Академический Документы
Профессиональный Документы
Культура Документы
ii Contents
Neem Oil Could Help Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Discovery of T-cells Hidden in Bone Marrow Can Help Beat
Brain Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Cancer Survivor, A Record Breaker Cyclist, Sets Upon a
New Challenge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Breaking – Cancer Research Finds Malaria Protein As a Method of
Diagnosing Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Breast Cancer Drug Proves Promising in Phase III Clinical Trials. . . . . . . . . . 47
New Chemical Found That Can Cause Self-Destruction in the
Brain Cancer Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Emerging Hopeful Glioblastoma Treatments. . . . . . . . . . . . . . . . . . . . . . . . . . . 51
Apples Reduce Chance of Cancer With Up To 25% . . . . . . . . . . . . . . . . . . . . . . 53
Researchers Explore Gene Therapy to Treat Endometrial Cancer. . . . . . . . . 55
New Treatment to Prevent Pleural Mesothelioma Recurrence. . . . . . . . . . . . 57
Safe Amount of Alcohol to Drink Is Zero . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
New Five Minute Procedure to Help With Enlarged Prostate. . . . . . . . . . . . . 61
Why You Should Start Drinking Chamomile Tea Today . . . . . . . . . . . . . . . . . . 63
Cholesterol-Lowering Drug, Statin, Can Better Blood
Cancer Treatments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Nivolumab Receives FDA Accelerated Approval for Treating Small
Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Prevent Colon Cancer with These Six Foods . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Cancer Blood Test Based on Protein Produced by Malarial Parasite can
Revolutionize Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Mesothelin Targeted CAR T-Cell Therapy Shows Efficacy in
Early Stages of Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Additional Inhibitor Could Reduce Brain Cancer Resistance
to Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Contents iii
Adelaide Researchers Looking for Better Treatment for
Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Innovative Genetic Testing Service to Help Cancer Patients. . . . . . . . . . . . . . 79
Beating Cancer by Discovering the Benefits of Beetroot. . . . . . . . . . . . . . . . . 81
Cancer-Targeted Immunotherapy for Offering Protection Against
Metastases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
Cure for Acute Leukemia Within Reach - First Time in 40 Years. . . . . . . . . . . 86
Benefits of Having Carrots Everyday. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
A Recent Ground-Breaking Study Could Minimize the
Side Effects of CAR T-Cell Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
Cancer Should Not Have to Be a Death Sentence!. . . . . . . . . . . . . . . . . . . . . . 92
Cancer May be Prevented by Maintain Body pH Level. . . . . . . . . . . . . . . . . . . 94
Simple Blood Test Can Reveal Skin Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96
Experimental Dog Treatment Could Save Human Lives. . . . . . . . . . . . . . . . . . 98
Cell Immunotherapy Provides Potential Cure for Advanced
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Health Risks for Occasional Smokers Considerably Higher than
Previously Believed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
Clubbed Nails May Indicate Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104
Cancer Patient Fights Terminal Cancer Through Alternative
Treatments!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106
Avoiding Getting Tattoos Lowers Cancer Risk. . . . . . . . . . . . . . . . . . . . . . . . . 108
Carol Neufeld’s, A Cancer Fighter, Inspirational Story. . . . . . . . . . . . . . . . . . 110
Hyperbaric Oxygen Treatment Has Surprising Results On
Cancer Survivor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .112
China approves Breakthrough Therapy Drug for Breast Cancer. . . . . . . . . . 114
Cell-to-Cell Communication Opens Way for Better Cancer Treatment. . . . 116
Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein. . . . . . 118
iv Contents
Array BioPharma Receives FDA Breakthrough Therapy Designation
for BRAFTOVI in Combination Drugs for Colorectal Cancer. . . . . . . . . . . . . . 120
Know About the Too Good-to-be-True Health Benefits of Turmeric. . . . . . 122
Garlic, the Ultimate Panacea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
Kale and Broccoli Could Prevent Colon Cancer. . . . . . . . . . . . . . . . . . . . . . . . 126
Supercomputer Joins Fight Against Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 128
Studies Suggest Aspirin Keeps Colorectal Cancer Away . . . . . . . . . . . . . . . . 130
Photodynamic Theory Beats Lung Cancer!. . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
Innovative Therapy to Cut Radiation Sessions for Prostate Cancer . . . . . . 134
Treatments Ensuring Quality of Life for Lung Cancer Patients! . . . . . . . . . . 136
Special Genes Discovered in Elephants That Resist Cancer. . . . . . . . . . . . . 138
A Major Vulnerability of Childhood Leukemia Discovered!. . . . . . . . . . . . . . 140
New Drug Puts Cancer Cells in Permanent Suspension. . . . . . . . . . . . . . . . . 142
Ways of Reducing the Risk of Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144
Chinese Tree Bark Compound Shows Anticancer Properties. . . . . . . . . . . . 146
Protein That Inhibits Breast Cancer Suppression Finally Blocked. . . . . . . . 148
Groundbreaking Immunotherapy Leads to Complete Remission
of Breast Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
University Of Toledo Professor Working On Cutting Edge Cancer
Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152
4 Little Girls Who Beat Cancer Reunite at Hospital for Touching Photo. . . . . 154
CAR T-Cell Therapy Might Alter the Treatment of Mesothelioma. . . . . . . . . 156
FDA Extends Age Limit for HPV Vaccine to Include Adults
between 27 And 45. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158
Drinking More Water can Help in Reducing Bladder Infections
in Women. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160
‘Death Cap’ Mushroom Could Aid in Cancer Fight. . . . . . . . . . . . . . . . . . . . . . 162
Contents v
Genetic testing: Not a One-and-Done Deal. . . . . . . . . . . . . . . . . . . . . . . . . . . 164
The Immune System of the Alpaca Reveals a Potential Treatment
for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166
New Cancer Vaccine Shows Early Promise For Patients With
Her2-Positive Cancers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
First Treatment for Advanced Skin Cancer Approved. . . . . . . . . . . . . . . . . . . 170
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Surgeons at Pennsylvania “Light Up” Tumors for Boosting
the Chances of Mesothelioma Survival . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
Taming Pediatric Leukemia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Top Do’s & Don’ts for Pancreatic Cancer Treatment. . . . . . . . . . . . . . . . . . . . 181
Nanoparticles, High Tech Weapons Fighting Brain Cancer. . . . . . . . . . . . . . 183
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
HPV Vaccine Removes Dozens of Tumors from Patient
With Advanced Skin Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
Cancer Cells Engineered to Trigger a Death Switch in
Other Cancer Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Prostate Cancer, Ovarian Cancer, Sarcomas and
More Cancer Types Now Linked to Lynch Syndrome . . . . . . . . . . . . . . . . . . . 193
Hundreds of Kidney, Skin and Blood Cancer Patients
May Be Cured from Breakthrough Drug. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Discovery Blocks Vicious Cycle of Inflammation and Tumor Growth. . . . . . 197
Nanoparticles can Help Battle Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . 199
Delta-tocotrienol Inhibitors Might Reduce Risk of
Tumor Invasion and Metastasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
vi Contents
Study Spares Breast Cancer Patients from
Unnecessary Chemotherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Long-term Study Reveals Lower Cancer Incidence from
Vegetable and Fruit Diet. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
New FDA Approved Drug Enters Leukemia Fight. . . . . . . . . . . . . . . . . . . . . . . 207
Cancer Treatment by Targeting Telomeres & Telomerase. . . . . . . . . . . . . . . 209
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Turmeric Can Cure Stomach Cancer: According to JNU Study. . . . . . . . . . . . 213
Modified Poliovirus Helps Treat Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . 215
Olive Oil – The Amazing Elixir. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
How To Minimize The Risks Of Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . 219
XTANDI Treatment for Prostate Cancer Gets FDA Approval. . . . . . . . . . . . . . 221
Urine Color: A Cancer Indicator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Prevent Ovarian Cancer with Aspirin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
All-new Advanced CAR-T Treatment Might Give Hope to the
Cancer Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
“Promising” Treatment Trial Gives New Hope for the
Deadliest Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
Vaccination for Hepatitis B Might Help in Preventing
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Newly Identified Biomarker Could Pave the Way for
Personalized Bladder Cancer Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
A Light-Emitting Wireless Implant to Kill Cancer . . . . . . . . . . . . . . . . . . . . . . 237
More Vitamin D May Offer Less Risk of Breast Cancer. . . . . . . . . . . . . . . . . . 239
Kidney Cancer Cure via Protein Targeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
New Study Could “Pause & Reverse” Lung Cancer. . . . . . . . . . . . . . . . . . . . . 243
Contents vii
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
When People Care There is HOPE!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Revolution in Melanoma Treatment for Patients. . . . . . . . . . . . . . . . . . . . . . 249
Blood Tests can Help in Predicting the Treatment for
Patients with Prostate Cancer: Study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251
Merck’s Keytruda on Its Way to Dealing with Head &
Neck Cancer Case. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
New Peptide Drug Targets Liver Cancer from Within. . . . . . . . . . . . . . . . . . . 257
Oral Bacteria – a Breakthrough Passage in Weight Loss,
Cancer Treatment, and Overall Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
How Your Diet Feeds Pancreatic Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
FDA Issues Breakthrough Therapy Designation for LENVIMA. . . . . . . . . . . . 263
Possible Male Breast Cancer Signs You Should Be Aware of . . . . . . . . . . . . 265
Could Wart Vaccines Really Treat Skin Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 267
Cancer Cannot Take Away Who You Are!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
New Cancer Treatment: Molecularly Targeted Therapy. . . . . . . . . . . . . . . . . 271
Arsenic Shows Surprising Benefits in Cancer Fight . . . . . . . . . . . . . . . . . . . . 273
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
The Sweet Potato – An Unexpected Weapon against Breast Cancer?. . . . . 279
New Vaccine Completely Removes Cancer in Mice. . . . . . . . . . . . . . . . . . . . . 281
Innovative Head and Neck Cancer Therapies . . . . . . . . . . . . . . . . . . . . . . . . . 283
Early Age Drinking May Lead To Aggressive Prostate
Cancer Later In Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
Combination of Molecules Found to be Effective in the
Treatment of Cancer in Mice. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
viii Contents
Scientists Discovered a Drug Target for Neurodegenerative
Diseases & Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
Red Meat May Not be as Bad as We Have Been Told – You decide!. . . . . . . 297
Primary Tumors Found to Inhibit Secondary Tumors. . . . . . . . . . . . . . . . . . . 299
Stem Cells Could Be an Effective Drug Delivery Tool for
Brain Cancer in Children. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
Metabolic Differences in Kidney Tumors Could Help
Better Treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303
Top Ways to Give Your Brain a Boost. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305
Eating Broccoli While Pregnant Could Help in
Preventing Breast Cancer in Child. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307
Switchable CAR-T Cells Target Pancreatic Ductal Adenocarcinoma. . . . . . . 309
FR900359, Discovered from Plants to Reduces Tumor Growth
in Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
Saving Healthy Cells in Brain Cancer Treatment, Synthetically. . . . . . . . . . 313
New Treatment Discovered to Fight Melanoma Better Than
Traditional Vaccine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
Discovery of New Metal-Based Inhibitor May Improve Treatments
for Triple-Negative Breast Cancer (TNBC). . . . . . . . . . . . . . . . . . . . . . . . . . . . .317
Could E. Coli Treatment Cure Crohn’s Disease?. . . . . . . . . . . . . . . . . . . . . . . . 319
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
A Tumor Suppressor – BRCA Associated Protein. . . . . . . . . . . . . . . . . . . . . . . 323
New Treatment for Hairy Cell Leukemia Approved By the FDA. . . . . . . . . . . 325
New Drug Can Help in Fighting Liver Cancer with Fewer Side Effects. . . . . 327
The Numerous Health Benefits of Brazil Nuts. . . . . . . . . . . . . . . . . . . . . . . . . 329
Treatment Might Help in Reducing the Risk of Esophageal
Adenocarcinoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Contents ix
Head and Neck Trial with NBTXR3 Nanoparticles Shows Promise. . . . . . . . 335
Zika Virus Offers Promise for Treating Fatal Brain Cancer
As Per a Study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
This Week in Oncology News. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
Top Health Benefits of Cinnamon. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343
Grapes May Help in Stopping the Growth of Cancer Cells. . . . . . . . . . . . . . . 345
Top Medicinal & Health Properties of Cayenne Pepper . . . . . . . . . . . . . . . . 347
Breaking Treatment Displays Promising Results in
Fighting Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349
Cutting Edge Radiotherapy Machine Introduced in the U.K.. . . . . . . . . . . . . 351
Vaccine to Possibly Treat Head and Neck Cancer. . . . . . . . . . . . . . . . . . . . . . 353
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Benefits of Flax Seed Could Include Cancer Prevention. . . . . . . . . . . . . . . . 357
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
How can Blueberries Help in Killing Cancer Cells?. . . . . . . . . . . . . . . . . . . . . 361
New Bladder Cancer Drug Shows Impressive Results. . . . . . . . . . . . . . . . . . 363
Japan Approves New Treatment for Advanced Hodgkin’s Lymphoma. . . . . 365
New Vaccine to Possibly Treat Incurable HPV-Related Cancers. . . . . . . . . . 367
Imfinzi Can Help To Fight Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369
Pediatric Osteosarcoma Drug Receives Orphan Drug Designation. . . . . . . 371
The Prognostic Importance of Antigen 45 (CT45) in Extending Life
of an Ovarian Cancer Patient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 373
Fighting Pancreatic Cancer! There is HOPE!. . . . . . . . . . . . . . . . . . . . . . . . . . . 375
FDA Approved for Leukemia! – Copiktra. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
Kevin Schwartzel saved the Life of Johnny Sawyer Dyer. . . . . . . . . . . . . . . . 379
x Contents
Two Leading Cancer Immunotherapy Researchers Receive
the 2018 Nobel Prize in Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381
Benefits of Antioxidants for the Overall Health. . . . . . . . . . . . . . . . . . . . . . . 383
FDA Greenlights First Treatment for Advanced Skin Cancer. . . . . . . . . . . . . 385
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
First Case of Complete Immunotherapy Response for
Kidney Cancer Patient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
Genetic Tumor Mapping Could Save Countless Lives. . . . . . . . . . . . . . . . . . . 391
Amazonian Plant Could Have Miraculous Anticancer Properties. . . . . . . . . 393
Milk Could Restore Gustatory and Olfactory Sensations to
Chemo Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
New Drug Enhances the Harvest of Bone Marrow . . . . . . . . . . . . . . . . . . . . . 397
Birmingham Hospitals Making Use of Herpes Virus for
Treating Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399
Categories. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
Contents xi
Breaking Cancer Research, Cancer Breakthroughs, Colorectal Cancer
A
new research by the researchers from Queen’s University Belfast
might be able to change the outcome of survival in patients with
bowel cancer across the world. The study is considered first of
its kind and has been funded by The Chancellor of Queen’s University
Belfast via Tom Moran Scholarship.
The therapeutic treatment could target and decimate bowel cancer
cells. It can improve the survival rate for patients diagnosed with very
poor survival outcome. The research includes the examination of gene
signatures to investigate Unfolded Protein Response (UPR), which is
a stress-response pathway pertaining to a bunch of cells. This UPR
could be utilized to treat bowel cancer in cases in which patients have
become resistant to treatments or have a poor survival outcome.
A
cute Myeloid Leukemia (AML) is one of the most aggressive
forms of cancers, harming bone marrow and causing it to
produce abnormal myeloblasts. Little innovation has arrived
regarding its treatments, given its variety and amount of proteins
causing cancerous cells to rapidly multiply and preventing them from
chemotherapy treatments. However, researchers from the Hebrew
University of Jerusalem might have come up with a dose of hope.
The researchers have established a new biological drug which acts as
a cluster bomb. The molecule has been developed by manipulating a
cancer cell chemically which succeeds in attacking multiple leukemic
proteins in a go, taking away leukemic cells’ ability to activate
New Drug Developed by Israeli Researchers That Kills Multiple Leukemic Proteins at Once! 3
more proteins in order to escape or evade given therapy. It destroys
oncogenes as well as activates P53 (a tumor suppressor gene).
Mice injected with acute leukemia showed 50 percent of cure rate. The
drug portrayed dramatic changes right after a single dose. According
to the researchers, almost all the signs of leukemia vanished overnight
in the mice. There were mice with leukemia as well as those injected
with human leukemia. Researchers claim that the drug worked on
even the most aggressive type of human leukemia.
AML has been treated with chemotherapy and stem cell injections so
far. This new drug comes in a pill form. It can cover the work of 3-4
other drugs which enables the patients to avoid additional therapies
and their intense side effects.
The phase 1 clinical study of this drug is hoped to be started at the
start of 2019. The drug is projected to take 2-3 years before it can be
commercialized. Researchers are now working on how to extend the
use of this drug for other types of cancers like melanoma, lymphoma,
colorectal and multiple myeloma cancers.
4 New Drug Developed by Israeli Researchers That Kills Multiple Leukemic Proteins at Once!
Breaking Cancer Research, Cancer Breakthroughs, Colorectal Cancer
C
onstant hard work had been continued by researchers to increase
the age limit for the patients suffering from bowel cancer. The
basic aim was to increase the number of survivors and to create
a ray of hope in patients all over the globe.
Finally, the researchers got what they were looking for!
Late Chancellor of Queen’s University Belfast through Tom Moran
Scholarship aided a project which aimed to invent a therapy for bowel
cancer patients, improving their lives and increasing their chances of
survival. It had never been done before.
A research project was established where two groups of patients were
formed. The focus was to find out how a bunch of cells respond to
U
nder the supervision of Professor Ute Moll, a team of researchers
from the Department of Pathology at Stony Brook University
School of Medicine showed that ablating a certain protein could
translate into reduced tumor growth with colorectal cancer (CRC).
Genetic manipulation is one of the procedures that are currently at the
forefront in terms of cancer treatments. Designing targeted solutions
that are more efficient and safer for patients is one of the methods
that is hoped to significantly improve outcomes and general health
in cancer cases.
In CRCs, the disease creates certain mutations, and approximately
sixty percent of times it is linked with the p53 gene, creating an
alteration for mutp53 R248Q by exchanging Arginine (R) for
T
he United States FDA (Food & Drug Administration) recently
granted the Breakthrough Therapy Designation to LOXO-292
for the treatment of lung & thyroid cancers. LOXO-292 is a
RET inhibitor that is used for the treatment of the individuals having
metastatic RET fusion-positive NSCLC (Non-small Cell Lung Cancer).
The drug is given to the patients who might require systemic therapy
and might be having the disease progression after the platinum-based
chemotherapy along with an anti-programmed cell death protein 1
(PD-1) or PD-L1 (an anti-programmed death ligand 1) therapy.
The LOXO-292 is also for the treatment of the patients having RET-
mutant medullary thyroid cancer – requiring systemic therapy and
E
very year, around 140,000 individuals in the United States are
diagnosed with colorectal cancer – a malignant form of cancer
that develops from a small polyp into tumor over the passage of
time. The screening process with the help of colonoscopy helps in
the detection & removal of the polyps – as such aiding in both the
early detection & prevention of colorectal cancers. However, when
the polyps become too large or difficult to get rid of by colonoscopy,
surgery is required.
In the latest technological advancement, the innovative robotic
system can now help in the removal of the colorectal lesions without
the involvement of any surgery. With the collaboration between
the Division of Gastroenterology & Hepatology and the Division
Large Colorectal Lesions Removed Without Surgery with the Help of High-Tech Robotic Systems 11
of Colorectal Surgery at NYU Langone Health has been the first-
ever center in New York to make use of the revolutionary Flex
Robotic System inside the gastrointestinal tract. While working
together, the leading colorectal surgeon named Mitchell Bernstein
and gastroenterologist named Seth A. Gross, were able to remove a
massive, premalignant colorectal lesion inside a woman. The woman
after the removal of the colorectal lesion was discharged later on the
same day itself.
This is the first time that a high-tech robotic platform has been
incorporated in the process of gastrointestinal endoscopy. This gives
the hope for future robot-aided surgeries in the effective treatment of
major diseases and ailments – all across the world.
12 Large Colorectal Lesions Removed Without Surgery with the Help of High-Tech Robotic Systems
Breaking Cancer Research
Supramolecule Engineered to
Fight Cancer
T
he battle against cancer is becoming more and more high-tech, as
scientists from Brigham and Women’s Hospital create a molecule
that can disable cancer cells.
The field of immunotherapy is currently buzzing, with new discoveries
and advancements happening seemingly every day. A new ally is
currently showing a lot of promise in laboratory trials and is expected
to make an important contribution of its own. Named AK750, the
synthesized molecule is highly complex and has a dual action.
One of the reasons why cancer is so difficult to tackle is because it
can hide from the immune system, by signaling a certain pathway,
CSF-1R. This starts a process which “polarizes tumor-associated
macrophages from an antitumor M1 phenotype to a pro-tumorigenic
M2 phenotype”. At this stage, antibodies just don’t recognize the
L
ove those fiber-rich, blood sugar-friendly, hormone-booster
vegetables? Good for you! This is because the healthy cruciferous
vegetables are known to be forming an integral part of healthy
lifestyles adopted by a majority of the world’s fit population.
The cruciferous vegetables obtain their name after the cross shape of
the petals that they grow in. Some of the most common examples of
the cruciferous vegetables that are grown across the world include
cauliflower, cabbage, broccoli, kale, arugula, Brussels sprouts, Bok
choy, turnips, and collard greens.
A
major bio marker of kidney disease can help in predicting the
“clear cell kidney cancer” – the most common form of kidney
cancer – several years before the actual diagnosis. The KIM-1
(Kidney Injury Molecule -1) could be detected in blood & urine which
is generally present at lower volumes in individuals with healthy
lifestyles.
The KIM-1 turns out to be a vital and highly useful biomarker for
predicting any major kidney injury. In a recent study that was published
in the journal Clinical Cancer Research by BWH Investigators,
explored that fact that whether or not a blood test can help in detecting
the higher levels of KIM-1 in the patients who might develop the
risks of developing kidney cancer – after around 5 years. The results
Novel Blood Tests Help in Predicting Risks & Survival of Kidney Cancer 5 Years Before Diagnosis 17
of the study reveal that KIM-1 biomarker helped in substantially
distinguishing between those who had the risks of developing kidney
cancer and those who did not.
The early detection of kidney cancer could be life-saving in several
ways. It can also help in the prevention of kidney cancer effectively.
The scientists claim that they can cure kidney cancer when it will
be detected at an early stage. Kidney cancer, however, turns out to
be asymptomatic and several patients who have kidney cancer have
usually developed the advanced stage at the time of diagnosis. The
results of the study reveal that with further refinement in the tests,
KIM-1 is known to have the potential of identifying the patients with
early stages of curable kidney cancer in an effective manner.
18 Novel Blood Tests Help in Predicting Risks & Survival of Kidney Cancer 5 Years Before Diagnosis
Breaking Cancer Research, Melanoma Cancer, Skin Cancer
C
ombining encorafenib (Braftovi) with binimetinib (Mektovi)
has yielded better results than any other form of treatment for
advanced melanomacurrently on the market.
A phase 3 COLUMBUS trial showed that patients put on a course
of encorafenib at 450 mg a day and binimetinib at 45 mg twice
daily (COMBO450), had up to 39% improved outcome compared
to any previous treatments. The overall survival rate went up, from
16.9 months to 33.6 months, and median progression-free survival
(PFS) from 7.3 months to 14.9 months. These very promising results
prompted a quick FDA approval.
It seems that the superior effectiveness lies within their ability to target
the BRAF mutation, common in most cases of melanoma. The gene
provides information for protein formation within cells and is also
M
ost people drink green tea just as a warm beverage or as a
supplement for their weight loss diet, but in fact, it has a
multitude of health benefits, and you should take advantage
of them right away.
If you are not a morning person and require a cup of coffee to get
your day started, you will be happy to hear that green tea also has
considerable levels of caffeine, just slightly less. The trade would
additionally help you with a number of natural antioxidants that
improve skin condition, get rid of toxins in the body and generally
boost the immune system.
Green tea, or Camellia sinensis, is already proven to reduce the risk
of hypertension and cardiovascular disease. It also does a great job
T
he idea of “Magic Bullet” is an old medical concept given by a
German Nobel laureate Paul Ehrlich in 1900. The concept is
to develop a medicine that can eliminate all tumor cells quietly
without harming normal cells, from any place they might be situated
in. Researchers from MU (University of Missouri), have come up with
such a specialized technique.
The study evaluates the workings of smart nanoparticles known
as aptamers. Aptamers can bind to specific targets along with any
therapeutic drug attached to them. The concept can be used to target
cancer cells.
