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Specific Mental Health Disorders: Child and Adolescent Mental Disorders 147

Further Reading Relevant Websites

McKee M, MacLehose L and Nolte E (eds.) (2004) Health http://www.aspher.org – Association of Schools of Public Health in the
Policy and European Union Enlargement. European European Region (ASPHER).
Observatory on Health Care Systems. Maidenhead, UK: Open http://www.eupha.org – European Public Health Association (EUPHA).
University Press. http://www.snz.hr/ph-see – Public Health Collaboration in South
Mossialos E, Dixon A, Figueras J and Kutzin J (eds.) (2002) Funding Eastern Europe (PH-SEE): A project of the Stability Pact.
Health Care: Options for Europe. European Observatory on Health http://www.euro.who.int/hfadb – World Health Organization. Health for
Care Systems. Maidenhead, UK: Open University Press. All Database. WHO.

Specific Mental Health Disorders: Child and Adolescent Mental


Disorders
A J Flisher, S Hatherill, and Y Dhansay, University of Cape Town, Cape Town, South Africa
ã 2008 Elsevier Inc. All rights reserved.

Introduction exemplifies the complex interaction of risk and protective


factors at different ecological levels (Table 3) (World
Reviews of the prevalence of child and adolescent psychi- Health Organization, 2005b).
atric disorders indicate that about one in five children and
adolescents suffer from such disorders (Table 1) some
examples of which are provided in Table 2 (World Health Public Health Significance
Organization, 2005b; Patel et al., 2008 ). This estimate
appears to be applicable to both genders, a range of ages It is important to recognize that these disorders do not
within childhood and adolescence, all social classes, and represent minor and transient responses to the normal
both high-, low-, and middle-income countries. In this challenges faced by children and adolescents. If this were
article, we have confined ourselves to psychiatric disor- the case, child and adolescent mental disorders would
ders in the narrow sense of the term. We have not have limited public health significance. On the contrary,
addressed intellectual or learning disabilities. they are associated with a great degree of impairment and
burden, longitudinal course into adulthood, long-term
economic implications, associations with risk behavior,
Etiology and stigma, each of which will be addressed below.

Whether a mental disorder develops in an individual and


Impairment and Burden
arises depends on the interplay between risk and protec-
tive factors. Risk factors are factors that increase the The term impairment refers to interference with psycho-
probability of developing a mental disorder, while protec- logical or physical functions in one or more of the follow-
tive factors moderate the effects of exposure to risk in the ing domains: Interpersonal relationships, academic/work
presence of one or more risk factors. For example, a performance, social and leisure activities, and the ability
person may have a strong family history of depression to enjoy and obtain satisfaction from life. By definition,
and thus be genetically predisposed to suffer from depres- impairment always accompanies the presence of a psychi-
sion. Loss of a parent in adolescence may serve as another atric disorder, as impairment is a necessary condition for
risk factor, which may then precipitate a major depressive existence of a psychiatric disorder according to the diag-
episode. However, if such a person has strong connections nostic systems in common use. Indeed, if impairment is
with other family members, school, and community, such not included in the diagnostic criteria, the prevalence of
a depressive episode may be averted. In this case, the child and adolescent psychiatric disorders in the general
adolescent may experience a normal grieving process, population would be two or three times the generally
which does not significantly adversely affect academic accepted prevalence. However, the extent of impairment
progress, relationships with peers, and physiological con- varies according to diagnosis, with phobias being the least
comitants such as appetite disturbance and fatigue. This likely to be associated with impairment, followed by anxiety
148 Specific Mental Health Disorders: Child and Adolescent Mental Disorders

