Вы находитесь на странице: 1из 20

Lonza’s chemical network

Diketene and HCN derivatives, heterocycles


and basic chemicals catalog
Pharma&Biotech

Nutrition

Agriculture

MaterialsScience

PersonalCare
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Content
About Lonza 3
Introduction 4
Diketene / ketene derivatives 6
Esters 6
Arylides 7
Alkylamides 8
Pyrazolones 9
Dehydroacetic acid 9
Lonzamon monomers 10
Other diketene derivatives 10

HCN derivatives 12
Heterocycles 14
Basic chemicals 16
Others 17
Alphabetical index 18
About Lonza
Lonza is the global leader in the production and support of active phar- From 1897 to the present day combining Swiss tradition with global
maceutical ingredients both chemically and biotechnologically. Biophar- experience, the company has had an enterprising character, adapting
maceuticals are one of the key growth drivers of the pharmaceutical and its offerings and services to the needs of customers and to changing
biotechnology industries. technologies. Throughout our history, we have maintained a strong
culture of performance, results and dependability that is valued by all
Lonza has strong capabilities in large and small molecules, peptides, of our customers.
amino acids and niche bioproducts which play an important role in the
development of novel medicines and healthcare products. In addition, Lonza’s cracker in Visp is the back bone of a comprehensive fully back-
Lonza is a leader in cell-based research, endotoxin detection and cell ward integrated chemical network. Our product portfolio consists of
therapy manufacturing. Furthermore, the company is a leading provider HCN- and diketene derivatives as well as basic chemicals which are key
of chemical and biotech ingredients to the nutrition, hygiene, preserva- raw materials and intermediates for many sophisticated applications.
tion, agro and personal care markets.

3
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Diketenes / ketenes
Diketene is a colorless liquid produced by dimerization of ketene. It is Alkylamides: Aliphatic amines react with diketene to result in alkyl-
a highly reactive building block which can be combined with numerous amides. Major products such as monomethyl- or dimethylacetoacet-
other chemical compounds to make a wide range of products. Because amides are manufactured as aqueous solutions with continuous pro-
of its high energy content, transport of diketene is forbidden. It is pro- cesses; other derivatives and water-free compounds are produced with
cessed further at the site of manufacture. Lonza is one of the world’s batch processes. The (alkyl-) acetoacetamides are used principally in
leading suppliers of diketene derivatives manufactured in its production the manufacture of insecticides. The derivatives are also deployed in
facility in Visp, Switzerland. Our diketene derivatives are used in the the pigment, pharmaceutical and polymer industries.
pharmaceutical, vitamin, agrochemical and pigment industries. The
niche markets are in cosmetics, plasticizers, paints. The acetoacyl group DHS / NaDHS: The catalytic dimerization of diketene yields dehydroacetic
in diketene derivatives has a broad functionality which can be used acid (DHS), which is a solid material. The free acid can be neutralized
for the production of further products. Lonza’s most comprehensive with sodium hydroxide and is available as the salt NaDHS or its monohy-
diketene product lines are those made with alcohols (aceto-acetic acid drate NaDHS-H2O. These products are used above all in the manufacture
and acrylate derivatives), aliphatic amines (alkylamides) and aromatic of PVC stabilizers and as preservatives in the cosmetic industries.
amines (arylamides). Lonza uses some of these to produce further
components (pyrazolones, aminocrotonates, side chains). Acrylic acid esters (acetoacetoxy monomers): Acetoacetoxyethyl meth-
acrylate (AAEMA), the most important product of this group, is made
The following summary provides an overview of the diketene derivative in a multipurpose batch production plant. It is used as a copolymer for
product groups: coatings and adhesives in emulsion polymerization (waterborne disper-
sions) or solvent polymerization (high solids), and provides improved
Diketene esters (acetoacetates): “Major” products such as methyl, mechanical and solvent resistance to water or organic solvents. It also
ethyl, isopropylester of acetoacetic acid are produced in a continuous promotes adhesion to metallic, mineral and wood surfaces.
process and purified by distillation. “Minor” derivatives are produced
batchwise in stirred vessel reactors. The products are used mostly in Other diketene derivatives: 4-Chloroacetoacetic acid ester is a highly
the dye, agrochemical, pharmaceutical and vitamin industries. versatile diketene derivative. It can be used in syntheses of various
pharmaceutical intermediates.
Arylamides: A large variety of arylamides are obtained by the reaction
of aromatic amines with diketene. Our most important products are AAA, Ketene: Lonza has the specific capability to perform a variety of reac-
AAOT, AAMX, AAOA, and AAOC; others are made regularly or on special tions with ketene. The production of ethyl 4, 4, 4-trifluoroacetoacetate
request. These derivatives are used mainly in the production of azo is one example for such a ketene reaction.
pigments; but also in the dye and agrochemical industries.
For more information about ketene / diketene chemistry and its various
derivatives, please ask for specific brochures and related literature or
send mail to diketene@lonza.com.

