1st IBRO UM5 School Program

First IBRO-‐UM5 Advanced School in Neuroscience

On

Basal Ganglia, Parkinson’s disease And Related Disorders
May 9-‐21, 2016

Faculty of Sciences
Centre of Rehabilitation and Neuroscience

Rabat

MOROCCO

Chair of the school: Prof Nouria Lakhdar-‐Ghazal
Faculty of Sciences – Mohammed V University

IBRO Scientific Committee of the school
Nouria Lakhdar-‐Ghazal (Morocco)
Abdesslam El Khamlichi (Morocco)
Abdelhamid Benazzouz (France)
Abdeljabbar El Manira (Sweden)
1

PROGRAM

May 8th: Arrival of Students

May 9th
Venue: Faculty of Sciences “Salle des Actes”
15:00 Presentation of students and lecturers, presentation of the program

17:00 -‐ 18:00: Opening lecture: Wail Benjelloun: (Past President of Mohammed V University;
Président de l’UNIMED -‐Union des Universités de la Méditerranée-‐ Rome, Italy)
-‐ Neuroscience and the early exchange of knowledge around the Mediterranean

18:00 -‐ 19:00: Welcome reception at the Faculty of Sciences

May 10th
Venue: National Centre of Rehabilitation and Neurosciences, Ibn Sina Hospital, Rabat

10:00 -‐ 10:45: Abdelhamid Benazzouz (Institut des maladies neurodégénératives, Equipe
Monoamines, Stimulation Cérébrale Profonde et Maladie de Parkinson, CNRS UMR 5293,
Université de Bordeaux, France):
-‐ Functional organization of the motor and non-‐motor circuits
15’ min discussion

11:00 -‐ 11:20: Coffee/Tea

11:20 -‐11:50: Najia El Abbadi (Service de Neurochirurgie, Hôpital Avicenne, Centre
Hospitalier Ibn Sina, Rabat)
-‐ Basal ganglia and development of stereotaxic surgery in humans:
15’ discussion

12:00 -‐ 14:30: Lunch

14:30 -‐ 15:00: W. Regragui (Service de Neurologie B, Hôpital des Spécialités de Rabat, Centre
Hospitalier Ibn Sina)
-‐ Clinical diagnosis of Parkinson's disease
15’ discussion

15:15 -‐ 15:45: Coffee/tea

15:45-‐18:00: Visit to the National Centre of Rehabilitation and Neurosciences

May 11th
Venue: Faculty of Sciences «Salle des Actes»

8:30 – 9:15: Abdelhamid Benazzouz
-‐ Involvement of basal ganglia in the pathophysiology of Parkinson’s disease
15’ discussion
2

9:30 -‐ 10:00: Mounia Rahmani (Service de Neurologie A et de Neuropsychologie, Hôpital des
Spécialités de Rabat, Centre Hospitalier Ibn Sina)
-‐ Medical management of Parkinson's disease
15’ discussion

10:15 -‐ 10:45: Coffee/Tea

10:45 -‐ 11:45: Abdelhamid Benazzouz
-‐ Deep brain stimulation in Parkinson’s disease
15’ discussion

12:00 -‐ 14:00: Lunch

Session 3: Neurochemical “signature” of Parkinson’s disease

14:00 -‐ 14:45: Abdelhamid Benazzouz
-‐ Dopamine control of extrastriatal basal ganglia: Physiology and Parkinson’s disease
pathophysiology
15’ discussion

15:00 -‐ 15:45: Philippe De Deurwaerdère (Institut des maladies neurodégénératives, Equipe
Université de Bordeaux).

-‐ The status of monoaminergic systems in Parkinson’s disease.
15’discussion

16:00 -‐ 16:20: Coffee/Tea

16:20 -‐ 19:00: Teachers and students
Which is the state of neuroscience research in Africa nowadays?

May 12th
Session 4: Pharmacology of dopamine-‐linked therapies

8:30 -‐ 9:15: Philippe De Deurwaerdère
-‐ Neurochemistry of L-‐DOPA, part 1: Beyond striatal dopamine in the benefit and motor side
effects of L-‐DOPA
15’ discussion

-‐ Neurochemistry of L-‐DOPA, part 2: Are classical antidepressant drugs adapted to the
situation of parkinsonian patients treated with L-‐DOPA?
15’ discussion
3

10:30 -‐ 10:50: Coffee/Tea

10:50 -‐ 12:30: Anas Tinakoua (IBRO Alumni; Post Doc, Unit of Biological Rhythms,
Neuroscience and Environment, Faculty of Sciences, Mohammed V University, Rabat,
Morocco)
-‐Journal Club «Are pesticides a risk factor for Parkinson’s disease?”

