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“Diabetic Foot Ulcer (DFU) Market & Drug Pipeline Analysis” gives comprehensive
insights on the various drugs being developed for the treatment of DFU. The report covers
all the drugs that are in various phases of development (Discovery, Preclinical and Clinical).
The pipeline focuses on novel pharmacologic drugs and regenerative medicines covering,
antibodies, stem cell therapies, recombinant proteins, Peptide therapies, RNA-based
therapeutics and others, but excludes symptom relief drugs, wound dressing, drug delivery
systems, generic combinations and radiation therapies. The report also covers some of the
hot targets in research for DFU treatments and related biomarkers.
Diabetic foot ulcers (DFUs) are poorly healing (chronic) wounds found most commonly on
the planter surface of the foot, and are among the most common and serious complications
resulting from diabetes. 25% of the diabetic population is at risk of DFU in their life time. In
2017, approximately, 14 Mn people worldwide suffering from DFU and more than half of all
foot ulcers infected require costly hospitalization and 1 in 5 require amputation. Various
types of grading systems such as Wagner Grade (WG) and University of Texas (US) are
used in assessing and documenting DFU. However, there is no universally accepted grading
system but clinicians employ any one of the existing systems depending on condition.
Wagner grade of classification is not recommended to assess the severity of DFU as per
NICE guidelines.
Smith & Nephew’s REGRANEX (becaplermin) Gel is the only FDA-approved recombinant
platelet-derived growth factor (PDGF) therapy for diabetic neuropathic ulcers. However, it
has some limitation such as the efficacy issues with pressure ulcers, venous stasis ulcers
and ischemic diabetic ulcers, and it is contraindicated with known skin cancers at the site of
application. Hence, there is a huge unmet need and demand for novel therapies to treat
DFU.
DFU Introduction
DFU grading, Treatment algorithm, Patient care pathway & Visiting patterns,
Clinical practice guidelines, Current SOC, Adjuvant therapies, Alternative
approaches, Unmet needs, ICD/CPT codes
Epidemiology
Market Data
Pipeline Analysis
Small Molecules
Large Molecules