Cosmetic Active Ingredients

C onstant innovation at the

service of Cosmetology

C
Founded in 1964, Sederma became
a member of the Croda International
Group in 1997. Sederma is
dedicated to the development of
onstant research of
proven efficacy
Equipped with a high-
performance and modern
Claim Substantiation laboratory,
Since 1964, Sederma has been
devoted to the development of active
ingredients and the creation of
innovative concepts for the Cosmetic
industry based on the mastery of
biotechnology, molecular synthesis
and vegetal extraction.

active ingredients and the creation
of innovative concepts for Personal
Care and Cosmetic products, based
on the mastery of biotechnology, fine
chemistry and vegetal extraction.
P
Sederma uses powerful in vitro,
ex vivo and in vivo tests to prove
the efficacy of the products.
roduction facilities at the
forefront of technology

Q
A team of competent researchers
Located near Paris, all Sederma
is responsible for the dynamism of
activities, from R&D and
manufacturing to administration
uality requirements the R&D laboratory. The Production
and warehousing, are gathered in a Sederma strives for continuous workshop and the Quality Control
7900 m² complex. laboratory are equipped with modern
improvement of quality and
service, it has received the and sophisticated equipment which
Sederma is a world leader in the
field of active ingredients intended following certifications: ISO ensures the constant quality of our
for the Cosmetic industry. We 14001 in 2003, OHSAS 18001 products.
have developed a unique range in 2007 and the Cosmetic
of biochemical actives, with
substantiated efficacy for wrinkle
Ingredient Good Manufacturing
reduction, sebum regulation, Practice in 2014.
moisturisation, skin firming, free
radical protection and a host of
other benefits. We offer a wide
range of cosmetic ingredients for
skin and hair care products which
are internationally sold to all major
cosmetic manufacturers.
P lant Cell Culture Active Ingredients

Thanks to the acquisition of the

Anti-ageing ORIGIN FORMULATION IECIC
company Istituto di Ricerche
Biotecnologiche (IRB) by Croda,
GARDECELL™ Protects the collagen network and stimulates its synthesis. Sederma is also offering an array of
plant cell-based ingredients with
MAJESTEM™ Remarkably lifts the neck and face skin by restoring the
guaranteed efficacy, reproducibility
mitochondrial dynamism and protecting the matrix integrity.
and absolute sustainability.
SENESTEM® Visibly fades signs of senescence.
Enhances skin viscoelastic properties and brightens senile Combining IRB know-how in plant cell
pigmented spots. culture and elicitation with Sederma’s
skills in claim substantiation and
Eye care production capacity, IRB by Sederma
is one of the leaders in cosmetic
ECHINACELL™ Prevents collagen loss and reduces capillary active ingredients issued from Plant
permeability to lessen dark circles. Cell Culture.

Environmental protection
SUSTAINABILITY
CITYSTEM™ Fights against visible and invisible pollution damage to the skin.
Protects, removes, strengthens and repairs. No biosphere destruction,
RESISTEM
®
Stimulates skin hormetic defence to make it fight against
No need for transportation,
pro-ageing agents by itself. No over exploitation of land,
No widespread use of solvents.
BUDDLEJA STEMS GX™ Protects dermis components from UV-induced
oxidative stress and matrix metalloproteinase (MMP)
activation. Inhibits inflammation.

SOURCING
Radiance
No crops,
RUBISTEM™ Helps reduce first signs of rosacea. No seasonality,
Recreates a lucid complexion. No suppliers,
RESISTEM® Decreases skin redness and enhances natural skin glow Unlimited availability.
thanks to an hormesis-like mechanism.

Seboregulating SAFETY & QUALITY

SEBULESS® Mattifies and equalises skin tone of oily and
acne-prone skin. No GMOs,
No fertilisers, no pesticides
No preservatives,
High quantity of phytochemicals.
ORIGIN FORMULATION CHINESE REGULATION
Water soluble
Plant extract Supercritical CO2 Water dispersible IECIC listed
Plant cell culture Oil soluble
Biotechnology
Preservative free *: Several versions available
Synthetic
**: Contact us
Matrixyl® has received the 25 Years of Innovation Award
that recognised the product that has had the greatest impact on
the Personal Care ingredients market in the last quarter-century.