4
Hydrocyanic acid (HCN)
Hydrogen cyanide is a extremely poisonous colorless or pale-blue liquid
that undergoes a wide variety of reactions. Lonza has manufacturing
capabilities to offer a solution of hydrogen cyanide in water (hydrocy-
anic acid) and producing its derivatives. HCN is used in metallurgical
and photographic processes. Furthermore, HCN is a starting material
for cyanogen chloride, cyanoacetates, cyanohydrins, sodium cyanide,
chelating agents and many more. Cyanogen chloride is a functional
building block for other Lonza products like cyanuric chloride and malo-
nonitrile. The cyanohydrins, give access to a variety of useful organic
compounds including the monomer methyl methacrylate, amino acids
via the Strecker synthesis, and the chelating agents EDTA and NTA.

Basic chemicals
Beside ketene and HCN chemicals Lonza’s cracker related product port-
folio also offers a selective number of basic chemicals. The chemicals
can be used as starting materials and processed further to yield coat-
ings, colorants, adhesives, medicines, agrochemicals and more.

Icons

Pharma

Colorants

Agriculture

Polymers

Nutrition

Various

5
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Methyl acetoacetate (MAA) Ethyl acetoacetate (EAA)


Diketene /  Esters   C5H8O3   C5H10O3
ketene
derivatives

Molecular weight   116.12  130.14


CAS RN   105-45-3  141-97-9
Minimum assay   99.0 %  99.0 %
Minimum stability   2 years  2 years
Melting point ca.   –28°C  –43°C
Boiling point ca.   170°C  180°C
Density g/cm3 (20°C)   1.077  1.03
EU labeling  Xi irritant  –
Packaging  drums, bulk  drums, bulk
Transport information  not restricted  not restricted

Isopropyl acetoacetate (IPAA) Isobutyl acetoacetate (AAisobutyl) t-Butyl acetoacetate (AA-t-butyl)

  C7H12O3   C8H14O3   C8H14O3

Molecular weight  144.17  158.20  158.20


CAS RN  542-08-5  7779-75-1  1694-31-1
Minimum assay  98.5 %  98.0 %  98.0 %
Minimum stability  2 years  2 years  2 years
Melting point ca.  –27°C  –20.5°C  –38°C
Boiling point ca.  185°C  205°C  71°C / 15hPa
Density g/cm3 (20°C)  0.998  0.974  0.970
EU labeling  Xi irritant  –  –
Packaging  drums, bulk  drums  drums
Transport information  not restricted  not restricted  not restricted

N-Benzyl-N-methyl-2-aminoethyl-
Benzyl acetoacetate (BAA) acetoacetate (AABME) Dodecyl acetoacetate (AAdodecyl)

  C11H12O3   C14H19NO3   C16H30O3

Molecular weight  192.22  249.31  270.42


CAS RN  5396-89-4  54527-65-0  52406-22-1
Minimum assay  –  95.0 %  96.0 %
Minimum stability  2 years  8 months  2–3 years
Melting point ca.  12°C  –  –
Boiling point ca.  275°C dec.  175°C dec.  190°C /20 hPa
Density g/cm3 (20°C)  1.114  1.067  0.914
EU labeling  Xi irritant  –  Xi irritant
Packaging  drums  drums  drums
Transport information  not restricted  not restricted  not restricted

6
2-Methoxyethyl acetoacetate 4-Nitrobenzyl acetoacetate
Ethyl benzoylacetate-91 (BESethyl-91) (AAmethoxyethyl) (30 % in toluene) (PNBAA 30T)

  C11H12O3   C7H12O4   C11H11NO5

Molecular weight  192.22  160.16  237.21


CAS RN  94-02-0  22502-03-0  61312-84-3
Minimum assay  91.0 %  97.5 %  270-330 g/l
Minimum stability  2 years  2 years  9 months
Melting point ca.  –  –  –
Boiling point ca.  93°C / 10 Pa  118°C / 26hPa  –
Density g/cm3 (20°C)  –  1.091  –
EU labeling  –  T toxic  F, Xn; R11-38-48/20-63-65-67
Packaging  drums  drums  iron drums 56.25 kg, 187.5 kg
Transport information  not restricted  not restricted  UN 1993, 3, PG II

Acetoacetanilide (AAA) Acetoacetanilide, flakes (AAA,flakes)

Arylides   C10H11NO2   C10H11NO2

Molecular weight   177.20  177.20


CAS RN   102-01-2  102-01-2
Minimum assay   99.5 %  95.0 %
Minimum stability   2 years  9 months
Melting point ca.   83.0°C  62.0°C
Boiling point ca.   –  –
Density g/cm3 (20°C)   –  –
EU labeling  Xn harmful  Xn harmful
Packaging  paper bags, big bags  big bags
Transport information  not restricted  not restricted

Acetoacet-o-toluidide (AAOT) Acetoacet-m-xylidide (AAMX)