Burke-Aguero, working in the Department of Molecular Biology and
Immunology in MU, explains that molecules are three-dimensional,
and they can have certain small patches attached to them like a
A
recent study with a new drug combination has been conducted
involving half of ovarian cancer and a third consisting of lung
cancer patients, who had established resistance to chemotherapy.
A total of 4,227 women had passed away in the UK in 2016 due to
ovarian cancer and 35,260 patients from lung cancer. Professor Paul
Workman from ICR says that such drug combinations could help
tackle adaption, drug resistance and evolution of cancer.
In the study, a drug called vistusertib has been combined with
chemotherapy that has succeeded in stalling the way cancer cells
tend to resist treatment and spread and grow. The result in the early
stages of study exceeded the expectations so much that now a phase
2 trial of the study is taking place. Dr. Susana Banerjee from The
A New Drug Combination Shrinks Tumors in Chemotherapy-Resistant Lung and Ovarian Cancer 25
Royal Marsden deems this option as very encouraging as no other
alternative is available for women with relapsed ovarian cancer.
In the large trial of the study, 140 women suffering from relapsed
ovarian cancer participated and were given paclitaxel (standard
chemotherapy) in combination with vistusertib. Researchers from
The Royal Marsden, ICR and other 9 such centers have tested the
combination on forty patients with squamous non-small lung cancer
and 25 women with high-level ovarian cancer. All these patients had
standard chemotherapy resistance. Initially, the tolerance of the drug
combination was tested and only a few side effects were observed.
52% ovarian cancer patients along with 35% lung cancer patients
had 30% of their tumors shrunken. The growth inhibited for 5.8
months on average.
A previous study had found that ovarian cancers resisting chemotherapy
possessed a higher level of p-S6K molecule that increased cancer cell
growth. In the current study, patients were given paclitaxel (80mg/
m2) with vistusertib (50mg) twice a day for three days over 6 weeks.
Vistusertib successfully canceled the mentioned function of p-S6K by
targeting the protein, mTOR1 and 2, which activates it. Hence cancer
cells stopped growing and resisting treatment, surprising researchers
with effective results.
This exciting news has given a lot of hope for patients who have
grown resistant to standard treatments. Hopefully, this may pave way
for more effective treatment for such patients.
26 A New Drug Combination Shrinks Tumors in Chemotherapy-Resistant Lung and Ovarian Cancer
Brain Cancer, Kidney Cancer, Lung Cancer, Melanoma Cancer,
Skin Cancer
M
elanoma is the most serious type of skin cancer that can be
deadlier if it encroaches into the brain. If it reaches the brain,
less than twenty percent of patients survive for more than
a year with traditional treatment. However, a recent study with a
new drug combination comes with hope for such patients and had
proven to increase their lifespans for more than a year for 82% of
such patients.
The drugs involved in the combination are ipilimumab (Yervoy) and
nivolumab (Opdivo), also the part of the class known as checkpoint
inhibitors. These drugs work to activate the immune system which
shrinks the brain tumors in turn in many melanoma patients. It served
to prolong the life of 94 patients from 28 medical centers situated in
the United States.
New Drug Combination Could Help Curb Melanoma That Has Spread to Brain 27
Enabling the immune system of a patient to fight against cancer by such
checkpoint inhibitors can lead to long term remissions from severe
forms of cancer, like lung and kidney cancer as well as melanoma.
Such a technique is called as immunotherapy. It may not work in
every case but when it does, it may show wonders.
Dr. Hussein A. Tawbi, the first author of this study, calls it great news
that may help many melanoma patients and other patients in general.
He suggests that this drug combination should be made part of initial
treatment for such melanoma patients and that these drugs should
also be put under test for patients with other types of cancer that have
reached the brain. According to his estimate, 200,000 patients emerge
per year alone in the U.S. who develop brain tumors projecting from
other types of cancer.
The results are not applicable for Glioblastoma or any brain cancer
that has started with in the brain first. Dr. Tawbi mentions that studies
with drug combinations are underway which can help such patients
as well.
28 New Drug Combination Could Help Curb Melanoma That Has Spread to Brain
Blood Cancer, Non-hodgkin’s Lymphoma Cancer
P
harmaceutical giants AbbVie, Janssen and Genentech have
combined their efforts to offer a new therapy course involving
a combination of drugs meant to help people suffering from
Waldenström’s macroglobulinemia (WM).
The Food and Drug Administration has approved the use of Imbruvica
(ibrutinib) and Rituxan (rituximab) combo in the treatment of a rare
and incurable type of non-Hodgkin’s lymphoma (NHL) that affects B
cells. Patients now have a less taxing alternative to the current standard
treatment – chemotherapy. In a press release, the Head of Clinical
Development, Thorsten Graef, M.D., Ph.D. said: “We are pleased to
have IMBRUVICA approved, both as a single agent and combination
therapy with rituximab, to provide an additional efficacious treatment
option for people living with Waldenström’s macroglobulinemia”.
The decision comes as a result of extensive research culminating with
a very revealing clinical trial. 150 participants were administered daily
T
his recent treatment option works by supporting and boosting
the body’s natural immune system in the fight against cancer.
In spite of sustained efforts from every national health institution
and even international groups, like the World Health Organization,
lung cancer continues to be a leading cause of mortality worldwide.
A general lack of awareness, the tendency to ignore the first signs
of disease and, for some, just the thought of having to undergo
chemotherapy, all contribute to making the malignancy even more
terrible.
Fortunately, a new form of treatment has been shown to be more
effective and improve survival rates compared to the current options,
while at the same presenting fewer negative effects.
S
cientists have found that certain mutations are most commonly
found in the cells of some typical types of cancers. As such,
finding the specific mutations in the cells can help in diagnosing
the particular type of cancer. By testing the cells for the purpose of
mutation can be used after the diagnosis process for seeing how the
particular cancer is responding to the given treatment. As a result,
genes have been found to be useful as an effective cancer cure in the
coming times.
A
s per a recent report, it has been found that patients with pancreatic
cancer have only 7 percent chances of surviving after the diagnosis
of the fatal disease for more than five years. This figure as stated
by Elliot K. Fishman – a leading researcher & radiologist at the John
Hopkins Hospital is the lowest rate for any cancer.
In the latest findings, the John Hopkins Hospital researchers have come
up with the observation that the technology of Artificial Intelligence
(AI) and deep Machine Learning can be utilized for changing the
statistic of the treatment of pancreatic cancer.
Deep learning has become a major part of the modern technology-
driven world. Several industries across the world are making use of
this revolutionary technology towards developing high-end automated
solutions.
A
t the recent China Expo 2018 held in Chongqing, China – a
high-tech focused ultrasound system for the treatment of cancer
tumors was developed by the nation. This research of treatments
for cancer has gained interest from all over the world.
The all-new ultrasound system referred to as the “Haifu Knife”
comes with the specialized feature – it can help in treating cancer
tumors present on the soft tissues without even cutting the body
open or invading the body with a laparoscope. Therefore, the given
revolutionary med-tech by China is termed to be completely non-
invasive for the treatment of cancer.
The system makes use of the principle of focalizing the ultrasound just
outside the body onto the target tumor cancer cells inside the body. As
F
ound in Indian sub-continent, Neem is an herb used for medicinal
purposes. Its use is common in traditional medicine and Ayurveda.
It has important anti-oxidants such as nimbin and azadirachtin,
which boost its medicinal uses. Its color could range from pale yellow
to green. Its essential oil can be obtained from its fruit and seeds by
solvent extraction, cold pressing technique or steam distillation.
Majorly its benefits can be antiseptic, antihistamine, antioxidant,
antifungal, antipyretic. Could all these factors help prevent cancer?
The answer is maybe because one of the most import benefits of this
herb is that it prevents cancer. The high content of antioxidants in
neem neutralize free radicals, reducing oxidative stress and any sort
of cell damage. It may be a beneficial tool against different types of
cancer such as prostate cancer and breast cancer. The most noticeable
function of Neem Oil is that it reverses the formation of malignant
tumors, reducing the ability of the cancer to spread. It also could
help in lowering the risk of cardiovascular diseases and rheumatoid
N
ot a single type of immunotherapy is available or approved by
the Food and Drug Administration (FDA) for treating brain
cancer. None of the trials have borne good clinical results.
However, recently in a research at Duke University, a breakthrough
discovery has been made which may turn the tables around.
Peter E. Fecci, M.D., Ph.D. is the director of the Brain Tumor
Immunotherapy Program at the Department of Neurosurgery in Duke
University. He reveals the key information regarding the research;
researchers have found that the most integral parts of the immune
system known as T-cells which disappear from the immune system in
brain cancer, were found hidden in the bone marrow of the patients.
If we return these T-cells to their respective places, immunotherapy
can work better against brain cancer.
Discovery of T-cells Hidden in Bone Marrow Can Help Beat Brain Cancer 41
Cancer tends to take upon the body’s immune system, causing T-cell
dysfunction which needs to be activated to reboot immune system.
GBM (glioblastoma) in particular is very immune suppressive tumor;
T-cell are actually missing in the body. Previously, it was thought
it occurred due to radiation or chemotherapy or maybe steroids
whereas it is discovered now that patient had an immune system of
an older person way before getting any treatment. T-cells were looked
for in the blood and spleen, but there weren’t any there as well as the
lymphoid organs appeared shrunken – an eccentric symptom to take
place.
Researchers then examined the bone marrow, for the reason that
maybe T-cells were not being produced enough but what they found
was surprising. Not only were the T-cells present in the bone marrow,
they were five times more than they should be. This was observed in
all the patients and mice who had brain cancer.
The case is not specific to brain cancer, be it lung cancer or breast cancer
or melanoma, the shrinkage of the spleens was only because T-cells
were hiding in the bone marrow. The problem of the dysfunction was
in T-cells; they were getting rid of the receptor called S1P1 which
would normally get them out of the bone marrow. Researchers
devised a way with a genetic alteration that caused these receptors to
stick with T-cells in mice; T-cells managed to get out and the immune
system activated quite well against the brain tumors.
The discovery is a big step forward, hopefully paving way for an FDA
approved immunotherapy for brain cancer.
42 Discovery of T-cells Hidden in Bone Marrow Can Help Beat Brain Cancer
Hope Stories
J
ames Golding has survived cancer, not only once but twice. And
neither time did he let go of his strong will. After battling cancer
for the first time, he took part in a charity ride to celebrate the
first anniversary of being cleared off from cancer. In that ride, he was
involved in a car accident which he survived back in 2010.
After going through cancer twice, Golding set on a cycling spree and
succeeded in breaking the world record of total distance covered in
seven days through cycling by crossing 1,766.2 miles. This is one of
the most incredible achievements. Golding now is set upon a new
challenge, he is taking part in a big biking ride for charity. The ride
would include 1.136 km long route of the OVO Energy tour of Britain,
extending from Wales up to London.
The charity ride will be taken alongside Phil Jones, who is the
managing director of technology giant Brother UK. One day before
the professionals get into the saddle, Golding and Jones will complete
every stage of the OVO Energy Tour of Britain. The starting point of
the route is Pembrey Country Park situated in Wales, continuing till
B
reaking – cancer research finds malaria protein as the key to
diagnosing cancer, in a recent study. The scientists around the
world keep researching new ways to diagnose and treat cancer
effectively towards improving the overall survival rates of the
patients – all around the world.
In an attempt towards this direction, a team of researchers has found
malaria protein as the key to diagnosing cancer in its early stages. A
team of researchers from the University of Copenhagen discovered
the new method of detecting cancer. The findings of the research were
posted in Nature Communications that explained how the specific
malaria protein has the capability of detecting the early-stage cancer
cells found in blood.
W
omen who have been diagnosed with advanced breast
cancer – carrying the BRCA1 & BRCA2 gene mutations, an
experimental cancer drug can help in improving the overall
survival rates.
The BRCA mutations are usually linked to enhancing the risk
for aggressive ovarian cancer & breast cancer. The drug, namely
“talazoparib,” is known for working by blocking the enzyme known as
PARP (Poly ADP ribose polymerase). Thus, the drug has been effective
in preventing cancer cells from killing the cells that are healthy.
In the phase III clinical trials of as many as 431 women – the trials were
funded by the makers of the drug, the women who received the drug
“talazoparib” were known to live longer without any progression of
G
lioblastoma is a fatal form of brain cancer. The tumors of
Glioblastoma emerge from the supportive tissues of the brain–
getting an ample supply of blood. This makes the treatment of
brain cancer even more difficult as the malignant cells continue to
multiply rapidly.
However, new research that has been carried out by the team of
researchers might serve to be the solution for brain cancer – that
could stop the brain cancer cells from spreading out too fast. The
research has discovered a new synthetic chemical compound known
as the “KHS101” – which is responsible for cutting off the “energy
supply” to the brain cancer cells.
C
ancer is one of the biggest burdens on society and a global
health issue. A great deal of sustained effort is being poured into
research and clinical trials, and even though progress is steady,
current treatment options are still limited and not as effective for all
cases.
The term cancer describes a series of diseases that cause unregulated
cell growth, and in the case of glioblastoma, it is glial cells. They have
a role in modulating nerve signal propagation, controlling the uptake
of neurotransmitters, but also neural recovery and local immunity,
some of the most important tasks required for good brain functioning.
A glioblastoma is an aggressive form of brain malignancy, accounting
for about 17% of all brain tumors and with a mortality rate of more
than 15.000 cases each year. For some decades now, the standard
treatment consisted of surgery and heavy chemotherapy, with limited
success. New targeted approaches are being developed, safer and
promising better results.
I
t seems that the old saying “an apple a day keeps the doctor away”
might actually have a seed of truth.
A massive investigative project was conducted by researchers
from the University of Perugia into claims that a natural diet full of
vegetables and fruits does actually influence the risk of developing
cancer. While there was a lot of information on the subject, reports
varied considerably – big differences in terms of sample sizes, intake
amounts, span of time etc.
Out of all the possible candidates, they settled on apples. “Our
interest was attracted by apples as they are the most consumed fruit
in European countries and a rich source of phytochemicals”.
G
enetic studies have brought a great contribution to the
understanding and treatment of many conditions and diseases.
Scientists from Australia are hoping to explain the mechanisms
behind ovarian cancer and possibly come up with a more effective
form of therapy
Ovarian cancer is one of the most common and deadly types of
malignancy worldwide. Because of the lack of awareness and the fact
that signs are often neglected, conventional treatments are not always
efficient enough.
Caroline Ford, a leading researcher at the University of New South
Wales in Australia, has been doing important research, focusing on
two genes that appear mostly at the initial stages of development.
ROR1 and ROR2 are thought to be responsible for promoting
metastasis and the rapid growth and spread of tumors.
O
ne of the biggest problems with treating any type of cancer is
trying to limit the chances of the disease coming back. Italian
scientists have come up with an ingenious way of concentrating
the therapy on a specific area.
The standard course of treatment for pleural mesothelioma patients
is radiation followed by surgery and then intravenous chemotherapy
drugs. The procedure has limited success in preventing recurrence and
has also the downside of making patients suffer the toxic side effects
of the drugs, reducing their quality of life.
One emerging alternative solution comes from Italy and involves
placing a polymer film coated with cancer drugs, pemetrexed and
cisplatin, directly on the mesothelial surface right after the operation.
This method has shown very little toxic side effects and allows for
higher concentration drugs to be administered.
I
n moderation, alcohol is generally considered to be safe and even
thought to provide some health benefits. A recent study comes and
contradicts many of these previous claims and recommends as little
consumption as possible.
An extended international project involving 195 countries and
spanning for more than two and a half decades, brought to light
some concerning data. While there is some data supporting the idea
that moderate drinking can be beneficial for some specific diseases,
in particular heart disease and diabetes, the study warns that “these
protective effects were offset by the risks associated with cancers,
which increased monotonically with consumption”.
The article, published in The Lancet, provides a number of worrying
statistics. For example, it was estimated that in 2016, alcohol use led
to 2.8 million deaths worldwide and was the primary risk factor in
premature death and disability among people with ages between 15
W
hile it is not considered a serious health issue, an enlarged
prostate creates considerable discomfort and can lead to a
series of associated problems. This new treatment does not
involve any surgery and presents minimal side effects.
It is estimated that 50% of men over the age of 60 will show signs
of an enlarged prostate (benign prostatic hyperplasia – BPH), and as
time passes, the percentage also increases. BPH happens when the
urethra narrows and the bladder needs to exert more pressure leading
to the bladder muscle to contract even when it shouldn’t. This results
in frequent trips to the bathroom and a constant feeling of uneasiness.
An enlarged prostate does not increase the risk or is an indication
of cancer, but symptoms can be similar to a regular checkup is
recommended. Left untreated, patients can develop some related
issues, like bladder stones, infections, damage to kidneys.
N
ature has always provided a helping hand when needed, and
it is fascinating to see that even serious diseases with which
modern medicine is struggling today, like cancer, could have a
more simple answer at hand.
Chamomile describes a series of plants similar to daisies that have
been used for centuries for their therapeutic properties. Going back
to ancient Egypt, a cup of tea would be a common remedy for fever,
pains or infections, while oils would be used in aromatherapy and
embalming.
In the present day, chamomile is a typical ingredient for cosmetic
products (creams, oils), in cooking recipes (aromatic sweets or drinks)
and a number of medications treating anything from the common
cold to cardiovascular diseases.
L
eukemia initiates in bone marrow, where blood cells are formed,
causing accumulation of abnormal white blood cells. The most
common type of blood cancer is Chronic Lymphocytic Leukemia
(CLL). Venetoclax is the drug federally approved which is used to
treat blood cancers.
Venetoclax activates particular pathways that regulate cell death,
hence promoting cancer cell death in CLL. The drug is a better
alternative than chemotherapy. However, a recent study, appearing
in Science Translational Medicine, reveals that cholesterol-lowering
drug, Statin, shows anti-cancer functions against multiple forms of
cancer.
Statin puts a stop to a specific pathway that reduces cholesterol
production in the body, however, this blockage also leads to lowering
F
or the first time, almost after two decades, a new drug has gained
FDA approval for treating metastatic small cell lung cancer (SCLC).
The drug, nivolumab, has been approved for those patients who
have not gone through a successful platinum-based chemotherapy or
any other type. Nivolumab now is the first ever immuno-oncology
drug for this disease.
The study that backs up FDA’s approval involves patients who have
metastatic or advanced tumors and platinum-based chemotherapy has
failed to stop the progression of their cancer. 109 such patients were
given 3mg/kg nivolumab, in every two weeks, without any regard
to PD-L1 status. Tumor assessment was started six weeks after the
Nivolumab Receives FDA Accelerated Approval for Treating Small Cell Lung Cancer 67
treatment and subsequent six weeks for six months. Later on, the
assessment was done after every 12 weeks.
According to the data from Blinded Independent Central Review,
13 patients showed a complete response to the therapy, 12 patients
exhibited partial response and 1 patient showed a full response to the
therapy. Average response duration was 17.9 months for a patient
who showed a response.
As for the AEs (adverse events), dyspnea, pneumonitis, pneumonia,
dehydration and pleural effusion were noticed in 2% of the
patients. Common AEs consisted of constipation, cough, dyspnea,
musculoskeletal pain, low appetite, diarrhea, nausea and fatigue in
about 20% of the patient.
Keeping the overall response rate in view, FDA gave accelerated
approval to the use of Nivolumab. The response duration was also
better. Approval will be continued if further supported by future
studies.
68 Nivolumab Receives FDA Accelerated Approval for Treating Small Cell Lung Cancer
Colorectal Cancer, Healthy Lifestyles, Prevention
A
part from genetic factor, colon cancer can be kept at bay if you
take care of your diet. The risk of this disease increases with age
and maintaining a diet benefiting your gut health can protect
you. Here are six foods that can push away the risk of colorectal
cancer.
Recently, a new research has revealed that certain leafy green
vegetables like cabbage, broccoli and kale can help prevent colon
cancer, regulating the gut’s health. The digestion of these vegetables
produces a compound called indole-3-carbinol I3C that lowers
inflammation in mice with cancer and lowers the risk of colon cancer
in mice altogether. This compound decreased the number of tumors
in mice with colon cancer.
E
xisting cancer blood tests utilize antibodies that can bind to
various kinds of cell surface proteins associated with cancer. Not
all cancers have such markers and the biggest difficulty in the
field of oncology is the accuracy of determining the stage at which
the cancer is.
However, a new research by Danish researchers can turn the tables
around. The method of detection pertains to a 2015 discovery,
according to which, a protein produced by malarial parasite, can
stick to cell-surface cancer cells whose occurrence is observed in 95%
cancer types. Applying this concept in the laboratory, they infused a
magnetic bead into a synthetically made malarial protein known as
rVAR2 and released it into a blood sample. Remarkably, the protein
Cancer Blood Test Based on Protein Produced by Malarial Parasite can Revolutionize Cancer 71
bound to the malignant circulating tumor cells (CTCs) only and the
researchers were able to isolate tumors from healthy cells through a
magnet.
Repetitive studies are required to demonstrate the results further,
however, published in Nature Communications, the results of the
research claim to not only detect cancer at stage 1 (before it spreads)
but at any other stage. It may also detect the phase in which cells of
the primary tumor transform into an invasive migratory mode, yet to
settle into secondary tumor formation. This phase otherwise is very
hard to detect. Metastatic cancer causes about 90 percent of death
due to cancer (7.4 million people worldwide).
Lead author, Ali Salanti, claims that this method can detect a substantial
number of cancer cells than any existing test. The researchers
conducted the experiment on prostate, colorectal, breast, lung cancers,
osteosarcoma and melanoma cell lines. The protein was found to stick
to all cancer cell types, bypassing healthy cells, particularly in liver,
lung and pancreatic cancer cases. When 10 isolated pancreatic cancer
cells were added into multiple healthy blood samples containing
about 25 billion RBCs and 35 million WBCs, rVAR2 caught 8 to 9
cancer cells each time.
Salanti adds that based upon the number of tumor cells their method
catches, it would be easy to tell whether a cancer is aggressive or not
and respective treatment could be given as soon as possible.
Having conducted the experiment with successful results in a large
pool of pancreatic cancer patients, hopefully, this new cancer blood
test is hoped to serve as the most efficient form of detecting cancer
at any stage!
72 Cancer Blood Test Based on Protein Produced by Malarial Parasite can Revolutionize Cancer
Breast Cancer, Lung Cancer, Mesothelioma Cancer,
Ovarian Cancer, Pancreatic Cancer
A
recent ongoing study has tested Mesothelin-targeted (CAR)
T-cell Therapy and it showed efficacy within the phase one of
the trial, in patients with mesothelioma, pleural disease, breast
cancer, non-small cell lung cancer. Followed by PD-1 checkpoint
inhibition treatment showed better results with hard-to-treat solid
tumors. The results have been announced at American Society of Gene
and Cell Therapy 2018 Annual Meeting.
Mesothelin is a beneficial therapeutic target as its presence is not
observed on normal mesothelial cells. It is a cell-surface antigen that
helps in differentiating tumors and is present in many cancers such
as pancreatic, lung, pleural, breast, ovarian and mesothelioma itself.
R
esistance to treatment is one of the biggest issues when treating
glioblastoma. The addition of a new inhibitor to the process
could make the tumors far more susceptible to treatment and
drastically improve success rates.
According to estimates from the American Cancer Society, more than
24,000 new cases of malignant glioblastoma are discovered each year
in the United States, making it one of the most common primary
brain tumors. Because of its aggressive nature, the median survival
rate for patients is just 14 months, so finding better therapy courses
is a priority.
One current treatment option recommended for brain cancer works
by effectively preventing the tumor from accessing blood vessels by
targeting vascular endothelial growth factor (VEGF), thus cutting off
its supply of energy and oxygen.
D
r. Luke Selth and Professor Lisa Butler, University of Adelaide’s
Freemasons Foundation Centre for Men’s Health, struggle to
find better treatments with accurate tools to efficiently diagnose
prostate cancer. Prostate cancer is the most frequent non-skin-based
cancer, affecting more than 18,000 Australian men and taking 3000
lives each year.
Luke and his team are focusing on two areas of prostate cancer. One
of these is Androgen Receptor (AR) that mainly drives prostate cancer
growth. The effort to study this area more is due to the fact that only
survival benefiting therapies are available which do not actually kill
the cancer. The second area is microRNAs which, according to Luke,
promote and inhibit metastasis; they have the ability to prevent the
process and can be used as markers of aggressive prostate cancer due
to their leakage in the blood from the tumors.
A
partnership program between Pathology Queensland and Metro
South Hospital and Health Service is offering a breakthrough
genetic service meant to improve medical care for cancer patients.
