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Table 1. Comparison of frequency, relative frequency and average of menses pain intensity before and after receiving fish
oil separately in first, second and two months after finishing treatment.
Group Before use After use (1stm) After use (2stm) Two month after
finishing use
Pain intensity frequency Percent frequency percent frequency percent frequency Percent
Very low 0 0.0 0 0.0 16 26.7 30 50
low 0 0.0 25 41.7 29 48.3 28 46.7
moderate 40 66.7 25 41.7 15 25 2 3
sever 20 33.3 10 16.7 0 0.0 0 0.0
total 60 100 60 100 60 100 60 100
mean 3.74 0.13 1.89 1.36
P value 0.0001 0.0001 0.0001 0.0001
Caspian J Intern Med 2 (3): Summer 2011
Comparison of the effect of fish oil and ibuprofen … 281
Table 2. Comparison of frequency, relative frequency and average of mense pain intensity before and after receiving
ibuprofen separately in 1st, 2nd and two month after finishing treatment.
Group Before use After use (1stm) After use (2stm) Two month after
finishing
Pain intensity frequency percent frequency percent frequency percent frequency percent
Very low 0 0.0 9 25 10 16.6 16 26.6
low 0 0.0 26 43.4 27 45 30 50
moderate 40 66.6 23 38.3 23 38.3 14 23.3
sever 20 33.3 2 3.3 0 0.0 0 0.0
total 60 100 60 100 60 100 60 100
Mean 2.39 1.24 1.14 1.09
P value 0.0001 0.0001 0.0001 0.0001
Discussion
With regard to fish oil effect on menstrual pain intensity, with other studies, we can say that the treatment effect of
the result of this study demonstrated a difference in pain fish oil and ibuprofen is not similar while the effect of fish
intensity before and after receiving fish oil (p=). In a oil is better than ibuprofen. About the comparison of pain
peformed study by Dolatian in 2004, the recovery percentage intensity in two groups after intervention, there was
after treatment decreased in half, but in this study she did not difference in the first month (p=0001) and in the second
perform any comparison with Ibuprofen (12). Also, Yaghmai month after treatment (p=0.0001) and two months after
et al. showed significant difference between the two groups finishing the treatment, there was a significant difference
(mefenamic acid and fish oil – mefenamic acid and placebo), (p=0.0001).
which is similar to the findings of our study (14). In , We can conclude that pain intensity and recovery
women suffering from primary dysmenorrhea received percentage after treatment in fish oil group were much more
mg/day vit B1 during months constantly and % had compared to Ibuprofen group.
recovery (5). In conclusion, fish oil is a drug with high acceptance and
In comparing pain intensity before and after receiving endurance and is effective in the treatment of patients who
ibuprofen, %, in the second month was % and in the suffer from primary dysmenorrhea and it can be substituted
third month was %. In performed a study by Sekhavat et with non-steroid antianfola matuar which has high
al., the recovery percentage after receiving ibuprofen was complication. Also, we recommend that some other
%, which is more than the recovery percentage of the researches be performed by prescribing various doses of fish
present study. The reason of this difference was the way the oil in loteal phase.
drugs were used in Sekhavat study.
In this study, ibuprofen was prescribed times a day and Acknowledgments
days a month (three days before and two days after mense We would like to thank all the students in our university
start) (15). But in other studies, in either way the drug use who cooperated in the fulfillment of this study.
was similar to the present study, similar results were
reported. In a performed study by Zamani, fish oil is as References
effective in the treatment of primary dysmenorrhea. In , 1. Juli A, Jolin. Pelvic pain and dysmenorrheal. In: Berek
Wilson et al. compared the effect of using 4 gr/day fish oil JS. Berek Novaks Gynecology. New York: Lippincott
and it was compared with placebo. This study shows that Williams & Wilkins 2002; pp: 351-421.
fish oil is more effective than placebo on primary 2. Latthe PM, Champaneria R, Khan KS. Dysmenorrhea.
dysmenorrhea (16). By comparing the present study results Clinical evidence 2011; 02:813. Available at: http://
www.consumerreports,org.healthy/resources/pdf/ clinical
– guidelines/ sr-dysmenorrhea-0813. pdf.
Caspian J Intern Med 2(3): Summer 2011
282 Zafari M, et al.
3. Jordan JA. Aspects of Student health. Adolescent 11. Proctor ML, Murphy PA. Herbal and dietary Therapies
gynecology. Br Med J 1977; 1: 98-9. for primary and secondary dysmenorrhea. Cochrane
4. Regidor PA, Regidor M, Rows S. Prospective database Syst Rev 2001; 3: CD002124.
Randomized Study Comparing the GnRH- agonist and 12. Dolatian M, Jafari H, Valaei N, et al. The effect of fish
Lynesternol in treatment Sever endometriosis. Gynecol oil on primary dysmenorrhea. J Zanjan Univ Med Sci
Endocrinol 2001; 15: 202-9. 2004; 47: 7-13. [In Persian].
5. Merrison BW, Daniels SE, Kotey P, Cantu N, Seidebery 13. Rakhshaee Z. Effect of three yoga poses (cobra-cat and
B. RofeCoxibe a specific Cyclooxygens–2 inhibitor in fish poses) in women with primary dysmenorrheal: A
primary Dysmenorrhea a randomized controlled trial. randomized control trial. J Pediatric Adolesceat Gynosol
Obestet Gynecol 1999; 94: 504-8. 2011; 24: 192-6.
6. Zhang WY, Liwan PO A. Efficacy of minor analgesic 14. Yaghmaei M, Moradi AV, Hosseini R. A comparison of
primary Dysmenorrhea: a systematic review. 1999 Br J therapeutic effect between mefenamic acid and
Obstet Gynecol 1998; 105: 280–9. mefenamic acid plus fish oil in reduction of the severity
7. Bernard ND, Scilli AR, Hurlock D, Bertron P. Diet and of pain in primary dysmenorrhea. J Med Faculy Guilon
sex- Hormone binding globulin, Dysmenorrhea and Univ Med Sci 2004; 49: 68-73. [In persion].
premenstrual symptoms. Obstet Gynecol 2000; 95: 245- 15. Sakhavat L, Karim Zadeh MA. Comparison of the
50. efficacy of vit B, (Thiamine) andzbuprofen in treatment
8. Sidani M, Campbell J. Gynecology. Select topics. Prim of primary dysmenorrheal in young girls, yazd, 2003. J
Care 2002; 29: 297-321. Shahid Sadoghi Univ Med Sci 2005; 13: 47-51. [In
9. Kastap KE. Nutrients and Nutrition agent Drug factors persion]
and comparisons. Translated by zargari A. 4the edition. 16. Zamani M, Arab M, Nasrollahi SH, Mani Kashani KH.
Tehran publication 2000 pp: 138-9. [In Persian]. The evaluation of fish oil (Omega-3 fatty acids) efficacy
10. Moghadomnia A, Mirhosseini N, Abadi MH, Omranirad in Treatment of primary dysmenorrhea in high school
A, Omidvar S. Effect of clupeonella grimmi female students in Hamadan. J Gorgan Med Sci 2005;7
(anchovy/kilka) fish oil on dysmenorrhea. East Mediterr (1): 39-42. [In Persian]
Health J 2010; 16: 408-13.