12:50 -‐ 14:30: Lunch

Session 5: Modelling of Parkinson’s Disease

14:30 -‐ 16:30: Frédéric Alexandre (Institut des Maladies Neurodégénératives, MNEMOSYNE
team – INRIA Bordeaux, CNRS UMR 5293, France)
-‐Introduction to Reinforcement Learning I: respondent conditioning, rewards and emotions
-‐ Introduction to Reinforcement Learning II: instrumental conditioning, needs and
motivations

16:30 -‐ 17:00: Coffee/tea

17:00 -‐ 18:30: Frédéric Alexandre
-‐ Modelling basal ganglia and Parkinson's disease
15’ discussion

May 13th all day
Venue: Neuroscience lab, Faculty of Sciences

8:30 -‐ 12:30: Anas Tinakoua (IBRO Alumni; Post Doc, Unit of Biological Rhythms,
Neuroscience and Environment, Faculty of Sciences, Mohammed V University, Rabat,
Morocco) & Abdelhamid Benazzouz (Institut des maladies neurodégénératives, Equipe
Université de Bordeaux, France)

Hands on:
• Monoamine depletion as animal model of Parkinson’s disease
• Stereotaxic injection in the medial forebrain bundle of pharmacological agents for
monoamine depletion
• Cognitive and motor tests for “Parkinsonian” rats (Rotarod, Open Field, Plus maze)

12:30 -‐ 14:30: Lunch

14:30 -‐ 18:00: Anas Tinakoua, Safa Bouabid & Alamy Meryem (Unit of Biological Rhythms,
Neuroscience and Environment, Faculty of Sciences, Mohammed V University, Rabat)

• Hands on: Cognitive and motor tests for “Parkinsonian” rats (Plus Maze, Morris
Water Maze) followed by perfusion and fixation of the brains for tyrosin-‐hydroxylase
immunocytochemistry
4

May 14
Venue: Neuroscience Lab & Chemistry Lab, Faculty of Sciences


• Hands on: High Phase Liquid Chromatography Technique

12:30 -‐ 14:00: Lunch


• Hands on: High Phase Liquid Chromatography Technique

18:30 -‐ 20:00: Certificates Ceremony

20:00: Gala dinner

May 15

8:30 -‐9:15: Karim Fifel (IBRO alumni-‐post Doc-‐ Leiden University Medical Center, The
Netherlands)
-‐Physiology of the circadian rhythm function
15’ discussion

9:30-‐10:15: KarimFifel

-‐Pathophysiology of circadian rhythm in Parkinson’s disease and animal models of the
disease
15’ discussion

10:30 -‐ 10:50: Coffee/Tea

10:50 -‐ 12:30: Students' oral presentations

12:30 -‐ 14:00: Lunch

Venue: Neuroscience Lab, Faculty of Sciences

14:00 -‐ 18:00: Karim Fifel, Safa Bouabid & Anas Tinakoua
• Hands on: Immunohistochemistry (Cutting brains and 1st step of incubation with
tyrosine hydroxylase primary antibody)

May 16
Venue: Faculty of Sciences « Salle des Actes »

5

8:30 -‐ 9 .15: Sten Grillner (Karolinska Institute, Departement of Neuroscience, Nobel Institute
of Neurophysiology, Stockholm, Sweden; Past IBRO Secretary General)
"The basal ganglia over 500 million years”

9:30 -‐ 10:15: Marina Bentivoglio (Department of Neuroscience, Biomedicine and Movement
Sciences, University of Verona, Verona, Italy; Past IBRO Secretary General)
-‐ Neuroinflammation in Parkinson’s disease and its models
15’ discussion

10:15 -‐ 10:35: Coffee/Tea

10:35 -‐ 11:20: Marina Bentivoglio
-‐ Neocortex, hippocampus and Parkinson’s disease
15’ discussion

11:35 -‐ 12:30: Sten Grillner
-‐ Why two IBRO Advanced School Sites in Africa?

12:30 -‐ 14:30: Lunch

-‐Non-‐motor symptoms in Parkinson’s disease
15’ discussion

15:30 -‐ 16:15: Nouria Lakhdar-‐Ghazal (Unit Biological Rhythms, Neuroscience &
Environment, Faculty of Sciences, Mohammed V University, Rabat)
-‐ Environmental pollutant as risk factor for Parkinson’s/Parkinsonism diseases
15’ discussion

16:30 -‐ 16:50: Coffee/Tea

16:50 -‐ 17:35: Safa Bouabid (IBRO Alumni; Post doc at Unit Biological Rhythms, Neuroscience
& Environment, Faculty of Sciences, Mohammed V University, Rabat, Morocco)
-‐ Manganism versus Parkinson's disease: similarities and differences
15’ discussion

17:50 -‐ 18:50: KarimFifel
-‐ Journal Club

May 17
Venue: Faculty of Sciences « Salle des Actes »

8:30 -‐ 9:15: Mimoun Azzouz (Chair of Translational Neuroscience, Director of Research &
Innovation, Department of Neuroscience, Sheffield Institute for Translational Neuroscience,
University of Sheffield, UK)
-‐ Introduction to motor neuron diseases
15’ discussion
6