At the new Australian Translational Genomics Centre (ATGC),
researchers have identified and classified genetic mutations in 100
patients suffering from blood cancer. They are hoping that data
collected from examining exome sequencing will help doctors make
a better prognosis and suggest the likely response for the different
treatment options.
“For 75 percent of patients the genetic mutations that were identified
could inform doctors about how the patients would respond to
particular treatments for their cancers, allowing personalised
B
eets have been long known to have amazing health benefits by
serving as nutritional sources of natural foods. However, in the
recent times, more than ever, beetroots have been scientifically
proven to have additional nutritional values and can help in the
prevention of cancer.
Labeled as “beetroot chemotherapy” after research by some health
experts, the scientific research finds that there have been surprising
cases of remission in the cancer patients who were asked to consume
beetroot on a daily basis.
Beetroot is a famous root vegetable – with its characteristic red color.
The vegetable is also rich in various nutrients including potassium,
manganese, iron, sulfur, magnesium, phosphorus, and several other
minerals. In addition to the nutrition importance, the additional
A
team of medical scientists at the VIB-UGent Center for Medical
Biotechnology has recently taken remedial steps towards the
development of the cancer-targeted immunotherapy for offering
protection against metastases. The research team has been successful
in developing a treatment in mice that can successfully destroy a part
of the tumor. In addition to this, the new form of cancer-targeted
treatment will also help in stimulating the body’s immune system for
attacking persistent cancer surviving cells.
The team of researchers has demonstrated that the treatment would
also provide protection against the development of tumor formation
in other parts of the body as well. The results of the research have
been published in Nature Communications.
Treatments like radiotherapy and chemotherapy are effective in
destroying the cancer cells. However, these treatments also tend to
A
cute leukemia happens to be one of the most aggressive forms
of cancer out there. While other forms of cancer might have
received the benefits of some type of cure & treatments, there
has not been any positive news when it comes to the patients having
acute leukemia – until now!
In new research, the team of researchers at the Hebrew University
of Jerusalem has come up with the all-new biological drug that can
help in treating leukemia. Professor Yinon Ben-Neriah along with his
research team at the university has developed the biological drug that
has been tested positive for around 50 percent of the lab mice tests
having acute myeloid leukemia.
Myeloid leukemia is responsible for producing a high quantity of
the specific type of proteins – together they form up the leukemic
V
ibrant orange carrots are much healthier than you expected
when you consume it on a daily basis. A lifestyle with “a carrot a
day” can help in the prevention of several diseases and promote
healthy nutrition all over.
Carrots are known to lower the risk of heart attack, reduce cholesterol
levels, reduce the signs of premature aging, improve vision significantly,
and also help in the prevention of various types of cancers – a recent
study suggests. In addition to these nutritional benefits, when you eat
carrots on a daily basis, it can also help in improving the quality of
skin, improving digestion, boosting the immune system, detoxifying
the body, boosting oral health, and protecting from a wide range of
cardiovascular diseases.
Carrots are low in calories and contain no fat. To top it all, they are
responsible for supplying significant doses of essential vitamins &
minerals to the body. While they might be immensely beneficial on
C
ar T-cell immunotherapy has shown results where it has cleaned
swept the diseases in terminal cases, however, still, there are cases
where there are not successes and patients still suffer some fatal
side effects. Hopefully, a study conducted by Seattle’s Fred Hutchinson
Cancer Research Center might eradicate these side effects and look
into differing aspects of these treatments.
Researchers examined the two main parts of CAR T-cell therapy; the
T-cells of the patients that fight against the disease and a synthetic
CAR (chimeric antigen receptor), fed into those T-cells to assist them
finding and destroying cancer cells, through the process of signaling.
Dr. Stan Riddell, Fred Hutch’s immunotherapy research center’s leader,
says that the mechanism of this signaling by the receptors is learned in
90 A Recent Ground-Breaking Study Could Minimize the Side Effects of CAR T-Cell Therapy
the study, as this has not been previously understood well. Dr. Riddell
along with Dr. Amanda Paulovich (mass spectrometry expert) and
Alex Salter examined and compared two different molecules used in
CAR T therapy, CD28 and 4-1BB.
Previously scientist thought that these molecules influenced the
behavior of the treatment because they used different proteins for
signaling. However, this is not the case. Salter from this study mentions
that the difference of behavior of the treatments originates from
the two receptor molecules themselves. They vary in the speed and
strength of their signaling. 4-1BB emits a weaker and slower signal in
contrast to CD28 emitting a faster and stronger signal. Surprisingly,
the stronger and faster receptor CD28 performs worse than 4-1 BB
when they were observed in mice with lymphoma.
CD28 had a strong anti-tumor action in the start but it receded as
it exhausted the T-cells. Whereas 4-1 BB did not exhaust the T-cells
and they retained their function. CD28 also leads to higher level of
cytokines due to its rapid signaling, which may have adverse side
effects.
Salter modified CD28 CAR to weaken its signal, increasing the
effectiveness of treatment by nulling the side effects. This design
should be followed in future CAR treatments, Salter says.
Understanding the mechanism of the CAR T treatment can reveal
more effective ways to tune the therapy to work better for the patients.
This way CAR T-cell therapies could become safer for people with the
passage of time and study.
A Recent Ground-Breaking Study Could Minimize the Side Effects of CAR T-Cell Therapy 91
Cancer, Lung Cancer, Ovarian Cancer
O
ne of the most traumatic experiences of life is to be diagnosed
with cancer. For long, the news of cancer development was
synonyms to a death sentence. But, now, science is shifting this
cruel course of life towards hope and optimism for healthy survival.
Now, various studies have come across with better treatments
and diagnostic tests that are revolutionizing the field of oncology.
Developments in immunotherapy and many alternatives to
chemotherapy itself are coming forth. Researches are being conducted
to minimize the side effects of anti-cancer drugs. Many cancers are
now treatable and sensitive cancers like lung and ovarian cancers have
seen better treatments.
Cancer’s power to dissipate the quality of patients’ lives is now being
taken away. Over the past decade, numerous breakthroughs have
p
H (potential of hydrogen) is a scale from 0-14 through which
we measure acidity or alkalinity of the body. The 0-6 range
indicates that a substance is acidic and a range of 8-14 indicates
that a substance is basic (alkaline). The maintenance of pH levels
slightly inclining more towards basicity (approximately 7.35 pH) is
considered to be optimum for the transfer of oxygen in the body.
However, our certain life choices can deplete the alkalinity of our
body, without which acidity increases, causing acidosis. Poor eating
habits, alcohol consumption, more intake of antibiotics, artificial
food colors and flavors, a higher level of sodium and preservatives
can cause this depletion. Sleeping habits, excessive exercise routine,
pollution, chemical and radiation exposure, chronic stress conditions
can affect the basicity of our body as well.
A
ustralian scientists claim to have developed a breakthrough
blood test that can detect skin cancer in the early stages and
considerably improve patient outcome.
Melanoma is an aggressive form of skin cancer and the rate of incidence
is currently on the rise. While the ozone layer shields against most
of the harmful UV rays coming from the Sun, continued exposure
and a history of sunburns increase the risk considerably. The World
Health Organization estimates that more than 130.000 new cases are
discovered each year.
There are a number of testing methods currently used, including visual
examination (usually with using dermoscopy) or reflectance confocal
microscopy, though not always reliable. Even the most trusted way of
taking a skin sample for biopsy cannot detect melanoma in the initial
stages and can be quite uncomfortable and expensive.
A team from the Melanoma Research Group at Edith Cowan
University in Perth, lead by Professor Mel Ziman, has announced
T
he incredible survival story of one dog could become the source
for a new brain cancer treatment for humans.
Emily is a 10-year-old Portuguese water dog and she was
diagnosed with brain cancer at the beginning of the year. Her owner,
Laura Kamienski, felt devastated upon hearing the news but was not
yet ready to just give on her longtime friend.
Even though treatment options for glioblastoma are very limited when
it comes to animals, Laura did not lose hope and when she heard
about the medical trials at Virginia-Maryland College of Veterinary
Medicine, she knew they had to try.
The procedure was risky and involved injecting the drug directly into
the tumor, in order to protect as much of the healthy tissue as possible.
A
team of researchers at UNSW Sydney & the California Institute
of Biomedical Research (CALIBR) has found out success with
an all-new, revolutionary cell-based immunotherapy for the
treatment of pancreatic cancer. A new scientific way of providing
treatment for advanced pancreatic cancer by making use of “killer
cells” has shown immense hope & promise in the field of medical
science.
The treatment has been conducted on mice and has been found to
be completely cancer-free by getting rid of the cancer cells that might
have already spread to lungs & liver. In the given study, the team of
researchers took pancreatic cancer cells from the patients who were in
the later stages of the disease. Then, the researchers transplanted the
cancer cells into mice. After this, the team went forward with taking
100 Cell Immunotherapy Provides Potential Cure for Advanced Pancreatic Cancer
the immune cells of the patient and modifying them for specifically
identifying and eliminating the tumor cells. This is the reason such
immune cells are referred to as CAR-T cells or “educative killer cells.”
Professor Chris Heeschen stated that after the injection of the educative
killer or CAR-T cells into mice, the team was able to find the cancer
cells in the body, stick to the same with the help of surface markers,
and then, eventually destroy the tumor cells. The treatment has been
found to be so effective that the mice went cancer-free completely.
In addition to finding great hop for the treatment of advanced
pancreatic cancer in the coming times, the team of researchers
was also successful in introducing a new, revolutionary technology
allowing the researchers to control the activity of the killer or CAR-T
cells completely.
Cell Immunotherapy Provides Potential Cure for Advanced Pancreatic Cancer 101
Cancer, Healthy Lifestyles, Lung Cancer, Prevention
M
ost people are aware of the health risks associated with smoking
– increased chance of developing cardiovascular or respiratory
diseases, diabetes, arthritis, a wide number of forms of cancer,
to name a few. Just because occasional smokers have fewer cigarettes
on average, doesn’t mean that they are safe from contracting these
complications.
Reports from the Royal College of Physicians of Ireland (RCPI) paint
a more troubling picture than previously believed. The latest article
highlights some staggering statistics regarding occasional smokers:
“smoking only about one cigarette per day carries almost half the
risk of developing coronary heart disease and stroke when compared
to smoking 20 cigarettes per day”. This seems to correlate with a
102 Health Risks for Occasional Smokers Considerably Higher than Previously Believed
previous report coming from Norway suggesting that occasional
smokers had a 38% higher mortality rate compared to non-smokers.
When it comes to lung cancer, the same release mentions that “women
between 35 and 49 years of age who smoke 1 – 4 cigarettes a day are
five times more likely to develop lung cancer when compared with
non – smokers. In men, the risk is threefold”.
The stats are particularly worrying for Ireland, where it is estimated
that about one in five adult smokers does so occasionally. Furthermore,
occasional smokers are more likely to smoke in social situations,
especially when there is also alcohol involved.
When it comes to countermeasures, the RCPI Policy Group on Tobacco
stated that the most effective way of deterring from smoking is tobacco
taxation. For every 1% increase in tax, there is an approximate 0.4%
reduction in smokers.
Reducing smoking-related health risks is a priority in the 21st century,
especially considering that the average smoker loses about 10 quality
years of life because of smoking.
Health Risks for Occasional Smokers Considerably Higher than Previously Believed 103
Cancer, Lung Cancer
I
t is a common practice among people that if they notice any kind
of strange symptom, like an unusual lump, a rough hoarse voice,
any sort of foreign body sensation, a long-lasting pimple, they go to
see their physician as soon as possible. However, clubbing of the nails
caused by the swelling of the fingertips is one symptom that might not
be taken seriously whereas it can be an indicator of chronic diseases,
specifically, lung cancer.
A woman, JeanJeannie Williams Taylor, from the United Kingdom
recently posted an image of her clubbed nail on social media and
surprisingly, she found out it is a symptom of lung cancer. She had
asked her followers if such a nail was seen by anyone and consequently,
she was urged by one follower to go for a thorough checkup. The
advice appeared a “tad extreme” for her, however, she took it and
went for a checkup.
C
arol Armstrong has fought with cancer for about twenty years
to the point when her cancer was announced to be incurable.
She was given just few months to live and the family had been
distraught with this result. However, Carol and her family, refused to
give up and took to look for any other remedy possible.
Carol was diagnosed with Bladder Cancer, which she managed to live
with through regular checkups and hospital visits. Carol claims that
the cancer never limited her. Even though her doctors had termed
her cancer to be low-grade, that it would not go out of the bladder,
a routine check-up conducted previous year revealed the presence
of tumors in her left lung. The tumor was in the near vicinity of the
heart and thus, it was almost impossible to operate on it. As a result,
Carol was given three to twelve months to live. This utterly shocked
the whole family.
E
uropean Union’s watchdog claims that ingredients used in making
tattoos’ ink can cause cancer. A vote for restriction on about 4,000
chemicals is required of the member states. Given the statistics,
12% of Europeans have tattoos, mostly appearing among ages from
18 to 35. Tattoos constitute permanent ingredients that can cause any
harmful effect in a lifespan.
The major concern is the lack of jurisdiction over what actually
goes into the tattoos, the ingredients bought from various chains
of suppliers to distributors and then to parlors. No standardized
requirement is issued upon them across the EU. According to Tony
Raita, from Finnish Tattooist Association, the cheap ink ingredients
being imported from China can be a potential problem, users mostly
do not know what goes into their inks and that can be really dangerous.
C
oming 28th August, a persistent cancer fighter, Carol Neufeld,
will be battling with ovarian cancer for 10 years. When she was
first diagnosed with cancer, she like most of the patients, could
not believe what she had was severe and when she was briefed with
treatment options, all she could think was, “What’s the use.” She
continued her fight though, went into remission after chemotherapy
that lasted 18 months. The next round of chemo, called Doxel, made
her feel like she was scorched under her arms and legs. Her battle
continued, and with it, she resolutely fought.
But among all these hardships, Carol found a purpose in helping
other people. She found more meaning in what she had than what
she had not, she claimed to be yet blessed with her husband, her
children, her grandchildren and even great-grandchildren. She believes
she is blessed to have God, to have the doctor she met at her initial
Reference:
http://chemocare.com/chemotherapy/drug-info/doxil.aspx
F
or David Wolfe, the same radiation treatment that saved his life
more than 10 years prior was now seriously affecting his health
and threatening to permanently confine him to a wheelchair. In
pain and out of options, he agreed to take part in an alternative form
of therapy.
In 2002 David was diagnosed with anal cancer. He followed the
standard radiation treatment at the University of Pennsylvania
Hospital and was declared healthy. With this terrible event behind
him, he picked up the pieces and for almost a decade lived a normal
life.
Everything changed in early 2013 when he started experiencing hip
pains. At first, the 55-year-old blamed aging and decided to tone
O
n July 31st, the China National Drug Administration (CNDA)
has approved the use of IBRANCE (palbociclib), a cyclin-
dependent Kinase 4/6 (CDK4/6) inhibitor designed for the
treatment of hormone receptor-positive, human epidermal growth
factor receptor 2-negative (HR+/HER2-) advanced or metastatic
breast cancer.
Cancer is slowly becoming the leading cause of death at a global level,
and unfortunately, China is one of the countries that has the worst
statistics. Among the approximately 270.000 new breast cancer cases
discovered each year, the mortality rate is close to 25%. Because of
lack of awareness and limited testing facilities, about one-tenth of
patients are diagnosed in the latter stages, meaning fewer treatment
options are available. Early breast cancer patients that undergo therapy
R
esearch is now being conducted in the ways through which cells
communicate with one another, as it can open a key to improving
treatments of serious diseases like cancer. One particular family
of such signaling molecules are known as Wnt Proteins which are
transported in between cells. These molecules signal for various cell
developmental processes.
The mechanism behind the transmission of Wnt proteins has been
found out just recently, that certain cell protrusions known as
cytonemes play a major role in the transmission of the signal for
controlling the rate of cell division.
Previously, researchers have believed that these signaling molecules
were in fact secreted by the cells into the extracellular space, from
where they would diffuse. Professor Steffen Scholpp, the Principal
A
study conducted for the second time establishes that with
more vitamin D binding protein circulation, there is a lesser
risk of developing kidney cancer. The related findings are in
correspondence with the previous results that also demonstrated the
inverse relationship between Vitamin D binding protein and risk of
kidney cancer, specifically Renal Cell Carcinoma, RCC.
The current study has been conducted since 1992, initiated in the
American Cancer Society Cancer Prevention Study-II (CPS-II)
Nutrition Cohort, involving 39,371 people who submitted their
blood sample, with no presence of cancer prior to submission. Prior
to June 30, 2009, it was observed that 87 out of these people went
through a primary diagnosis of RCC. The data related to diagnosis
was assimilated by means of self-reported questionnaires, medical
records’ reviews and NDI (the National Death Index).
118 Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein
The results revealed that a higher level of serum DPB concentration
led to a lowered risk of RCC. Those participants who had higher
levels of DPB were younger, mostly females, non-smokers and had a
lower BMI (body mass index).
According to Dr. Alison Mondul, an assistant professor of epidemiology
at the University of Michigan and the author of this study, it has
been revealed that risk of developing kidney cancer is not caused by
vitamin D itself, however, to estimate the presence of free vitamin D
versus that which is bound in circulation seems important as other
molecular structures like hormones in our body can have an effect
on us if they are free. However, free Vitamin D was also found to be
not associated with the development of renal cell carcinoma. These
associations are positive in colorectal cancer, prostate cancer, lung
cancer and bladder cancer, however, for renal sites, the case of vitamin
D’s effect differs and it requires more research.
DPB has been found to influence cancer formation in this case, outside
of its general role of transporting Vitamin D metabolites to various
sites in our bodies. The statistical power of the study is meager
because of the rarity of RCC cases. Further studies will be conducted
in the non-white population as kidney cancer incidence occurs more
in black men in the United States than white men.
Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein 119
Cancer Breakthroughs, Colorectal Cancer
A
rray BioPharma recently made the announcement that is has
received the Breakthrough Therapy Designation from the
United States FDA (Food & Drug Administration) for the
drug encorafenib BRAFTOVI in combination with the drugs namely
binimetinib (MEKTOVI) & cetuximab for the treatment of the
patients having BRAF V600E mutation metastatic colorectal cancer
(mCRC). The patients who have BRAF V600E-mutant mCRC tend to
have a higher mortality rate (usually double) in the case of the patients
having mCRC without the mutation. In the current scenario, there
are no specific therapies that are approved for meeting the treatment
requirements of such patients.
120 Array BioPharma Receives FDA Breakthrough Therapy Designation for BRAFTOVI
The Breakthrough Therapy Designation is an FDA-approved process
of expediting the development & review of the drugs that are aimed
at treating a serious health condition. In this designation process,
the preliminary clinical evidence suggests that they might be able to
demonstrate significant improvement over the existing therapies on
over a single clinically crucial endpoint.
BRAFTOVI, also referred to as “encorafenib,” is a small oral molecule
“BRAF” kinase inhibitor. At the same time, MEKTOVI, also known
as “binimetinib,” is yet another small oral molecule MEK inhibitor.
These drugs are aimed at targeting the key enzymes in the MAPK
referring to the pathway RAS-RAF-MEK-ERK. In the United States,
the drug combination of BRAFTOVI & MEKTOVI is given approval
by the FDA for the treatment of metastatic or unresectable melanoma
with BRAF V600E or V600K mutations.
Colorectal cancer, amongst all other forms of cancer, is the third most
common type of cancer occurring men across the world. By giving the
patients the combination of the drugs is expected to bring some hope
into the treatment of colorectal cancer in the coming times
Array BioPharma Receives FDA Breakthrough Therapy Designation for BRAFTOVI 121
Healthy Lifestyles, Nutrition, Prevention
I
f you tend to have some ailment, there are good chances that you
might be suggested the idea of some turmeric-based treatment at
some point in life. There are thousands of manuscripts and reports
published about the potential health benefits of “curcumin” – the
active ingredient found in turmeric.
What is Turmeric?
Turmeric is a world-famous spice that appears similar to ginger.
The spice is known for its bright yellow shade and is usually used
in preparing a wide range of cuisines. Also referred to as the “Indian
Saffron,” the spice is grown widespread across India along with other
areas including Asia & Central America. Turmeric is known to add
flavors to the dishes and is also a major component of several religious
ceremonies. Its medicinal usage has been in practice in the ancient
science of Ayurveda for the past 4,000 years.
O
ne of the oldest and most common spices used daily throughout
the world, garlic has a unique taste that you either love or hate.
Claims of medicinal properties go back at least as far as Ancient
Egypt, where it was prescribed as a stimulant or for fighting infections.
Recent scientific studies exploring their rumors have brought to light
some unexpected results.
Even though the modern pharmaceutical industry still relies, at least
in part, on natural remedies, folk medicine continues to exist, in spite
of having no or little proven scientific data. While in most cases, the
healing properties are non-existent or exaggerated, garlic seems to
have incredible hidden potential and may help fight a series of diseases
and conditions.
Garlic is rich in vitamins B and C as well as many essential minerals
like potassium, magnesium, phosphorus, calcium. A growing number
of supplements are based on garlic or garlic extract.
A
team of researchers from the Francis Crick Institute is
investigating claims that diets which include certain vegetables,
like kale, cabbage and broccoli, could, in fact, reduce gut
inflammation and the overall risk of developing colon cancer.
While it is well established that natural and balanced diets have great
influence when it comes to protecting the body from developing
certain conditions or diseases, the underlying mechanisms still remain
unclear. The recent article that appeared in the medical journal
Immunity, examined the health benefits of an indole-3-carbinol (I3C)
rich diet and revealed some interesting results.
I3C is a compound found mostly in cruciferous plants (cabbage,
broccoli, Brussel sprouts etc.) and is responsible for activating the
aryl hydrocarbon receptor (AhR) protein. AhR acts like a sensor that
C
omputer giants IBM have partnered with the Memorial Sloan
Kettering Cancer Center in order to help the oncology community
by providing one of the most complex artificial intelligence units
in existence, Watson.
Medicine is one of the fields that has benefited the most from
technological evolution, and can now boast some impressive
innovations like nanoparticles targeting specific cells in the body,
extremely precise and powerful medical lasers or robot-assisted
interventions. These tools are extraordinary and have saved or
improved the lives of countless patients, but now, a new ally is hoping
to further tip the balance in our favor, an artificial brain.
A
spirin, one of the most common over the counter drugs, generally
taken for pain, fever or inflammation, seems to have another
potential use – the prevention of colorectal cancer (CRC).
Acetylsalicylic acid (ASA) or simply aspirin is a nonsteroidal anti-
inflammatory drug (NSAID) and works by inhibiting the enzyme
cyclooxygenase-1 (COX-1) responsible for the production of
prostanoids, mainly thromboxane and prostaglandins. This, in turn,
affects the formation of prostaglandin-endoperoxide synthase 2
(PTGS2 of COX2) an agent associated with a number of types of
cancer.
While the exact mechanism through which ASA acts to prevent
colorectal cancer is still unknown, it seems that by disrupting
phosphatidylinositol 3-kinase (PI3K) signaling, there is a reduction
J
ohn Sansone discovered he had kidney cancer back in 2012 when
he noticed blood coming in his stool and a sharp pain at his side.
He went through a surgery which removed the tumor growing on
his kidney. He was relieved, but nine months later, he noticed blood
in his coughs. Consequently, his reports showed the cancer to have
reemerged, reaching his lungs.
The diagnosis had come right after 9 months of his marriage and
served like a death call for Sansone. He believed he wouldn’t live for
as long as none of the treatments quite worked on him, except for
a short while. He was left nauseous and weak and utterly hopeless.
But then he recalls his treatment at the Cancer Treatment Centers of
America, at the hands of Dr. Sharad Chandrika.
W
ith more than 160.000 new cases each year, prostate cancer is
the second most common types of cancer in the United States.
It is estimated that approximately 30.000 people will die as a
result, just in 2018.
These statistics might soon see dramatic changes, as a new form of
radiotherapy, stereotactic ablative radiotherapy (SABR), is currently
showing impressive results. The procedure involves thin beams of
radiation aimed directly at the tumor, from different angles. The
technique allows the application of high doses of radiation with little
damage to nearby healthy tissue.
T
he number of deaths due to lung cancer is more than those
caused by any other type of cancer, for both men and women,
Centers for Disease Control and Prevention claim. According to
the American Cancer Society, 234,030 new cases of lung cancer will
appear in 2018 and out of these, 154,050 are expected to not make
it through the disease.
However, according to the American Cancer Society, the North
American Association of Central Cancer Registries and the Centers
for Disease Control and Prevention, the death rate due to lung cancer
was low from 2011 to 2016. The data for these findings was from
forty-two states, about 89% of the total population of the country.
