9th European Congress on Menopause and Andropause / Maturitas 71, Supplement 1 (2012) S1–S82
209
KNOWLEDGE, ATTITUDES, AND PRACTICES REGARDING CERVICAL
CANCER SCREENING AMONG PHYSICIANS IN WESTERN REGION OF SAUDI
ARABIA
N. Anfinan. King Abdulaziz University Hospital, Jeddah, Saudi Arabia
To evaluate knowledge and practice of the Pap test, the role of HPV in
the etiology of cervical cancer, and attitudes regarding the HPV vaccine of
female physicians in the western region of Saudi Arabia.
210
PROPHYLACTIC CERCLAGE IN TWIN PREGNANCY
N. Asnafi 1,2 , Z. Basirat 1,2 , K. Hajian 1 , B. Taheri 1,3 . 1 Fatemeh Zahra Infertility
and Reproductive Health Research Center, Babol University of Medical
Sciences; 2 Obstetric & Gynecology Department; 3 Department of Social
Medicine, Fatemeh Zahra Infertility and Reproductive Health Research Center,
Babol University of Medical Sciences, Babol, Iran
Objective: Preterm birth (PTB) is a common cause of neonatal morbidity
and mortality. This condition is more common in multiple pregnancies
which Increased by Assisted Reproductive technology (ART). The aim of
this study is to compare the effect of cervical cerclage in twin pregnancy
for preventation of preterm delivery.
Method: In this case-control study, pregnant women with twin pregnancy
confirmed by early second trimester sonography were devided into two
groups. Women who accepted cerclage were defined as group I and the
others without cerclage were as group II. Two groups matched for parity
and maternal age. Cerclage was performed at 13-15 weeks of gestational
age. Then the women were followed until delivery. Delivery <35 weeks
was determined as PTB. The patient with Major fetal anomalies, systemic
disease, therapeutic cerclage and Induced Labor excluded from the study.
Results: Of the 80 twin pregnancy, cerclage was performed in 50 women
(groups I) and 30 women hadn’t cerclage (group II). In group I, 22
pregnancies (44%) had PTB and 28 women had term pregnancy (56%). Also
in group II, 12 (40%) pregnant women had PTB and others (18 cases, 60%)
had term delivery. there was no significant difference between two groups
with and without prophylactic cerclage (P=0.817).
Conclusion: Prophylactic cerclage couldn’t prevent preterm birth in twin
pregnancy without other risk factor.
211
EFFECT OF PRAVASTATIN ON ENDOTHELIAL FUNCTION AND
ENDOTHELIAL PROGENITOR CELLS IN HEALTY POSTMENOPAUSAL
WOMEN
M. Bracaglia, F. Ianniello, L. Quagliozzi, L. Donati, F. Basile, C. Di Cesare,
M. Viggiano, B. Carducci, A. Caruso, G. Paradisi. Catholic University of Sacred
Heart, Roma, Italy
Introduction: Coronary heart disease is the leading cause of morbidity and
mortality in post-menopausal women. Among statins, Pravastatin has been
shown to significantly reduce fatal and non-fatal cardiovascular events in
primary and secondary prevention trials.
Objectives: The aim of the present research was to investigate whether
treatment with Pravastatin can modify some indices of cardiovascular risk
in healthy postmenopausal women such as significant reductions in both
total, LDL cholesterol and triglycerides levels.
Method: Twenty patients were randomized in double-blind fashion to
treatment for 8 weeks with either Pravastatin 40 mg/day or placebo, and
subsequently, after one-week wash-out, crossed-over to the alternative
treatment (placebo or Pravastatin) for the following 8 weeks. We per-
formed clinical and laboratory investigations, before and at the end of
each treatment period, to evaluate patient response to the treatment with
Pravastatin.
Results: After eight weeks Pravastatin therapy reduced the median LDL
and total cholesterol (p<0.01 in both cases). In contrast, insulin level
and insulin sensitivity did not show any difference with regard to values
observed after placebo treatment. The absolute number of Endothelial
Progenitor Cells-Colony Forming Unit (EPC-CFU) was significantly increased
by Pravastatin treatment (30.6% increase, p<0.05) and the number of
senescent cells was significantly decreased.
