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PREVENTIVE MEDICINE II

OCCUPATIONAL POISONS
PPT of Ma. Victoria P. Cruz, MD, FPAFP

TOPIC OUTLINE
I. Inorganic Arsenic
A. Occupational Sources
B. Occupations Exposed
C. Route of Exposure
D. Exposure Levels
E. Toxicity Effects
• Acute Toxicity
• Chronic Toxicity
F. Confirmatory Diagnostic Test
G. Treatment
H. Hazard to Environment
I. Preventive Measures
1. Primary Preventive Measures
2. Secondary Preventive Measures
II. Lead
A. Occupational Sources
B. Occupations Exposed
C. Route of Exposure
D. Exposure Levels
E. Absorption
• Children
F. Distribution
• Blood
• Soft Tissue
• Bone
G. Effects
H. Mechanism of Action & Symptoms
1. Disrupts the enzymatic step in heme & globin
production
2. Disrupts the physiological effects of calcium,
glutamate
3. Readily crosses the BBB & placenta
4. Impedes Vitamin D conversion
5. TOXICITY: Produces lesions of the proximal tubule
and loops of Henle
6. DOUBLING OF BLOOD LEAD: causes SBP to rise
I. Diagnostic Tests
J. Management
K. Regulation
L. Preventive Measures
• Workplace
• Home
III. Mercury
A. Sources
• Environmental Exposures
B. Occupational Sources & Occupations Exposed
C. Route of Exposure
D. Clinical Manifestations
• TRIAD of Mercury Poisoning
• Organ Systems of HIGH exposure
• Organ Systems of LOW exposure
E. Diagnostic Tests
F. Treatment
G. Prevention
• OSHA:
• NIOSH:
H. Administrative Order 21 (AO 21)

Paulo, G.M.V. 1 of 3
PREVENTIVE MEDICINE II: PATIENT SAFETY

TOPIC OUTLINE
IV. Organophosphate
A. Occupational Sources
B. Occupations Exposed
C. Route of Exposure
D. Mechanism of Action
E. Clinical Manifestations
• SLUDGE
• DUMBELLS
F. Effect
• Mild (20-40% dep)
• Moderate (40-60% dep)
• Severe (>60% dep)
G. Clinical Types
• Type I:
• Type II: Intermediate Syndrome
• Type III: Organophosphate-induced delayed
polyneuropathy (OPIDP)
H. Diagnostic Tests
I. Management & Treatment
• First Aid
• Active Treatment
• Specific Antidote
V. Another Pesticide: Carbamates
A. Effect
VI. Hydrogen Sulfide
A. Occupational Sources
B. Occupations Exposed
C. Route of Exposure
D. Exposure Levels
E. Mechanism of Action
F. Effect: PULMONARY EDEMA
G. Effects to Exposure
• By duration
o Acute Exposure
o Chronic Exposure
• By amount
o 10ppm
o 1000-2000ppm
H. Diagnostic Tests
I. Management & Treatment
• Emergency Care
• Antidotal Therapy
o 3% Sodium Nitrate
o Pyridoxine
• Emergency department Care

Paulo, G.M.V. 2 of 2
SUBJECT: TOPIC

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Surname, A. B., Surname, A. B., Surname, A. B. 3 of 3


PREVENTIVE MEDICINE II: PATIENT SAFETY

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REFERENCES

Paulo, G.M.V. 4 of 2

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