Table 1 Selected studies of the prevalence of child and childhood and adolescence specifically. However, among
adolescent psychiatric disorders in children and adolescents 15–44-year-olds, we know that five of the ten leading
Age range Prevalence causes of DALYs lost are psychiatric disorders (unipolar
Setting (years) (%) depressive disorders, alcohol use disorders, self-inflicted
injuries, schizophrenia, and bipolar mood disorder) (Murray
Australia 18–24 27.0
Brazil 7–14 12.7
and Lopez, 1996). Furthermore, there is an important
Canada, Ontario 4–16 18.1 mental health or behavioral contribution to the etiology
Ethiopia 1–15 17.7 of a further three of the ten leading causes DALYs lost
Germany 12–15 20.7 (HIV/AIDS, road-traffic accidents, and violence). It is
India 1–16 12.8 probable that similar findings are applicable to child-
Hawaii 13–19 26.0
Japan 1–16 15.0
hood and adolescence. Such data have contributed to an
Netherlands 13–18 8.4 increased appreciation of the public health importance of
Spain 8, 11, 15 21.7 psychiatric disorders.
Switzerland 1–15 22.5
United Kingdom 13–15 29.4
United States
. High-risk Native Americans, 14–16 29.4 Longitudinal Course of Mental Disorders in
Northern Plain reservation Childhood and Adolescence
. North Carolina 13 12.7
14 9.7 There are two types of studies that address the longitudi-
15 14.2 nal course of child and adolescent psychiatric disorders.
16 12.7
. Service users in five sectors of
First, there are studies that look back, by documenting the
12–15 57.4
care, San Diego, CA proportions of people with disorders in adulthood that
had an age of onset in childhood or adolescence. The most
Data from Patel V, Flisher AJ, Nikapota A, and Malhotra S (2008) sophisticated of these studies was conducted by Kessler
Promoting child and adolescent mental health in low and middle
income countries. Journal of Child Psychology and Psychiatry;
et al. (2005). They reported that 75% of all adults with
World Health Organization (2005b) Child and Adolescent Mental psychiatric disorder had an age of onset of 24 years or less,
Health Policies and Plans: Mental Health Policy and Service 50% had an age of onset of 14 years or less, and 25% had
Guidance Package. Geneva: World Health Organization and cita- an age of onset of 7 years or less. For anxiety disorders, the
tions therein. corresponding ages were 21, 11, and 6 years or less.
Second, there are studies that look forward. There is
disorders and finally major depressive disorder and exter- good evidence of continuity of disorders that manifest
nalizing disorders such as conduct disorder and attention themselves in childhood or adolescence into adulthood.
deficit hyperactivity disorder. Furthermore, the extent of In major depressive disorder, for example, depressed ado-
impairment is correlated with factors, independent of the lescents are at two to seven times increased odds of being
nature of the psychiatric disorder. These include the extent depressed as adults. Furthermore, about one-third of chil-
of comorbidity, either a long or short duration of psycho- dren or adolescents with a major depressive disorder will
pathology, psychosocial adversity (in generalized anxiety later develop bipolar disorder, and this is more likely
disorder), and mothers’ ratings of the extent of conduct if there is a family history of bipolar disorder, psy-
features (in children with conduct disorder). chotic symptoms, or a manic response to antidepressants.
Angold et al. (1998) reported that there is a positive Attention deficit hyperactivity disorder has three possible
association between impairment and parental perceived outcomes in adulthood, each of which occurs in about
burden of care, although the direction of the causality has one-third of children with the disorder: (1) Develop-
yet to be elucidated. The perceived burden of care was mental delay, in which over the course of time the individ-
predicted by the child or adolescent’s total symptom ual no longer manifests impairing symptoms; (2) continual
score, the child or adolescent’s level of impairment, the display, in which impairment related to ADHD persists
presence of externalizing disorders (as opposed to inter- into adulthood, although there are insufficient signs and
nalizing disorders), and the existence of preexisting men- symptoms for the diagnosis to be conferred; and (3) devel-
tal health problems on the part of the parent. opmental decay, in which the diagnosis remains applicable
A further aspect of burden is the burden imposed by in adulthood, often accompanied by other psychopathol-
the disability suffered by the child or adolescent with ogy such as substance abuse and personality disorder.
a psychiatric disorder. This can be quantified by the Autistic disorder almost always is associated with lifelong
disability-adjusted life years (DALYs) that are lost, which impairment. However, there is considerable variation in
includes loss due to both mortality and disability, for outcome, with about 15% achieving independence in
each disorder. We do not have estimates of the DALYs adulthood and a further 15–20% being able to function
lost due to child and adolescent psychiatric disorders in independently with periodic support.
Specific Mental Health Disorders: Child and Adolescent Mental Disorders 149