Anti-ageing ORIGIN FORMULATION IECIC

OPTIM HYAL™
Smoothes the skin by stimulating hyaluronic acid neosynthesis and sustaining its turnover.
MAJESTEM ™
Visible lifting action on the neck and face, for a majestic beauty.
SENESTEM ®
Visibly fades signs of senescence. Enhances skin viscoelastic properties and brightens senile pigmented spots.
MˇEIRITAGE™ Restores the epidermis integrity, stimulates collagen synthesis and fades age spots.
Inspired from Traditional Chinese Medicine.
SKIN TIGHTENER ST2™
Marine and plant ingredients associated for an immediate tightening, lifting and firming effect.
STEROCARE PH ™
Red clover isoflavones to address the needs of mature skin.
BIOPEPTIDE CL™
Collagen chain fragment to decrease wrinkles and reinforce the epidermis.
BIOPEPTIDE EL™
Chemotactic fragment of elastin that firms and restores the skin’s elasticity.
DERMAXYL ®
Anti-wrinkle repairing complex, based on the matrikine technology.
IDEALIFT®
Fights against skin sagging and improves resistance to gravity.
MATRIXYL® 3000 *
Anti-wrinkle matrikine association that fights against photo-ageing and chrono-ageing.
RENOVAGE™ High-tech global anti-ageing ingredient that controls skin space-time continuum by acting on
the four dimensions of skin ageing: surface, depth and time.
RIGIN™ *
Hydrates, protects and smoothes the skin in only 15 days.
ESSENSKIN™
Fortifies and restructures thin and fragile mature skin.
JUVINITY™ Visibly reduces the signs of ageing on the face and décolleté.
Smoothes wrinkles, restructures and densifies the dermis.
MATRIXYL® SYNTHE’6®
Powerful anti–wrinkle peptide acting on 6 skin–rebuilding essentials and tested with success on the forehead.
DYNALIFT ™
Immediate and durable tightening effect resulting in smoothness and radiance of the skin.

Eye care
EYELISS™
Reduces bags and puffiness under the eyes.
HALOXYL ™
Fights against the accumulation of blood degradation products around the eyes to
decrease dark circles.
WIDELASH® Helps eyelashes appear longer, fuller and stronger by promoting follicle keratinocyte
proliferation and ensuring optimal anchorage.
BEAUTIFEYE® A global eye contour treatment: lifts the upper eyelid, reduces crow’s feet wrinkles,
fades away dark circles and decreases puffiness. **
Brightening - Lightening ORIGIN FORMULATION IECIC

MEDIATONE™
Highly purified skin tone mediator with a tailor-made approach for dark skin and Asian skin.
KERATOLINE C PS™
Brightening by enzymatic peeling, gentle alternative to AHAs.
ETIOLINE ™
Increases homogeneity of skin tone.
MELASLOW PH™
Promotes complexion brightening and age spot depigmentation.
WONDERLIGHT™
Helps decrease hyperpigmentation accentuated by age and stress.
ARBUTIN ™
Molecule with lightening properties.
LUMISKIN™
Upstream regulation of tyrosinase synthesis for a brightening effect on dark skin.
LUMISPHERE™
Instant and long term skin brightener with a soft focus effect on lines, pores and imperfections.
MELACLEAR 2 NP ™
Soft depigmentation by enzymatic peeling combined with melanin synthesis regulation.

Calming - Sensitive skin

NG SHEA
Soothes inflammation by strengthening the epidermis and restoring the barrier function.
UNSAPONIFIABLE™
BACOCALMINE PH™
Ayurvedic care for reactive and sensitive skin.
CENTAURIUM EL ™
Anti-inflammatory, protection of elastin and hyaluronic acid.
PACIFEEL™
Addresses both signs (unpleasant sensations, redness, dryness) and causes of sensitive and reactive skin.
SIEGESBECKIA PH™
Anti-inflammatory, protection of collagen.
CALMOSENSINE SP ™
Messenger of happiness and muscle relaxation. Modulates perception of unpleasant sensations, enhances well being,
alleviates tension to prevent the onset of expression lines and wrinkles.
SUBLISKIN™
Comfort and reinforcement of thin and fragile skin. **

Energising
CHRONODYN™
Chronobiological cell energiser, tones and firms the skin, reduces signs of fatigue.
OXYLASTIL PH® ™
Cell oxygenation for an anti-ageing efficacy.
HYDRERGY PH™
Moisturising and energising, rich in vitamins. Smoothing effect.
ENERGISOME Q10 PH™
Vectorised Coenzyme Q10, stimulation of cell respiration.