  C11H13NO2   C12H15NO2
Pharma

Colorants

Agriculture
Molecular weight  191.23  205.26
CAS RN  93-68-5  97-36-9
Minimum assay  99.5 %  99.5 % Polymers
Minimum stability  2 years  2 years
Melting point ca.  103.5°C  89°C
Boiling point ca.  –  – Nutrition
Density g/cm3 (20°C)  –  –
EU labeling  Xn harmful  Xn harmful Various
Packaging  paper bags, big bags  paper bags, big bags
Transport information  not restricted  not restricted

7
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Acetoacet-4-chloro-2,5-dimethoxy-
Acetoacet-o-chloroanilide (AAOC) Acetoacet-o-anisidide (AAOA) anilide (ASIRG)
Diketene /    C10H10ClNO2   C11H13NO3   C12H14ClNO4
ketene
derivatives

Molecular weight  211.65  207.23  271.70


CAS RN  93-70-9  92-15-9  4433-79-8
Minimum assay  99.5 %  99.5 %  98.0 %
Minimum stability  2 years  2 years  2 years
Melting point ca.  103.5°C  83.5°C  104°C
Boiling point ca.  –  –  –
Density g/cm3 (20°C)  –  –  –
EU labeling  Xn harmful  Xn harmful  Xn harmful
Packaging  paper bags  paper bags, big bags  paper bags
Transport information  not restricted  not restricted  not restricted

Acetoacet-5-chloro-2-methoxy- Potassium N-(acetoacetyl)


anilide (AAMOC) sulfanilate (AAsulfanil-K)

  C11H12ClNO3   C10H10KNO5S Alkylamides

Molecular weight  241.68  295.36 


CAS RN  52793-11-0  70321-85-6 
Minimum assay  99.0 %  96.0 % 
Minimum stability  2 years  2 years 
Melting point ca.  92°C  >300°C 
Boiling point ca.  –  – 
Density g/cm3 (20°C)  –  – 
EU labeling  –  –
Packaging  paper bags  paper bags, big bags
Transport information  not restricted  not restricted

N,N-Dimethylacetoacetamide
N-Methylacetoacetamide (MMAA) (DMAA-80) N,N-Diethylacetoacetamide (DEAA)

  C5H9NO2   C6H11NO2   C8H15NO2

Molecular weight  115.13  129.16  157.21


CAS RN  20306-75-6  2044-64-6  2235-46-3
Minimum assay  70.0 %  80.0 %  98.0 %
Minimum stability  2 months  6 months  3 months
Melting point ca.  –  –  –
Boiling point ca.  110°C  106°C  213°C
Density g/cm3 (20°C)  1.078  1.060  0.995
EU labeling  –  –  –
Packaging  drums, bulk  drums, bulk  drums, bulk
Transport information  not restricted  not restricted  not restricted

8
Acetoacetamide (AAmid) 3-Methyl-5-pyrazolone (MP)

  C4H7NO2 Pyrazolones   C4H6N2O

Molecular weight  101.11  98.11


CAS RN  5977-14-0  108-26-9
Minimum assay  98.5 %  99.0 %
Minimum stability  18 months  2 years
Melting point ca.  52°C  217°C
Boiling point ca.  –  –
Density g/cm3 (20°C)  –  –
EU labeling  – –
Packaging  paper bags drums
Transport information  not restricted not restricted

3,5-Dimethylpyrazole (DMP) Dehydroacetic acid (DHS)

  C5H8N2 Dehydroacetic acid   C8H8O4

Molecular weight 96.13  168.15


CAS RN 67-51-6  520-45-6
Minimum assay 99.0 %  99.0 %
Minimum stability 3 years  2 years
Melting point ca. 107°C  109°C
Boiling point ca. 218°C  –
Density g/cm3 (20°C) –  –
EU labeling – Xn harmful
Packaging drums paper bags
Transport information not restricted not restricted

Dehydroacetic acid, sodium salt Dehydroacetic acid, sodium salt


(NaDHS) monohydrate (NaDHS-H2O)

  C8H7O4Na   C8H9O5Na
Pharma

Colorants

Agriculture
Molecular weight 190.13 208.15
CAS RN 4418-26-2 64039-28-7
Minimum assay 99.0 % 98.0 % Polymers
Minimum stability 2 years 2 years
Melting point ca. – 109°C
Boiling point ca. – – Nutrition
Density g/cm3 (20°C) – –
EU labeling Xn harmful Xn harmful Various
Packaging drums drums
Transport information not restricted not restricted

9
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

2-(Acetoacetoxy) ethylmetha­crylate Propane-1.1.1-triyltrimethyl tris


(AAEMA) (acetoacetate) (AATMP)
Diketene /  Lonzamon monomers   C10H14O5   C18H26O9
ketene
derivatives

Molecular weight  214.21 386.4


CAS RN  21282-97-3 22208-25-9
Minimum assay  95.0 % 92.0 %
Minimum stability  1 year 2 years
Melting point ca.  –60°C –30°C
Boiling point ca.  100°C / 1hPa 300°C
Density g/cm3 (20°C)  1.122 –
EU labeling Xi irritant –
Packaging drums drums
Transport information not restricted not restricted

Squaric acid (QS) Diethyl squarate (QS, diethyl)