Table 2 Examples of some common and/or important child and adolescent mental disorders

Attention deficit hyperactivity A persistent pattern of inattention and/or hyperactivity-impulsivity that is more frequent and severe
disorder (ADHD) than typically observed in children at a comparable level of development
Autistic disorder The essential features are onset before the age of three; qualitative impairment in social
interaction; qualitative impairment of verbal and nonverbal communication; and disturbed
motor behavior or activities as manifest, for example, by stereotyped body movements
Conduct disorder Repetitive and persistent pattern of behavior, lasting at least 12 months, in which the basic rights
of others and major age-appropriate societal norms or rules are violated
Delirium Transient and usually reversible mental disturbance that has fluctuating symptoms that usually
develop over hours or days. Clinical features include the following: fluctuating awareness and
attention; disturbed sleep–wake cycle; restlessness, irritability, anxiety, emotional lability OR
decreased psychomotor activity; disorientation; disorganized thinking; memory impairment;
and hallucinations and other perceptual disturbances
Generalized anxiety disorder The essential feature of this disorder is excessive or unrealistic anxiety or worry, for example about
achieving and about future events such as wars or world catastrophes
Major depressive disorder A major depressive disorder is present if there is an onset of either depressed or irritable mood or loss
of interest in former pleasurable activities lasting for a period of at least 2 weeks, accompanied by
several of the following: increased or decreased appetite; insomnia or hypersomnia; increased or
decreased motor activity; difficulty concentrating with fall-off in school work; feelings of
worthlessness or guilt; fatigue or loss of energy; and suicidal thoughts or behavior
Obsessive-compulsive disorder In this disorder, there is the presence of obsessions or compulsions or both, which are recognized
as excessive or unreasonable
Panic disorder There are recurrent panic attacks in which intense fear is accompanied by acute somatic
symptoms of anxiety
Posttraumatic stress disorder This disorder is present if there are recurrent, distressing, and intrusive images or flashbacks of the
(PTSD) traumatic experience; marked avoidance of particular people, places, or other reminders of the
experience; and symptoms of anxiety or increased sympathetic arousal as manifest, for
example, by difficulty sleeping, poor concentration, exaggerated startle response, and
restlessness. Depression, anxiety, and conduct disorder may accompany PTSD, or be an
alternative outcome to traumatic experiences
Schizophrenia In schizophrenia one finds delusions, hallucinations, disorganized speech, catatonic behavior, and
negative symptoms
Separation anxiety disorder There is excessive and persistent anxiety (lasting for at least 4 weeks) about separation from those
to whom the child is attached

In conclusion, there is evidence from retrospective and long-term economic implications of child and adolescent
prospective studies of considerable continuity of psychi- psychiatric disorders are scanty and confined to the direct
atric disorders from childhood to adulthood. This clearly costs of a subset of disorders in the US and the UK (Romeo
provides support for increased resources to be allocated to et al., 2005). However, the existing data confirm that the
child and adolescent psychiatric services, although evi- long-term costs associated with child and adolescent psy-
dence is currently sparse that early intervention will chiatric disorders are large. For example, the treatment
result in improved long-term prospects. costs for youth with ADHD are approximately double
those for youth without ADHD; the cumulative costs of
public services utilized through to adulthood by indivi-
Long-Term Economic Implications of Child and
duals with antisocial behavior in childhood were ten
Adolescent Mental Disorders
times higher than for those with no antisocial behaviors
Given the continuity of psychiatric disorders from child- by the age of 28 years, and the annualized cost in adulthood
hood or adolescence into adulthood, one would expect for those who suffered from both depression and conduct
that there would also be economic implications of child disorder was more than double that of the group with major
and adolescent psychiatric disorders that would persist depression alone (Romeo et al., 2005).
into adulthood. Such economic costs can be direct or It can be seen that the potential economic impact of
indirect. The former are generally easier to evaluate and successfully implementing proven prevention and early
reflect pharmaceutical costs, primary health-care costs, intervention strategies for children with disruptive behav-
emergency department visits, and outpatient and inpatient ior disorders is enormous (World Health Organization,
care. The latter are generally more difficult to evaluate and 2005b). The characteristically recurring nature of the
reflect the caregiver costs, unemployment, decreased pro- mood disorders and the strong evidence for their conti-
ductivity, and increased demand on the education, social nuity into adult life would seem to suggest an equally
services, and criminal justice systems. Existing data on the compelling argument for early intervention and even
150 Specific Mental Health Disorders: Child and Adolescent Mental Disorders