Environmental protection
CITYSTEM™
Fights against visible and invisible pollution damage to the skin. Protects, removes, strengthens and repairs.
VENUCEANE™
Anti-ageing active offering protection against both UV and IR damage.
BACOCALMINE PH ™
Free radical scavenger, protects from inflammation.
MˇEIRITAGE ™
Reinforces the barrier function and counteracts the oxidative stress from UV and pollution.
NG SHEA BUTTER™
Soothes, regenerates and protects the skin from external aggressions.
OSMOPUR ™
Protecting complex against smoke and heavy metals.
PACIFEEL™
Improves skin resilience, helps sensitive and reactive skin to fight against
environmental aggressions.
FRUITBIO™
A natural treatment against pollution particle adhesion on the hair.
ECODERMINE™
Preservation and restoration of skin’s ecosystem.
RESISTEM ®
Stimulates skin hormetic defence to promote detoxification and tissue regeneration.
Lip care ORIGIN FORMULATION IECIC

NG SHEA
Repairs damaged lips. Rich in unsaponifiables.
UNSAPONIFIABLE™
MAXI-LIP™
Brings volume and moisture, smoothes lip contours.
VOLULIP ™
Lip plumper with anti-ageing and hydration effects.

Moisturising & Nourishing

NG SHEA
Strengthens the epidermis, restores barrier function and improves moisture level.
UNSAPONIFIABLE™
HYDRAPROTECTOL SP™
All the benefits of snail mucus for a long-lasting and in-depth hydration.
DNA GEL PH ™
Moisturising and cell repair for skin elasticity and suppleness recovery.
ICHTYOCOLLAGEN PH™
Native fish collagen with film-forming and moisturising properties.
OLIGOCEANE PH™
Provides oligo-elements and mineral salts for the maintenance of cellular life.
BIRCH SAP PH
™
Oligo-elements for cutaneous firmness and moisturisation, especially for men.
LIPEXEL™
Compensates cutaneous lipid deficiencies, decreases water loss,; also tested in loose powder for make-up application.
MOIST 24 PH™ *
24-hour long-lasting moisturiser, creates water supplies.
VEGESOME® MOIST 24™
Adds moisturising benefits to powder make-up. Powder

CERAMIDE 2™
Cutaneous barrier regeneration, identical to natural ceramide of the skin.
CERAMIDE HO3™
Reinforcement of the cutaneous barrier and of the cellular cohesion
OSMOCIDE 4 ™
Moisturises and allows to formulate with less preservatives.
AQUALANCE™
Osmoprotectant skin moisturiser for a progressive rehydration of the various skin layers.
REVIDRATE®
Recreates the skin’s own natural moisture by supporting the water and lipid balance in the epidermis.

Radiance
KOMBUCHKA PH™
Improvement in skin quality (smoothing, radiance), anti-glycation, lipofilling effect.
PHYTOTONINE™
Regulates the cutaneous microcirculation to reduce skin redness and improve luminosity.
PRODIZIA® Promotes a visible reduction of cutaneous signs of fatigue caused by glycation and
glycoxidation.
NP DIVATONYL™
Refines skin grain for a mattifying effect and radiance enhancement.
RESISTEM ®
Decreases skin redness and enhances natural skin glow thanks to an hormesis-like
mechanism.
CHROMOCARE™
Evens and rejuvenates skin complexion by fighting against oxidative stress.