Other diketene / ketene   C4H2O4   C8H10O4


derivatives

Molecular weight  114.06 170.17


CAS RN  2892-51-5 5231-87-8
Minimum assay  98.5 % 98.0 %
Minimum stability  2 years 12 months
Melting point ca.  293°C 4–8°C (solidification)
Boiling point ca.  – 95°C / 0.1 hPa
Density g/cm3 (20°C)  1.82 1.15
EU labeling – T toxic; R21-25-36/37/38-42-43
Packaging drums iron drums
Transport information not restricted UN 2810, 6.1, PG III

Diacetoacet-1,4-phenylenediamide Diacetoacet-2,5-dimethyl-1,4-
Diacetoacet-o-tolidide (DiAA-o-tolidid) (DiAAphen) phenylenediamide (DiAA DM)

  C22H24N2O4   C14H16N2O4   C16H20N2O4

Molecular weight 380.45 276.29 304.38


CAS RN 91-96-3 24731-73-5 24304-50-5
Minimum assay 98.0 % 98.5 % 98.0 %
Minimum stability 2 years 2 years 2 years
Melting point ca. 206°C 171°C 232°C
Boiling point ca. – – –
Density g/cm3 (20°C) – – –
EU labeling – – –
Packaging bag-in-box, drums paper bags paper bags
Transport information not restricted not restricted not restricted

10
Diacetoacet-2-chloro-5-methyl-1,4- Diacetoacet-2,5-dichloro-1,4-
phenylenediamide (DiAA MC) pheny­lene­diamide (DiAA DC) Methyl 3-aminocrotonate (ACMe)

  C15H17ClN2O4   C14H14Cl2N2O4   C5H9NO2

Molecular weight 324.77 345.18 115.13


CAS RN 41131-65-1 42487-09-2 14205-39-1
Minimum assay 97.0 % 97.0 % 98.0 %
Minimum stability 5 years 5 years –
Melting point ca. 192°C 197°C 81°C
Boiling point ca. – – 112°C / 55hPa
Density g/cm3 (20°C) – – –
EU labeling – – Xi irritant
Packaging paper bags paper bags drums
Transport information not restricted not restricted not restricted

1,4-Butyleneglycolbis Thiodiglycolbis
(3-amino­crotonate) (BGAC) Diketene-acetone adduct (DAA) (3-aminocrotonate) (TGAC)

  C12H20N2O4   C7H10O3   C12H20N2O4S

Molecular weight 256.30 142.16 288.37


CAS RN 14205-47-1 5394-63-8 13560-49-1
Minimum assay 96.0 % 93.0 % 96.0 %
Minimum stability 2 years 3 months 2 years
Melting point ca. 146°C 12°C 88°C
Boiling point ca. – 66°C / 3mbar –
Density g/cm3 (20°C) – 1.094 –
EU labeling – F flammable N environment
Packaging bag-in-box drums fibre container
Transport information not restricted UN-No.: 1993, 3, PG II UN-No.: 3077, 9, PG III

2,5-Dimethyl-2,4-dihydro-
pyrazol-3-on (DMPO) Ethyl 4-chloroacetoacetate (CAAEt)

  C5H8N2O   C6H9ClO3
Pharma

Colorants

Agriculture
Molecular weight  112.13 164.59
CAS RN  2749-59-9 638-07-3
Minimum assay  >98.0 % 97.0 % Polymers
Minimum stability  – 1 year
Melting point ca.  117–118°C –8.5°C
Boiling point ca.  105–115°C / 8 hPa 220°C Nutrition
Density g/cm3 (20°C)  1.14 1.212
EU labeling  Xi irritant T toxic, N environment Various
Packaging  – drums
Transport information  not restricted UN-No.: 2922, 8, PG II

11
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Ethyl 4,4,4-trifluoroacetoacetate Methyl 3,3-dimethoxypropanoate (E)-Methyl 3-methoxyacrylate


(ETFAA) (PRSMe,DM) (E-MMA)

Diketene /    C6H7F3O3   C6H12O4   C5H8O3


ketene
derivatives

Molecular weight 184.12  148.16  116.12


CAS RN 372-31-6  7424-91-1  34846-90-7, 5788-17-0 (linear structure)
Minimum assay 98.0 %  98.0 %  ≥98.0 %
Minimum stability 6 months  12 months  2 years
Melting point ca. –39°C  <–65°C  2–3°C
Boiling point ca. 131°C  77°C / 26 mbar  95°C / 100 hPa
Density g/cm3 (20°C) 1.2586  1.06  1.07
EU labeling Xn harmful  –  –
Packaging drums  –  –
Transport information not restricted  not restricted  not restricted

Methyl 4-methyl-3-oxopentanoate
(OPMe, 4-methyl)

  C7H12O3
Pharma

Colorants

Agriculture
Molecular weight 144.17
CAS RN 42558-54-3
Minimum assay 98.0  % Polymers
Minimum stability 12 months
Melting point ca. –75°C
Boiling point ca. 192°C Nutrition
Density g/cm3 (20°C) 1.01
EU labeling – Various
Packaging drum or iso-container
Transport information not restricted

