RAJGAD DNYANPEETH’S COLLEGE OF PHARMACY, BHOR

Name of the Candidate and

1. Address:

2. Name of the Institute:

Course of Study and

3. Subject:

4. Date of admission to course

Title of the Topic:

FORMULATION & EVALUATION OF CELECOXIB SOLID DISPERSION.

5.

1
PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

ACADEMIC YEAR-2018-19

2
6.
Brief Resume of Intended Work:

6.1: Need for the Study:

Oral drug delivery is the most popular, simplest and easiest way of administering drugs. Because of
the greater stability, smaller bulk, accurate dosage and easy production, solid oral dosages forms
have many advantages over other types of oral dosage forms1
The term solid dispersion defined as the dispersion of one or more active ingredient in an inert
carrier or matrix at solid state prepared by melting (fusion), solvent, or the melting solvent method.
Sekiguchi et.al. Suggested that the drug was present in a eutectic mixture in a microcrystalline state2
Solid dispersions are one of the most successful strategies to improve drug release of poorly water-
soluble drugs. The solid dispersion refers to a group of solid products consisting of at least two
different components, generally a hydrophilic matrix and a hydrophobic drug. Several hydrophilic
carriers like Polyethylene glycol (PEGs), Polyvinyl Pyrrolidone (PVP), Hydroxypropyl cellulose
(HPC), β-Cylodextrin etc have been investigated as inert matrices for enhancing solubility and
dissolution rate.
The approaches that have commonly been used to overcome drawbacks associated with poorly
watersoluble drugs, in general includes micronization, salt formation, use of surfactant and use of
pro- drug
The formulation of drugs having low aqueous solubility using solid dispersion technology has been
an active area of research since 1960
The selective COX-II inhibitor which belongs to BCS class-II having low aqueous solubility and
high membrane permeability. The bioavailability of selective anti hypertensive have low to elicit the
required pharmacological effect, hence making it a suitable candidate for the proposed research work
with an aim of improving its oral bioavailability.

6.2: Review of literature.

1. It stated that improved its dissolution of solid dispersions of Ibuprofen were prepared using
polyethylene glycol 20000 in a relatively easy and simple manner, characterized by scanning
electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform
infrared spectroscopy (FTIR), and evaluated for solubility and in vitro drug release.3
2. Solid dispersions of poorly water soluble drug Irbesartan in hydrophilic carrier matrix have
been reported as the better method to improve theirsolubility and dissolution rate.4
3. Solid dispersions of Anti-Hypertensive drug Felodipine were prepared by using poly acrylic
3
9. Signature of the Candidate:

10. Remarks of the Guide:

11. Name and Designation

the Guide:

11.2 Signature:

11.3 Co-guide

11.4 Signature:

11.5 Head of the Department:

11.6 Signature:

4
12 12.1 Remarks of the chairman and Principal:

12.2 Signature:

PRINCIPAL,
RAJGAD DNYANPEETH’S COLLEGE OF PHARMACY,
BHOR, PUNE