Table 3 Selected risk and protective factors for mental health of children and adolescents

Domain Risk factors Protective factors

Biological Exposure to toxins (e.g., tobacco and alcohol) in Age-appropriate physical development
pregnancy Good physical health
Genetic predisposition Good intellectual functioning
Head trauma
Hypoxia at birth and other birth complications
HIV infection
Malnutrition
Other illnesses
Psychological Learning disorders Ability to learn from experiences
Maladaptive personality traits Good self-esteem
Sexual, physical, and emotional abuse and neglect High level of problem-solving ability
Difficult temperament Social skills
Social
a) Family Inconsistent care giving Family attachment
Family conflict Opportunities for positive involvement in family
Poor family discipline Rewards for involvement in family
Poor family management
Death of a family member
b) School Academic failure Opportunities for involvement in school life
Failure of schools to provide an appropriate Positive reinforcement from academic achievement
environment to support attendance and learning Identity with a school or need for educational
Inadequate/inappropriate provision of education attainment
c) Community Lack of community efficacy Connectedness to community
Community disorganization Opportunities for constructive use of leisure
Discrimination and marginalization Positive cultural experiences
Exposure to violence Positive role models
Lack of a sense of place Rewards for community involvement
Transitions (e.g., urbanization) Connection with community organizations including
religious organizations

From World Health Organization (2005b) Child and Adolescent Mental Health Policies and Plans: Mental Health Policy and Service
Guidance Package. Geneva: World Health Organization.

prevention in an effort to divert children from a possible treatment interventions that address either risk behavior
trajectory of lifelong difficulties associated with substan- or psychiatric disorders would benefit from addressing the
tial individual and societal costs. other aspect.

Associations with Risk Behavior Stigma


There is robust international evidence that there is The term stigma is derived from a Greek word and refers
covariation between risk behaviors such as violent behav- to a mark that denotes a shameful quality in the individual
ior, sexual behavior, suicidal behavior, dangerous road- thus marked. It is a complex phenomenon that is modified
related behavior, and use of tobacco, alcohol, and other by the culture and contexts in which it occurs. There are
drugs (Flisher et al., 2000). Furthermore, this cluster of risk five interrelated processes that combine to create stigma:
behaviors appears to share common correlates, for exam- (1) people identify and label human characteristics, and
ple psychiatric disorder (Flisher et al., 2000). This has been differences that are regarded as relevant and consequen-
established both for the cluster as a whole and individual tial are determined; (2) stereotyping takes place in that
components of the cluster. What is not clear is the direc- the labeled person is associated with undesirable charac-
tion of the causal relationship. Thus, the psychiatric disor- teristics; (3) there is separation of the stigmatized group
der could cause the risk behavior or the risk behavior could (them) from those who are stigmatizing (us); (4) the stig-
cause the psychiatric disorder or they could both be caused matized group experiences discrimination and loss of sta-
by other factors. It is probable that the nature of the rela- tus; and (5) the stigmatizing group exercises power. The
tionship varies according to the particular risk behaviors association of mental illness with irrational, dangerous, and
and psychiatric disorders in question. However, whatever unpredictable behavior and the misconception that mental
the nature of the relationship, there are clear implications illness is not a true illness has resulted in those with psy-
for public health. Specifically, preventive, promotive, or chiatric disorders being subject to stigmatization.
Specific Mental Health Disorders: Child and Adolescent Mental Disorders 151

