Thioridazine

Definisi : Thioridazine hydrochloride is 2-methylmercapto-10-[2-(N-methyl-2-piperidyl) ethyl]

phenothiazine

Function : Thioridazine hydrochloride tablets are indicated for the management of schizophrenic
patients who fail to respond adequately to treatment with other antipsychotic drugs. Due to the risk of
significant,potentially life threatening, proarrhythmic effects with thioridazine treatment,
thioridazinehydrochloride tablets should be used only in patients who have failed to respond adequately
to treatmentwith appropriate courses of other antipsychotic drugs, either because of insufficient
effectiveness orthe inability to achieve an effective dose due to intolerable adverse effects from those
drugs.Consequently, before initiating treatment with thioridazine hydrochloride tablets, it is
stronglyrecommended that a patient be given at least two trials, each with a different antipsychotic drug
product,at an adequate dose, and for an adequate duration (see WARNINGS and
CONTRAINDICATIONS).However, the prescriber should be aware that thioridazine hydrochloride tablets
have not beensystematically evaluated in controlled trials in treatment refractory schizophrenic patients
and itsefficacy in such patients is unknown.

Dossage

Adult : PO Initial: 50-100 mg tid, gradually increased if necessary. Usual daily dose: 200-800 mg in 2-4
divided doses. Max: 800 mg/day

Contraindication

Patients w/ reduced levels of CYP2D6 isoenzyme, congenital long QT syndrome or history of cardiac
arrhythmias; severe CNS depression or comatose states of any cause; hypertensive or hypotensive heart
disease of extreme degree. Concomitant use w/ drugs that prolong QTc interval, CYP2D6 isoenzyme
inhibitors and drugs which reduce thioridazine clearance by other mechanisms.

Indication :skizofrenia

Golongan :antipsikotik golongan C