Softbox Systems

Company, Product and Services Overview

© 2008 Softbox Systems Ltd

International Patents Pending
About Us:
Founded 1995 – Temperature Control Packaging Specialist

Qualified systems to ship single vial to bulk manufactured drug

Supply Pharma clients in more than 50 countries

Manufacturing in the UK, USA, India, Singapore, Australia & UAE

Award winning innovative product development team

UK based validation and testing services

Capability to supply globally and service locally

© 2007 Softbox Systems Ltd

Clients we work with…

© 2007 Softbox Systems Ltd

We Make Specialist Passive TCP systems for…

Biomedical PI650 compliant packaging

Biotech domestic and international shippers

High performance IMP/Clinical Trial Supplies shippers

Bulk shippers for distributing finished drug products

Air Cargo systems that integrate with airline ULD’s

Frozen, Chilled and Protected Ambient temperature ranges

Shipping durations up to 120 hrs and beyond

Some examples of our Temperature Control Packaging Systems

Softbox Silverbox EPS

Pallet Shipper Silverpod

© 2007 Softbox Systems Ltd

Biomedical PI650 Packaging Systems

Conform to IATA Packaging Instruction 650

Use a 95kPa pressure bag compliant to ICAO technical

instruction for the safe transport of dangerous goods by air

Available as both ambient and protected ambient systems

Ambient System Protected Ambient System

Dry Ice (Frozen) Shippers

EPS Shippers available in a range of sizes (3-60

Litres) and wall thicknesses to suit most payloads.

Offering high performance, cost effective insulation

for products that need to be maintained Frozen (<-
20C) using Dry Ice.

Our frozen EPS Shippers have validated durations

from 72 to 192 hours and are supplied with Softbox
or customer branded outer cartons.

© 2007 Softbox Systems Ltd

Polybox (EPS) Temperature Control Shippers

Pre-qualified EPS Shippers available in a range of 3

sizes, offering 7, 14 and 28 Litre payload space

They offer good performance cost effective insulation for

products that need to be maintained Chilled or at
Controlled Room Temperature

The same shipper can be used for both 2-8C and 15-25C
temperature control; cool packs are just inserted at
appropriate temperatures

The Polybox range offers shipping durations from 48 to

96 hours and are also supplied with protective outer
cartons.

8
© 2007 Softbox Systems Ltd
Silverbox IMP/Clinical Trial Supplies Shippers

Very robust pre-qualified LDPE Shippers available in a

range of 3 sizes, offering 6, 13 and 28 Litre payload space

96 hour validated performance at 2-8C and 15-25C

Double skin of coolant packs protect from extreme high

and low ambient temperatures

Frozen ice packs inserted straight from cold stores

Made from 100% recyclable materials

Clients using these systems report dramatic reductions in

temperature excursions over alternative shippers
TempCell IMP/Clinical Trial Supplies Shippers

Enhanced versions of the Silverbox range using high

performance XPS insulation

Available in a range of 3 sizes, offering 7, 14 and 28 Litre

payload space

Smaller and lighter making them cheaper to ship

Up to 120 hour validated performance at 2-8C and 15-

25C

Double skin of coolant packs protect from extreme high

and low ambient temperatures

Frozen ice packs inserted straight from freezer

 XPS Pallet Shippers - New for 2010!

Visual Assembly

© 2007 Softbox Systems L

Pallet Shippers (XPS Insulation) – New for 2010!

Product space from 264 to 663 litres

120 hour plus Performance

Validated for 2-8°C and 15-25°C

Euro and US pallet sizes available

Small, Medium and Large heights

Manufactured in UK, US

Made from 100% recyclable materials

Year round packing configurations –

no Summer/Winter consideration
Large and Medium Std XPS Pallet Shippers

Attribute XPS Large Pallet Shipper XPS Medium Pallet

Shipper
External Dimensions 47 x39 x 61 inches 47 x 39 x49 inches
Internal Dimensions 35 x 26.5 x 43 inches 35 x 26.5 x 31 inches
Payload Capacity 651 litres 488 litres
Volumetric Weight 683lbs 555.5 lbs
Dead Weight 355bs 304.2 lbs
Cool Packs Used 36 x Pharmacool 3000g 30 x Pharmacool 3000g
Validated Period (2-8°C) 120 hrs (Summer) 120 hrs (Summer)
120 hrs (Winter) 120 hrs (Winter)
Validated Period (15-25°C) Testing in Progress Testing in Progress