Psychiatric patients and their families are doubly Table 4 Examples of child and adolescent mental health
challenged: They are faced with the struggle caused by promotion interventions
their impairment and they are confronted with chronic Domain Interventions
stress caused by the stigma that is associated with psychiat-
ric disorders. As a result of these challenges, they are Strengthening Develop self-efficacy (the perception that
individuals one can achieve desired goals through
deprived of the opportunities such as good schooling and one’s own action)
wide social networks, which in turn adversely affect self- Encourage self-determination
esteem, and hence academic performance and economic Enhance life skills of adolescents
well-being. Children and adolescents are particularly vul- Foster belief in the future
nerable to stigma for four main reasons (World Health Improve the quality of parent–infant
relationship
Organization, 2005b): Nurture a clear and positive identity
. They are less likely to be able to advocate on their own Promote competencies in the social,
emotional, cognitive, behavioral, and
behalf; moral domains
. Immature cognitive development results in children and Recognize positive behavior
adolescents being more likely to think dichotomously Strengthening Develop facilities and structures to enable
about opposites such as good and bad, and thus more communities constructive and healthy use of leisure
likely to temper negative with other, less negative or time of children and adolescents
Establish prosocial norms
positive, responses, and hence accept negative labels; Improve social connectedness of schools
. The stigma suffered by children and adolescents may and neighborhoods
also affect the parents, which in turn could affect the Promote bonding (emotional attachment
quality of parenting that they are able to offer; and commitment) with family, peer group,
. There is limited understanding of child and adolescent school, community, and culture
Provide opportunities for prosocial
psychiatric disorders, which implies that symptoms that involvement with family, peers, and adults
are attributable to a psychiatric disorder may be attrib- Removing Develop and implement economic policies
uted to other causes, such as passive aggression in the case barriers to that reduce poverty
of depression or overt oppositionality in the case of good mental Develop and implement legislation that
attention deficit hyperactivity disorder; and their psychi- health protects the human rights of children and
adolescents, for example around
atric disorders may persist into adulthood, which implies trafficking and sexual and physical abuse
that any effects of stigma may persist for equally long. Improve access to good-quality education
and health services

Interventions for Child and Adolescent Funk M, Gale E, Grigg M, Minoletti A, and Yasamay MT (2005)
Mental Disorders Mental health promotion: An important component of a national
mental health policy. In: Herman H, Saxena S, and Moodie R (eds.)
Mental Health Promotion Promotion Mental Health: Concepts, Emerging Evidence, Practice,
pp. 216–225. Geneva, Switzerland: World Health Organization.
The aim of mental health promotion is to enhance posi-
tive mental health, which can be defined as the:
reducing the prevalence of child and adolescent mental
. . . capacity to achieve and maintain optimal psychologi-
disorders. However, the empirical justification for this
cal functioning and well-being. It is directly related to the
statement is currently somewhat flimsy, partly because
level reached and competence reached and competence
of the methodological challenges of demonstrating out-
achieved in psychological and social functioning . . .
comes of upstream interventions (such as those men-
Child and adolescent mental health includes a sense of
tioned above) on downstream outcomes such as specific
identity and self-worth; sound family and peer relation-
disorders in specific individuals (Patel et al., 2008).
ships; an ability to be productive and to learn; and a
capacity to use developmental challenges and cultural
resources to maximize development (Department of Mental Disorder Prevention
Health, Republic of South Africa, 2003: 4).
In contrast to mental heath promotion, mental disorder
The focus is on enhancing protective factors through prevention aims to reduce the prevalence of specific dis-
goals such as strengthening individuals, strengthening orders, by focusing on risk factors. There are a number of
communities, and removing barriers to good mental interventions for specific disorders that have been shown
health (Table 4) (Funk et al., 2005). What is the relevance to be effective, at least for populations in high-income
of mental health promotion for child and adolescent countries. Examples of disorders and interventions that
mental disorders? The relevance is that mental health have been shown to be effective include (Durlak and
promotion interventions arguably also contribute to Wells, 1997; World Health Organization, 2004):
152 Specific Mental Health Disorders: Child and Adolescent Mental Disorders

