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3. Results
3.1 Nutritional status
Comparison of peripheral blood nutritional status indexes Hb (g/ L), TP (g/L), ALB (g/L), PA (mg/L) and TF (g/L) contents
between
two groups of patients before and after intervention was as follows: before intervention, differences in peripheral blood Hb, TP,
ALB, PA
and TF levels were not statistically significant between two groups of patients (P>0.05); after intervention, peripheral blood Hb,
TP, ALB, PA and TF levels in both groups were significantly higher than those before intervention, peripheral blood Hb, TP,
ALB, PA and TF levels
in observation group were higher than those in control group, and differences were statistically significant (P<0.05), shown in
Table 1.
4. Discussion
Enteral nutrition is the main method to provided heat and nutrition for patients that cannot eat through the mouth, the nutritional
intervention has also been widely used for patients with cerebral infarction, but some severe patients are also with gastrointestinal
tract
Before intervention 9.13±0.96 8.45±0.98 10.32±0.97 8.91±0.85
After intervention 10.14±1.25* 9.11±0.97* 9.14±0.98* 7.86±0.82*
Observation group 44
Before intervention 9.12±0.98 8.47±0.92 After intervention 12.87±1.69*# 11.26±1.15*# 10.35±0.93 8.89±0.84
7.59±0.97*#
6.12±0.75*# Note: compared with same group before intervention, *P<0.05; compared with control group after intervention,
#P<0.05.
Yi 154 Zhang et al./ Journal of Hainan Medical University 2017; 23(12): 151-154 mucosa, and the increase of DAO and
D-lactate contents is closely related to the intestinal function status[15]. In the study, serum DAO and D-lactate contents were
compared between two groups of patients before and after nutritional intervention, and it was found that serum DAO and
D-lactate contents decreased in both groups after enteral nutrition intervention, but the decrease in serum DAO and D-lactate
contents was more significant in observation group, it explains that adding bifidobacterium can be more effective to repair the
function of intestinal mucosa, and this is also one of the internal causes of the enhanced protein synthesis ability after absorption
of nutrients.
There are pathogenic bacteria, probiotics, opportunistic pathogen and other bacteria in normal human intestinal tract, they
inhibit and rely on each other in human intestinal digestion environment under physiological condition, and the stable and
balanced relationship is beneficial to the body[16]. There is intestinal flora imbalance in the majority of patients with severe
cerebral infarction, the specific performance is that the bifidobacterium, lactobacillus and other predominant bacteria count
decrease while the enterobacter, enterococcus and other opportunistic pathogen count increase, it eventually leads to the decrease
of the intestinal mucosal barrier function and the damage to immune mechanism, and local intestinal canal inflammation can
appear and further increase nutrition absorption barriers[17]. Adding Bifidobacterium to enteric nutrition preparations can
increase the predominant flora count and inhibit the opportunistic pathogen reproduction so as to optimize the bowel function. In
the study, the probiotics and opportunistic pathogen count were compared between two groups of patients, and it was found that
the number of probiotics bifidobacterium and lactobacillus in both groups of patients after intervention were more than those
before intervention, the number of opportunistic pathogens enterobacter and enterococcus were less than those before
intervention, and the changes in above flora in feces in observation group were greater than those in control group, confirming
that adding bifidobacterium can optimize the intestinal flora distribution, then optimize intestinal function and promote the
absorption of enteral nutrition preparations.
Bifidobacterium-containing enteral nutritional intervention can effectively optimize the nutritional status and reverse the
intestinal flora disorder in patients with severe cerebral infarction, is helpful for the recovery of patients, and is worthy of
popularization and application in clinical practice in the future.
References
[1] Lee Y, Kim WS, Paik NJ. Gender differences in physical activity and
health-related behaviors among stroke survivors: data from the 5th Korea
national health and nutrition examination survey. Top Stroke Rehabil 2017; 24(5): 381-387. [2] Pan Dan-feng, Zhou Jin-yang.