Conditioning of Frozen cool packs No No

required?
Year round packing configuration Yes Yes
Qty per full 42.5ft Trailer 48 59
Flat Packed for Shipping /Storage Yes: 53 x 41 x 30 Yes: 48 x 41 x 30

© 2007 Softbox Systems L

 - Air Cargo Solutions (Single Use)

Passive systems design to hold 1 & 2 US or pallets

High performance Extruded Polystyrene (XPS) Insulation

Cost effective alternative to Active ULD Systems

Flat packs to reduce delivery, storage & repositioning costs

Ideal for 2-8°C, 15-25°C, -20°C products

1 & 2 pallet systems tested against origin to destination profiles

Manufactured from 100% recyclable materials

© 2009 Softbox Systems Ltd

– Simple Assembly & Shipping

© 2009 Softbox Systems Ltd

 - Single Pallet Shipper

Perimeter
Refrigerant System Top of Payload
Refrigeration System

Customer Product Pallet

(Holds US Pallet to 1150mm height)

High Performance XPS

Insulation Panels

Edge Protection Ext Dims: 1570 x1370 x 1560mm

System Int Dims: 1244 x1044 x1150mm
Internal Volume: 1,495 litres
Volumetric Weight: 559kg
Tare Weight: 228kg

Custom Wooden Pallet

© 2009 Softbox Systems Ltd

 - Half LD7 (PMC & PAG) System

PMC Accommodates 2 US Pallets Refrigerant System

Container on LD7 Air Pallet 2 Containers per LD7 Air Pallet

© 2009 Softbox Systems Ltd

 - LD7 PMC Half System
High Performance
XPS Insulation Panels

Edge Protection
System
Perimeter
Refrigerant System

Top of Product Load

Refrigerant System

Customer Product
Pallets/Payload
PMC Air Pallet Configuration
Ext Dims: 2398 x 1568 x 1590mm
Int Dims: 2084 x 1254 x 1150mm
Internal Volume: 3,005 litres
Volumetric Weight: 996kg
Tare Weight: 390kg

Custom Wooden Pallet

Please Note: System built on custom wooden pallet to enable handling with Fork Truck.
I.E. NO ROLLER BED REQUIRED. © 2009 Softbox Systems L
- Dedicated Silverpod Testing Chamber

© 2008 Softbox Systems Ltd

International Patents Pending
Methodology of Validation Temperature Ramps

Mapping of the real time temperatures

Analysis of the transportation processes

Set up of the standard « Summer » / « Winter » profiles

Test and validate the packaging against ramps

– multiple temperature loggers are placed in the

temperature controlled packaging at the top, middle,
bottom, sides of the product space at extremities.

– A validation document is produced including results,

materials tested, calibration of the loggers and other
relevant data

Full validation reports to support all solutions

Express Distribution Temperature Ramps
Standard Summer Ramp
24 / 48 / 72 Hours Summer Delivery / Temperature Testing Cycle
Hours Temp Action
4 18°C Courier collects at approximate 17:00.
(Assume shipment is packed in customer premises at 13:00)

2 25°C Delivery to Local Express Depot

2 20°C Processing at Local Express Depot
3 20°C Transport to Hub
2 20°C Processing at Hub
3 15°C Overnight Transport to Import/Export Hub
2 16°C Transport to Delivery Depot
2 20°C Processing at Delivery Depot
3 35°C Transport to Customer
1 18°C Processing in Customer's Building
24
7 18°C
3 20°C
Additional transit time for connecting flight or awaiting
3 25°C
customs clearance
2 25°C
9 18°C
48
16 20°C Customs Clearance Awaiting Delivery
2 25°C Transport to Depot
2 20°C Processing at Depot
3 35°C Transport to Customer
72
Technical Support and Services
Calculation of customer product mix
Technical Support and Services
Design of customized packaging solutions
Technical Support and Services
Temperature mapping of specific lanes

Asian Temperature Mapping December 2002 DHL Trade lanes ex Singapore

40

35

30

25
Temperature (°C)

20

15

10

-5
0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190

Time (hours)

Taiwan Malaysia USA Japan Hong Kong

Technical Support and Services

Added value and transparency through specialist support

Cold chain evaluation assessment

Comprehensive validation services

Live trial support services

Bespoke product development

For more information on Softbox Systems
products please contact…

John Hammes – Softbox Systems Ltd.

General Manager- North America

Email: john.hammes@softboxsystems.us

Office: 541-389-9183

Travis Wren-Softbox Systems Ltd.

Sales Manager- North America

Email: travis.wren@softboxsystems.us

Office: 541-317-2822

© 2008 Softbox Systems Ltd

International Patents Pending