With so many people suffering from this disease, the most important
thing is to ensure that these patients maintain a quality of life. Doctors
O
ne of the few animals that can resist cancer is elephants. Naked
Mole Rats and Sharks are also found to resist cancer. However,
the discovery of this characteristic in elephants is recent and
researchers look for ways to understand and apply the concept of
cancer resistance in elephants to human biology.
Scientists from the University of Chicago have discovered a specific
gene that prevents cells in elephants from developing cancer, called
LIF6. The cells activate LIF6 if any sort of damage takes place in the
cells. LIF6 has the ability to break down the mitochondria of these
cells, killing them eventually. This way dead cells do not pass on the
DNA and cancer fails to spread.
C
hildhood leukemia is a severe case to be treated. Over the years,
better treatments have come forth but a few particular types of
this cancer remain incurable, such as the mixed lineage leukemia,
with the death rate of 50%.
But now recent research is making an appearance in an issue in journal
PNAS, reveals that a protein called LEDGF/p75 is regulated by a molecular
modification that alters its electric charge, called phosphorylation.
LEDGF/p75 plays role in the regulation of gene expression by attaching
other proteins to particular epigenetic spots on chromatin. This function
is hindered by two diseases, mixed lineage leukemia and HIV. There
is not much known about LEDGF/p75 interactions with its binding
partners in this biological regulation which limited better way of
targeting LEDGF/p75 interactions in these diseases.
T
his new approach is the result of more than a decade of research
and testing done by scientists at Walter and Eliza Hall Institute
in Melbourne, Australia.
Under the coordination of Associate Professor Tim Thomas and
Associate Professor Anne Voss, the team has been focusing on
inhibiting KAT6A and KAT6B proteins, known malignancy markers.
Both of these two compounds are responsible for cell proliferation,
effectively driving tumor growth.
“Early on, we discovered that genetically depleting KAT6A
quadrupled the life expectancy in animal models of blood cancers
called lymphoma. Armed with the knowledge that KAT6A is an
important driver of cancer, we began to look for ways of inhibiting
the protein to treat cancer”, said Professor Thomas.
I
n case you haven’t heard, October is Breast Cancer Awareness
Month! This is an international campaign, supported by thousands
of organizations around the world, which tries to draw attention on
this issue and promote early detection and treatment.
According to estimates from the World Cancer Research Fund,
2018 brought more than 2 million new breast cancer cases. As with
many of the other types of malignancy, genetics and hormones play
an important role in one’s chance of developing cancer, but there
are other factors, which you can have a bit more control over, that
influence this outcome.
Ways-of-Reducing-the-Risk-of-Cancer
How can you reduce the risk of developing breast (or other types of)
cancer?
A
ccording to a recent study, a natural derivative found in a rare
Chinese tree, namely Camptothecin, presents a strong antitumor
characteristic and offers a low toxicity profile.
Pancreatic ductal adenocarcinoma (PDAC) is a common form of
cancer with an articularly low outcome. Even the more aggressive
courses of treatment only produce about 6-8% five year survival rates.
The fact that pancreatic tumors are very dense makes the delivery
of cancer-fighting drugs a big challenge. This is where the work of a
research team from the Roswell Park Comprehensive Cancer Center
comes in.
According to their press release, “a novel camptothecin analogue
named FL118, which does not use TOP1 as its anticancer therapeutic
target, effectively eliminated human colorectal and head/neck tumors
T
he majority of breast cancers present with an abnormality in the
p53 gene, a powerful tumor suppressor. In its absence or if it is
damaged, patients have a higher risk of developing the disease
or the resulting tumor becoming particularly resistant to treatment.
“Despite decades of research, there had been no satisfactory way to
overcome the deleterious effects of p53 loss – until now”, said Sanjay
Awasthi, a professor at Texas Tech University Health Sciences Center
(TTUHSC) School of Medicine and research leader. This even raised
the interest of the Department of Defense, who awarded him a grant
based on his study, “Prevention of Breast Cancer by Haploinsufficiency
of RALBP1”.
Protein-That-Inhibits-Breast-Cancer-Suppression-Finally-Blocked
The P53 gene is called “the guardian of the genome”, as it is essential
for regulating cell division and the prevention of tumor formation. “If
B
iological therapies have been a big focus in the recent landscape
of cancer treatments. These are treatments relying on substances
made from living organisms and used to treat malignancies.
Among the different approaches, Adoptive Cell Transfer (ACT)
has already shown some incredible potential when it managed to
completely remove any trace of the disease from a patient suffering
from breast cancer. This is a procedure where the most active T cells,
a specific kind of immune antibody, are harvested from the tumor,
grown in laboratory conditions and then injected back into the body.
Groundbreaking-Immunotherapy-Leads-to-Complete-Remission-
of-Breast Cancer
The article describing this remarkable case detailed how ACT along
with tumor-infiltrating lymphocytes (TILS) were used to target the
particular tumor mutation. After previously unsuccessful courses of
C
ancer is the most lethal disease and finding its potential treatment
is the biggest challenge for the scientists. The major hindrance
in cancer research is the requirement of funds. Recently, the
University of Toledo got a huge fund by Susan G. Komen of Northwest
Ohio for a cutting-edge research to find novel treatments for a very
aggressive and recurring Triple Negative Breast Cancer (TNBC).
Research depicts about 15% of the breast cancer to be TNBC affecting
younger people more.
University-Of-Toledo-Professor-Working-On-Cutting-Edge-
Cancer-Research
Dr. Amit Tiwari, an Assistant Professor in the College of Pharmacy in
UT has discovered a promising new drug for Triple Negative Breast
Cancer where patients resist conventional chemotherapy. He opines
that cancer cells should be targeted in a non-conventional way in
T
he most heart-shattering thing is to see small and innocent children
attacked by fatal diseases like cancer. The ages when they should
be playing with their toys, they receive severe chemotherapeutic
treatments to get rid of cancer. Cancer occurs irrespective of the ages
and has no mercy on the tiny tots. Such merciless was the story of
four little girls who fought their ways successfully through cancer.
154 4 Little Girls Who Beat Cancer Reunite at Hospital for Touching Photo
McKinley, Chloe, Ava, and Lauren are the pretty little girls who
defeated cancer at Johns Hopkins All Children’s Hospital in Florida.
During their treatments in 2016, the four became fast friends in the
hospital halls becoming a silver lining in the cloud for each other. At
that time, they gathered for a photo shoot for the first time that had
been on the fly. Ava, Lauren, and McKinley were diagnosed with acute
lymphoblastic leukemia and Chloe was diagnosed with a rare lung
cancer at the ages of 2 and 3. The girls reunited a few days back to
pose for a colossal photo.
Ava’s mother, Alyssa Luciano told that the first picture of the four
friends was taken together during their active treatments when they
were all bald little babies. Lauren’s mother, Shawna Glynn stated
that the friendship of the girls help in easing their difficulties, like
Lauren didn’t have any hair but seeing her friends look the same way
provided her normalcy. Lauren’s treatment has been completed a few
days back. McKinley’s mother, Karen Moore told that seeing the girls
strong together was a great source of comfort for the parents.
The girls again gathered in 2017 for another photo session wearing
T-shirts with printed motivational words. However, the reunion of
the girls this year for the photo shoot is more meaningful as each
wore gold T-shirts with “survivor” written on them providing strength
and hope to other children fighting cancer in the Childhood Cancer
Awareness month of September. The mothers of the fantastic four are
very happy with their motivational friendship and plan to meet next
year again for another photo to track their recoveries.
4 Little Girls Who Beat Cancer Reunite at Hospital for Touching Photo 155
Breast Cancer, Lung Cancer, Mesothelioma Cancer
D
r. Prasad Adusumilli – the leading scientist and Thoracic
surgeon at MSK (Memorial Sloan Kettering) Cancer Center
believes that personalized gene therapy can soon help in
changing the manner pleural mesothelioma is being treated in the
current scenario.
Currently, Dr. Prasad is serving as the principal investigator of a
phase I clinical trial that involves the participation of customized
immune cells – referred to as CAR (Chimeric Antigen Receptor)
T-cells, showing relevant improvement in the overall treatment of
mesothelioma. As per Dr. Prasad, the revolutionary CAR T-cells might
change the overall method of treating mesothelioma in the coming
times.
T
he Food and Drug Administration has decided to support
vaccination for older adults that previously were not eligible. By
raising the age limit, there is a potential for protecting another
generation from the cancer-causing disease.
HPV, or human papillomavirus, is an umbrella term for more than
150 related viruses that are transmitted through intimate contact. The
infection either presents no symptoms or leads to warts, but generally
tends to go away on its own.
In recent years, a clear connection has been revealed between some
forms of HPV and an increased risk of cancer. In most cases, it affects
the genital area, for both men and women, but can also appear in the
back of the throat, including the base of the tongue and tonsils.
158 FDA Extends Age Limit for HPV Vaccine to Include Adults between 27 and 45
“Today’s approval represents an important opportunity to help
prevent HPV-related diseases and cancers in a broader age range,” said
Peter Marks, M.D., Ph.D., director of the FDA’s Center for Biologics
Evaluation and Research in a press release.
He added that “The Centers for Disease Control and Prevention has
stated that HPV vaccination prior to becoming infected with the HPV
types covered by the vaccine has the potential to prevent more than
90 percent of these cancers, or 31,200 cases every year, from ever
developing”.
Gardasil 9, the vaccine recommended for the procedure could help
protect the estimated 14 million new cases diagnosed each year in the
United States. Among them, approximately 16.000 people will die
from cervical cancer caused by certain HPV viruses.
Cherise Rohr-Allegrini, of The Immunization Partnership in San
Antonio, commented that “There’s a sweet spot between age 9 and
15 where with just two shots you develop sufficient immunity to be
protected, but that doesn’t mean it’s not effective the older you are.
Over 15, we require three shots to get that level of immunity, and
we’ve now seen adults, as well, can become sufficiently immune if
they’ve gotten the three shots“.
Cherise is a long-time advocate of vaccination and says that even
if you test positive for one strain, it is “definitely worthwhile to get
vaccinated to prevent infections with other strains of HPV”.
FDA Extends Age Limit for HPV Vaccine to Include Adults between 27 and 45 159
Healthy Lifestyles, Prevention, Uterine Cancer
A
s women, drinking additionally 1.5 liters of water on a daily
basis can help in reducing bladder infections – especially in
premenopausal women by around 50%. This has been observed
by a recent study led by Dr. Yair Lotan –Professor of Urology at the
Simmons Cancer Center.
Under the impact of the controlled trials, women who had the habit
of drinking of additional around 1.5 liters of water on a daily basis
reflect around 48 percent fewer cases of repeated bladder infections in
comparison to those who consumed lesser amounts than the desired
volume of daily water intake. Women drinking more water turned out
to be healthy in the long run. Reduced bladed infections can also help
to prevent several diseases.
160 Drinking More Water can Help in Reducing Bladder Infections in Women
Dr. Lotan states that there stands a significant difference in the overall
health of women who consumed more water daily. The given findings
prove beneficial as more than half of the women’s population around
the world report bladder infections – one of the most common
infections in women.
The physicians in the given finding suggest that increased fluid
intake can help in reducing bacteria growth. Moreover, it also helps
in limiting the ability of bacteria to attach itself to the bladder and
cause infections. The common symptoms that are associated with
uncomplicated cystitis – a common UTI (Urinary Tract Infection)
are difficult or pain during urination, the feeling of the full urinary
bladder, increased frequency or urgency of urination, possibly blood
in the urine, and mild tenderness towards the lower abdominal area.
As most of the cases of bladder infections in women are treated with
the help of antibiotics, the increase in the fluid intake could help in
reducing the use of antibiotics at the same time. As such, this helps in
controlling the antibiotic resistance of the body as per the researchers.
In this study, Dr. Lotan makes use of robotic, minimally invasive, and
open surgical methods for treating kidney, bladder, prostate, testicular,
and ureteral cancer. He is a leading surgeon at UT Southwestern’s
Harold C. Simmons Comprehensive Cancer Center. Dr. Lotan is
clinically recognized for his contributions in the field of coming up
with urine markers for bladder cancer treatment along with molecular
markers in other forms of urologic cancers.
Drinking More Water can Help in Reducing Bladder Infections in Women 161
Breaking Cancer Research, Pancreatic Cancer
A
good general rule is to stay away from poisonous plants, especially
ones that have such a threatening name, but researchers from
The University of British Columbia were not deterred. They
managed to synthesize a compound from the deadly mushroom in
the hope it can be used to treat cancer cells.
The story might sound a bit strange at first – using a known poison
to fight tumors, but in reality, there have been similar theories starting
with the early 1980s. In fact, only a few years ago, there was a study
that tested this exact claim, though the investigation did not go further
because of how difficult it is to extract samples.
Amanita phalloides, or more commonly the “Death cap” mushroom,
produces α-amanitin, a bicyclic octapeptide regarded as one of the
deadliest known peptide toxins on Earth. Just managing to derive the
G
enetic testing holds a special place in revealing genetic changes
that are involved in causing hereditary cancers. Testing
laboratories have been encouraged by a new research study at
UT Southwestern Medical Center to update their records and aware
physicians when the genes are reclassified. Genetic testing results
from 1.45 million people were revised which depicted the subsequent
reclassification of likely or unlikely cancer association of about 25
percent of “variants of uncertain significance”.
Genetic variations are classified as “benign,” “likely benign,” “variant
of uncertain significance,” “likely pathogenic,” or “pathogenic”.
Reclassification of a variant to be “pathogenic” might matter a lot
to the patient. A patient might add MRI scans to their mammogram
screening program or want to have prophylactic surgery if he has a
broken BRCA gene. Likewise, if a variation is reclassified as “benign”
References:
https://www.sciencedaily.com/releases/2018/09/180925140415.htm
https://www.utsouthwestern.edu/newsroom/articles/year-2018/
cancer-related-gene-variations.html
C
ancer is the major cause of deaths all around the world and
scientists are working hard to find its potential treatments.
Sometimes, the prospective treatments are found in the natural
world like the immune system of camelids. EGF (Epidermal Growth
Factor) causes cancer when dysregulated and numerous therapeutic
tools that have the potential to block its activity have been described
by Institute for Research in Biomedicine (IRB Barcelona) and the Vrije
Universiteit Brussel (VUB).
No inhibitors have been designed for EGF up till now, but researchers
have isolated a family of nanobodies from camelids derived from
alpacas which possess a therapeutic effect by inhibiting EGF.
Previously, the advanced treatments have been established against the
EGR receptor (EGFR) but the patients developed resistance leading
to the decreased efficacy. The new inhibitors have been designed by
166 The Immune System of the Alpaca Reveals a Potential Treatment for Cancer
employing an evolving biotech tool, nanobodies which have high-
affinity for EGF.
References:
https://www.sciencedaily.com/releases/2018/10/181002103005.htm
https://www.ncbi.nlm.nih.gov/pubmed/20033049
The Immune System of the Alpaca Reveals a Potential Treatment for Cancer 167
Breast Cancer, Colorectal Cancer, Lung Cancer, Ovarian Cancer
T
he major challenge these days lies in finding an effective treatment
against all types of cancers. Developing potential vaccinations
is an important effort in this regard where many scientists are
making their marks. A new vaccine has recently been developed which
is of a great advantage to patients with metastatic HER2-positive
cancers who had not received any HER2-targeted therapeutic before.
6 out of 11 cancerous patients depicted clinical benefit after receiving
more than the lowest dose of the vaccine.
New-Cancer-Vaccine-Shows-Early-Promise-For-Patients-With-
Her2-Positive-Cancers
According to Jay A. Berzofsky, immunotherapy is by far most
successful as it has lesser side effects than traditional chemotherapy
and destroys cancer by rationalizing the exquisite specificity of the
168 New Cancer Vaccine Shows Early Promise For Patients With Her2-Positive Cancers
immune system. Here, an immune response is triggered by using a
vaccine approach against HER2 that might be a cause of ovarian,
breast, lung, gastroesophageal and colorectal cancers. The novel
vaccine developed for HER2-overexpressing cancers has shown
promising results paving new therapeutic paths.
Berzofsky and colleagues customize the vaccines for each patient by
using immune cells isolated from their blood which is then modified
in several ways and injected back to the patients intradermally. This
vaccine has a huge potential of eliminating established and aggressive
tumors in addition to lung metastases in mice. During the dose
escalation portion of clinical trials, it was observed that the patients
did not respond to 5 million dendritic cells per injection but about
54% patients responded to 10 million or 20 million dendritic cells per
injection. The dose was safely increased to 40 million dendritic cells
per injection which offered enhanced clinical benefit.
The researchers plan to combine the vaccine with checkpoint inhibitor
therapy in future to increase the number of benefitting patients. The
only limitation of the treatment is that it has no placebo control with
a relatively small, phase I clinical trial. However, the additional trials
will be satisfactorily promising.
References:
https://www.sciencedaily.com/releases/2018/09/180930153540.htm
New Cancer Vaccine Shows Early Promise For Patients With Her2-Positive Cancers 169
Bladder Cancer, Breakthrough Therapy Designation, Head and
Neck Cancer, Kidney Cancer, Lung Cancer, Melanoma Cancer,
Non-hodgkin’s Lymphoma Cancer, Skin Cancer
T
he FDA has just announced that Libtayo is now officially the
first and only form of treatment for patients with cutaneous
squamous cell carcinoma (CSCC) or locally advanced CSCC
who do not qualify for courses of radiation or surgery.
In a press release, Michael R. Migden, M.D., Professor at The
University of Texas MD Anderson Cancer Center and lead investigator
in the pivotal CSCC clinical program, said: “Today’s FDA decision is
great news for patients with advanced CSCC, who previously had
no approved treatment options. This is especially true because these
patients are no longer candidates for curative surgery or radiation.
Libtayo is an important new immunotherapy option for U.S. physicians
to help address a significant unmet need in this patient group.”
P
ARP inhibitors are approved by the Food and Drug Administration
for the treatment of certain breast and ovarian cancers. But could
they one day be given the green light to help patients with the
deadliest form of lung cancer? Early study findings published in the
Journal of Clinical Oncology show promising results.
Investigators at The University of Texas MD Anderson Cancer Center
in Houston discovered that adding the PARP inhibitor veliparib to
a standard chemotherapy regimen improved overall responses rates
(ORR) in patients with relapsed small cell lung cancer (SCLC).
“Small cell lung cancer is one of the most difficult to treat cancers
once it has relapsed because it is so drug resistant,” Lauren Averett
Byers, M.D., associate professor of Thoracic/Head and Neck Medical
172 PARP Inhibitors May Bring New Hope to Patients With Small Cell Lung Cancer
Oncology, told CURE in an interview. “There are currently no
approved targeted drugs for small cell lung cancer and no established
biomarkers to guide treatment selection for patients, even though
research from several groups has now shown that there are different
subsets of small cell lung cancer that, in the lab, respond differently
to specific targeted therapies.”
The phase 2 trial, which was supported by funding from the National
Institutes of Health (NIH)/NCI and The LUNGevity Foundation,
included 104 patients with relapsed SCLC, including some with
advanced disease with brain metastasis, from seven cancer centers
in the United States. Many patients had failed prior standard
chemotherapy.
In the trial, patients randomly received either veliparib or placebo
twice daily with the chemotherapy agent Temodar (temozolomide),
which are both oral medications. This occurred between 2012 and
2015.
Although progression-free survival (PFS) was the primary endpoint,
the investigators determined there was no statistically significant
difference between both groups. PFS was 36 percent in the Temodar/
veliparib group compared with 27 percent in the Temodar/placebo
group. In addition, overall survival (OS) was similar between the two
groups at 8.2 months and seven months, respectively.
However, investigators saw a significant difference in ORR, which
was almost three times higher in the Temodar/veliparib group
compared with the Temodar/placebo group (39 percent versus 14
percent, respectively).
“To find that the addition of the targeted PARP inhibitor therapy
enhanced response rates, and to demonstrate a novel, easy to perform
biomarker could potentially help us identify those patients who
get benefit from adding veliparib to chemotherapy, was incredibly
exciting,” Byers said.
Researchers also determined that a group of patients whose tumors
expressed the protein SLFN11 — about half of patients with SCLC
have this at the time their cancer is diagnosed — experienced a PFS
(5.7 versus 3.6 months) and OS (12.2 versus 7.5 months) benefit.
PARP Inhibitors May Bring New Hope to Patients With Small Cell Lung Cancer 173
“SLFN11’s job is to make sure that cells with lots of DNA damage
don’t keep trying to replicate themselves and, rather, undergo cell
death, which is why we think this makes sense as a biomarker for
PARP inhibitor therapy, not just for lung cancer but potentially for
other cancers where PARP inhibitors are used as well,” Byers said.
“If these results are validated in other studies, it could become the
first predictive biomarker for SCLC and allow us to apply a more
personalized approach to treating SCLC,” she added.
Although some toxicities were experienced, such as blood count
deficiencies, treatment generally was well tolerated, Byers said.
“The main side effect was that we saw on patient’s blood work that
they often had lower blood counts, especially platelets and white
blood cells, which is a known side effect of these two drugs,” she
said. “During the trial, we ended up decreasing the starting dose of
the chemotherapy (Temodar) which helped address the low blood
counts.”
Lung cancer is the leading cause of cancer death in the United States
for men and women. In 2018, more than 240,000 adults will either
receive a diagnosis of SCLC or non-small cell lung cancer — the more
common type of the disease.
To examine this further, Byers is testing veliparib at a higher dose
in combination with Temodar in the frontline setting. Through an
NIH grant Byers will also be able to study whether PARP inhibitors,
combined with immunotherapies, improve responses in SCLC.
“(This trial) shows the potential for translational research,” Byers
said. “I hope in the next few years PARP inhibitors will become a
treatment we can offer our patients routinely.”
174 PARP Inhibitors May Bring New Hope to Patients With Small Cell Lung Cancer
Breast Cancer, Cancer, Colorectal Cancer, Healthy
Lifestyles, Nutrition, Prevention, Prostate Cancer
A
diet that aims at encouraging healthy eating along with physical
activity while discouraging alcohol consumption has been linked
to the lowered risks of cancer including breast, prostate, and
colorectal cancers.
A recent study published in Cancer Research – a leading journal of the
American Association for Cancer Research stated the importance of a
healthy diet towards lowering the overall risks of developing cancer.
The research headed by Mathilde Touvier – head of the Nutritional
Epidemiology Research Team was found saying that amongst all the
possible risk factors being linked to cancer, proper nutrition & ample
physical activity are the best-known modifiable lifestyle aspects that
could contribute to lowering the overall risks.
A
group of surgeons at the University of Pennsylvania is conducting
experiments upon a new technology that could substantially
enhance the chances of survival amongst the Mesothelioma
patients. This is done by ensuring that patients having malignant
pleural mesothelioma can have their cancers removed.
The complete removal of the cancer cells can create a major difference
between life & death. This is because even the slightest remnants of
the cancer cells could quickly grow back into tumors. However, the
process of the complete resection known as “macroscopic complete
resection” is not easy.
Therefore, for improving the chances of removing as many cancer cells
as possible, the team of researchers at the University of Pennsylvania
Surgeons at Pennsylvania “Light Up” Tumors for Boosting the Chances of Mesothelioma Survival 177
at the Abramson Cancer Center has come up with the innovative
technology -“TumorGlow”. This technology is a type of intraoperative
imaging technique that makes even the slightest clusters of cancer cells
glow under the impact of the near-infrared light rays.
As per the study, this advanced technique has the capability of
improving the overall precision & accuracy of treating cancer during
surgeries. It also helps in facilitating the earliest detection of the small
cancer tumors for ensuring better outcomes of the cancer treatment.
Towards testing the overall success & feasibility of the given “light up”
technique, the team of researchers at the University of Pennsylvania
took help from 20 patients having malignant pleural mesothelioma.
The patients who were about to have their cancer surgeries were
injected with the given dye of the “TumorGlow” machine 24 hours
before the operation.
During the cancer surgery, the doctors made use of the infrared light
to help them guide to as many groups of cancer cells as possible.
The given samples of cancer cells that looked suspicious were then
removed.
178 Surgeons at Pennsylvania “Light Up” Tumors for Boosting the Chances of Mesothelioma Survival
Cancer Cures, Leukemia Cancer
L
eukemia research by Cincinnati Children’s Hospital Medical
Center gives us hope on a higher percentage of getting leukemia
cured.