S77
Conclusions: Pravastatin did not increase in tube like formation by EPC
and did not improve endothelial function. Despite the known beneficial
effect on lipids, Pravastatin do not seem to improve other cardiovascular
risk factor, at least in healthy postmenopausal women.
212
Effectiveness of hysteroscopic management of abnormal uterine
bleeding in peri- and post-menopausal women
E. Cumashi, I. Burk I., E. Pavlakis, D. Musa, P. Skolarikos. A’ Department of
Obstetrics and Gynecology, “Helena Venizelou” Hospital, Athens, Greece
Aim: To evaluate the efficacy, safety and benefits of hysteroscopy in the
management of abnormal uterine bleeding in middle age women.
Methods: In this prospective study participated 196 consecutive patients,
middle age 45±10 years, who underwent operative hysteroscopy because
of abnormal uterine bleeding due to endometrial polyps, submucosal
myomas, septum and adhesions diagnosed by ultrasonography, hysteros-
alpingography or diagnostic hysteroscopy. We used the 5mm operative
hysteroscope, the Versapoint Bipolar Electrosurgical system and mechanical
instruments. Normal saline was used for distension of the uterine cavity.
Results: No endometrial malignancy was missed. The major number of the
lesions were endometrial polyps and submucosal myomas. Mean duration
of the procedure was 17.3 min (range 4-37) and mean postoperative
hospital stay was five hours (range 2-24 hours). There were no major com-
plications. Three women reported postoperative uterine bleeding, which
was managed conservatively and one patient experienced fluid overload.
In all cases malignancy was excluded with histological diagnosis. During
postoperative follow-up (36 months) the majority of patients were free of
symptoms.
Conclusion: Hysteroscopy represents an effective and safe method for the
management of benign intrauterine pathology and furthermore, in our
study endometrial malignancy was not missed. Moreover, hysteroscopy has
the advantages of quick recovery, early return to normal activities, reduced
hospital stay and increased satisfactory for the patient.
213
MENOPAUSAL SYMPTOMS AND CORRELATED FACTORS IN 45-60 YEARS
OLD WOMEN, TEHRAN, 2011
F. Darsareh 1 , S. Taavoni 2 . 1 Nursing and Midwifery Faculty, Tehran University
of Medical Sciences, Tehran, Iran; 2 Midwifery Countinuing Eucation
Office+Research Institute for Islamic & Complementary Medicine (RICM,
TUMS), Tehran University of Medical Sciences, Tehran, Iran
Physiological and psychological changes during pre and post menopause
may lead to negative impact and controlling related factors may improve
quality of life of menopause women.
Aim: To determine correlated factors of menopausal symptoms.
Material and methods: This is a cross sectional study, which 350 volunteer
women with age 45-60 years, whom had been visited in health clinics of
Tehran University of Medical Sciences (Year 2011) were interviewed by
using questioner, which had two main parts of Personal characteristics,
and Menopausal Rating Scale (MRS). Deceptive and inferential statistic test
were used. All ethical points were considered.
Results: 57.1% of samples were menopause with average age 51.9±4.55.
The most three prevalent symptoms in all premenopause and post
menopause women were: depressive mood (64.3%), joint and muscular
discomfort (61.4%) and irritability (59.1%). Symptoms were mild in 44.6%,
moderate in 38.6%, severe in 12% of the participants. The most common
related factors of menopausal symptoms had seen in smokers, and their
own and spouse educational level (p<0.01). Higher education level had
significant correlation with severity of symptoms.
Conclusions: Postmenopausal women presented higher rates of psycho-
logical symptoms, and need more consultation. Since there were more
severe symptoms in Smokers, and samples with higher education, it seems
these groups need more follow up, guiding and consultation program. It is
suggested to be done same study with more samples in other districts and
other cities, for comparing the results.