Adenine Cyanuric chloride A (CC A) Cyanuric chloride AS (CC AS)


HCN   C5H5N5   C3Cl3N3   C3Cl3N3
derivatives

Molecular weight  135.13  184.41  184.41


CAS RN  73-24-5  108-77-0  108-77-0
Minimum assay  98.0–102.0 %  99.5 %  99.5 %
Minimum stability  2 years  6 months  6 months
Melting point ca.  360°C  145.0–147.0°C  145.0–147.0°C
Boiling point ca.  –  193°C / 1013 hPa  193°C / 1013 hPa
Density g/cm3 (20°C)  –  –  –
EU labeling  –  –  –
Packaging  drums  bags in box  big bags
Transport information  not restricted  not restricted  not restricted

12
2-Methoxyethyl cyanoacetate
Allyl cyanoacetate (CNESallyl) Butyl cyanoacetate (CNESbutyl) (CNES methoxyet)

  C6H7NO2   C7H11NO2   C6H9NO3

Molecular weight  125.13  141.17  143.14


CAS RN  13361-32-5  5459-58-5  10258-54-5
Minimum assay  99.0 %  99.0 % ≥99.0 %
Minimum stability  2 years  2 years  2 years
Melting point ca.  –40°C  –  –
Boiling point ca.  89–90°C / 5 hPa  109.0°C / 13.0 hPa  257°C / 1000 hPa
Density g/cm3 (20°C)  –  0.998–1.002  –
EU labeling  T toxic; R25  –  –
Packaging  drums 200 kg  drums 200 kg  iron drums 200 kg, container
Transport information  UN 3276, 6.1, PG III  not restricted  not restricted

Malononitrile (85 % in methanol)


Chlorosulfonyl isocyanate (CSI) Malononitrile (MDN) (MDN)

  CClNO3S   C3H2N2   C3H2N2 ; CH4O

Molecular weight  141.53  66.06  98.11


CAS RN  1189-71-5  109-77-3  109-77-3
Minimum assay  99.0–100.3 %  99.0 %  83.5–86.5 %
Minimum stability  12 months  18 months  2.5 months
Melting point ca.  –  – 19.5°C
Boiling point ca.  1060°C  218–219°C  –
Density g/cm3 (20°C)  1.626  1.0494 (35°C)  1.011 (35°C)
EU labeling  C corrosive; R14-20/21/22-34  T toxic, N environment; R23/24/25-50/53  T,N; R10-23/24/25-39/23/24/25-50/53
Packaging  drums  drums  drums, rail tank wagon
Transport information  UN 3264, 8, PG I  UN 2647, 6.1, PG ll  UN 2929, 6.1 (3), PG ll

3-Aminocrotononitrile (Diacetonitril) Sodium dicyanamide (Na-dicyanamide) 1,1,3,3-Tetramethylguanidine (TMG)

  C4H6N2   C2N3Na   C5H13N3

Molecular weight  82.11  89.03  115.18


CAS RN  1118-61-2  1934-75-4  80-70-6
Minimum assay  96.0 %  ≥97.0 %  99.0 %
Minimum stability  8 months  2 years  1 year
Melting point ca.  40–67°C  >260°C  –
Boiling point ca.  –  –  162°C / 1013 hPa
Density g/cm3 (20°C)  0.9520 (77°C)  –  0.92
EU labeling  –  –  –
Packaging  drums  drums, BB packaging on request  drums, bulk
Transport information  not restricted  not restricted  not restricted

13
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Akolidine 10 Akolidine 11 Akolidine 12


(Pyridine, alkyl derivatives) (Pyridine, alkyl derivatives) (Pyridine, alkyl derivatives)
Heterocycles   All akolidines contain the following components:

Molecular weight  –  –  –
CAS RN  68391-11-7  68391-11-7  68391-11-7
Minimum assay  –  –  –
Minimum stability  –  –  –
Melting point ca.  –  –  –
Boiling point ca. –  –  –
Density g/cm3 (20°C)  0.978–0.990  1.018–1.034  1.024–1.038
EU labeling  –  –  –
Packaging  iron drum, bulk  iron drum, bulk  iron drum, bulk
Transport information  not restricted  not restricted  not restricted

2-Amino-4,6-dimethoxypyrimidine 2-Chloro-4,6-dimethoxypyrimidine 2-(5-Ethyl-2-pyridyl)ethanol


(ADMP) (DMP, 2-Chlor) (PRD-2-etol, 5-Et)

  C6H9N3O2   C6H7ClN2O2   C9H13NO

Molecular weight  155.16  174.59  151.21


CAS RN  36315-01-2  13223-25-1  5223-06-3
Minimum assay  98.0–101.0 %  98.0–100.3 % 95.0 %
Minimum stability  2 years  2 years  2 years
Melting point ca.  96–98°C  102–104°C  45°C 
Boiling point ca.  –  –  147–149°C
Density g/cm3 (20°C)  –  –  1.042
EU labeling  –  –  –
Packaging  drums  drums  iron drum 200 kg
Transport information  not restricted  not restricted  not restricted