AML or Acute Myeloid Leukemia is caused by a disruption on the
genetic programming of blood cells with the defect of chromosome
11q23. The survival rate is ranging from 20-40 percent. This urged
the scientists of Cincinnati Children’s Hospital to look for a more
effective treatment by doing a research with mice and donated human
cells.
According to H. Leighton Grimes, PhD, principal investigator and
Sarah Meyer, PhD, a former member of the Grimes Laboratory, the
cancerous blood cells died and were replaced by healthy white blood
cells when scientists blocked the target molecule on human AML cells
in combination with other known treatments.
P
ancreatic cancer is known to grow slowly and spread quickly – before
it gets discovered. This is the reason why most of the pancreatic
cancer cases are quite typical to diagnose & treat properly. If you
have been diagnosed with pancreatic cancer and you are suggested in-
depth pancreatic cancer treatment – what should you do?
To start with, you must feel confident about the pancreatic treatment
that you will receive from the given healthcare team. You must seek a
healthcare team that is able to emotionally, physically, and mentally
understand your specific requirements. If you are just about to begin
your pancreatic cancer treatment, here are some top do’s & don’ts
for you to consider:
■■ DO See a Proper Specialist: When you visit a medical specialist
dealing in the field of pancreatic cancer, you can help in
B
iomedical research involving nanoparticles is being tested as it
could pave the way for a new and more effective drug-delivering
method against glioblastoma, the most aggressive form of brain
cancer.
Nanotechnology might be the key to figuring out a cure for cancer
once and for all. Scientists are using microscopic particles that are
embedded with powerful drugs to target specific cancer cells. Their
ability to permeate the blood-brain barrier makes them ideal for a
more directed and controlled approach.
The latest development was creating a nanoparticle able to transport
two different compounds: one that actively damages and reduces the
tumor cells, and another that renders them unable to regenerate.
A
n Australian team of scientists announced they have discovered
a way of revealing if a patient has melanoma with just a blood
test.
Researchers from Edith Cowan University are confident they can
catch the disease in the very early stages before it can start spreading
through the human body.
The survival rate over an initial period of five years for patients who
are diagnosed early on is over 90%. This drops considerably, below
50%, if the melanoma had time to expand and affect other areas.
The prospect of replacing extensive investigations with a simple
medical test is impressive. The standard procedure right now is to have
I
s classed as a non-provitamin A carotenoid, lycopene the red
pigment found in tomatoes, watermelon or pink grapefruit. It is
associated with a number of health benefits including helping with
maintaining a good circulation, reducing cardiovascular risks and the
likelihood of developing cancer.
It should be pointed out, not every fruit or vegetable which has red
color also contains lycopene. The highest amount can be found in fresh
tomatoes, but even after processing, they still retain a considerable
concentration.
A
patient whose situation seemed hopeless managed to lose
any trace of advanced skin cancer, simply based on a doctor’s
intuition.
The story seems unbelievable, yet it’s true.
An elderly woman, in her 90’s, with countless squamous cell tumors
on her right leg, went to Sylvester Comprehensive Cancer Center,
where she was seen by a resident dermatologist.
Because the tumors were so numerous and considerable in size, the
normal treatment, which is surgery, was out of the question. The
situation seemed bleak.
Aware of the possibility of there being a connection between human
papilloma virus (HPV) and some types of skin cancer, Dr. Anna
Nichols had the idea of trying something more unconventional.
HPV Vaccine Removes Dozens of Tumors from Patient With Advanced Skin Cancer 189
The procedure involved several sessions where 9-valent HPV vaccine
was administered intratumoral, between March 2016 and February
2017. Within 11 months from the first injection, all the tumors
disappeared and did not show any sign of reoccurrence.
Even though the doctors were expecting some slight improvements,
no one could predict the actual success. Squamous cell carcinoma
(SCC) is number two on the list of the most common types of skin
cancer and has a high chance of returning.
Now the patient is on her way to celebrating her 100th birthday thanks
to the unusual approach. This was the first documented instance of
complete regression from using the HPV vaccine for treating other
forms of cancer.
The case is sure to spark new interest and more in-depth research
into SCC.
190 HPV Vaccine Removes Dozens of Tumors from Patient With Advanced Skin Cancer
Cancer, Cancer Cures
C
ancer is the leading cause of death worldwide and the treatments
are either in experimental phases or clinical trials. Scientists
and researchers are striving hard day and night to find novel
therapeutic strategies that eliminate cancer at all stages. Genetic
Engineers have introduced a new strategy, whereby they manipulated
certain wandering cancer tumor cells to secrete a special protein.
This protein when interacts with the localized tumor cells, elicits a
death switch in them, ultimately killing them. The wandering cancer
cells possess an integrated suicide switch that compels them to kill
themselves before they start another generation of tumors.
The scientists previously utilized the tumor cells in circulation to
target the localized tumor cells via certain viruses that eradicate
cancer. However, this method is old and the hardworking researchers
devised a new technology to tackle the lethal cancers. This new gene
editing technology, CRISPR/Cas9 edits the cancerous genes in such a
Cancer Cells Engineered to Trigger a Death Switch in Other Cancer Cells 191
way that their entire line of action is maneuvered, thus being granted
the refined characteristic of self-devastation when they are of no use.
CRISPR/Cas9 technique has created a buzz and revolutionized the
whole world of science.
Reinshagen and his coworkers have hit upon a new approach to
exterminate localized tumor cells by taking potential benefit of
the “self-homing” behavior of the tumor cells. The “self-homing”
principle reveals tumor cells to relocate to the main tumor site
wherever inoculated in the circulatory system. Reinshagen utilized
these tumor cells as therapeutic carriers or vectors that might carry
therapies and transfer them to the main tumor site, thus following
their “self-homing” behavior. The scientists carefully designed these
self-targeting tumor cells to secrete the ligands that target specific
death receptors on the resident tumor cells. The ligands upon binding
the receptor sites kill the main tumor cells but the planted cell itself
survives. In order to kill the savior cell before it becomes a culprit
in promulgating new tumor cells, certain drugs are induced that
trigger a cellular suicide system. This method has been reported really
convenient, safe and efficient by the scientists after they tested it on a
series of mouse models at preliminary and advanced stages of cancer.
The above-mentioned methods are being used and refined in science
research in order to fight cancer to the best levels. We can hope to nib
the cancer in the bud in the near future when these methods will be
implemented.
192 Cancer Cells Engineered to Trigger a Death Switch in Other Cancer Cells
Ovarian Cancer, Prostate Cancer
Prostate cancer, ovarian cancer, sarcomas and more cancer types now linked to Lynch syndrome 193
New cancer types linked to Lynch syndrome
Before the new cancer types (including cancers of the ovary, stomach,
urothelial tract, and small bowel, and less frequently – cancers of the
brain, biliary tract, pancreas, and prostate) were linked[3] to Lynch
syndrome, scientists performed a genetic analysis of about 15,000
tumor samples from 50 different cancer types. They were looking for
glitches known as high microsatellite instability (MSI-H).
This genetic marker (MSI-H) is typically associated[4] with a lot of
genetic abnormalities found in common tumors.
194 Prostate cancer, ovarian cancer, sarcomas and more cancer types now linked to Lynch syndrome
Blood Cancer, Cancer Breakthroughs, Kidney Cancer, Lung
Cancer, Prostate Cancer, Skin Cancer
C
ancer is a lethal disease finding ways in the world of therapeutics
to be completely cured. Newer drugs are being formulated by
scientists and marketed by the pharmaceutical companies at
a rapid pace in order to entirely wipe out cancer. Approximately
40,000 cases of skin, breast, lung, bowel, and prostate are annually
reported by the Irish Cancer Society. Health Service Executive (HSE)
is playing significant roles in fighting cancer by approving the newest
drugs for cancer therapy. Recently, HSE has approved a breakthrough
drug, nivolumab for financial reimbursement that could benefit
thousands of skin, kidney and blood cancer patients.
Nivolumab is produced by Bristol-Myers Squibb and marketed under
the brand name Opdivo. This drug is controversial due to its high cost
Hundreds of Kidney, Skin and Blood Cancer Patients May Be Cured from Breakthrough Drug 195
ranging from €50,000-€100,000 ($65,000 to $130,000) per patient
per year. It has been revealed by Simon Harris, Minister for Health
that the public health service has been sending applications to HSE
to reimburse the treatments for almost 8 indications by nivolumab.
After consulting with the department and assessing the circumstances,
HSE has approved reimbursement of nivolumab for treating renal
cell carcinoma (kidney cancer), melanoma (skin cancer) and Hodgkin
lymphoma (blood cancer), instigating from 9th October.
In order to avoid the misuse of the drug, HSE would not support
metastatic or locally advanced non-small cell lung cancer. Mr.
Harris made it clear that HSE would not support the patients in
private hospitals. Health insurers must deal directly with the private
hospitals if they want to link their policy on the cover for treatment
through nivolumab. HSE is considering all the applications after the
detailed assessment process. The recommendation of merely Opdivo
(nivolumab) or its combination with Yervoy (ipilimumab) by HSE has
been confirmed by Bristol-Myers Squibb. This reimbursement process
provides a potential benefit to the eligible patients with advanced
kidney cancer, advanced melanoma and a hostile blood cancer,
classical Hodgkin lymphoma (cHL).
Reimbursement of nivolumab monotherapy or combined therapy
with ipilimumab has also been announced for advanced melanoma
patients by Kay Curtin of Melanoma Support Ireland. Benjamin
Hickey, General Manager of Bristol-Myers Squibb believed that
advanced lung cancer patients would also be able to attain nivolumab
treatment in future on Irish Health Service, as they are working hard
to find such a possibility
196 Hundreds of Kidney, Skin and Blood Cancer Patients May Be Cured from Breakthrough Drug
Breast Cancer, Cancer Technology, Thyroid Cancer
A
utotaxin is an enzyme that is generated by the body for
regeneration and repair of tissues, but on the other side, it acts
as a catalyst for the growth of tumors. It also facilitates the
growth of other inflammatory conditions like arthritis, colitis and
cancer specially breast cancer and growth of thyroid tumors.
Researchers from the University of Alberta believe that by targeting
this enzyme which is causing vicious growth of tumors and resistance
in its treatment they can more effectively fight breast and thyroid
cancers.
A team under the leadership of David Brindley from the University of
Alberta supports this research. They believe that Autotaxin produces
lysophosphatidic acid which promotes the survival and growth of
cancer cells. The beneficial effects of radiotherapy and chemotherapy
N
anotechnology has brought a revolution to the whole world of
science and especially in the field of cancer therapeutics. The
discovery of nanoparticles has paved a way for the treatment of
cancer. Glioblastoma multiforme is the most dangerous and aggressive
cancer of the brain that is extremely hard to treat. Researchers have
developed a new mechanism of delivering the drugs to the brain
cancer cells by using nanoparticles as carriers and they are designed to
cross the blood-brain barrier and deliver two drugs at a time. Crossing
the blood-brain barrier and binding the tumor cells readily is quite
an achievement of nanoparticles. Holding two different compounds
by nanoparticles serve the purpose of destroying the DNA of tumor
cells by one drug and inhibiting the DNA repair mechanism by the
second drug so that they cannot nullify the effect of the first drug by
repairing the previously destroyed tumor cells.
T
he World Health Organization classifies lung cancer as the most
common type of cancer worldwide, both in men and women. The
mortality rate is so high that about 1 in 5 deaths are as of result
of this terrible disease
News of a possible new way of dealing with lung cancer brought a lot
of hope not only in the medical world but also for millions of patients
around the globe.
A recent study exploring the possibility of using Delta-tocotrienol,
a compound found in vitamin E, has surfaced. As it has shown to
have anticancer properties, it is being tested on several types of non-
small cell lung cancers (NSCLC), including squamous cell, large cell
Delta-tocotrienol Inhibitors Might Reduce Risk of Tumor Invasion and Metastasis 201
carcinoma and adenocarcinomas, to try and inhibit signals between
tumors cells. By preventing matrix metalloproteinase 9 (MMP-9)
migration and invasion of other cells, researchers are trying to prevent
cancer development at initial stages, as soon as possible after diagnosis.
Over the past decades, lung cancer has become more and more
frequent, and unfortunately, the survival rate past five years has not
improved at all, barely reaching 5% out of all cases.
A vaccine that could directly attack tumor cells by attenuating cell
invasion and possibly delaying metastasis in NSCLC, would be an
important breakthrough.
While the study concludes that “treatment with the tocotrienol mixture
resulted in a dosedependent and significant decrease in cell growth,
cell migration, tumor invasiveness, and induction of apoptosis”, it is
important to remember that these are only preliminary findings and
the road to seeing these results put into application is still ahead.
202 Delta-tocotrienol Inhibitors Might Reduce Risk of Tumor Invasion and Metastasis
Breast Cancer
T
he fight with cancer has deep and serious repercussions not only
on the patient but also for their family. A new study brings hope
to breast cancer patients that they might be spared the thought
of dealing with chemotherapy.
The usual course of action when a patient is diagnosed with
cancer involves chemotherapy, surgery and radiation. Each of these
procedures comes with some risks and discomfort.
While preoperative chemotherapy has the benefit of reducing the
tumor in size, making patients that might not otherwise be suitable
candidates become eligible for surgery, it also has some heavy side
effects, including: weakness, nausea, dizziness, pains.
The Trial Assigning Individualized Options for Treatment,
or TAILORx, was an international effort, gathering data from
W
hile the fact that there is a clear connection between healthy
diets that include high amounts of fruit and vegetables and
cancer prevention is something generally known and somewhat
well documented, there are still many questions surrounding the
matter. This is where a recent study comes in and shines some much-
needed light.
The project was started almost 40 years ago and relied on two studies
that worked in parallel. Combined, Nurses’ Health Study (between
1980‐2012) and NHSII (taking place between 1991 and 2013),
interviewed more than 180.000 women between ages 27 through 59.
Out of them, approximately 10.900 cases of breast cancer emerged.
From follow-ups over the next 30 years, researchers were able to
uncover some very interesting data.
By monitoring levels of hormone receptor status and molecular
subtypes, the study concluded that “higher intake of fruits and
vegetables, and specifically cruciferous and yellow/orange vegetables,
may reduce the risk of breast cancer, especially those that are more
likely to be aggressive tumors.”
Long-term Study Reveals Lower Cancer Incidence from Vegetable and Fruit Diet 205
More importantly, the article reveals concrete information about
which types of fruit and vegetables were more effective. For example,
blueberries and strawberries were rated higher, same with carrots,
kale and cauliflower.
When it comes to amounts, the study mentions that anything above
five and a half servings a day had a noticeably higher effect over
cases where only two and a half servings were had. One serving was
measured as one cup raw or a half cup of chopped or cooked fruit/
vegetables.
The study comes as a reminder that eating fresh, organic meals has
many health benefits, including preventing cancer incidence
206 Long-term Study Reveals Lower Cancer Incidence from Vegetable and Fruit Diet
Blood Cancer, Cancer Technology, Leukemia Cancer
P
atients suffering from acute myeloid leukemia (AML) have a
reason to be hopeful for their future as a new FDA drug has just
been approved.
The Food and Drug Administration recently sanctioned the use of
Ivosidenib and gave some much-needed help to doctors and patients
alike. Following several decades where there was a limited number
of choices for treating AML, there is now another option in the fight
against cancer.
Ivosidenib (Tibsovo) is an isocitrate dehydrogenase-1 inhibitor that
works on decreasing oncometabolite 2-hydroxyglutarate production,
in instances where a certain genetic mutation (IDH1) is found.
Clinical trials have shown increased efficacy, and out of the 174 cases
taking part, more than 30% showed complete remission in the course
T
he researchers across the world are working diligently towards
finding a cure for cancer. Recently, a study based on the observation
of telomeres & telomerase worked towards finding the cure for
cancer. Could bring about an alteration in the telomere length (TL)
result in the prevention of cancer & aging? The researchers are yet
to find that out!
Cancer is typically an age-related genetic ailment manifested only
when the normal cells of the body acquire genomic instability over
a given period of time and obtain the ability to undergo replicative
immortality. The weakening of the telomere & telomerase during
cell divisions generates a condition of chromosomal instability. This
contributes to major genomic rearrangements that could lead to
tumorigenesis in some cases.
T
he Food and Drug Administration, the U.S. agency responsible
for overseeing and approving new medical treatments, designated
LOXO-101, a selective inhibitor of tropomyosin receptor kinase,
as “Breakthrough Therapy”. This means that the drug has shown
significant health advantages to be fast-tracked and prioritized in
development.
The clinical trials involved 41 patients with several types of cancer
(including sarcoma, lung cancer, breast cancer, gastrointestinal
stromal tumor, thyroid cancer) that were unresponsive to other forms
of therapy. One or two dosed, ranging from 50mg to 150 mg, of
LOXO-101 were administered orally for 28-day cycles.
LOXO-101 Receives Breakthrough Therapy Designation from FDA and Is Ready to Fight Solid Tumors 211
Larotrectinib, or LOXO-101, revealed positive responses in the
majority of the test subjects, and up to 21% tumor regression in some
of the cases. The gene fusions were noticed with NTRK1 or NTRK3,
but patients that had no NTRK, displayed not responses.
The most common side effects reported were fatigue (grade 1 or 2) in
about 30 percent of the patients, followed by dizziness and nausea in
nearly 20 percent of cases. Considerably fewer and lighter than what
most other treatment courses induce.
Josh Bilenker, M.D and chief executive officer of Loxo Oncology
mentioned in a press release that “data presented to date from the
ongoing adult and pediatric studies of LOXO-101 have demonstrated
durable anti-tumor activity across TRK fusion cancers, further
validating LOXO-101’s potential to address the unmet medical need
among patients with these genetically defined cancers”.
Plans for further research, including one relating to TRK fusions, are
underway and look very promising. Additional clinical sites are also
expected to be opened.
212 LOXO-101 Receives Breakthrough Therapy Designation from FDA and Is Ready to Fight Solid Tumors
Cancer Cures, Nutrition, Prevention, Stomach Cancer
S
tomach or gastric cancer is the cause of numerous deaths
worldwide, the death rate is particularly high in developing
countries. Scientists are striving hard to discover new therapies
for stomach cancer. In this struggle, a research team from the
Department of Biotechnology of the Jawaharlal Nehru University
(JNU) has revealed the high efficacy of turmeric in treating stomach
cancer.
The food contaminated with Helicobacter Pylori bacteria forms ulcers
in the stomach and the constant consumption of such food leads to
stomach cancer. Curcumin is a bioactive component of turmeric and
protects against Helicobacter Pylori infections after being oxidized.
Scientists employed turmeric in effectively targeting stomach cancer
after studying the impacts of curcumin. The team of 5 Biotechnology
students Rohit Tiwari, Alka Yadav, Jyoti Gupta, Jyoti and Achyuth
A
n ingenious new method is currently being tested as a possible
treatment for glioblastoma, one of the most common and
malignant types of brain cancer.
By genetically modifying the poliovirus, a team of doctors from Duke
University Medical Center is attempting to extend the life expectancy
of those affected by this most aggressive form of cancer.
Leading the research is Matthias Gromeier, M.D., who has dedicated
more than 20 years to this project already. He managed to use the
virus as a transport mechanism and at the same take advantage of its
ability to quickly spread inside the host.
The clinical trials are being conducted on 61 patients who are
currently ineligible for any other form of treatment. The usual course
of action is surgery followed by radiation and chemotherapy, but the
F
or thousands of years, long before science was able to prove all
the health benefits it can provide, olive oil has been considered a
remarkable liquid possessing a multitude of uses and beneficial
properties for humanity. Nowadays, besides cooking, olive oil has also
found applications in other areas, like cosmetics or pharmaceutics.
Native to the Mediterranean region, the olive tree favors warmer
climates with an abundance of sunshine and constant high
temperatures. Medium in size, with oblong leaves, it produces some
beautiful flowers and eventually the fruit, small drupes. The oil is
extracted through a process of pressing the ripened fruit.
What makes olive oil so special is the amount of monounsaturated fatty
acids (MUFAs) along with antioxidants like polyphenols, phytosterols
and vitamin E. Fat is one of three macronutrients essential for the
human diet, together with proteins and carbohydrates.
T
he cases of pancreatic cancer worldwide are rising. This has
prompted the medical researchers all around the world to look
for an effective way to minimize the risks of pancreatic cancer.
Though pancreatic cancer cannot be prevented and there are no easy
diagnostic tests for it, through proper awareness & adoption of a
healthier lifestyle, people all around the world can still minimize the
potential risks out there.
T
wo of the biggest pharmaceutical companies, Astellas Pharma
Inc. and Pfizer Inc., have been given the green light to introduce
a supplemental New Drug Application, XTANDI, as a treatment
for men suffering from prostate cancer. The Food and Drug
Administration, the U.S. regulatory body, has made this decision
following very promising results stemming from a trial series of Phase
3 PROSPER.
Xtandi, or enzalutamide, which was already offered as medication
for patients dealing with castration-resistant prostate cancer, has
now an extended application and can be prescribed to men with non-
metastatic cancer. It means that so far, XTANDI is the sole approved
oral solution for both metastatic and non- metastatic cancer.
I
t should be our primary concern to look out for any indicator of
cancer in our bodies. Recognizing the symptoms in early stages is
of utmost importance to an effective treatment of cancer. Hence,
we should make it our habit to keep check on the color of our urine.
It is especially advisable for people above the age of 50 to regularly
check their urine color before flushing, according to the Public Health
England, as it can be a potential indicator of cancer. Nevertheless, a
report according to Mail Online reports that only 16% of people
over the age of 50, likely at the risk of developing bladder and
kidney cancers, check their urine’s color regularly. A campaign by
Public Health England, “Be Clear on Cancer”, specifically focuses
upon spreading the word of checking urine color as blood in urine is
an early symptom in two-thirds of all the bladder cancers and fifth
of kidney cancers. It is emphasized repeatedly by medical experts
how vital it is for people to acknowledge early cancer symptoms to
avoid intense treatments in the future.
References:
https://www.dailytrust.com.ng/cancer-why-you-should-always-check-
your-urine-262328.html
https://www.express.co.uk/life-style/health/977626/cancer-
symptoms-urine-healthy-colour-wee-blood
T
he fifth leading cancer responsible for most women deaths
is Ovarian Cancer, much to its being detected in later stages.
According to two new studies, it is revealed that a daily
low dose of aspirin can help prevent ovarian cancer. Dr. Mitchell
Kramer, director of obstetrics and gynecology at Northwell Health’s
Huntington Hospital in Huntington, N.Y. commends these researches
by asserting that a daily low dose of 81 mg aspirin can serve to be
more than an ounce of prevention for women both with and without
ovarian cancer.
Researchers, from U.S. National cancer institute and the Moffitt
Cancer Center in Tampa, Fla., claim that inflammation has a role in
developing cancer and can aggravate cancer outcomes. Aspirin and
NSAIDs (non-aspirin nonsteroidal anti-inflammatory drugs) have
been already proved to lower certain types of cancer, especially colon
cancer. Now, aspirin has been found to cause 10% reduction in the
development of ovarian cancer if a low dose is taken daily. It also
J
udy Wilkins had tried as many as four different chemotherapy
sessions for eradicating her cancer. After bleak expectations, Wilkins
had to face the reality that she might have only a few months
to live. It was then that her cancer care & research team at Dana-
Farber/Brigham & Women’s Cancer Center tried introducing her to a
new form of advanced cancer treatment referred to as the “CAR-T”
Cell Therapy. With the help of this revolutionary immunotherapy
treatment, Wilkins is now cancer free.
Dana-Farber happens to be the only cancer research center in New
England that offers the nation-wide clinic trials of the innovative CAR
T-cell Therapy treatment. CAR (shot form for “Chimeric Antigen
Receptor) T-Cell Therapy treatment is a type of cellular treatment
therapy that makes use of the self-immune system of the patient
towards rallying an attack on the cancer cells. The T blood cells (white
blood cells) are programmed in a manner that they start killing the
All-new Advanced CAR-T Treatment Might Give Hope to the Cancer Patients 227
cancer cells. The T cells are removed from the blood of the patient
and engineered for sprouting special structures referred to as CARs
(Chimeric Antigen Receptors) on the subsequent surface. When the
T blood cells are re-infused into the patient’s system, the CAR T-cells
are then able to identify & kill the cancer cells.
In the period of the past five years, the revolutionary treatment of CAR
T-cell Therapy has emerged to be a potentially effective treatment for
some cancer patients – some with bladder cancer, blood cancer, and
others. The FDA (Food & Drug Administration) of the USA recently
gave the first-ever approval to the advanced CAR T-Cell Therapy
treatment for treating the young adults having B-cell ALL (Acute
Lymphoblastic Leukemia).