Seboregulating
SEBULESS®
Mattifies and equalises skin complexion of oily and acne-prone skin.
NORMASEB PH ™
Normalisation of the sebaceous activity.
SEBOMINE SB12 PF™
Regulates the cutaneous microflora of oily and acne-prone skin.
EVERMAT™
Pore size, skin shine and sebum flow reduction.
AC.NET ™
Holistic treatment for oily and acne-prone skin.
Hair care ORIGIN FORMULATION IECIC

APISCALP™
Restores scalp integrity to provide purity and comfort for a happy scalp.
FRUITBIO™
Smoothes the hair cuticles to strengthen and protect the hair fibre.
HELIOGENOL™
Protects against free radical damage on dyed and natural hair.
CAPILECTINE SP™
“Growth factor like” ingredient for the stimulation of hair growth and vitality.
CERAMIDE A2 PH ™
Reinforces hair sheath; protects and repairs hair from chemical aggressions.
HAIRSPA™
Soothes and moisturises the scalp, relieves scalp discomfort.
CAPIGEN SP™
Prevention of hair loss and normalisation of sebum secretion.
PROCAPIL ®
Prevents hair follicle ageing to help fight against premature hair loss.

Pilosity
CAPISLOW PH™
Moderates regrowth of unwanted body hair. Anti-inflammatory effect.
KELISOFT™ *
Slows down hair growth speed, refines hair diameter and calms down inflammation.

Silhouette sculpture
LEGANCE®
Global anti-ageing for legs, improves the appearance and comfort of the legs.
ZINGERSLIM®
Oil soluble fat burner, encourages drainage of fat.
ESCULOSIDE™
Pure molecule with veinotonic and anti-inflammatory properties.
PHYTOTONINE ™
Microcirculation regulation to relieve heavy legs.
PLEURIMINCYL™
Medicinal Chinese plant stimulating lipolysis through Protein G activation.
REDULITE™
Fights against water retention.
UNISLIM PH ™
Contouring effect for men and women by a cholesterol-mimetic action.
VOLUFILINE™
Helps promote body volume by stimulating adipose tissue formation.
LIPOCARE™
Reduces «orange peel» appearance of skin and increases skin firmness.
BIO-BUSTYL PH ™
Bust and body firming complex.
BODYFIT™
Fights against adipose tissue by cellular reverse differentiation.
OVALISS™
Reduces and contours the double chin.
VEXEL SP ™
Firming and slimming nanovesicles.
INTENSLIM®
Natural fat burner, fights fat accumulation, particularly on the stomach area.
PHYTOSONIC™
Adipocyte shedding by ultrasound-like effect.

Stretch marks
REGESTRIL™
Association of two matrikines to prevent and repair stretch marks.
DARUTOSIDE™
Ethnobotanical molecule to prevent and repair stretch marks. **

Tan accelerator
TYR-EXCEL™
Promotes tanning speed and intensity. Improves moisture retention.
 sederma

SEDERMA SAS
29 rue du Chemin Vert
F-78612 Le Perray en Yvelines cedex
tel ++ 33 1 34 84 10 10 fax ++ 33 1 34 84 11 30
sederma@sederma.fr www.sederma.com

SEDERMA Inc
300 Columbus Circle
Edison NJ 08837 USA
tel ++ 1 (732) 692 1652 fax ++ 1 (732) 417 0804
sederma-usa@croda.com www.sederma.com

SEDERMA GmbH
Herrenpfad-Süd 33
41334 Nettetal Germany
tel ++ 49 21 57 817318 fax ++ 49 21 57 817361
sederma@sederma.de www.sederma.com

Non-warranty: The information in this publication is believed to be accurate and is given in

good faith, but no representation or warranty as to its completeness or accuracy is made.
Suggestions for uses or applications are only opinions. Users are responsible for determining
the suitability of these products for their own particular purpose. No representation or
warranty, expressed or implied, is made with respect to information or products including,
without limitation, warranties of merchantability, fitness for a particular purpose, non-
infringement of any third party patent or other intellectual property rights including, without Member of Croda International Plc.
limit, copyright, trademark and designs. Any trademarks identified herein, unless otherwise
noted, are trademarks of the Croda group of companies. ©2016 Sederma

Printed April 2016 03/16 PCS PG 025 V2 EN