.

PROCEDURES:

NOTE: Perform the sedimentation volume for suspension using the cylindrical
graduates, as follows:

1. Perform the sedimentation volume by using a 100ml graduated cylinder.

2. Pour 100ml of the suspension into the graduated cylinder. This serves as the
initial volume (Vo). Let it stand for about 3 hours.

3. After 3 hours, check the volume of the suspension. Record this as the ultimate
volume (Vu).

4. Perform three trials.

5. Compute for the sedimentation volume, using the formula.

F = Vu

Vo

Where: F is the sedimentation volume

Vu is the ultimate volume

Vo is the initial volume

6. The sedimentation value is between the limits 0 to 1. If the sedimentation

volume is 1, no sedimentation occurred. This means that the suspension is
aesthetically pleasing, no visible clear supernatant liquid.
WORKSHEET

Name : Date :

Group No. : Score :

EXPERIMENT 9

HOMOGENEITY TEST

DATA AND RESULT:

Data Trial 1 Trial 2 Trial 3

Initial volume (Vo)

Ultimate volume (Vu)
Time started

Time finished

Sedimentation volume (F)

COMPUTATION:

F= Vu / Vo

CONCLUSION:
QUESTION/S:

1. Give the importance of In-Process Quality Control.

2. What are the other IPQC for suspension? Describe each.