228 All-new Advanced CAR-T Treatment Might Give Hope to the Cancer Patients
Cancer Breakthroughs, Cancer Cures, Cancer Technology,
Pancreatic Cancer
A
team of researchers based in London have come with a new,
revolutionary way of treating the deadliest and the most common
cancer – pancreatic cancer. The all-new advanced treatment, as
per the researchers, appears “very promising.”
A team of scientists at the Barts Cancer Institute & King’s College
in London has seemingly cured mice having pancreatic cancer by
“Promising” Treatment Trial Gives New Hope for the Deadliest Cancer 229
providing them immunotherapy that makes use of the white blood
cells for attacking the cancer tumors.
This approach of the trial appears similar to the one that is being
successfully tested on children having leukemia. Around 10,000
individuals in the United Kingdom get diagnosed with pancreatic
cancer every year. Out of them, only about 12 percent of the patients
are able to survive for over 12 months.
Pancreatic cancer gets spotted only once after it has spread significantly.
However, it can be cured through surgery during the early stages.
Through the given research, the team of scientists claims that they
have possibly achieved what seemingly cures pancreatic cancer in the
animal models. The signs look positive in the case of the humans as
well.
The treatment process involves the harvesting of the white blood
cells and engineering them in a manner such that they multiply –
before re-infusing them into the body. During the same time, a virus
is altered for causing the cancer cells to transmit signals that help in
identifying them to the given immunotherapy treatment. The news of
the treatment appears immensely promising.
The given treatment is under discussion for the license by NHS for
treating leukemia in children. The researchers are looking into the
aspect of long-term survival of the children who might otherwise die
230 “Promising” Treatment Trial Gives New Hope for the Deadliest Cancer
Pancreatic Cancer, Prevention
A
s per a new study, it has been found that a specific Hepatitis B
infection served to be a predictor for the future of pancreatic
cancer by around 24 percent.
The researchers of the study analyzed the association that existed
between the Hepatitis B infection “HepB” & pancreatic cancer. They
even analyzed the independent mortality of the predictors.
The researchers concluded that this turns out to be the largest study
towards revealing that Hepatitis B virus infection could increase the
risk of developing pancreatic cancer by as much as 24 percent. There
have been previous research items published in the years 2012 &
2015 that indicated that the HepB infection turned out to be the
“causal agent” of enhancing the risks of developing pancreatic cancer.
G
enetic research is making considerable strides towards finding
safer and more efficient ways of dealing with bladder cancer.
With about 80.000 new cases, in the U.S. alone, each year, this
is the fourth most common type of cancer in men.
For most people, the discovery of a new strain of cancer might not
sound like particularly good news, but scientists are very excited about
isolating “p53-like bladder cancer”. Named after the gene signature it
is associated with, this is one of the more aggressive variants.
Part of the enthusiasm is related to the process used to identify it. By
using a computational method, called ActMi, along with MicroRNA
molecules, they were able to accurately distinguish p32 from among
Newly Identified Biomarker Could Pave the Way for Personalized Bladder Cancer Treatment 233
other types of bladder cancer. This could lead to better-personalized
care and improved survival rates.
The interdepartmental-run study also showed promise when it came
to possibly using microRNAs data to generate better solutions for
treating the disease. P53-like bladder cancers have proven to be more
resistant to standard chemotherapy, which also made finding an
adequate course of treatment more difficult.
In a press release, Jun Zhu, Ph.D., Professor of Genetics and Genomic
Sciences at Mount Sinai stated that: “Our computational methods not
only provided us with deeper insights into the cellular mechanisms
underlying this elusive type of bladder cancer but also reveal the
potential of microRNAs as therapeutic targets in treating it.”
By having better understanding of the structure and composition
of the tumors, and the tools to accurately distinguish between the
different strains of cancer, science can improve the odds in our favor.
234 Newly Identified Biomarker Could Pave the Way for Personalized Bladder Cancer Treatment
Breast Cancer, Colorectal Cancer, Healthy Lifestyles, Lung
Cancer, Melanoma Cancer, Nutrition, Prevention, Prostate
Cancer, Skin Cancer
K
nown as the fruit of paradise in ancient times, the pomegranate
might have been concealing some amazing therapeutic properties
that are just now being brought to light.
The exotic fruit, noted for its unique flavor, has seen uses in
gastronomy, cosmetics, but also pharmaceutics. Full of antioxidants
and rich in anthocyanins, ellagitannins and hydrolysable tannins,
pomegranates have been shown to have anti-inflammatory properties,
as well as lower heart disease risk and blood pressure.
The list of health benefits seems to be getting longer as
recent evidencelinks pomegranates with not only preventing but also
as a possible adjutant in the treatment for cancer. As one of the leading
C
ancer continues to be one of the leading causes of death in many
parts of the globe. That is why researchers and scientists have
been continuously working on newer, safer methods to kill
cancer. One of the newest devices to treat cancer is this light-emitting
wireless implant.
The use of light to kill cancer cells is not new technology. Medically
known as photodynamic therapy, the use of light has already been
used for quite some time now to treat certain types of cancers. In this
therapy, the patient takes a drug designed to make the cancer cells
vulnerable to light. Once vulnerable, the doctor will then shine a light
on the area where the tumor is for about 10 to 45 minutes. The doctor
does this with the aid of an endoscope, which is a small flexible tube.
A
new study reveals an association between higher levels of
Vitamin D and Lower Risk of Breast Cancer. The study has been
published in PLoS One and includes data derived from clinical
trials carried out at Creighton University of Omaha, Nebraska as well
as GrassrootsHealth (California based non-profit).
More than 5000 women aged 55 or older were examined in the study.
The results showed that women with vitamin D blood levels of 60
ng (nanograms) per ml (milliliter) had eighty percent lesser risk of
developing breast cancer as compared to the ones with 20ng/ml or
lower. Ranging from 20-60 ng/ml vitamin D blood level exhibited a
trend of lower risk of breast cancer with a higher level of Vitamin
D. This again, is fundamental, an association, not a direct link of
prevention of breast cancer. However, the main investigator, Joan
Lappe, a professor at the Creighton University, claims that Vitamin
I
t has been found that accumulation of a certain protein in kidneys
can boost cancer cell growth which can serve as a target. The
research has been conducted by researchers from the United States,
China and Singapore and the report has been published in China
Science Daily.
Seventy percent of kidney cases pertain to clear cell renal cell
carcinoma. 90% of these patients suffer from loss of the tumor
suppressor gene VHL induced by a genetic change. In the absence
of this tumor suppressor, a protein named ZHX2 accumulates in the
cell, which increases cancer growth. The US has taken an initiative
to approve drugs for battling the absence of VHL but so far patients
show resistance to these alternatives or little response. Therefore,
other targets are being sought after by the researchers.
According to the lead researcher, Zhang Qing, from University of
North Carolina School of Medicine, loss of VHL leads to a large
A
team of researchers has discovered a way of stopping & reversing
the growth of lungcancer with the help of a potent combination
of three unique molecules.
The study – known for being a potential cancer cure – observed
that the two BH3-mimetics along with one FGFR inhibitor were
capable of blocking the cell survival process of lung cancer cells quite
successfully. The results were so successful that the pre-clinical models
not only helped in stopping the growth of the tumors but also aided
in the tumors to shrink away.
The particular research that was led by Dr. Clare Weeden along with
others from the Walter & Eliza Hall Institute published its results in
the Oncogene journal.
C
ancer is slowly becoming a global issue. The World Health
Organization reports that cancer is responsible for almost 9
million deaths each year, about one in six people is struck down
by this terrible disease, and these statistics are only getting worse.
Everyone is at risk from this silent killer that does not discriminate.
While new treatments and medication are constantly being developed
and implemented almost daily, there is still a problem with making
them affordable and accessible to everyone. In India, the second
largest country in the world, cancer is a particularly big problem,
with mortality rates reaching 70%. The main reason is late detection,
usually due to lack of information.
New Initiative Could Prove Life-saving for Indians Suffering from Cancer 245
Some good news is on the horizon for the citizens of India. A new
program is currently underway, the Free Cancer Chemotherapy
Scheme. Currently, only APST patients are eligible for receiving free
chemotherapy treatment, but there are plans to cover all working
individuals in the near future.
Dr. Syam Tsering, head of the radiation and oncology department at
the Tomo Riba Institute of Health & Medical Sciences (TRIHMS),
Naharlagun, said that in 2017 about 450 patients took advantage
of this project. For men, the most common cases presented were for
stomach, liver and lung cancer, while most women suffered from
stomach, breast and cervix tumors. Among the more prevalent factors,
he included obesity, sedentary lifestyles and lack of exercise.
The facilities at TCC offer chemotherapy, radiation and oncology
though they are a bit understaffed, with only six junior specialist
doctors present. With substantial funding on the way, Dr. Tsering is
hopeful that more people will register to benefit from this program and
that he can make a real difference in the healthcare of his countrymen.
246 New Initiative Could Prove Life-saving for Indians Suffering from Cancer
Breast Cancer, Hope Stories, Lymphoma Cancer
L
yndsey Hollback was diagnosed with Hodgkin’s Lymphoma at
the age of 19 years. Even after 6 rounds of chemotherapy, her
cancer continued getting worse. After two more successive rounds
of chemotherapy, 18 radiation treatments and being in & out of
remission – she chose the option of a bone marrow transplant.
https://www.insideedition.com/media/videos/cancer-survivor-meets-
bone-marrow-donor-first-time-45777
Luck was on her side! A stranger named Jacob Murray from Virginia
ended up being her match for the transplant. It was an emotional
connection between the two of them. Jacob had lost his best friend
to the same disease. Knowing that a bone marrow transplant could
save and transform Lyndsey’s life completely, Jacob came forward
with the proposal of being the bone marrow donor. Jacob felt the
immediate urge to help Lyndsey who needed him for saving her life!
Jacob delayed no more and jumped into the idea of saving her from
A
fter several years of research with little progress, the cancer
researchers have finally made major revolutions in the past few
years in the treatment of melanoma – the most serious kind
of skin cancer. So, what is the key to these medical advances? The
concept of “Immunotherapy” is helping the cancer patients suffering
from Melanoma to live longer.
Recently, the breakthrough treatment for Melanoma was introduced
to a patient suffering from skin cancer who had lost one of his ears
to the disease. George Dodds had been fighting Melanoma (Skin)
cancer since 1962. Having survived as many as 6 major surgeries,
George had lost his ear to Melanoma. Still, cancer kept spreading.
Until recently, the cancer was found in his lungs.
A
blood test can help in predicting the optimal treatment for
patients who have advanced prostate cancer – as per a recent
study. A collaborative study on an international level that was
conducted between the Memorial Sloan Kettering Cancer Center,
Lawson Health Research Institute, Epic Sciences, and the Royal
Marsden is the first-ever study that has concluded that a blood test
will be helpful in predicting the treatment of the patients having
advanced prostate cancer.
The study finds that the blood test will help in determining how the
patients having prostate cancer will respond to particular treatments
leading to the survival of the patient.
Blood Tests can Help in Predicting the Treatment for Patients with Prostate Cancer: Study 251
The study made use of a specific liquid biopsy test that was developed
by a leading molecular diagnostics company named Epic Sciences.
This test was aimed at examining the CTCs (Circulating Tumor Cells)
in the blood samples obtained from the patients having advanced
prostate cancer. This test turns out to be useful to the patients who
might be deciding upon to make the shift from hormone-targeting
therapy to chemotherapy. The Circulating Tumor Cells (CTCs) are the
cancer cells that tend to develop a tumor and enter the bloodstream.
As such, this tumor starts invading the other vital organs of the body
which leads to the spreading of cancer.
The given test by Epic Sciences will help in determining whether or
not the CTCs of the given patient contain a specific protein known
as “AR-V7” in the nucleus of the cells. The particular research team
is focused on determining whether or not the presence of the protein
AR-V7 will predict the specific treatment would help in treating
cancer. The results of the study revealed that patients who had tested
positive for the AR-V7 protein responded to chemotherapy, while the
negative ones responded to hormone-targeting therapy effectively.
252 Blood Tests can Help in Predicting the Treatment for Patients with Prostate Cancer: Study
Cancer Cures, Cancer Technology, Head and Neck Cancer
T
he Keytruda drugs by the leading drugmaker Merck might be
on its way to be used in cases of head & neck cancers – the area
wherein it has faced queries previously.
The leading New Jersey-based drugmaker – the Merck claimed that in
the particular phase 3 trial that was conducted on untreated patients
previously, the drug Keytruda has produced excellent results. The
drug topped the standard-of-care medical regimen including Erbitux
by Eli Lilly. This helped in extending the overall chances of survival
in the patients having tumors. This was achieved by expressing a
particular level of the PD-L1 biomarker.
The result was obtained from an in-depth analysis of the given trial.
The results also revealed that Keytruda has yet not satisfied the other
major endpoints of the study which is aimed at measuring the overall
Merck’s Keytruda on Its Way to Dealing with Head & Neck Cancer Case 253
time to cancer progression. However, the overall survival is usually
considered the significant standard in the trials related to cancer. As
such, the drugmaker Merck will be taking up the winning situation
in the given department across the world.
In the current scenario, Keytruda bears the approval in performing
trials on patients with neck & head cancers – but only in those
patients who cancer symptoms might have worsened during or after
chemotherapy. After the in-depth checking of the given approval,
Keytruda failed in proving that it could help in extending the lives of
the patients in the given group of cancers.
However, Merck is not simply following the route of monotherapy
when it comes to treating neck & head cancers. The latest results
have been obtained from the trials on Keynote-048 – s study that
has been examining the role of Keytruda as the major part of the
cocktail having platinum chemo along with the chemo drug named
5-fluorouracil
254 Merck’s Keytruda on Its Way to Dealing with Head & Neck Cancer Case
Breast Cancer, Cancer, Colorectal Cancer, Esophagus Cancer,
Leukemia Cancer, Liver Cancer, Melanoma Cancer, Pancreatic Cancer,
Prevention, Prostate Cancer, Skin Cancer, Stomach Cancer
F
or the longest time, natural remedies have been the backbone
of any medical treatment. Today, science is looking to improve
modern medicine and find alternative solutions by drawing
inspiration from what nature has to offer.
Mushrooms have been used for their pharmaceutical properties
throughout history, especially in Eastern cultures. More recently,
researchers have tried to test and quantify the results of their
therapeutic effects, and more notably, the claim that they might have
anticarcinogenic properties. Their findings were quite surprising.
A team comprised of doctors from several institutions, including the
Far Eastern Federal University and the University of Lausanne, has
P
reliminary reports are indicating a possible breakthrough in
the fight against hepatocellular carcinoma (HCC) with the
development of a new drug called FFW.
Accounting for almost one-fifth of all cancer diagnoses worldwide
and with an incidence of over half a million new cases each year, HCC
is quickly becoming a global issue. Fast growing and particularly
aggressive, the survival rate is less than 50% past the first year.
A team of scientists from the Cancer Institute at the National
University of Singapore is hoping to reduce these terrible statistics
with the help of a new drug that targets the SALL4 protein, associated
with a number of cancers, including lung tumors and leukemia.
Until now, the only treatment course was Sorafenib, which
unfortunately has many negative side effects (nausea, high blood
L
ooking for more reasons to focus on your overall oral health? You
must know that oral bacteria is responsible for affecting a wide
spectrum of the health & lifestyleaspects including the overall
diet, metabolism, cardiovascular system, brain & its health, and so
more.
The scientists nowadays are focusing their attention on the role of
the oral bacteria towards serving as a breakthrough passage for the
treatment of weight loss, health management, and most important
– cancer treatment. Scientists have revealed that over 700 bacteria
strains get swiped from the cheeks all around the world. As such, this
fact makes our mouths the 2nd largest microbiome in the entire body.
Given the immense population of the bacteria in the given strains, the
Oral Bacteria – a Breakthrough Passage in Weight Loss, Cancer Treatment, and Overall Health 259
scientists are looking forward to figuring out the individual roles of
the bacteria strains in improving the overall health conditions.
By analyzing out the specific combination of bacteria that will help
in making an individual healthy or sick could be a significant step
in starving off the world from such diseases. For example, there are
certain bacteria that are the main culprits behind the plethora of gum-
related issues including plaque, gum bleeding, cavities, and so more.
The fact that the scientists find interesting is that oral bacteria tend
to exist all over the body and are thus, linked to a host of additional
medical issues.
The all-new knowledge of linking oral bacteria being a breakthrough
in the prevention & treatment of cancers and other diseases has been
made possible by the latest advancements in RNA & DNA decoding
along with microscopic imaging. A new research report also stated
that oral bacteria might have a direct impact on the occurrence of
cancer.
260 Oral Bacteria – a Breakthrough Passage in Weight Loss, Cancer Treatment, and Overall Health
Healthy Lifestyles, Nutrition, Pancreatic Cancer
A
lthough nutrition tends to be a critical component in
everyone’s life, there is no specific study indicating the cause of
poor nutrition is the cause of pancreatic cancer. However, if you
tend to lead a sedentary lifestyle with a fat-rich diet, then you might
enhance the overall risks of developing pancreatic cancer.
A recent study has revealed that a diet containing high volumes of
fat-rich products might lead to pancreatic cancer in the long run. This
is because of the interaction that occurs between the fat-rich diet and
CCK (cholecystokinin) – a digestive hormone.
It has been found that the diet high in fat content triggers the secretion
of the digestive hormone “CCK” by the small intestine. People
who tend to consume a diet rich in saturated fats on a daily basis
usually have higher levels of CCK. This increases the overall risks of
developing pancreatic cancer.
T
he Eisai Co. Ltd. and Merck & Co. Inc. Kenilworth – has
recently announced that the United States FDA (Food &
Drug Administration) has granted the Breakthrough Therapy
designation for LENVIMA (the generic name as Lenvatinib Mesylate)
– the oral kinase inhibitor available out there developed by Eisai.
The grant was also given for the anti-PD-1 therapy KEYTRUDA
(with its generic name as Pembrolizumab) By Merck & Co. Inc. –
used for treating the patients having advanced & metastatic non-
microsatellite instability or pMMR (proficient mismatch repair) EC
(endometrial carcinoma).
The therapy of the combination of LENVIMA & KEYTRUDA is
currently under joint development by Eisai & Merck & Co. Inc.
This is a part of the major strategic collaboration between the two
companies that was announced in March 2018. This is going to
E
ven though the risk of breast cancer in men is quite low, being
aware of the signs and seeking professional help in time is more
imperative than ever.
The phrase “breast cancer” is so strongly associated with women, that
most of the time people completely put it out of their head that men
too can be affected. In fact, this is the main reason a lot of the times
it is detected considerably later than it should be. In fact, my older
brother had male breast cancer, and luckily his cancer is in remission.
It is true that men have less breast tissue, and also the incidence is only
a fraction compared to cases in women, but there is still a risk, and
the consequences for ignoring them can be deadly.
A
remarkable study published in the JAMA Dermatology describes
the case of a 97-year-old woman suffering from squamous cell
cancer being treated with wart vaccines. As a result, all the
tumors were cleared.
When it comes to elderly patients, it can be hard to determine the best
course of action. The attending doctor, Anna Nicols, had only three
options, all of them risky, none of them pleasant: either prescribe
radiation and force the patient to undergo a difficult treatment with
lots of heavy medication; recommend amputation, a dangerous
operation in these circumstances; or let the disease take its course
and just try to alleviate the symptoms.
While at the Miami School of Medicine University, she had seen two
experimental cases where the HPV vaccine was used with moderate
A
parent, a husband, a friend, a son, a hero, Paul, is a determined
fighter against cancer. Strongest people are not those who
manage to overcome difficulties, but those who know how
to live through their difficulties without changing who they are.
A technician in the emergency room of the hospital, Paul, when hit by
stage IV lung cancer, stood tall and tackled with it just the way he has
tackled life so many times before. This inspirational personality has
been a basketball coach for girls and is a homeless shelter volunteer.
His humble personality continues to work for the people’s betterment
even when his own life took on such an endangering turn of life.
The key to his success is that he does not believe in focusing on the
problems but works his way around them.
C
ancer drugs are designed to attack and kill cancer cells, but
poisonous as they are, they also harm normal healthy cells that
can produce adverse side effects for the cancer patients. Patients
experience these side effects in the appearance of their skin and hair
fall. They start to look weak in stature. Especially those patients who
are under heavier doses. However, now researchers may have come
with a breakthrough in cancer treatment that can deduct all these
mishaps.
The therapy thus comes forth is known as Molecularly Targeted
Therapy, in which drugs are formulated at a molecular level, built
specifically to harm and slay only cancer cells. Their structure is made
S
cientists have made an unexpected discovery when they paired a
form of arsenic trioxide with a leukemia drug, all-trans retinoic
acid (ATRA). The combination of the two seems to have beneficial
effects in cancer treatment.
A team of researchers at Beth Israel Deaconess Medical Center
was investigating claims that arsenic could have some anti-cancer
properties, following information that public drinking water
containing small amounts of the substance was connected to lower
cancer incidence. Putting together an oxide of arsenic (ATO), which
was cleared as safe by the FDA, and ATRA showed an impressive
positive effect against acute promyelocytic leukemia (APL).
While it is still unclear what are the actual processes taking place, initial
data suggests that the duo is targeting the Pin1enzyme, which is linked
with several types of cancer. Pin1 is believed to be responsible for
W
alnuts have been found to prevent and even initiate killing
cancer cells, according to several studies conducted on them.
The reason for this cancer-killing property resides in the rare
phytonutrients that are rarely found in other foods. These compounds
(the quinone juglone, tannin tellimagrandin, flavanol morin4) are
well known for inhibiting cancer. Also, walnuts are the only type of
nut having plant-based alpha-linolenic acid ALA, as well as various
antioxidants, minerals and vitamins, beneficial in preventing cancer.
Researchers at UC Davis claim that whole walnut or walnut oil, can
slow down prostate cancer in mice. A handful of walnuts per day can
greatly reduce the risk of breast cancer and growth of tumors. Most
importantly, they reduce the level of hormone IGF-1 that is potentially
responsible for the development of breast and prostate cancer.
G
uava, a tropical fruit grown worldwide, has more to itself
than it sweet acrid taste. Its leaves are a source of many health
benefits and are used in many forms of traditional medicines.
The antioxidant properties of these leaves are very effective, more
than the fruit itself, according to a research conducted in 2007 and
published in the Journal of Food and Chemistry.
Tea made with guava leaves has been drunk for ages in Asian countries
as it proves very effective in treating diarrhea, diabetes, cold and flu,
cholesterol and most importantly, it portrays anti-cancer action. For
this reason, the effects of guava leaves, along with its seeds, overall
plant and leaf oil, have been tested for chemotherapeutic properties.
A study conducted in 2010 by a medical scientist tested the use of
guava leaves for prostate cancer. The results showed that utilizing
guava extract can actually minimize the size of the tumor. Another
N
atural diets based on fresh and organic fruits and vegetables are
commonly recommended for preventing and managing cancer
diagnoses. While there is clear evidence that they provide a wide
variety of health benefits, there isn’t a lot of specific data on which
greens are more effective and the mechanism involved.
China has invested heavily in healthcare and medical research in later
years and now has a very respectable scientific community. Articles
published by Chinese teams regularly make the news, as is with this
story.
A recent study has put forward some interesting claims about the
potential anti-cancer properties of sweet potatoes. It is all based on a
newly isolated phytosterol, β-sitosterol-D-glucoside (β-SDG), though
the specific interactions are still unclear.
L
aboratory trials at Scripps Research Institute in San Diego have
revealed incredible results, with a new vaccine that, when paired
with an adjuvant, managed to have 100% success rate on mice
with melanoma.
“This co-therapy produced a complete response—a curative response—
in the treatment of melanoma”, reported Research Professor Dale
Boger, one of the co-authors of the paper.
Melanoma is a type of skin cancer that typically appears following
extended exposure to ultraviolet rays. It has a pretty low incidence
rate, but a high mortality rate, as it can be difficult to identify in the
early stages.
By adding Diprovocim, a molecule synthesized in a lab environment,
to the anti-PD-L1 therapy (checkpoint inhibitors part of the
A
new wave of new cancer treatment options is emerging and is set
to change the current courses involving chemotherapy, radiation
and surgery.
Some of the new alternatives do seem like taken from fiction movies.
Immunotherapy, or bionic therapy, is based on boosting the body’s
defenses by using mutated or artificial antibodies. Usually, the immune
system takes care of any abnormal cells inside the body. In the case
of cancer, the diseases can mask its presence, eluding the reach of
antibodies.