5-Ethyl-2-methylpyridine (MEP) 6-Hydroxynicotinic acid (NS,6-Hydroxy) Sodium nicotinate (NS-Na)

  C8H11N   C6H5NO3   C6H4NNaO2

Molecular weight  121.18  139.11  145.09


CAS RN  104-90-5  5006-66-6  54-86-4
Minimum assay  – 97.5–100.3 %  99.0–100.3 %
Minimum stability  1 year  2–3 years  3 years
Melting point ca.  –70.9°C  314 –316°C  410°C
Boiling point ca.  178.3°C  –  –
Density g/cm3 (20°C)  0.918–0.921  –  –
EU labeling –  –  –
Packaging  iron drum 180 kg  drums  drums
Transport information  not restricted  not restricted  not restricted

14
Niacin min. 99.5 % (NS fg) Niacinamide USP (NSA USP) Meta™ metaldehyde (META tc)

  C6H5NO2   C6H6N2O   C8H16O4

Molecular weight  123.11  122.13  176.21


CAS RN  59-67-6  98-92-0  108-62-3
Minimum assay  99.5–100.3 % 99.0–101.0 % 98.0–99.8 %
Minimum stability  3 years  3 years  3 years (10°C)
Melting point ca.  234.0–237.0°C  128.0–131.0°C  246°C
Boiling point ca.  –  –  –
Density g/cm3 (20°C)  –  –  –
EU labeling  –  –  –
Packaging  paper bags, big bags  bag-in-box 20 kg  bag-in-box 25 kg
Transport information  not restricted  not restricted  not restricted

Paraldehyde (PARA) 2-Picoline (Picoline,2) 4-Picoline (Picoline,4)

  C6H12O3   C6H7N   C5H7N

Molecular weight  132.16  93.13  93.13


CAS RN  123-63-7  109-06-8  108-89-4
Minimum assay 99.5 %  99.0 %  >98.0 %
Minimum stability  60 days  2 years  –
Melting point ca.  –  –66.8°C  3.6°C
Boiling point ca.  –  125–130°C  145.4°C
Density g/cm3 (20°C)  0.993–0.997 kg/l (20°C)  –  0.954
EU labeling  –  –  T toxic; R10, R20/22, R24, R36/37/38
Packaging  iron drum 200 kg, bulk  iron drum 180 kg, bulk  –
Transport information  not restricted  not restricted  not restricted

4,6-Dimethoxy-2-[(phenoxy-
Pyrimidine (<0.5 % water) carbonyl)amino]pyrimidine
(Pyrimidine W<0.5) (ADMP-carbamat)

  C4H4N2   C13H13N3O4
Pharma

Colorants

Agriculture
Molecular weight  80.09  275.26
CAS RN  289-95-2  89392-03-0
Minimum assay  98.5–100.0 %  97.0–101.0 % Polymers
Minimum stability  2 years  2 years
Melting point ca.  20–22°C  120–122°C
Boiling point ca.  122–24°C  > 250°C Nutrition
Density g/cm3 (20°C)  1.016  –
EU labeling  –  – Various
Packaging  drums  drums
Transport information  not restricted  not restricted

15
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Acetaldehyde (AcAl) Acetic acid (glacial) (ES 99) Acetic anhydride (ESanhydrid)
Basic   C2H4O   C2H4O2   C4H6O3
chemicals

Molecular weight  44.05  60.05  102.09


CAS RN  75-07-0  64-19-7  108-24-7
Minimum assay  99.5 %  99.5–100.0 %  99.5 %
Minimum stability  1 year  2 years  2 years
Melting point ca.  –123.5°C  15.8–16.3°C  –73°C
Boiling point ca.  21°C  113–115°C / 933 hPa  –
Density g/cm3 (20°C)  0.784–0.786 kg/l (15°C)  1.050 g/ml (20°C)  1.0820
EU labeling  –  –  –
Packaging  drums, bulk  drum 200 kg, bulk  drums 200 kg, rail tanker
Transport information  not restricted  not restricted  not restricted

Ammonia aqueous (Ammonia 24)


Ammonia techn. (Ammonia tc) approx. 24.5–24.9 % chemically pure Nitric acid 65 %

  NH3   NH3   HNO3

Molecular weight  17.03  17.03  63.01


CAS RN  7664-41-7  1336-21-6  7697-37-2
Minimum assay  99.8 %  24.5–24.9 %  65.0–65.5 %
Minimum stability  2 years  2 years  –
Melting point ca.  –  –  –33°C
Boiling point ca.  33.4°C / 1013 hPa  –  121°C / 1013 hPa
Density g/cm3 (20°C)  0.609  0.9150–0.9110 g/ml (15°C)  –
EU labeling  –  –  –
Packaging  rail tanker  drums, road and rail tanker  rail tanker
Transport information  not restricted  not restricted  not restricted

