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Fluid and Electrolyte Management of the Surgical Patient Nov 5, 2013
OUTLINE Table 2. Total Body Water (TBW) as a Fraction of Total Body Weight
I. Water and Electrolyte Physiology Population Fraction (kg)
II. Composition of Fluid Compartments Infants 0.8
III. Body Fluid Changes Children 0.65
IV. Maintenance Water Requirements Adult Men 0.6
V. Maintenance Salt Requirements
Adult Women 0.5
VI. Perioperative Fluid Requirements
Elderly Men 0.5
VII. Disturbances in Fluid Balance
VIII. Disturbances of Sodium Homeostasis Elderly Women 0.45
IX. Disturbances of Potassium Homeostasis NOTE: Infants are prone to dehydration thus fluid resuscitation is more
X. Disturbances of Calcium Homeostasis aggressive. As they age, TBW increases. Exceptions are Obese and Elderly
XI. Disturbances of Magnesium subjects!
XII. Disturbances of Phosphorus Obese:
o less TBW per unit of weight and a relatively expanded
WATER AND ELECTROLYTE PHYSIOLOGY ECV compared to ICV due to the relatively low water
Table 1. Functional Body Fluid Compartments content of adipose tissue
Elderly:
% of TBW Volume of TBW Male (70Kg) Female (60Kg) o Body water composition is also altered in the elderly
such that by 80 years of age, TBW contributes only 50%
Extracellular Extracellular 14, 000 mL 10, 000 mL
of total body weight secondary to muscle atrophy (less
Volume 20% Volume
intracellular volume)!
Plasma 5% Plasma 3,500 mL 2,500 mL
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SURGERY 1.1
o For the maintenance water requirement of a 70kg man, o Capillary leak may persist as long as 24hrs into the
first 20kg is equal to 1.5L and the remaining 50kg is postoperative period and should be considered as part of
multiplied by 20 (equal to 1L), therefore water ongoing losses in the immediate postoperative period.
requirement is 2.5L. On-Going Fluid Losses
o Usually represent GI losses from stomas, tubes (ileostomy
Maintenance Salt Requirements or colostomy tubes, NGTs), drains, or fistulae (any
Typically, an individual consumes 3-5 g (100 to 250 mEq/day) of abnormal communication between two epithelialized
dietary salt per day; balanced by salt losses in sweat, stool and structures common morbid fistula is presence of
urine. enterocutaneous fistula)
o In perioperative patients, maintenance of sodium is The electrolyte composition of the output depends on the source
achieved with 1-2 mEq/kg/day of effluent (i.e. saliva, colonic juice, gastric juice, etc)
o So for a 70kg man, he would have a maintenance sodium
requirement of 70-140mEq/day Table 6. Electrolyte content of different organs
Renal conservation of sodium is extraordinary and in some cases Source Volume (ml) Na Cl K HCO H
of profound volume depletion, urinary losses of sodium may be Stomach 1000-4200 20-120 130 10-15 - 30-100
less than 1 mEq/day due to aldosterone Duodenum 100-2000 110 115 15 10 -
Normal potassium intake is approximately 40 to 120mEq/day, Ileum 1000-3000 80-150 60-100 10 30-50 -
approximately 10% to 15% of which is excreted as normal urinary
Colon 500-1700 120 90 25 45 -
losses.
(diarrhea)
o body potassium stores can be maintained with an intake of
Bile 500-1000 140 100 5 25 -
approximately 0.5 to 1.0mEq/kg/day
Pancreas 500-1000 140 30 5 115 -
Table 5. Electrolyte content of different solutions
Na K Cl Ca Lactate Glucose Different effluent have different electrolyte component, thus the
Normal Saline (0.9% NSS) replacement fluid should be chosen to best approximate the
154 0 154 0 0 0
composition of the ongoing losses.