Monoclonal antibodies and checkpoint inhibitors have already been
successfully used in the treatment of cancers and mark the basis for
a number of new drugs, including Nivolumab and Pembrolizumab.
Because these courses employ the body’s own resources to fight the
T
eenagers who develop a habit of drinking regularly could be
exposing themselves to some serious health risks, including
developing forms of prostate cancer.
A study examining the effects of lifetime alcohol intake in relation to
cancer diagnoses found that men who had consumed seven or more
drinks per week, between the ages of 15 and 19, were almost three
times more likely to suffer from high-grade prostate cancer in their
adulthood. Moderate drinkers with ages 20 to 49 also face increased
risks compared to non-drinkers.
The results come following a survey conducted at the Durham Veterans
Affairs Medical Center on 650 men participating in a decade-long
project. Biopsies revealed 238 cases of low-grade prostate cancer and
88 cases with higher grade malignancy.
Early Age Drinking May Lead To Aggressive Prostate Cancer Later In Life 285
Researchers believe that one of the reasons behind these alarming
findings might be the fact that adolescence is a period when the
prostate sees important growth, making it more susceptible to cancer-
causing agents.
While the article puts forward some startling perspectives, authors
were quick to mention that, even though there is evidence of a link
between alcohol intake and cancer, there is not enough conclusive
data to suggest that it is the primary culprit. In comparison, current
alcohol intake was not associated with prostate cancer.
The paper ends by concluding that “among men undergoing prostate
biopsy, heavier alcohol intake earlier in life and higher cumulative
lifetime intake were positively associated with high-grade prostate
cancer diagnosis, while current intake was unrelated to prostate
cancer”.
Knowing potential dangers ahead of time and making decisions
accordingly can drastically improve lifetime health and life expectancy.
286 Early Age Drinking May Lead To Aggressive Prostate Cancer Later In Life
Breast Cancer, Healthy Lifestyles, Nutrition, Prevention
M
atcha tea seems to be the latest global trend. Its popularity has
gotten so big, that even companies like Starbucks and Lipton
are trying to capitalize on it. While it is advertised as providing
several health benefits, scientists are exploring another possible
property, anti-cancer capabilities.
In case you haven’t heard, matcha is basically finely ground green tea
leaves grown and harvested under some special conditions. Lately, it’s
seen a lot of attention as a natural supplement for a number of diets
and nutrition regimens, including weight loss, cardiovascular or liver
problems.
A recent study looks to further the list of health benefits the tea can
provide by examining claims that it can fight cancer. Laboratory trials
involving matcha green tea (MGT) and breast cancer samples revealed
some fascinating results. While the whole process is still unclear, it
T
hink of a healthy and balanced diet as more than just fuel
necessary to power the body for day-to-day activities, but also
as a way of reducing the risk of chronic diseases and even cancer.
Doctors recommend varied meals with plenty of vegetables and
fruits because they provide a number of essential compounds, like
antioxidants, vitamins, minerals, anti-inflammatories and also
phytonutrients. These are natural chemicals that help the immune
system in its continuous fight against germs, bugs and all other
threats. Carotenoids, just one of the thousands of such chemicals,
are responsible for giving carrots their trademark orange tint, or that
beautiful bright red in tomatoes.
Between three and five servings of greens daily seems to be the ideal
ratio. It can seem much, but remember that you are spreading them
Dietary Tips that May Help to Stave Off Cancer – What Do You Have to Lose? 289
across the whole day. You don’t need to carefully measure the amounts
every time, just aim to have them on about half of the plate for each
meal.
As you start to change your nutrition more towards a plant-based
diet, keep in mind to increase hydration too. You will be incorporating
more fiber so you need to drink plenty of water throughout the day.
Most people are worried that a healthy diet somehow means a
dramatic change in eating habits. It’s not. You are just shifting the
focus more on vegetables or healthier alternatives, and the change
should be gradual. For example, consider having a piece of fruit as a
snack, instead of the usual sweets or chips.
Something as simple as switching from white rice to brown rice can
make a big difference. They are very similar, but this way you get
more proteins and healthy fatty acids. Another simple tip is to have a
wide selection of foods from different color groups. This way you can
ensure you’re getting many of the different phytonutrients.
While you won’t really notice the effects of this healthy lifestyle
change immediately, you will definitely be glad you did later in life.
290 Dietary Tips that May Help to Stave Off Cancer – What Do You Have to Lose?
Healthy Lifestyles, Nutrition, Prevention
N
ow you might wonder “could coconut oil be a benefit?” Indeed
yes! Even after having a bad reputation in the past era, the
recent technological breakthroughs & advancements in the
field of medical science have proven that coconut oil contains “good”
saturated fat and is thus, known to be immensely healthy.
The unique combination of fatty acids that are found in pure coconut
oil can impart a myriad of potential health benefits. Right from
effective weight loss to improved functioning of the brain, and so
more – there are several health benefits of pure coconut oil.
Pure coconut oil is known to contain lauric acid – a medium-chain
fatty acid that gets converted to monolaurin in the body. Lauric acid
is known to be immensely beneficial for minimizing the effects of
parasites, viruses, bacteria, infections, and fungi.
Coconut oil is also known to contain around 86.5 percent of saturated
fatty acids along with 5.8 percent of monounsaturated fatty acids
R
esearch has it that immunotherapy is one of the best most effective
ways of treating cancer wherein the own immunity cells of the
patient are coded to attack the tumor. This approach turns out
to be successful. However, it turns out expensive as it gets customized
as per the specific requirements of each patient. Recent experiments
in the field of cancer research & treatment have come up with a
comparatively less expensive approach that could help in activating
the immune system of any individual against cancer.
Scientists are injecting tumors with specific molecules and viruses for
finding something that would activate the entire immune system of
the body to kill tumor & any other form of metastases. There have
been successful results in some animals including mice, but not in
A
medical research team based in Bhubaneswar, India has
discovered the downregulation of a protein named “TRIM16”
could help in the treatment of neurodegenerative diseases and
cancer. In the hope for coming across a potential treatment for cancer
and other neurodegenerative diseases in the coming future, this
observation can set a benchmark in the pretext of the same.
The team of researchers at the Institute of Life Sciences, Bhubaneswar
has found that the activation of a specific type of protein named
TRIM16 can serve to be a potential therapeutic strategy for the
treatment of a wide array of neurodegenerative diseases including ALS
(amyotrophic lateral sclerosis), Alzheimer’s disease, and Parkinsons’s
disease. In addition to this, the inhibition of the specific protein
in the cancer cells could help in bringing about a reduction in the
Scientists Discovered a Drug Target for Neurodegenerative Diseases & Cancer 295
proliferation of tumor. The results of the study were published in THE
EMBO Journal.
The study by the medical team that was carried out in lab mice and
test tubes has revealed that the particular protein TRIM16 has the
ability to protect the cancer cells from oxidative stress. As such, the
inhibition of this protein could lead to the reduced amount of tumor
growth in the body.
296 Scientists Discovered a Drug Target for Neurodegenerative Diseases & Cancer
Healthy Lifestyles, Nutrition
I
t has been recently found by the researchers from McMaster
University situated in Hamilton, Ontario, that high-level intake of
cheese and red meat tends to increase human lifespan. Red meat and
cheese have made their way back to a healthy diet according to these
researchers. A steak or a slice of cheddar doesn’t come with as much
alarm as we thought.
According to the study, those people who ingested 120 g of unprocessed
meat and 3 portions dairy daily, seemed to benefit the most from it. It
was seen that death risk decreased by a good 25% in these people, not
to mention the risk of death-inducing heart attack which minimized
by 22%. The researchers took factors like wealth, education and
health habits into account as well.
Red Meat May Not be as Bad as We Have Been Told – You decide! 297
Andrew Mente, a McMaster Professor of epidemiology and nutrition
says that their findings seem to be challenging the conventional
conceptions regarding unprocessed meat intake and full-fat dairy.
Mente recommends that three portions of dairy and one portion of
unprocessed red meat or white meat per day can be beneficial and
protective. From their data, it is evident that saturated fat is more
beneficial than carbs. White meat (chicken or turkey) were also found
to exhibit similar benefits according to the researchers. The researchers
also mentioned that eight portions of fruits and vegetables along with
half a portion of beans and nuts can also be beneficial.
Dr. Salim Yusuf from McMaster Medical School is a teacher of
cardiovascular disease. He also emphasizes that the results of their
study have shown that unprocessed meat and dairy products are
beneficial for the health of the heart and boosts heart longevity. He
further adds that these results differ from the currently recommended
diet options.
The study adds a completely new perspective on what we think is
healthy or not!
298 Red Meat May Not be as Bad as We Have Been Told – You decide!
Breaking Cancer Research, Breast Cancer
M
etastasis is the process through which a cancer spreads to other
parts of the body. The key to survival rate is to put a stop to
metastasis. It has been found recently in a study that primary
tumors can hamper the growth of a secondary tumor by developing
a particular mechanism.
Recent work against metastasis includes targeting protein that protects
the loose tumor cells and other mechanisms that help cells tarnish the
main tumor. Studying metastasis in mice, researchers have now found
a new mechanism at play. A development of an eccentric ecosystem
in which breast tumors let out signals to “breakaway cells” which are
making their way to other areas of the body. It was found that these
signals actively stopped the secondary tumors from growing.
A
recent study by the researchers from UNC Eshelman School
of Pharmacy and University of North Carolina Lineberger
Comprehensive Cancer Center have established stem cells
grafted from skin cells that can hunt cancer and thus deliver drugs to
decimate medulloblastoma tumors growing faster after surgery.
Previously, in a study, it has been shown that such stem cells could
deliver drugs to glioblastoma cells (deadliest cancer cells). Now in the
new study appearing in PLOS ONE shows that these can also be used
to target medulloblastoma cells and prolong patient life. It is most
important to see if this works for children.
Hingtgen from UNC Eshelman School of Pharmacy says that
chemotherapy and radiation are very harmful to the developing brain
in children, hence, the new alternative treatment could bring a quality
of life benefits. He and his team studied the natural ability of stem
cells to reach tumors and utilized it like a FedEx truck that can lead
Stem Cells Could Be an Effective Drug Delivery Tool for Brain Cancer in Children 301
to the right location and feed cytotoxic drugs to the tumor cells. He
claims that the skin cells are converted into something that can crawl
to find infiltrative tumors.
Laboratory models of the brain after receiving surgery when they
were inserted with these drug-fed stem cells showed 15 times decrease
in tumors’ size. Average survival in mice was observed to be 133%.
Their lives were prolonged by 123% when inserted with human stem
cells.
It was also discovered that after surgically removing the tumor from
the brain through standard treatment, the remaining cancer cells tend
to grow faster and became aggressive. Scott Elton, a co-author of
the study, calls it a holy grail if the stem cells made from patients’
own cells can be used to target these tumor cells. They can also be
made beneficial for other rare types of brain cancers in children.
He acknowledges that most of the medulloblastoma cases occur in
children and side effects with this alternative can be dramatic but with
more exploration, it would be made better for that 30 % of children
for whom standard therapy does not work.
It is hoped that this treatment could be an effective alternative to
standard treatment which comes with developmental and neurological
side effects and prolong patients’ lives.
302 Stem Cells Could Be an Effective Drug Delivery Tool for Brain Cancer in Children
Kidney Cancer
K
idney cancer is among the 10 most prevalent cancers around
the world. 70% of kidney cancers include clear cell renal cell
carcinoma (ccRCC) which results from the accumulation of
sugar and fat. Dr. Kevin Courtney and his team along with other
professors set to investigate how kidney tumors utilize glucose which
serves as the main source of energy for most of the tissues.
They used labeled glucose in an intraoperative infusion during a
surgery meant to eliminate kidney cancer. It was found that ccRCC
use glucose entirely different from other tissues, instead of breaking
down glucose via tricarboxylic acid cycle for extracting energy, they
stopped short of it, which indicates that they must have some other
energy source upon which they survive.
T
he brain is the most vital part of the human body. A brain handles
it all – the emotions, the memory, the thoughts, and so more.
However, as we get old, the power of our brain starts degrading
with age. We cannot alter the cycle of aging. However, we can take up
some healthy steps towards boosting the overall power of our brain
to strengthen the memory and thinking process.
A study reveals that as people move beyond the age of 60 years, it
is all about maintaining good, healthy lifestyle habits that help in
keeping the brain strong and lively. Here are some additional tips
from the experts:
Controlling Medical Conditions: Some of the specific medical concerns
associated with the process of aging can affect the brain as well. For
instance, high blood pressure during the middle age has been linked
to a higher risk of developing dementia in the later stages of life.
Therefore, it is considered the best option to act upon controlling the
medical conditions in the right age itself to prevent any major issues
later on in life.
P
regnancy diets usually recommend eating plenty of vegetables
and fruits so as to provide the necessary balance of nutrients,
vitamins and minerals to the baby. One recent study suggests that
mothers that eat broccoli sprouts could, in fact, pass on to their child
a certain resistance to breast cancer.
The article in question appeared in the American Association for
Cancer Research publication and puts forth the idea that many
cruciferous vegetables, like broccoli, Brussels sprouts, cauliflower,
cabbage, have particular anti-cancer properties. This is in great part
due to the high amount of Sulforaphane (SFN) these plants possess,
a compound which reactivates tumor suppression genes and blocks
genes that promote the growth and spread of cancer cells.
Eating Broccoli While Pregnant Could Help in Preventing Breast Cancer in Child 307
Breast cancer is one of the most widespread forms of malignancy, and
one of the most important risk factors is genetic background. The
ability to reduce the risk of future development could help prevent
millions of new cases and save countless lives.
The paper notes that: “Bioactive dietary components such as
sulforaphane (SFN), an isothiocyanate from cruciferous vegetables
including broccoli sprouts (BSp), cabbage, and kale, has been shown
to reduce the risk of developing many common cancers through
regulation of epigenetic mechanisms”.
Laboratory tests were conducted only on mice so far, but scientists
hope to translate the work to human trials and possibly recreate the
results. The rodents were fed the equivalent of about four cups (266g)
of broccoli each day, though people would require less. Feeding the
mice with the same amount at later stages in life did not yield similar
findings.
It could be a good idea to start incorporating these greens into your
current diet, it can’t do any harm.
308 Eating Broccoli While Pregnant Could Help in Preventing Breast Cancer in Child
Breaking Cancer Research, Pancreatic Cancer
P
ancreatic ductal adenocarcinoma (PDAC) is one of the most
common causes of cancer-related deaths in the world, and in
spite of sustained medical efforts, the incidence rate is rising.
Chimeric antigen receptor T (CAR-T) has already shown incredible
success in treating hematological diseases. The procedure involves
harvesting T-Cells from the patient, combining them with engineered
receptors and then injecting them back to fight the cancer cells. This
type of immunotherapy offers significant advantages over standard
courses. It’s better targeted and safer for the patient, compared to
chemotherapy or radiation.
The study sought to apply CAR-T therapy on other types of cancer,
like PDAC, where results were not as impressive. The team, comprised
of doctors from Australia, the U.K. and the U.S.A., realized that by
R
esearch to control cancer and to fight with it has been continued
for years. Deadly Eye cancer has frequently seen in people. There
is a pigmented layer of cells in the iris of the eye which causes
the Ocular Melanoma. The tumor arises from the pigmented cells that
reside in Uvea giving color to the eye. These melanocytes are different
from retinal cells which do not cause eye cancer. It causes 3 to 5%
of life loss.
Cancerous cell growth in melanoma is due to overactive signaling.
G alpha q is present in cancer of the eye and to make the best use
of it to cure cancer, researchers at Washington University School of
Medicine in St. Louis discovered a natural plant compound called
FR900359. This compound belongs to the primrose family of plants.
The goal is to shut down the entire signaling cascade in melanoma,
C
hemotherapy and radiations are frequently done for treating
cancer patients though it harms the healthier cells as well. In
case of brain cancer similar processes were carried out previously
but now an undiscovered field has been discovered. It has solved the
complication that was due to destruction of healthy cells.
Nano medicine, a new branch of medical field in which BXQ-350
acts as a drug. It is produced when a human lysosomal protein called
Saposin C is combined with Nanobubbles of a fat molecule known
as Phospholipid dioleoyl phosphatidylserine. Fat nanoparticles
face no hindrance by the blood-brain barrier, so it can help to treat
glioblastoma. Xiao Yang, a genetic researcher discovered it. It has no
side effects or dose-limiting toxicities.
R
ecently, a molecule has been identified by scientist that promotes
the fighting ability of our immune system when added to a
cancer vaccine. The study has made an appearance in PNAS,
claiming that Diprovocim (a molecule), when added to an existing
cancer vaccine effectively, drew anti-cancer cells to the target site of
cancer tumors. Experiments conducted on mice further suggest that
this molecule addition can improve chances of recovery especially
when drug therapy stops working.
According to a professor involved in the study, Dale Boger, the co-
therapy showed a curative response in treating melanoma. The plus
point is that this vaccine prepares the immune system for any returning
tumors, hence decreasing the risk of cancer recurrence. Boger adds
New Treatment Discovered to Fight Melanoma Better Than Traditional Vaccine 315
that this cancer vaccine acts just like the other vaccines that prepare
the immune system to ward off external pathogens, should they arrive.
Diprovocim is used as an adjuvant which is a molecule that enhances
a vaccine’s capability to fuel up the immune response in the body. This
molecule is modifiable and can be prepared easily in the lab.
Mice with aggressive melanoma were divided into three groups who
were given anti-cancer therapy anti-PD-L1. Eight mice were injected
with the cancer vaccine alone, another eight with Diprovocim along
with the cancer vaccine and another eight with cancer vaccine plus
alum (alternative adjuvant). A 100% rate of survival was seen in mice
injected with Diprovocim plus cancer vaccine over 54 days. 25%
survival rate was observed in the cases of alum plus cancer vaccine
and a zero percent survival rate in the cases of cancer vaccine alone.
Boger calls the result to be exciting, given how the vaccine worked
along with anti-PD-L1 anti-cancer therapy. Further experiments were
conducted, all of which showed Diprovocim boosting the cancer-
fighting ability of the vaccine. It successfully stimulated the immune
system to produce tumor-infiltrating leukocyte which enhanced the
vaccine’s working.
316 New Treatment Discovered to Fight Melanoma Better Than Traditional Vaccine
Breast Cancer, Esophagus Cancer, Lung Cancer
A
new metal compound has been discovered by the researchers
from Hong Kong Baptist University, that has the ability to
inhibit enzyme actively associated with TNBC (triple negative
breast cancer). The enzyme, KDM5A (lysine-specific demethylase 5A)
has been inhibited with minimized toxicity in mice.
The compound developed by the team consists of rhodium which
potentially and specifically inhibits KDM5A by effectively targeting
it, as compared to other inhibitors. Dr. Edmond Ma Dik-lung has said
that the presence of KDM5A is more in breast cancer as well as the
brain, gastric and lung cancers. It promotes carcinogenesis and creates
resistance against drugs. Very limited KDM5A inhibitors are present
to date with the current one proving most effective.
R
esearchers at a laboratory in Vancouver are looking to possibly
cure Crohn’s diseases based on the incredible recovery made by
one of their patients.
It all started when a patient at the InspireHealth care center suffering
from pancreatic cancer started getting worse. He eventually came
down with an infection, but surprisingly, his tumors also shrank.
Further examinations found that this had happened with other two
patients in similar conditions.
Crohn’s disease is a type of inflammatory bowel disease (IBD) that can
cause serious problems, including severe abdominal pain, diarrhea
and bloating. Currently, there is no cure and those suffering usually
need to take immune-suppressing medications throughout their lives,
leaving them open to a series of possible side effects.
G
astrointestinal cancer – a type of cancer of the different organs
of the digestive system, is one of the most common forms
of cancer across the globe. The overall death rate due to
gastrointestinal cancer is quite high around the world. Although several
chemotherapeutic agents have been successful in the prevention &
treatment of gastrointestinal cancer, still most of them are immensely
expensive and complicated. As such, researchers keep looking for
natural ingredients to serve as effective modes of the treatment of
cancer of different types.
Out of all the natural ingredients, Ginger (Zingiber Officinale) has
been known to serve as the safest and the most effective medicinal
spice for treating a wide range of diseases and medical ailments
Role of Ginger & Its Constituents in the Treatment of Gastrointestinal Cancer 321
including dysentery, heartburn, nausea, loss of appetite, cough, and
so more. Recent medical research has found that ginger along with its
active components including 6-shogaol and 6-gingerol exercise anti-
cancer properties towards fighting gastrointestinal (GI) cancer.
The anti-cancer & nutritional properties of ginger & its active
components lie in the presence of the signaling molecules including
PI3K, COX-2, STAT3, XIAP, and so more. Relevant evidence from
animal, in vitro, and epidemiological studies have revealed that
ginger along with its active components might help in suppressing
the overall growth of cancer of several types including colon, breast,
skin, ovarian, oral, renal, and GI cancers. The anti-cancer properties
of ginger along with its active constituents could be associated with
the anti-inflammatory, antioxidant, and anti-mutagenic properties
along with other biological activities.
Several preclinical studies have revealed that ginger extracts along
with its constituents are known to possess antineoplastic and
chemopreventive properties in the treatment of GI cancer. As such,
there is great hope in the treatment of GI cancer with the help of
ginger and its constituents.
322 Role of Ginger & Its Constituents in the Treatment of Gastrointestinal Cancer
Breaking Cancer Research, Mesothelioma Cancer
A
protein was found to be in relation with tumor suppression. The
protein was associated with the BRCA gene.
BAP1 gene was identified as a gene related to cell death in the
eye, kidney, bile duct, mesothelioma and other cancers but it wasn’t
clear how it suppresses tumors.
Mutation in BAP1, BRCA1 and BRCA2 genes results in cancer. This is
because DNA is damaged in an irreparable way and cells face genetic
modifications. This is said by the National Cancer Institute. These
genetic alterations cause cancer.
Ferroptosis is a well-established form of cell death which plays a very
important role in suppressing tumors. Cystine is an amino acid which
is helpful for tumor growth and expansion of cancerous cells. It also
helps in producing a large number of molecular oxygen carriers in
lipids. SLCA11 is a cystine transporter which is repressed and this aids
ferroptosis. This suppression is mediated by the BAP1 gene.
T
he course of intravenous injections with Lumoxiti (moxetumomab
pasudotox-tdfk) is now available to the American public suffering
from relapsed or refractory hairy cell leukemia (HCL).
Part of a new type of treatment called CD22-directed cytotoxin, the
procedure is addressed to patients that have already received at least
New Treatment for Hairy Cell Leukemia Approved By the FDA 325
one previous systemic therapies, including those involving a purine
nucleoside analog.
Richard Pazdur, M.D., director of the FDA’s Oncology Center of
Excellence said in the press release that “Lumoxiti fills an unmet need
for patients with hairy cell leukemia whose disease has progressed
after trying other FDA-approved therapies”.
The clinical trial that supported this decision had 80 total participants,
63 male, and an average age of 60 years. Each one had undergone
prior treatments unsuccessfully. They had administered 40 µg/kg of
Lumoxiti intravenously on days 1, 3, and 5 of 28-day cycles, for up
to 6 cycles.
About 30% of cases reached complete response (CR), defined as
“maintenance of hematologic remission for more than 180 days”,
and the overall response rate was about 75%.
As with most heavy forms of treatment, some adverse effects can be
expected, most commonly swelling, nausea, fatigue, headache, fever,
constipation, anemia and diarrhea.
Additional warnings can be seen on the box. These inform of the
risk of developing capillary leak syndrome, with symptoms including
difficulty breathing, weight gain, hypotension, or swelling of arms,
legs and/or face.
The FDA also granted Fast Track and Priority Review designations
to Lumoxiti, meaning the drug has significant potential in treating a
serious condition and is to have a higher preference in evaluating the
results.
326 New Treatment for Hairy Cell Leukemia Approved By the FDA
Breaking Cancer Research, Liver Cancer
A
team of researchers has come up with an all-new, revolutionary
drug named FFW that could potentially help in the treatment of
liver cancer or HCC (Hepatocellular Carcinoma). This discovery
by the researchers has opened several doors for coming up with highly
effective treatments for liver cancer with fewer side effects.
HCC (Hepatocellular Carcinoma) or primary liver cancer serves to
be a major form of fast-growing cancer in the human beings. Patients
having HCC are generally known to survive typically for around 11
months after the disease diagnosis. HCC is known to account for
more than 90 percent of the major forms of liver cancers. Thus, it
poses a major health concern – especially in the Asia Pacific region.
