Kesimpulan

Formulasi oral berbasis pelarut organik terbukti lebih unggul dari formulasi surfaktan non ionik atau
formulasi siklodekstrin. Hasil ini dapat membantu merumuskan formulasi pediatrik lainnya obat larut air
yang buruk, untuk membantu peracikan apotek

Daftar Pustaka

Aleksovski, A., Dreu, R., Gasperlin, M., Planinsek, O., 2015. Mini-tablets: a contemporary system for
oral drug delivery in targeted patient groups. Expert Opin. Drug Deliv.12 (1), 65–84.

Clarke's Analysis of Drugs and Poisons [Internet]. Pharmaceutical Press ([cited September 8, 2016].
Available from:). https://www.medicinescomplete.com/mc/clarke/2010/.

Committee for Human Medicinal Products (CHMP), 2006. Reflection Paper: Formulations of Choice
for the Paediatric Population London: European Medicines Agency.

Committee for Human Medicinal Products (CHMP), 2014a. Background Review for Cyclodextrins
Used as Excipients. European Medicines Agency, London.

Committee for Human Medicinal Products (CHMP), 2014b. Background review for the excipient
propylene glycol. London: European Medicines Agency.

Holvoet, C., Vander Heyden, Y., Plaizier-Vercammen, J., 2005. Inclusion complexation of lorazepam
with different cyclodextrins suitable for parenteral use. Drug Dev. Ind. Pharm. 31 (6), 567–575.

Joint FAO/WHO Expert Committee on Food Additives, editor, 1974. Toxicological Evaluation of
Certain Food Additives with a Review of General Principles and of Specifications. Food and Agriculture
Organization of the United Nations, Rome.

Joint FAO/WHO Expert Committee on Food Additives Meeting, World Health Organization,
International Program on Chemical Safety, editors, 1982W. Toxicological Evaluation of Certain Food
Additives. WHO/FAO, Geneva.

Lee, W.M., Lugo, R.A., Rusho, W.J., Mackay, M., Sweeley, J., 2004. Chemical stability of
extemporaneously prepared Lorazepam suspension at two temperatures. J. Pediatr. Pharmacol. Ther. 9
(4), 254–258.

Lee, W.M., Lugo, R.A., Cash, J., Rusho, W.J., Mackay, M., Welkie, K., 2005. The accuracy and

precision of measuring Lorazepam from three liquid preparations. J. Pediatr. Pharmacol. Ther. 10 (1), 36–
42.
 Lexicomp Online®, 2016. Pediatric & Neonatal Lexi-Drugs®. Lexi-Comp, Inc, Hudson, Ohio.

McMullan, J.T., Pinnawin, A., Jones, E., Denninghoff, K., Siewart, N., Spaite, D.W., et al., 2013. The
60-day temperature-dependent degradation of midazolam and Lorazepam in the prehospital
environment. Prehosp. Emerg. Care 17 (1), 1–7.

Mennella, J.A., Beauchamp, G.K., 2008. Optimizing oral medications for children. Clin. Ther. 30 (11),
2120–2132.

O'Neil, M.J., 2006. The Merck Index: an Encyclopedia of Chemicals, Drugs, and Biologicals. Merck,
Whitehouse Station, N.J.

Siddegowda, M.S., Ramakrishn, R.A., Yathirajan, H.S., 2012. Facile thermal rearrangement of
Lorazepam and Oxazepam. Indian J. Chem. Sect. B Org. Med. Chem. 51 (11), 1628–1632.

van Riet-Nales, D.A., de Jager, K.E., Schobben, A.F., Egberts, T.C., Rademaker, C.M., 2011. The
availability and age-appropriateness of medicines authorized for children in The Netherlands. Br. J. Clin.
Pharmacol. 72 (3), 465–473.