DAFTAR ISI

Hal.

HALAMAN SAMPUL ......................................................................................... ...................ii

HALAMAN JUDUL ............................................................................................ ...................ii
LEMBAR PERSETUJUAN ................................................................................. ...................iii
LEMBAR PENGESAHAN .................................................................................. ...................iv
HALAMAN PERNYATAAN ORISINALITAS ................................................. ...................v
KATA PENGANTAR .......................................................................................... ...................vi
LEMBAR PERNYATAAN PERSETUJUAN PUBLIKASI ............................... ...................viii
RIWAYAT HIDUP .............................................................................................. ...................ix
ABSTRAK ............................................................................................................ ...................ii
DAFTAR ISI......................................................................................................... ...................ii
DAFTAR TABEL ................................................................................................. ...................iv
DAFTAR GAMBAR ............................................................................................ ...................v
DAFTAR LAMPIRAN ......................................................................................... ...................ii
DAFTAR SINGKATAN ...................................................................................... ...................vi
BAB 1 PENDAHULUAN ................................................................................... ...................1
1.1 Latar Belakang ............................................................................................... ...................1
1.2 Rumusan Masalah .......................................................................................... ...................4
1.3 Tujuan Penelitian ........................................................................................... ...................4
1.4 Manfaat Penelitian ......................................................................................... ...................5
BAB 2 TINJAUAN PUSTAKA ......................................................................... ...................6
2.1 Demam Berdarah Dengue .............................................................................. ...................6
2.1.1 Definisi DBD ............................................................................................ ...................6
2.1.2 Epidemiologi DBD ................................................................................... ...................6
2.1.3 Etiologi DBD ............................................................................................ ...................7
2.1.4 Vektor Virus Dengue ................................................................................ ...................7
2.1.5 Patogenesis DBD ...................................................................................... ...................8
2.1.6 Manifestasi Klinis DBD ............................................................................ ...................10
2.1.7 Diagnosis DBD ......................................................................................... ...................13
2.1.8 Pemeriksaan Penunjang ............................................................................ ...................15
2.1.9 Diagnosis Banding .................................................................................... ...................16
2.1.10 Penatalaksanaan ........................................................................................ ...................17
2.1.11 Komplikasi ................................................................................................ ...................18
2.1.12 Prognosis ................................................................................................... ...................18
2.2 Trombosit ....................................................................................................... ...................18
2.2.1 Produksi Trombosit................................................................................... ...................18
2.2.2 Struktur Trombosit .................................................................................... ...................19
2.2.3 Fungsi Trombosit ...................................................................................... ...................19
2.2.4 Platelet Distribution Width (PDW) .......................................................... ...................20
2.2.5 Mean Platelet Volume(MPV) ................................................................... ...................21
2.3 Status Gizi ...................................................................................................... ...................22
2.3.1 Pengaruh Status Gizi terhadap DBD......................................................... ...................23

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BAB 3 KERANGKA TEORI, KERANGKA KONSEP DAN HIPOTESIS.. ...................24
3.1 Kerangka Konsep ........................................................................................... ...................24
3.2 Hipotesis ........................................................................................................ ...................25
BAB 4 METODE PENELITIAN....................................................................... ...................26
4.1 Desain Penelitian ........................................................................................... ...................26
4.2 Lokasi dan Waktu Penelitian ......................................................................... ...................26
4.3 Populasi dan Sampel Penelitian ..................................................................... ...................26
4.4 Cara Pengumpulan Data ................................................................................ ...................27
4.5 Variabel Penelitian ......................................................................................... ...................28
4.6 Definisi Operasional ...................................................................................... ...................29
4.7 Pengolahan dan Penyajian Data ..................................................................... ...................30
4.8 Analisis Data .................................................................................................. ...................30
4.9 Alur Penelitian ............................................................................................... ...................31
4.10 Jadwal Kegiatan ............................................................................................ ...................32
BAB 5 HASIL PENELITIAN ............................................................................ ...................26
5.1 Gambaran Umum ............................................................................................ ...................30
5.2 Karakteristik Sampel ....................................................................................... ...................30
5.3

BAB 6 PEMBAHASAN ...................................................................................... ...................26

6.1 Interpretasi dan diskusi hasil ........................................................................... ...................30
6.1.1 Analisis D.................................................................................................. ...................30
6.2 Keterbatasan Penelitian ................................................................................... ...................30
BAB 7 PENUTUP ............................................................................................... ...................26
7.1 Kesimpulan ..................................................................................................... ...................30
7.2 Saran ............................................................................................................... ...................30
DAFTAR PUSTAKA ........................................................................................... ...................33

Lampiran ............................................................................................................. ...................26

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 DAFTAR TABEL

Hal.
Tabel 2.1 Klasifikasi WHO 2011 untuk derajat keparahan infeksi dengue ..... ......................14
Tabel 4.1 Definisi operasional ......................................................................... ......................27
Tabel 4.2 Jadwal kegiatan penelitian ............................................................... ......................30
Tabel 5.1 Karakteristik pasien demam berdarah dengue berdasarkan jenis kelamin..............30
Tabel 5.2 Karakteristik pasien demam berdarah dengue berdasarkan kelompok usia............30
Tabel 5.3 Karakteristik pasien demam berdarah dengue berdasarkan nilai berat badan.........30
Tabel 5.4 Karakteristik pasien demam berdarah dengue berdasarkan derajat keparahan........30
Tabel 5.5 Karakteristik pasien demam berdarah dengue berdasarkan kelompok usia............30
Tabel 5.6 Distribusi frekuensi pasien infeksi dengue berdasarkan nilai MPV RSUD AWS...30
Tabel 5.7 Distribusi frekuensi pasien infeksi dengue berdasarkan nilai status gizi RSUD
AWS...30
Tabel 5.8 Distribusi frekuensi pasien infeksi dengue berdasarkan nilai MPV RSUD AWS...30
Tabel 5.9 Distribusi frekuensi pasien infeksi dengue berdasarkan nilai MPV RSUD AWS...30
Tabel 5.10 Distribusi frekuensi pasien infeksi dengue berdasarkan nilai MPV RSUD AWS...30

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 DAFTAR GAMBAR

Hal.
Tabel 2.1 Hipotesis Secondary Heterologous Infection................................... ......................9

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DAFTAR LAMPIRAN

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 DAFTAR SINGKATAN

ADE : Antibody Dependent Enchancement

ADP : Adenosin Diphospat
C : Complement
CFR : Case Fatality Rate
DBD : Demam Berdarah Dengue
DD : Demam Dengue
DENV : Dengue Virus
ELISA : Enzym-linked Immunosorbent Assay
Ig : Imunoglobulin
IL : Interleukin
IR : Incidence Rate
Kemenkes RI : Kementerian Kesehatan Republik Indonesia
MPV : Mean Platelet Volume
PAF : Platelet Activating Factor
PDW : Platelet Disttribution Width
RNA : Ribonucleic Acid
SSD : Sindrom Syok Dengue
TNF-α : Tumor Necrosis Factor Alpha
USG : Ultrasonografi
WHO : World Health Organization

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