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DAFTAR ISI

DAFTAR ISI .................................................................................................. i


DAFTAR TABEL ......................................................................................... iii
DAFTAR GAMBAR ..................................................................................... iv
DAFTAR LAMPIRAN………………………………………………… ...... vi

BAB 1 PENDAHULUAN ............................................................................. 1


1.1 Latar Belakang………………………………………………………. ...... 1
1.2 Rumusan Masalah…………………………………………………. ......... 4
1.3 Hipotesa…………………………………………………………….. ....... 3
1.4 Tujuan Penelitian ………………………………………………….. ........ 5
1.5 Manfaat ................................................................................................... 5

BAB 2 TINJAUAN PUSTAKA .................................................................... 4


2.1 Kanker ...................................................................................................... 4
2.1.1 Definisi ..................................................................................... 4
2.1.2 Pertumbuhan Penyakit Kanker ................................................. 7
2.1.3 Jenis-Jenis Penyakit Kanker ..................................................... 8
2.2 Depresi ..................................................................................................... 11
2.2.1 Definisi ..................................................................................... 11
2.2.2 Penyebab Depresi ..................................................................... 12
2.2.3 Gambaran Klinis ...................................................................... 13
2.2.4 Kuisioner Kesehatan Pasien-9 .................................................. 14
2.3 Nyeri ........................................................................................................ 19
2.3.1 Mekanisme Nyeri ..................................................................... 20
2.3.2 Sensitisasi Perifer ..................................................................... 20
2.3.3 Sensitisasi Sentral ..................................................................... 21
2.3.4 Nosiseptor................................................................................. 22
2.3.5 Perjalanan Nyeri ....................................................................... 23
2.3.6 Klasifikasi Nyeri ...................................................................... 25

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2.3.7 Penilaian Nyeri ......................................................................... 30
2.4 Hubungan Depresi Terhadap Timbulnya Nyeri Pada Pasien Cancer ...... 33
2.5 Kerangka Teori ........................................................................................ 35
2.6 Kerangka Konsep ..................................................................................... 36
BAB 3 METODE PENELITIAN .................................................................. 30
3.1 Desain Penelitian ..................................................................................... 38
3.2 Tempat dan Waktu Penelitian .................................................................. 38
3.3 Populasi dan Sampel ................................................................................ 38
3.3.1 Populasi ........................................................................................ 38
3.3.2 Sampel .......................................................................................... 38
3.4 Besar Sampel ............................................................................................. 39
3.5 Teknik Pengambilan Sampel.................................................................... 39
3.6 Kriteria Inklusi, Eksklusi, Putus Uji, ....................................................... 39
3.6.1 Kriteria Inklusi .............................................................................. 31
3.6.2 Kriteria Eksklusi ........................................................................... 31
3.6.3 Kriteria Putus Uji .......................................................................... 40
3.7 INFORMED CONSENT............................................................................ 31
3.8 Alat dan Cara Kerja................................................................................... 31
3.8.1 Alat ................................................................................................ 32
3.8.2 Cara Kerja ..................................................................................... 32
3.9 Identifikasi Variabel ............................................................................ 33
3.8 Analisa Data .............................................................................................. 33
3.9 Identivikasi Variabel .................................................................................. 41
3.9.1 Variabel Bebas .............................................................................. 41
3.9.2 Variabel Tergantung ...................................................................... 41
3.10 Rencana Manajemen Dan Analisis Data ................................................. 41
3.11 Definisi Operasional ................................................................................ 41
3.12 Alur Penelitian ........................................................................................ 43
DAFTAR PUSTAKA ..................................................................................... 44

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DAFTAR TABEL

\ Halaman
Tabel 2.1 Kuesioner Patient Health Questtionaire-9 (PHQ-9)................ 9
Tabel 2.2 Interpretasi derajat depresi menurut PHQ-9
(Kroenke K dan Spitzer, 2001) ............................................................... 10

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DAFTAR GAMBAR

Halaman
Gambar 2.1 Prevalensi Penyakit Kanker pada Penduduk
(%) Menurut Kelompok Umur Tahun 2013 .................................. 9
Gambar 2.2 Proporsi Faktor Risiko Penyakit Kanker pada
Penduduk Menurut Kelompok Umur Tahun 2013 ........................ 10
Gambar 2.3 Mekanisme sensitisasi perifer .................................... 21
Gambar 2.4 Pain Pathway.............................................................. 24
Gambar 2.5 Pathophysiology of cancer pain ................................. 29
Gambar 2.6 Wong Baker Faces Pain Rating Scale........................ 30
Gambar 2.7 Verbal Rating Scale ................................................... 31
Gambar 2.8 Numerical Rating Scale ............................................. 31
Gambar 2.9 Visual Analogue Scale ............................................... 32
Gambar 2.10 Kerangka Teori ........................................................ 35
Gambar 2.11 Kerangka Konsep ..................................................... 36
Gambar 3.1 Alur Penelitian ........................................................... 43

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LAMPIRAN

NO JUDUL HALAMAN
1 Riwayat Hidup Peneliti 43
2 Jadwal Pertahapan Penelitian 44
3 Lembar penjelasan mengenai penelitian 45
4 Lembar Persetujuan Setelah Penjelasan 46

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