Clinical research of individualized enteral
nutritional support in stroke patients after surgery. Parenteral Enteral Nutrition 2015; 22(2): 98-101. [3] Kim M, Oh GJ, Lee YH.
Association between stroke status and
depression in a community setting: The 2014 Korea National Health and
Nutrition Examination Survey. J Clin Neurol 2017; 13(1): 55-61. [4] Amiano P, Chamosa S, Etxezarreta N, Arriola L,
Moreno-Iribas C,
Huerta JM, et al. No association between fish consumption and risk
of stroke in the Spanish cohort of the european prospective investigation
into cancer and nutrition (EPIC-Spain): a 13·8-year follow-up study.
Public Health Nutr 2016; 19(4): 674-681. [5] Akatsu H, Nagafuchi S, Kurihara R, Okuda K, Kanesaka T, Ogawa N, et
al. Enhanced vaccination effect against influenza by prebiotics in elderly
patients receiving enteral nutrition. Geriatr Gerontol Int 2016; 16(2): 205- 213.
[6] Majid HA, Cole J, Emery PW, Whelan K. Additional oligofructose/
inulin does not increase faecal bifidobacteria in critically ill patients
receivingenteral nutrition: a randomised controlled trial. Clin Nutr 2014; 33(6): 966-972. [7] Zhao Lili. Application of early
enteral nutrition in patients with severe
cerebral vascular disease. China Med Pharm 2014; 4(20): 153-156. [8] Yang Xiaomei. Early enteral nutrition and clinical nursing
in treating
cerebral stroke. China Pharm 2017; 26(5): 62-65. [9] Hou Jihong. Influence of bifidobacterium tetravaccine tablets combined
with enteral nutrition on complications of digestive canal and intestinal
mucous membrane barrier function of patients with severe stroke. Chin J Pharmacoepidemiol 2016; 25(1): 11-13. [10] Jena I,
Nayak SR, Behera S, Singh B, Ray S, Jena D, et al. Evaluation
of ischemia-modified albumin, oxidative stress, and antioxidant status in
acute ischemicstroke patients. J Nat Sci Biol Med 2017; 8(1): 110-113. [11] Kimura Y, Yamada M, Kakehi T, Itagaki A, Tanaka
N, Muroh Y.
Combination of low body mass index and low serum albumin level leads
to poor functional recovery in stroke patients. J Stroke Cerebrovasc Dis 2017; 26(2): 448-453. [12] Ye Han-shen, Song Xue-ping,
Yang Jun. Effects of different nutritional
approaches on the nutritional status and neural functional recovery of
patients with mild and severe stroke. J Pract Med 2014; 30(8): 1270- 1273.
[13] Ma Geng-ping, Kang Quan-li, Chen Shan-wen. Effect of early immune
nutrition supply on nutritional status and immunological indexes in
patients with severe craniocerebral injury. J Hainan Med Univ 2015; 21(4): 498-502. [14] Zhang L, Fan X, Zhong Z, Xu G, Shen
J. Association of plasma diamine
oxidase and intestinal fatty acid-binding protein with severity of disease
in patient with heat stroke. Am J Emerg Med 2015; 33(7): 867-871. [15] Xin X, Dai W, Wu J, Fang L, Zhao M, Zhang P, et al.
Mechanism
of intestinal mucosal barrier dysfunction in a rat model of chronic
obstructive pulmonary disease: An observational study. Exp Ther Med 2016; 12(3): 1331-1336. [16] Cao Ping, Yu Cheng-gong.
Effect of triple viable bacterium of bacillus on
intestinal microflora and inflammation factors in patients with infectious
diarrhea. Chin J Biochem Pharm 2015; 35(6): 62-65. [17] Wu Li-juan, Li Jing-ping, Guo Bang-wei. Additionalbifidobacteria
in
severe stroke patients receiving enteral nutrition. Parenteral Enteral Nutrition 2016; 23(4): 220-223.