Академический Документы
Профессиональный Документы
Культура Документы
COURSE DESCRIPTION
This course utilizes a multidisciplinary approach to prepare students with a foundational
understanding of the normal structure and function of the renal system. It includes a review of
the basic functional principles of the organs of urine production and excretion including the
gross anatomy, histology, and embryology of the kidney and urinary tract. A thorough
investigation of the essential physiology of kidney function will include the primary renal
processes, urine formation, and renal blood flow. In addition, the renal system’s role in ion
regulation, acid-base balance, fluid volume, and salt-water balance will be examined along with
the regulatory control mechanisms of these functions. An understanding of the renal system will
be accomplished through student involvement in lectures, directed student assignments, and
relevant interactive clinical correlation sessions.
2. Describe the role of the kidneys in body fluid volume, homeostasis of II, III
2, 3,
ions, and acid-base balance. 10
COURSE MATERIALS
See the below required textbook list. Many of the required text books are available free online
through the library.
POLICIES
Please refer to student handbook and catalog for KCU-COM academic and course policies.
ATTENDANCE
Attendance of lectures and laboratories is based on the university’s stated attendance policy.
Refer to the student handbook for more information.
EVALUATION
The student will receive a numerical grade in the form of a percent and letter grade at the end of
the course. The student must achieve a cumulative grade of 70% or higher on graded
assessments to pass the course.
POINT ALLOTMENT
The following table is a breakdown of the allotment of points. These values are subject to
change with notice.
Quiz 1 5
Exam 1 60
Exam 2 60
ANATOMY
Histology: A Text and Atlas with Correlated Cell and Molecular Biology (7th ed.), Pawlina, W.,
Wolters Kluwer, c. 2016.
ISBN: 978-1-4511-8742-7.
The Developing Human: Clinically Oriented Embryology (10th ed.), Moore, K.L., Persaud,
T.V.N., and,Torchia, M.G., Elsevier, c 2016.
ISBN: 978-0-323-31338-4. Available on Clinical Key.
Clinically Oriented Anatomy (8th ed), Moore, K.L., Dalley, A.F.,and Agur, A.M.R., Lippincott
Williams & Wilkins, c 2018.
ISBN: 978-1-4963-4721-3. (paperback); E-ISBN: 978-1-4963-8942-8 (digital)
OPTIONAL
BRS Physiology (Board Review Series) (6th ed.) / Costanzo, Linda.
Wolters Kluwer Health, c2014.
ISBN: 978-1451187953 (paperback)
2017-2018 OMS I Textbook List
Endocrine and Reproductive Physiology (4th ed.) / White, Bruce; Porterfield, Susan P.
Elsevier/Mosby, c2013.
ISBN: 978-0323087049 (paperback)
E-ISBN: 978-0323088282
Larsen’s Human Embryology (5th ed.), Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., and Francis-
West, P.H., Elsevier Churchill Livingstone, c. 2015.
ISBN: 978-1-4557-0684-6. Available on Clinical Key.
Moore’s Anatomy Review PrepU for Clinically Oriented Anatomy, Lippincott Williams & Wilkins,
c2018.
ISBN: 978-1-4963-9916-8
Robert (Jason) Walker, PhD (Course Angela Pierce, DC, PhD (Course Director/Phase II
Director/Phase I Director) Director)
Office SEP 453 Office 2616
816-654-7208 417-208-0656
RWalker@kcumb.edu APierce@kcumb.edu
Sarah Keim Philip Brauer, PhD
Office SEP 239 Office 2606
816-654-7546 417-208-0666
SKeimJanssen@kcumb.edu PBrauer@kcumb.edu
Objectives: After reading the text, attending the lecture, and using online resources, the
student physician should be able to:
1. Describe the location and relationship of the kidneys and ureters to neighboring structures at
the gross anatomy level.
2. Describe the major nerve and blood supply to the kidneys and the vascular branches found
within the kidney.
3. Describe and identify the basic internal gross anatomy of the kidney.
4. Describe the location and morphological characteristics of uriniferous tubules and renal
corpuscles.
5. Describe and identify the structural features and role of the glomerulus, Bowman’s capsule,
podocytes and mesangial cells.
7. Describe the location, morphological characteristics, and general functions of the proximal
convoluted and straight tubules, loop of Henle, distal convoluted tubules, and collecting
ducts.
8. Identify the targets of aldosterone and antidiuretic hormone within the uriniferous tubules.
10. Describe the microscopic appearance of the juxtaglomerular apparatus and describe its
basic function.
11. List the components of the urinary tract. Describe transitional epithelium and its unique
characteristics and explain where this epithelium is found.
12. Describe the microscopic anatomy of the ureter, bladder, and urethra and how they differ
between males and females.
Renal Embryology (Dennis/Keim)
Dev. Human: Ch 12 – stop at ‘Dev of Genital System’
Larsen’s: Ch 15 – stop at ‘Genital System arises w/Urinary System’
OBJECTIVES
After reviewing the relevant reading material and studying the lecture notes, students should
demonstrate knowledge of:
1. Describe general aspects of nitrogen excretion (pages 254-255; Fig. 15.1), particularly the following
correlation boxes: Hartnup disease (blue, p. 93) and cystinuria (blue, p. 93).
2. Summarize the significance of the urine-derived metabolites that are associated with errors in
phenylalanine metabolism (p. 262-267; Fig. 15.9, 15.10, 15.12), particularly the following correlation
boxes: Tetrahydrobiopterin/dihydrobiopterin (green, p. 268), Phenylketouria (blue, p. 268), Tyrosinemia
(blue, p. 268), Alkaptonuria (blue, p. 268).
3. Summarize the mechanism of toxicity of ammonia and uric acid (p. 270 and 278; Fig. 15.13 and 16.5A),
particularly the following correlation boxes: Ammonia toxicity (blue, p. 273), Gout (blue, p. 278), Uric
acid levels as a diagnostic marker for gout (orange, p. 278)
4. Recall the urine-derived metabolites associated with errors in urea cycle and pyrimidine metabolism (p.
270- 273; Fig. 15.14, 16.7 and Table 5), particularly the following correlation boxes: Hyperammonemia
(blue, p. 273), Carbamoyl phosphate synthetase II (cytosolic) (green, p. 273).
5. Recall the urine-derived metabolites associated with heme catabolism (p. 290-293; Fig. 16.13),
particularly the following correlation boxes: Direct and indirect bilirubin (blue, p. 292).
This resource is provided to assist you in addressing the learning objectives in preparation for lecture
presentation.
Page 1
Learning Objectives
Dr. A. Shnyra
Primary References: Abbas AK, Lichtman AH. Basic Immunology. Second Edition, Saunders Elsevier, pp.
185-191.
The immune system and kidney disease: basic concepts and clinical implications. 2013. Nature
Reviews in Immunology vol. 13, p.738