. Alcohol misuse: School-based individual-level education address the gap between the need for interventions and
and skills training combined with a mass media cam- the available services. Only 7% of countries worldwide
paign, parent education and organization program, train- had a clearly articulated, stand-alone child and adolescent
ing community leaders and local policy changes; mental health policy (World Health Organization, 2005a).
. Anxiety: Teaching skills to manage anxiety symptoms However, a larger proportion of countries have child
more effectively; and adolescent mental health content integrated into
. Conduct disorder: Child or adolescent behavior manage- other policies, and/or have child and adolescent mental
ment, social skills for child or adolescent, multimodal health programs. The proportions of counties with any
school programs, and prenatal or early childhood child and adolescent mental health policy or programs are
programs; lowest in the Africa region, where 33% have the former
. Depression: Improving cognitive and problem-solving (generally integrated into policy documents from other
skills, group interventions that focus on cognitive style sectors such as child protection, social welfare, education,
and problem solving; or human rights), while 6% have the latter (World Health
. Pathological eating behavior: Increasing self-esteem Organization, 2005a). The corresponding figures for
and improving general eating habits and behavior; Europe are 96% and 67%. It is ironic that those countries
. Schizophrenia: Low-dose neuroleptic medication and with the largest proportion of children and adolescents
cognitive behavior therapy; are least likely to have a child and adolescent mental
. Suicide: School-based intervention with school suicide health policy. Other selected key aspects of the current
policy, teacher consultation and training, education to situation include:
parents, stress management and life skills curriculum,
. There are no countries that have a data information
and a crisis team.
system for child and adolescent mental health service
outcomes at the national level.
. In the vast majority of countries outside of North
Treatment America and Europe, systems for the care of children
It is important to develop a comprehensive treatment plan and adolescents with mental disorders do not exist, and
for each child or adolescent and the family, which requires when they do exist they are based in hospitals or custo-
psychiatric services. This plan should: dial settings with minimal or no community-based
services.
. address each problem or disorder that was identified in . Even when services are present, there are consider-
the assessment; able barriers to accessing it, such as stigma, lack of trans-
. aim to modify all modifiable etiological factors in the portation, inability to pay for services, inability of the
biological, psychological, and social domains; service providers to communicate effectively in the ser-
. involve both the family and the child or adolescent in vice users’ home language, and lack of public knowledge
treatment; about mental disorders in children and adolescents.
. include all contributory settings, especially the school; . In countries in all economic categories, these services are
. make use of the unique contributions of all appropriate generally paid for by temporary and vulnerable sources
members of the clinical team. of funding such as the service user (or their family),
There is a rapidly expanding evidence base on the nongovernmental organizations and international grants,
efficacy and effectiveness of interventions for child and as opposed to more stable government funding.
adolescent mental disorders. Specifically, there is good
evidence of the effectiveness of certain antidepressant
and antipsychotic agents and of psychotherapy (especially The Way Forward
behavioral and cognitive behavioral treatments for anxi-
ety and mood disorders) (Evans et al., 2005). The first step in responding to the scenario is to develop a
child and adolescent mental health policy with an asso-
ciated plan. The WHO has published a guideline on how to
The Current Response develop a child and adolescent mental health policy and
plan (World Health Organization, 2005b), which provides a
We have argued above that the public health significance step-by-step approach that can be used by policy makers
of child and adolescent mental disorders is enormous, and and planners. The steps for developing a policy are as
that there is evidence that preventive and treatment inter- follows: gather information and data for policy development;
ventions (at least) can be effective. In light of these con- gather evidence for effective strategies; undertake consulta-
siderations, the response on the part of the health and tion and negotiation; exchange with other countries; set
other systems has been insufficient to meaningfully out the vision, values, principles and objectives of the
Specific Mental Health Disorders: Child and Adolescent Mental Disorders 153