Nitrosylsulfuric acid 40 % (SS,Nitrosyl 40) Malonic acid (MA)

  HNO5S   C3H4O4

Molecular weight  127.08  104.06


CAS RN  7782-78-7  141-82-2
Minimum assay  39.5–40.5 %  99 %
Minimum stability  2 years  1 year
Melting point ca.  –12 – –3°C  134°C (Mettler)
Boiling point ca.  333°C  –
Density g/cm3 (20°C)  1.893  –
EU labeling  –  Xi irritant; R36
Packaging  rail tanker  bags
Transport information  not restricted  not restricted

16
2,6-Diethyl-4-methylaniline (DEMA) 2,6-Diisopropylaniline (DIPA) 4,4-Dimethoxy-butan-2-one (DMB)
Others   C11H17N   C12H19N   C6H12O3

Molecular weight  163.26  177.29  132.16


CAS RN  24544-08-9  24544-04-5  5436-21-5
Minimum assay  >98.0 %  92.0 %  >92.0 %
Minimum stability  1 year  1 year  2 years
Melting point ca. –12°C – –7°C –45°C  –83 – –81°C
Boiling point ca.  –  257°C / 1013 mbar  169–71°C
Density g/cm3 (20°C)  0.945  0.940  0.9977
EU labeling  Xn harmful; R21/22  R52/53  –
Packaging  steel drums, bulk  iron drum 180 kg, bulk  drums, bulk
Transport information  not restricted  not restricted  not restricted

Valeronitrile (VN)

  C5H9N
Pharma

Colorants

Agriculture
Molecular weight  83.13
CAS RN  110-59-8
Minimum assay  99.5 % Polymers
Minimum stability  2 years
Melting point ca.  –
Boiling point ca.  139–141°C / 1013 hPa Nutrition
Density g/cm3 (20°C)  0.7990
EU labeling  – Various
Packaging  drums, bulk
Transport information  not restricted

17
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Alphabetical index

Page Product Abbreviation Page Product Abbreviation

A D
6
1 Acetaldehyde AcAl 9 Dehydroacetic acid DHS
16 Acetic acid (glacial) ES 99 9 Dehydroacetic acid sodium salt monohydrate NaDHS-H2O
16 Acetic anhydride ESanhydrid 9 Dehydroacetic acid sodium salt NaDHS
9 Acetoacetamide AAamid 11 Diacetoacet-2-chloro-5-methyl-1,4-phenylenediamide DiAA MC
7 Acetoacetanilide AAA 11 Diacetoacet-2,5-dichloro-1,4-phenylenediamide DiAA DC
8 Acetoacet-4-chloro-2,5-dimethoxyanilide ASIRG 10 Diacetoacet-2,5-dimethyl-1,4-phenylenediamide DiAA DM
8 Acetoacet-5-chloro-2-methoxyanilide AAMOC 10 Diacetoacet-1,4-phenylenediamide DiAAphen
7 Acetoacet-m-xylidide AAMX 10 Diacetoacet-o-tolidide DiAA-o-tolidid
8 Acetoacet-o-anisidide AAOA 8 N,N-Diethylacetoacetamide DEAA
8 Acetoacet-o-chloroanilide AAOC 10 Diethyl squarate QS, diethyl
7 Acetoacet-o-toluidide AAOT 16 2,6-Diethyl-4-methylaniline DEMA
10 2-(Acetoacetoxy)ethyl methacrylate AAEMA 11 Diketene-acetone adduct DAA
12 Adenine Adenine 16 2,6-Diisopropylaniline DIPA
14 Akolidine 10 Akolidine 10 16 4,4-Dimethoxy-butan-2-one DMB
14 Akolidine 11 Akolidine 11 15 4,6-Dimethoxy-2-[(phenoxy-carbonyl)amino]pyrimidine (ADMP-carbamat)
14 Akolidine 12 Akolidine 12 8 N,N-Dimethylacetoacetamide DMAA
13 Allyl cyanoacetate CNESallyl 11 2,5-Dimethyl-2,4-dihydro-pyrazol-3-on DMPO
14 2-Amino-4,6-dimethoxypyrimidine ADMP 9 3,5-Dimethylpyrazole DMP
13 3-Aminocrotononitrile Diacetonitril 6 Dodecyl acetoacetate AAdodecyl
16 Ammonia aqueous approx. 24.5–24.9 % chemically pure Ammonia 24
10 Ammonia techn. Ammonia tc E
6 Ethyl acetoacetate EAA
B 7 Ethyl benzoylacetate BESethyl
6 Benzyl acetoacetate BAA 11 Ethyl 4-chloroacetoacetate CAAEt
6 N-Benzyl-N-methyl-2-aminoethylacetoacetate AABME 14 5-Ethyl-2-methylpyridine MEP
13 Butyl cyanoacetate CNESbutyl 14 2-(5-Ethyl-2-pyridyl)ethanol PRD-2-etol, 5-Et
6 t-Butyl cyanoacetate AA-t-butyl 12 Ethyl 4,4,4-trifluoroacetoacetate ETFAA
11 1,4-Butyleneglycolbis(3-aminocrotonate) BGAC
H
C 14 6-Hydroxynicotinic acid NS,6-Hydroxy
4
1 2-Chloro-4,6-dimethoxypyrimidine DMP, 2-Chlor
13 Chlorosulfonyl isocyanate CSI I
12 Cyanuric chloride A CC A 6 Isobutyl acetoacetate AAisobutyl
12 Cyanuric chloride AS CC AS 6 Isopropyl acetoacetate IPAA

