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Difference Between Basophil and

Eosinophil
August 27, 2015 Posted by Hasa

Key Difference – Basophil vs Eosinophil

Let us first briefly look at the composition of blood, to understand the Difference
Between Basophil and Eosinophil clearly. Blood is mainly composed of white blood cells,
red blood cells, platelets, and plasma. Plasma is the fluid part of the blood and represents
more than half of blood’s volume. White blood cells make up about 1% of the entire blood
volume, and red blood cells make up about 45%. The white blood cells or leukocytes are
classified into cells with or without granules. Granular leukocytes include neutrophils,
eosinophil and basophil and nongranular leukocytes include lymphocytes and monocytes.
The key difference between basophil and eosinophil is that Basophils can stimulate
inflammation responses by releasing heparin, histamine, and
serotonin while Eosinophils provide important defense against parasites by
phagocytosis and producing antihistamines.

What is Basophil?
Basophils are granular leukocytes with an S-shaped multi-lobed nucleus and are similar
to the size of eosinophils. These cells stimulate inflammation responses by releasing
heparin, histamine, and serotonin. Biologists believe that basophils are produced and
matured in the bone marrow. Certain morphological and functional features of basophils
are equal to mast cells, which are common in tissues. Basophils are hardly seen in the
blood of healthy humans, because once they release, they circulate for a few hours in the
blood and migrate to the tissues where they last a few days. Basophils have relatively few
granules, which are water soluble. Therefore, identifying basophils in blood is quite difficult.
However, when basic stains are used to identify, the cytoplasm of the basophils stain blue

in color.
What is Eosinophil?
Eosinophils are bone marrow derived granular leukocytes with two-lobed nucleus. They
provide an important defense against parasites by phagocytosis and produce
antihistamines. When acid stains are used, the cytoplasm of the eosinophil stains in red.
Usually, 1% to 5% of white blood cells are eosinophils. Very low number of eosinophils are
found in the blood circulation of healthy persons because these cells are primarily tissue-

dwelling cells.

What is the difference between Basophil and


Eosinophil?
Characteristics of Basophil and Eosinophil
Nucleus of cell
Basophil: Basophil has S-shaped multi-lobed nucleus.
Eosinophil: Eosinophil has two-lobed nucleus.
Staining color
Basophil: Cytoplasm of basophil stains blue in basic stains.
Eosinophil:Cytoplasm of eosinophil stains red in acid stains.
Abundance
Basophil: 0.5% or less of leukocytes are basophils.
Eosinophil: 1-5 % of leukocytes are eosinophils.
Function
Basophil: Basophils can stimulate inflammation responses by releasing heparin,
histamine, and serotonin.
Eosinophil: Eosinophils provide important defense against parasites by phagocytosis
and produce antihistamines.

Image Courtesy:
“Blausen 0352 Eosinophil” by BruceBlaus. When using this image in external sources it
can be cited as:Blausen.com staff. “Blausen gallery 2014”. Wikiversity Journal of
Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. – Own work. (CC BY 3.0
) via Wikimedia Commons
“Blausen 0077 Basophil” by BruceBlaus. When using this image in external sources it
can be cited as:Blausen.com staff. “Blausen gallery 2014”. Wikiversity Journal of
Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. – Own work. (CC BY
3.0) via Wikimedia Commons

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