9:15 -‐ 10:00: Mimoun Azzouz
-‐ “Principles of gene therapy”
15’ discussion

10:15 -‐ 10:45: Coffee/Tea

10:45 -‐ 11:45: Mimoun Azzouz
-‐ Gene-‐based therapeutics for Parkinson’s disease and related motor disorders
15’ discussion

12:00 -‐ 14:30: Lunch

"Preparation of scientific papers and publishing business"

May 18

8:30 -‐ 12:30: Safa Bouabid & Anas Tinakoua
-‐ Hands on: Immunohistochemistry (2nd and 3rd incubations, revelation in 3-‐3’
diaminobenzidine/H2O2; observation)

12:30 -‐ 14:30: Lunch

14:30 -‐ 17:30: Safa Bouabid & Anas Tinakoua (Unit of Biological Rhythms, Neuroscience and
Environment, Faculty of Sciences, Mohammed V University, Rabat, Morocco)

-‐ Hands on: Immunohistochemistry -‐ continuation: observation and semi quantification of
labelled neurons

May 19: Free

May 20th
Venue: Faculty of Sciences “Salle des Actes"

8:30 -‐ 9:15: Abdeljabbar El Manira (Karolinska Institute, Department of Neuroscience, Nobel
Institute of Neurophysiology, Sweden)
-‐ Neural circuits for motor actions I
15’ discussion

9:30 -‐ 10:15: Abdeljabbar El Manira
-‐ Neural circuits for motor actions II
15’ discussion

10:30 -‐10:50: Coffee/Tea

7

10:50 -‐ 11:20: Maria Benabdeljlil (Service de Neurologie A, Hôpital des Spécialités de Rabat,
Centre Hospitalier Ibn Sina)
-‐ Neuropsychology of basal ganglia
15’ discussion

11:35 -‐ 12:05: M. Boutarbouch (Service de Neurochirurgie, Hôpital des Spécialités de Rabat,
Département d’Anatomie, Faculté de Médecine et de Pharmacie de Rabat) & M. Jiddane
(Service de Neuroradiologie, Hôpital des Spécialités de Rabat, Centre Hospitalier Ibn Sina)
-‐ Imaging insight into basal ganglia function and pathology
15’ discussion

12:30 -‐ 14:00: Lunch

14:00 -‐ 18:30: Students' oral presentations

May 21st

8:30 -‐ 9:00: A. Melhaoui (Service de Neurochirurgie, Hôpital des Spécialités de Rabat, Centre
Hospitalier Ibn Sina)
-‐ Basal ganglia and other movement disorders
15’ discussion

9:15 -‐ 9:45: Mounia Rahmani & Mustapha Alaoui-‐Faris (Service de Neurologie A et de
Neuropsychologie, Hôpital des Spécialités de Rabat, Centre Hospitalier Ibn Sina)
-‐ Basal ganglia and neuropsychiatric diseases
15’ discussion

9:45 -‐ 10:05: Coffee/Tea

10:05 -‐ 10:35: Y. Arkha (Service de Neurochirurgie, Hôpital des Spécialités, Rabat)
-‐ Role of radiosurgery in the management of lesions located in basal ganglia

10:35 -‐ 12:30: Workshops at Centre National de Rehabilitation et de Neurosciences, Centre
Hospitalier Ibn Sina, Rabat
W. Regragui (Service de Neurologie B, Hôpital des Spécialités de Rabat, Centre Hospitalier Ibn
Sina) & M. Rahmani (Service de Neurologie A et de Neuropsychologie, Hôpital des Spécialités
de Rabat, Centre Hospitalier Ibn Sina)
-‐Patient selection for surgery of Parkinson’s disease

12:30 -‐ 14:30: Lunch

14:30 -‐ 17:30: Workshops at Centre National de Rehabilitation et de Neurosciences, Centre
Hospitalier Ibn Sina, Rabat Continuation

Najia El Abbadi (Service de Neurochirurgie, Hôpital Avicenne, Rabat) et A. Melhaoui
(Service de Neurochirurgie, Hôpital des Spécialités, Rabat)
8

-‐ Stereotaxy in basal ganglia lesions (case demonstration)

Y. Arkha & A. Melhaoui (Service de Neurochirurgie, Hôpital des Spécialités, Rabat)
-‐Management of basal ganglia lesion with gamma knife radiosurgery (case
demonstration)
17:30 -‐ 18:30: Closing Lecture
Abdeslam El Khamlichi (WFNS Honorary President, Department of Neurosurgery,
Mohammed V Souissi University and National Neuroscience Centre, Rabat)
-‐ Regional training centres are the key solution to bring neurosciences into light in sub-‐
Saharan Africa:

9

1st IBRO UM5 School Program

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-­‐ Stereotaxy in basal ganglia lesions (case demonstration)

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-‐ Stereotaxy in basal ganglia lesions (case demonstration)