M
6
1 Malonic acid MA
13 Malononitrile (85 % in methanol) MDN
13 Malononitrile MDN
15 Meta™ metaldehyde META tc
7 2-Methoxyethyl acetoacetate AAmethoxyethyl
13 2-Methoxyethyl cyanoacetate CNES methoxyet
9 3-Methyl-5-pyrazolone MP
12 Methyl 3,3-dimethoxypropanoate PRSMe,DM
11 Methyl 3-aminocrotonate ACMe
12 (E)-Methyl 3-methoxyacrylate E-MMA
12 Methyl 4-methyl-3-oxopentanoate OPMe, 4-methyl
8 N-Methylacetoacetamide MMAA
6 Methyl acetoacetate MAA

18
Page Product Abbreviation

N
5
1 Niacin min. 99.5 % NS fg
15 Niacinamide USP NSA USP
16 Nitric acid 65 %
7 4-Nitrobenzyl acetoacetate (30 % in toluene) PNBAA 30T
16 Nitrosylsulfuric acid 40 %  SS,Nitrosyl 40

P
5
1 Paraldehyde PARA
15 2-Picoline Picoine,2
15 4-Picoline Picoline,4
8 Potassium N-(acetoacetyl)sulfanilate AAsulfanil-K
10 Propane-1,1,1-triyltrimethyl tris(acetoacetate) AATMP
15 Pyrimidine (<0.5 % water) Pyrimidine W<0.5

S
3
1 Sodium dicyanamide Na-dicyanamide
14 Sodium nicotinate NS-Na
10 Squaric acid QS

T
3
1 1,1,3,3-Tetramethylguanidine TMG
11 Thiodiglycolbis(3-aminocrotonate) TGAC

V
16 Valeronitrile VN
www.lonza.com

Administration / Sales offices


technical service

Switzerland Europe Asia


Lonza Ltd Lonza Benelux BV Lonza Guangzhou Ltd
Muenchensteinerstrasse 38 Aluminiumstraat 1 39, Jinhui Road
4002 Basel PO Box 3148 Haizhu District
Tel + 41 61 316 81 11 NL-4823 AL Breda CN-Guangzhou 510288
contact@lonza.com Tel +31 76 542 51 00 Tel +86 20 8433 8998
contact.nl@lonza.com contact.cn@lonza.com

USA Lonza Biotec sro Lonza Japan Ltd


Lonza Inc. Okruzní 134 Kyowa Shinkawa Bldg 8F
90 Boroline Road CZ-281 61 Kouřím 2-20-8, Shinkawa, Chuo-ku
Allendale, NJ 07401 Tel +42 0321 738 654 JP-Tokyo 104-0033
Tel +1 201 316 9200 contact.cz@lonza.com Tel +81 3 5566 0612
contact.allendale@lonza.com contact.jp@lonza.com
Lonza France Sàrl
55, rue Aristide Briand
FR-92309 Levallois-Perret Cedex
Tel +33 1 40 89 99 00
contact.fr@lonza.com

Lonza Cologne GmbH


Nattermannallee 1
DE-50829 Köln
Tel + 49 221 99 1990
info.cologne@lonza.com

Lonza Ltd Representation Office


Dunaház III. lépcsöház II. em 2
Boráros tér 7
HU-1095 Budapest IX
Tel +36 1 215 94 19
contact.hu@lonza.com

Lonza Ltd Representation Office


ul. Smolenskiego 4 m 15
PL-01-698 Warsaw
Tel +48 22 833 87 45
contact.pl@lonza.com

Lonza Ibérica S.A.U. (Unipersonal)


Vía Augusta, n° 18, 2a Pta, izda
ES-08006 Barcelona
Tel +34 93 238 54 60
contact.es@lonza.com

Lonza Biologics plc


Suite 3, Building A
The Courtyard
Severn Drive
The information contained herein is believed to be correct
Tewkesbury Business Park and corresponds to the latest state of scientific and technical
GB-Tewkesbury GL20 8GD knowledge. However, no warranty is made, either expressed
Tel +44 1684 292 728 or implied, regarding its accuracy or the results to be obtained
contact.uk@lonza.com from the use of such information. Some products may not be
available in all markets or for every type of application. Any
user must make his own determination and satisfy himself
that the products supplied by Lonza Group Ltd and the informa-
tion and recommendations given by Lonza Group Ltd are (i)
suitable for intended process or purpose, (ii) in compliance
with environmental, health and safety regulations, and (iii)
will not infringe any third party’s intellectual property rights.

© 2011 Lonza Ltd