policy; determine the areas for action; and identify the roles mental disorders presenting for the first time in childhood
and responsibilities of the various stakeholders. The steps and adolescence represent serious conditions associated
for developing a plan are as follows: determine the strategies with markedly impaired functioning and significantly
and time frames; set indicators and targets; determine the lower quality of life, for both the child or adolescent and
manor activities; and determine the costs, available their families. Even child or adolescent disorders tradi-
resources and the budget. The plan should be backed up tionally viewed as mild, such as the anxiety disorders, are
by sufficient resources and political will to ensure wide- increasingly being construed as possible precursors of
spread implementation. more serious and enduring mental health problems. In a
It is not appropriate to specify in detail the outcomes of substantial proportion of cases, psychiatric diagnosis in
the process of developing policies and plans for a country, childhood or adolescence foreshadows psychiatric diag-
province, region, or district. Indeed, as is obvious from the nosis in adulthood. An alternative view would suggest that
steps that have just been listed, this would contradict the child and adolescent psychiatric disorders provide us with
letter and spirit of the guidelines. However, a broad con- a tantalizing window of opportunity for changing this
sensus has emerged in recent years as to the key standards gloomy trajectory. The exciting challenge for child mental
that should characterize a child and adolescent mental health services is the prevention and early detection of
health service, whether in a high-, middle-, or low- these disorders; the implementation of evidence-based
income country, which are summarized in Table 5. interventions with both short- and long-term clinical
and cost effectiveness; and the development of mental
health systems that ensure equitable access to such inter-
Conclusion ventions. We are in the earliest stages of meeting this
challenge and exploiting this opportunity.
Far from being minor or transient variations in response
to childhood adversity, or a medicalization of society’s
intolerance of challenging childhood behaviors or inade- See also: Adolescent Health; Child Abuse/Treatment;
quate parenting, it has become increasingly apparent that Mental Health and Substance Abuse; Mental Health
Policy; Mental Illness, Historical Views of; School Health
Table 5 Key standards for child and adolescent mental Promotion; Social Gradients and Child Health; Specific
health service planning and provision
Mental Health Disorders: Eating Disorders; Specific
Core features of child and adolescent mental health services Mental Health Disorders: Mental Disorders Associated
. Include child and adolescent mental health in primary health With Aging; Specific Mental Health Disorders: Trauma
care practices
and Mental Disorders.
. Provide a continuum of services
. Balance promotion, prevention, treatment, and rehabilitation
. Prioritize children and adolescent most at risk
Evidence and service planning
. Assess levels of service provision and need regularly Citations
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Specific Mental Health Disorders: Depressive and Anxiety Disorders


I B Hickie, The University of Sydney, Sydney, NSW, Australia
ã 2008 Elsevier Inc. All rights reserved.

Introduction everyday clinical practice. For example, simple checklists


can be widely circulated through e-health, media, print,
Following the development of standardized diagnostic and health-care distribution systems (see Figure 1 for an
systems in the early 1980s (e.g., Research Diagnostic example from the SPHERE-program in Australia).
Criteria of Spitzer and colleagues and the DSM-III of Clinical debate as to the best ways to describe the rela-
the American Psychiatric Association) and their incor- tionship between different anxious and depressive pheno-
poration into large-scale epidemiological studies, there types (e.g., mixed anxiety and depression, generalized
has been widespread acceptance of the dimensional nature anxiety and its relationship to dysthymia (symptoms of
of the common anxiety and depressive disorders. Such depression), and major depression), and between different
dimensional concepts can be readily incorporated into depressive dimensions (e.g., major versus minor depres-
large-scale population-health and health service develop- sion and unipolar versus bipolar spectrum disorders) will
ment plans. Importantly, they place an emphasis on detec- continue until more discrete pathophysiological pathways
tion and active management of the very common mild and are identified. The development of future international
moderately severe cases. In this environment, the center diagnostic systems (e.g., DSM-V) has signaled this neces-
of clinical management is shifted from specialist care set- sary move from over reliance on imprecise cross-sectional
tings (for more severe, prolonged, treatment-resistant, phenotypes to diagnostic categories based on putative
comorbid and medically complicated) to primary care. causal paths.
These broad concepts of depression and anxiety have A great deal of academic effort has been expended in
predictive value for key outcomes such as response to epidemiological and clinical studies that seek to differen-
available treatments, disability, and premature death. They tiate anxiety from depressive disorders or subtype the
incorporate the key symptom domains (e.g., affective, cog- multiple and complex presentations of these conditions.
nitive, sleep–wake cycle, somatic, behavioral, and self- These efforts have reflected traditional but simplistic
harm) and they can also be readily incorporated into belief systems about causality (e.g., psychosocial vs. bio-
public and professional education campaigns as well as logical) or the relevance of subtyping to the selection

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