Dextrose 5% in water (D5W) 0 0 0 0 0 50
o Nasogastric losses are typically replaced by NSS + KCl;
D5W ½ NS 77 0 77 0 0 50 lactated ringer’s solution not used because of low/deficient
2/3 D5W, 1/3 NS 50 0 50 0 0 33 potassium content
Lactated Ringer’s 130 4 109 3 28 0 o Losses from a duodenal fistula may best be replaced using
Although 0.9% saline is used frequently, the relatively high lactated Ringer’s solution because of bicarbonate content
concentration of chloride results in a hyperchloremic metabolic and also potassium content of hepatobiliary or duodenal
acidosis because of the inability of the renal tubule to excrete juice.
excess chloride. o Intractable vomiting, expect for hypochloremic,
Lactated Ringer’s solution contains lactate which is converted to hyponatremic metabolic alkalosis. You can give NSS and KCl
bicarbonate via hepatic metabolism. This can buffer acid in cases Lecture notes: For patients with gastric outlet obstruction (gastric
of shock, etc. However, this is contraindicated to patients with contents cannot go beyond the pylorus), the expected electrolyte
liver pathology! abnormality would be hyponatremic and hypochloremic, and
could also develop hypokalemia.
PERIOPERATIVE FLUID REQUIREMENTS
“Perioperative” → first 12-24 hours after ongoing a surgical CLINICAL EVALUATION
procedure 1. Reassess the patient frequently to determine intravascular volume status
Appropriate management of fluids and electrolytes in the a. Evaluation of heart rate, blood pressure, and most importantly, hourly
perioperative period requires a flexible yet systematic approach urine output (most reliable indicator of hydration status)
to ensure that fluid administration is appropriately tailored to the In pediatric population, adequate hydration is indicated by
patient’s changing requirements. urination of a minimum of 1ml/kg/hr. In adult population,
o Requirements are based on: deficits, maintenance adequate hydration is indicated by urination of a minimum of
requirements, and any ongoing losses 0.5ml/kg/hr. Any values below is indicative of inadequate
Deficits approximate intraoperative blood loss. Also includes fluid hydration
losses from evaporative or third space fluid sequestration. Resting tachycardia (>90 beats/min) is assumed to be a common
o due to the shift of crystalloid from the intravascular space occurrence in hypovolemic patients, but tachycardia in the supine
to the interstitium, crystalloid should replace blood loss in position is absent in majority of patients with moderate to severe
a ratio of 3-4:1 blood loss (which is why heart rate is not reliable).
o Third Spacing: extensive dissection at the operative site Hypotension in the supine position is also an insensitive marker of
induces a localized capillary leak, the result of which is blood loss (usually appears in the advanced stages of hypovolemia
extravasation of intravascular fluid into the interstitium - blood loss exceeds 30% of blood volume)
with edema formation (amount from fluid escape from b. Orthostatic Vital Signs
intravascular to interstitium). A significant orthostatic change is defined as any of the ff: ↑ pulse
Inguinal herniorrhaphy- loss of 4 ml/kg/h rate of at least 30 beats/min; ↓ systolic pressure > 20mmHg, or
Aortic aneurysm repair- loss 8 ml/kg/h dizziness on standing
Third Spacing can also be induced by presence of Occurs because of pooling of blood going into lower extremities
infection, inflammation or burns (widening of about 7-8kgs that induces a shift in the heart rate and blood
endothelial spaces) pressure
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SURGERY 1.1
HYPERNATREMIA
Serum Na:> 145 mEq/L
Invariably associated with HYPERTONIC STATES
o Hypovolemic ↑Na: vomiting, diarrhea and forced diuresis
o Euvolemic ↑Na: free water loss via lungs, skin or open
wounds or from Diabetes Insipidus
o Hypervolemic ↑Na: most often iatrogenically induced from
resuscitation with hypertonic fluids
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HYPERCALCEMIA
Ca > 10.4mg/dL or ionized Ca > 5.6mg/dL
In hospitalized patients, MALIGNANCIES account for most cases
In general population, HYPERPARATHYROIDISM and MALIGNANCY
together comprise >90% of all cases
Other causes include toxicity from drugs (thiazides, lithium, Vit A or D),
thyrotoxicosis
Clinical manifestations of HYPERCALCEMIA
o ECG changes- shortened QT interval, prolonged PR and QRS intervals,
increased QRS voltage, T-wave flattening and widening, and
atrioventricular block (which can progress to complete heart block and
cardiac arrest)
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