In the search for the potential treatment of liver cancer, the researchers
have come up with the revolutionary drug FFW in the treatment of
New Drug Can Help in Fighting Liver Cancer with Fewer Side Effects 327
the disease with minimal side effects. In the given study, the team
deeply studied SALL4 – a protein that is associated with the growth
of tumors – as the prognosis maker and the respective drug target for
the treatment of HCC along with other forms of cancers including
leukemia and lung cancer.
The drug molecules that are known to work upon SALL4 usually
require the particular target proteins to contain a small pocket in the
3D structure wherein the particular drug could reside and implement
its effects. The targeting of the SALL4-NuRD interaction that serves
to be the cancer cell-specific target tends to represent an exciting scope
for the overall development of the therapeutic options in the potential
treatment of liver cancer.
In the latest research, the researchers have also demonstrated some
effective strategy towards accurately targeting oncogenes – which
was previously considered as un-druggable. Moving forward, the
researchers can generate great scope for the overall treatment of liver
cancer through effective drug therapy.
328 New Drug Can Help in Fighting Liver Cancer with Fewer Side Effects
Healthy Lifestyles, Nutrition, Prevention, Thyroid Cancer
I
n shades of brown, with a smooth texture and earthy flavor, Brazil
nuts offer a series of health benefits that you should definitely know
about.
Native to areas of Brazil, Columbia, Venezuela, Guiana, and Peru,
you will find that the nut is not technically a nut, but rather a seed.
They grow in mostly undisturbed forests in coconut-shaped shells,
and require up to 14 months to mature. There can be anywhere from
8 to 24 seeds grouped inside, 1.5 to 2 inches long.
What makes Brazil nuts so desirable is their nutritional value. Packed
with fiber, minerals, vitamins, healthy fats and a whole slew of
proteins, this fruit is rightly considered a superfood.
Because of the high amounts of omega 3 fatty acids, you will regularly
see Brazil nuts being prescribed to reduce the risk of cardiovascular
E
ven though drugs and treatments are always tested extensively
before being released for the general public, it does happen
sometimes to find these sort of unexpected interactions, where
one medicine helps with a totally different condition.
A multinational study compiling data from more than 50 years
of medical reports discovered this surprising connection between
gastroesophageal reflux disease (GERD) treatment and esophageal
adenocarcinoma. More than 930.000 patients from Denmark,
Finland, Iceland, Norway, and Sweden, who either underwent
antireflux surgery (48.414) or were treated with GERD medication
only (894.492), were observed through follow-ups.
In the western world, it is estimated that somewhere between 10 and
20 percent of the population develops GERD. This digestive disorder
I
f you wanted any more confirmation that having junk food regularly
is bad for you, then look no further. The article was published in
the Public Library of Science Journal and reaffirms the notion that
a natural and balanced diet is essential for a healthy life.
The comprehensive article gathered data from almost 500.000
participants of different ages (20 to 70 years old) living across 10
European countries (Denmark, France, Germany, Greece, Italy,
the Netherlands, Norway, Spain, Sweden, and the UK.), including
sociodemographic information, educational level, lifestyle, personal
and familial history and anthropometric measurements (e.g., height,
weight, waist, and hip circumferences).
Dietary intake assessment questionnaires asking detailed information
about types of food consumed, portion sizes, 7-day nutrition records
were collected throughout the 15 years the project was operating.
M
edical nanotechnology is one of the fields right on the forefront
of the fight against cancer. Nanobiotix, a leading industry
giant, is hoping to bring out a new form of cancer treatment,
and so far results look promising.
NBTXR3 is an “aqueous suspension of nanoparticles” containing
inert inorganic hafnium oxide (HfO2) crystals, “designed to penetrate
cancer cells and remain within the tumor”. The procedure involves
administering an intratumoral injection that allows the nanoparticles
to accumulate within the abnormal cells. Radiation is them applied
to the tissue, causing the HfO2 particles to emit high amounts of
electrons, killing the cancerous formation.
For the Nanobiotix trials, phase I was conducted in order to determine
the recommended dosage. 18 patients received either 15% or 22%
doses, with a 12-month cut-off date. At both 12 and 23 month
Head and Neck Trial with NBTXR3 Nanoparticles Shows Promise 335
follow-ups, all patients were alive, the only patient fatality being at
26 months.
The treatment was designed to work on a wide variety of cancers,
including solid tumors, prostate cancer, liver, breast. Phase II is
focusing on head and neck cancer with locally advanced squamous
cell carcinomas.
The nanoparticles offer a series of advantages over standard courses,
the first being that it requires only the one initial injection. They
also provide longer circulation time, better penetration into cellular
membranes and can carry a series of different compounds. Overall,
the procedure is much more targetable and safer on the patient.
Several other trials are running at the moment across the world,
testing for possible effects on esophageal cancer, glioblastoma, and
cervical cancer.
336 Head and Neck Trial with NBTXR3 Nanoparticles Shows Promise
Brain Cancer, Breaking Cancer Research
I
n a recent study, a team of international researchers has successfully
declared the hope of finding the treatment for the fatal brain cancer
in the Zika virus. This study was published after the initial results
of the study found in mice. The study was recently published in mBio
Journal and stated the success of the team of researchers in finding a
potential treatment for the deadly brain cancer in the form of Zika
virus.
Glioblastoma or brain cancer is known to be one of the deadliest
forms of cancers out there. It is responsible for killing over 15,000
adults in the United States of America alone each year. Currently,
Glioblastoma remains incurable as the patients of this deadly disease
tend to experience a high rate of recurrence of cancer even after
receiving the standard treatments of radiation, chemotherapy, and
surgery.
Zika Virus Offers Promise for Treating Fatal Brain Cancer As Per a Study 337
Zika-Virus-Offers-Promise-for-Treating-Fatal-Brain-Cancer-
As-Per-a-Study
Pei-Yong-Shi – a leading virologist at the University of Texas claims
that during the Zika epidemic, the researchers learned that the virus
tends to preferentially attack & infect the neural progenitor cells in
the fetus. As such, the virus was responsible for causing devastating
microcephaly in the babies that were born to such infected mothers.
The team of researchers made the connection that the Zika virus
could potentially infect the glioblastoma cells as well. This is because
the given cells tend to have similar properties to that of the neural
stem cells.
The first objective of the research team was to ensure if there was a
safe way of determining the usage of the Zika virus in the patients
for attacking the cancer cells. The researchers have been successful in
coming up with the promising live-attenuated candidate for the Zika
vaccine, referred to as ZIKV-LAV. This vaccine has shown to be safe,
effective, and non-virulent in the protection of the infection in mice.
338 Zika Virus Offers Promise for Treating Fatal Brain Cancer As Per a Study
Breast Cancer, Colorectal Cancer, Esophagus Cancer,
Head and Neck Cancer, Healthy Lifestyles, Melanoma Cancer,
Nutrition, Prevention, Skin Cancer
B
lack raspberries (BRB) are known to inhibit a wide range of
cancers in the pre-clinical trials or models including the models
of skin, oral, colon, breast, and esophageal cancer. Several
promising preclinical results have led to the evaluations of clinical
results in the patients who are at the higher risk of developing cancer.
Medical research that has investigated the role of black raspberries
in offering the potential treatment for cancer in the coming times.
The results of the studies in clinical settings of blackberries or
raspberries (BRB) have revealed the positive effects of several cancers
including preneoplastic lesions or colon, esophageal, and oral cancers.
The treatment of cancers with black raspberries has resulted in the
historical regression of oral intraepithelial neoplasia that is associated
with the overall improvement in the histologic grade. In addition to
this, the results have also revealed the significant reduction in the loss
I
t’s always great to see a full week of stories involving emerging
cancer treatment options or advancements in the field. Here are
some of the more relevant events in recent days:
A study published in the Journal of the National Cancer Institute
revealed that even though autologous hematopoietic stem cell
transplant is one of the more effective procedures when it comes to
treating multiple myeloma, it is still underused in many facilities. Just
one in five eligible patients (out of a total 13,494) that are part of
the California Cancer Registry received the operation. Surprisingly
enough, it was not due to new therapies rendering the procedure
obsolete, but rather a number of interconnected factors, including
lack of awareness and reluctance from older patients.
Recently we saw three leading oncology practices come together
to form OneOncology, “a patient-centric, physician-driven, and
I
f you wish to ensure healthy lifestyles for yourself and your entire
family, it is important to go for choosing nutritional food choices
in the first place. The food that we consume on a daily basis plays a
vital role in determining the overall health & well-being of the body.
One such food item that tops the list when it comes to imparting a
wide range of potential health benefits is cinnamon.
Cinnamon is a highly tasty and nutritional healthy spice that plays a
vital role in promoting health and in the prevention of a wide array
of diseases & ailments. Here are some of the potential health benefits
of consuming cinnamon as a spice selection in your food items:
Strong Medicinal Properties: Cinnamon is an almost magical spice
that has several powerful medicinal properties known to mankind.
There are two main types of cinnamon including Ceylon cinnamon
and Cassia cinnamon. Scientists believe that the compound
F
or those looking forward to adopting healthy lifestyles, eating
something healthy & nutritional can help significantly. There are
several natural ingredients that can help in the prevention of major
diseases and medical ailments. Out of all such natural ingredients,
grapes turn out to be the healthiest and the most nutritious. In a recent
study, it has been found that grapes can help in stopping the overall
growth of the cancer cells effectively.
Grapes are known to contain natural chemicals that have the
capability of stopping the growth of the cancer cells naturally. The
team of researchers claims that the benefits lie in consuming grapes as
the whole fruit, and not as supplements. When you eat the whole fruit,
the bioactive components of the fruit go directly into the bloodstream
URL:
https://www.webmd.com/cancer/news/20050331/grapes-may-stop-
cancer-cells
L
ooking forward to adopting healthy lifestyles for yourself & your
family? Cayenne Pepper is one such spice out there that serves to
be a host of several medicinal as well as nutritional properties for
your overall health & well-being. Most of the medical researchers
out there regard Cayenne Pepper as the kind of medicinal herbs out
there. Owing to its wide range of medicinal properties, the magical
spice offers prevention from deadly diseases including cancer, heart
diseases, and digestion problems.
Since centuries, the hot fruit of the Cayenne plant known as the
Capsicum Annuum has been utilized as an excellent culinary spice
for treating a wide range of diseases and medical ailments. Cayenne
Pepper is found to be rich in healthy compounds including Vitamins
A, B, C, potassium, calcium, and others. Various studies have revealed
that Cayenne Pepper helps in rebuilding the stomach tissues along
B
ladder cancer is one of the more common forms of malignancy,
affecting millions of people around the world. Most of the
time, treatment options are limited and risk of reoccurrence is
particularly high.
Cancer can be very expensive to treat. Chemotherapy, radiation,
possibly several subsequent operations, not to mention every other
medication dealing with adverse effects, special diets – costs pile up
quite quickly. This is where the new therapy comes in.
Gemcitabine is an “antineoplastic” or “cytotoxic” chemotherapy
drug. It is administered through intravenously right in the affected
area. The procedure only takes a couple of hours and patients can
go home afterwards. Another advantage is the fact that is readily
available.
T
he Royal Marsden and The Institute of Cancer Research (ICR)
have unveiled a groundbreaking piece of technology that will
revolutionize cancer treatment.
The MR Linac (Elekta Unity) is a system that can simultaneously scan
the body for tumors and also deliver targeted radiation treatment
more effectively. It has a special design that allows the magnetic coils
of the MRI to work alongside the linear accelerator’s X-ray beams
and not interfere with each other.
In a press release, Alison Tree, MD, Consultant Clinical Oncologist at
The Royal Marsden and Team Leader at ICR revealed that “Tumor
shape and position relative to healthy tissue evolves over the course of
treatment and can change during an individual treatment session. The
ability to detect those changes and adapt therapy in real time allows
C
onventional vaccines work by training the immune system to
recognize the particular “antigens” displayed by foreign invaders
such as bacteria or viruses. When it comes to cancer, the situation
is a bit different, because of the way the mutated cells divide.
Researchers from the University of Pennsylvania are looking into the
amazing recovery story of a man who went from having head and
neck cancer, which spread to his lymph nodes and skin, to complete
remission following an experimental vaccine with Opdivo. Surprising
as it might sound, this is not the only case of apparent miraculous
recovery, several reports had recently surfaced regarding HPV (Human
Papilloma Virus) vaccines having a similar effect.
The drug in question, MEDI0457, was initially developed by Inovio
using technology pioneered at Penn University. It is based on a DNA
N
ot much attention has been heeded to the consumption of fish
and its effect on cancer risk. It has been associated with affecting
cardiovascular diseases. However, now NCBI (National Center
for Biotechnology Information) has conducted investigations into
fish consumptions and risk of particularly selected neoplasms, by
collecting data from 1983 up to 1996 in Italy.
The investigations reveal a consistent pattern of preventive action
against digestive tract cancer risk by the consumption of fish. Inverse
association in case of the larynx, ovarian and endometrial cancers
was also found as well as multiple myeloma. As for the risk of cancers
pertaining to liver, breast, bladder, gallbladder, thyroid, kidney or
lymphoma, no pattern of risk of cancer was found in relation to fish
F
laxseeds are known to have hormone-like effects as they are a
source of phytoestrogenic compounds named lignans. It can affect
the length of the menstrual cycle and symptoms of menopause. It
may decrease blood pressure, help with diabetes, reduce cholesterol
and protect kidneys from damage.
One vital function of flaxseed is its ability to affect intracellular signals
inside our bodies which otherwise play a role in the growth of prostate
and breast cancer. Given it has phytoestrogenic factors, patients with
ER+ (estrogen receptor positive) breast cancer should use flaxseed
carefully, seeking medical advice from a general practitioner.
Studies including post-menopause women have shown that the
supplementation of flaxseed increased the ratio of those hormones
A
ccording to a review by the National Center for Biotechnology
Information (NCBI), an association between citrus fruits and
risk of gastric cancer has been found. The review was conducted
by investigating available data and publications on diet and stomach
cancers since April 2007. All of the collected data exhibited the given
association.
It was found, in reference with 14 articles and several other studies, a
28% reduction in stomach cancer risk was linked with higher intake
of citrus fruits. The studies asserted the protective action of citrus
fruits against stomach cancers.
Pancreatic, Gastric and Various Cancers May Help with Prevention from Citrus Fruit 359
Another investigation of electronic databases and references of
various publications and studies up to December 2007 was conducted
that studied the linkage between pancreatic cancer risk and intake of
citrus fruits. General variance methods were used for extracting the
results regarding higher and lower intake of citrus fruits in association
with pancreatic cancer risk from these articles. Nine articles (4 case
studies and 5 cohort studies) were found to be eligible. An inverse
association between intake of citrus fruits and pancreatic cancer
risk was observed, albeit the results did vary substantially across the
studies.
Another review studied eligible data from Italy and Switzerland,
covering 955 stomach cancer, 527 laryngeal cancer, 1,294 prostate
cancer, 767 renal cell cancer, 454 endometrial cancer, 3634 large bowel
cancer, and 1031 ovarian cancer cases. The investigation revealed that
citrus fruits also portray a protective role against digestive cancers and
the cancers of the upper respiratory tract. However, any such viable
associations for endometrial, prostate, breast, ovarian and renal cell
cancers have not been found.
Hence, a suitable intake of citrus fruits is highly recommended, after
taking in your doctor’s advice.
360 Pancreatic, Gastric and Various Cancers May Help with Prevention from Citrus Fruit
Cervical Cancer, Healthy Lifestyles, Nutrition, Prevention, Prostate
S
everal studies have revealed that at least one-third of the cancers
are linked to the kind of food that we eat on a regular basis. As
per the World Cancer Research Fund International, the overall
diet plays an important role in the development of specific cancers.
At the same time, there are certain food choices that can help in
the prevention of cancer development. Out of all such food options,
Blueberries are regarded as the “super foods” when it comes to
adopting healthy lifestyles and the prevention of cancer.
Blueberries are full of antioxidants that are known to offer an array
of potential health benefits. By observing the cervical cancer treatment
results, a team of researchers has come to the conclusion that by
the addition of blueberry extracts to the radiation therapy of cancer
treatment, it can help in improving the overall efficacy of the given
treatment.
E
ach year, bladder cancer is responsible for thousands of deaths.
Even though there are a number of treatments available, this form
of the disease is particularly difficult to treat.
Steve Baker is a true survivor. For the better part of the last 25 years,
he has been battling several types of malignancy. In the beginning, it
was skin cancer, then it attacked his kidneys, and more recently he
has been affected by cancer of the bladder. Serenely, Steve admits that
there might have been more, but that he stopped looking a while back.
Many would have given up, but Steve never faltered. After so much
bad news, his luck finally changed for the better. He did not know
it at the time, but the moment he entered a clinical trial for a low-
grade invasive cancer of the urinary system would be one he would
remember for the rest of his life.
A
dcetris (brentuximab vedotin) has recently become an option
for patients dealing with CD30-positive Hodgkin’s lymphoma.
Japan is joining a list of more than 70 other countries where this
treatment has already been approved.
Seattle Genetics, Inc. has partnered with Takeda Pharmaceutical
Company Limited to provide a therapy based on Adcetris in
combination with doxorubicin, vinblastine, and dacarbazine (AVD),
as a frontline solution for this type of cancer.
“This approval marks another important milestone in expanding
the Adcetris brand globally and redefining the way newly diagnosed
Hodgkin lymphoma patients are treated around the world,” said
Clay Siegall, Ph.D., President and Chief Executive Officer of Seattle
Genetics in a short press release.
R
esearchers at The University of Texas MD Anderson Cancer
Center have just concluded a phase II trial on a tumor-specific
vaccine that combined with an immune checkpoint inhibitor
managed to shrink cancerous formations in 30% of patients.
“That encouraging response rate is about twice the rate produced by
PD1 checkpoint inhibitors in previous clinical trials, so these results
will lead to larger, randomized clinical trials of this combination”,
said Bonnie Glisson, M.D., professor of Thoracic/Head and Neck
Medical Oncology at MD Anderson.
The findings were published in the latest issue of JAMA Oncology.
The article details how the combination of the ISA101 vaccine that
targets peptides produced by the HPV16 genotype of the virus, along
with nivolumab, a checkpoint inhibitor responsible for blocking the
activation of PD-1 on T cells, works together.
A
straZeneca, a multinational, pharmaceutical and biopharmaceu-
tical company studied to create a drug that would help patients
fighting lung cancer. The drug is for the patients in which the
lung cancer had not spread.
The results of the study named Pacific were published, and it stated
that the immune system of a person can attack the tumor to kill it
before the cancer spreads.
The Imfinzi medicine has helped to lower the death risk of persons
by one-third, who were being treated with Chemotherapy alone
previously. These were the people were in the third or fourth stage
of cancer.
Pascal Soriot, an executive at the company, puts the success on the
center of his successful appeal to shareholders, which was to reject a
takeover bid from Pharm Giant Pfizer four years ago. Companies like
Merck and Bristol-Myers Squibb had already developed successful
T
he Food and Drug Administration (FDA), the agency tasked with
overseeing public health in the U.S., has given this classification
to CLR 131, a drug designed by Cellectar Biosciences for
the treatment of a rare type of cancer affecting children, pediatric
osteosarcoma.
The Orphan Drug Designation is a special status granted to “a drug or
biological product to treat a rare disease or condition upon request of
a sponsor”. This comes with a number of incentives, namely a market
exclusivity period of seven years, increased support and assistance
from the FDA, the possibility of receiving tax credits for research,
grants and a waiver of the New Drug Application user fee.
John Friend, M.D., chief medical officer of Cellectar said in a press
release that “this orphan designation for osteosarcoma is the fourth
P
atients who are living through a High-Grade Serious Ovarian
cancer may have greater chances of survival after this new
treatment through immunotherapy and Chemotherapy.
A cancer antigen named as 45 (CT45), which has been identified
during a proteomic analysis. These antigens are regarded as promising
targets for tumor therapy. Patients with a higher level of antigen show
that they may survive for a longer time.
Authors of Max Plank Institute in Germany studied about this and
they claim that one among six patients with Ovarian Cancer lives
disease free in the next ten years. These are the patients being treated
with surgery and carboplatin/paclitaxel Chemotherapy. 80% among
these have to seek Chemotherapy frequently. There haven’t been any
The Prognostic Importance of Antigen 45 (CT45) in Extending Life of an Ovarian Cancer Patient 373
molecular mechanisms identified for patients who survive and those
who don’t.
Investigators made an analysis and published the results. Here
paraffin embedded patient samples were studied. Among them, 11
HGSOC chemoresistant patients (median DFS, 190 days) and 14
chemosensitive patients (DFS, 1, 160 days).
Researchers studied almost 90,000 protein samples and came to know
that patients with high CT45 expression depicted a better chance of
survival and along this had a median DFS of 2,745 days as compared
to 366 days in rest of the patients. They could have been living for
2,903 days while other patients had 1,078 survival days. The study
was repeatedly confirmed.
Marion Curtis from the University of Chicago said that tumors
response to carboplatin which is due to CT45. CT45 and PP4
phosphate complex interact, and this connects CT45 to DNA damage
pathways.
Finally, the research creates a hope for us that if CT45 is activated
in a tumor, it could help in a more effective treatment for cancer by
carboplatin.
374 The Prognostic Importance of Antigen 45 (CT45) in Extending Life of an Ovarian Cancer Patient
Pancreatic Cancer
C
ancer is a fatal disease in which unwanted cells grow repeatedly
and harm the body of a person. Pancreatic cancer is also among
lethal cancer types which may kill a person. It’s the third most
deadly form of cancer. Many people become a victims each week.
It is not easy to diagnose the disease when it is at its initial stages
and this is because of the location of the pancreas. The Pancreas is
located deep inside the body. The six-inch long organ rests behind the
stomach, in the abdomen.
The location hurdles make the disease treatment resistant and
sometimes the disease becomes immune to chemotherapeutic
treatments.
Both of these problems can be part of the reason for the person
experiencing shorter a much shorter life after he or she has been
P
eople who are a victim to Chronic Lymphocytic Leukemia, Small
Lymphocytic Leukemia or Follicular Leukemia (FL) face the
disease in either relapsing or recurring conditions.
A drug has been recently approved by FDA for treating these types of
blood cancer. It is named as Copiktra which is a dual Inhibitor of PI3K
delta and PI3K gamma and is administered in the form of capsules.
Copiktra is used for treating FL in patients who have received two
prior systematic therapies.
It wasn’t easy to get the drug approved and a randomized open-label
trial helped to achieve its approval. Arzerra (Ofautmumab) was a drug
compared in a trial with Duvelisib. Patients were either administered
with Arzerra or Duvelisib
Arzerra group got 300 mg of the drug once in a week initially, which
later became 2000 mg once weekly in 7 doses and then, 2000 mg split
in 4 weeks. Copiktra group patients were given 25 mg of dose each
T
his story is about a reunion between two people, one who needed
life and other who gifted it. Sawyer wanted to meet Schwartzel
who saved his life.
Schwartzel was a physician assistant from San Diego who got himself
enrolled with “Be The Match” Registry. This shows his kind nature
and love for humanity. He was asked to donate in 2017 for Johnny
Sawyer Dyer.
Johnny Sawyer Dyer was diagnosed with acute myeloid Leukemia in
2017. He stayed and was treated at East Tennessee Children’s Hospital
in Knoxville before he was to receive a bone marrow transplant.
The transplantation was to be done at Tristar Centennial Medical
Center in Nashville. Sawyer was eight years old when he received the
transplant.
T
he highly prestigious Nobel Prize in the field of Physiology
or Medicine was received by two leading immunotherapy
researchers in the field of cancer treatment. James P. Allison
from the United States of America & Tasuku Honjo from Japan
were awarded this prestigious award for their impressive work on
unwinding the theory of the immune system of the body for attacking
cancer. This medical theory has served to be a breakthrough in the
field of cancer treatment that has led to the advent of a completely
new range of drugs. Moreover, the revolutionary immunotherapy for
cancer treatment has also brought about everlasting remissions to
several patients who did run out of possible options.
Before the discoveries of Dr. Honjo and Dr. Allison, most of the
cancer treatment included radiation, surgery, hormonal changes, and
Two Leading Cancer Immunotherapy Researchers Receive the 2018 Nobel Prize in Medicine 381
chemotherapy. A statement that was released by the Nobel Committee
hailed the accomplishments of the scientists as they have helped in
the establishment of a completely new principle for the treatment of
cancer.
On the basis of the works of the scientists, the drugs belong to the
specific class referred to as “Checkpoint Inhibitors.” Earlier attempts
made by other medical researchers in the given field towards recruiting
the immune system for fighting cancer sometimes did work, but at
other times, most of them did not work. Dr. Honjo & Dr. Allison
were able to succeed in the case wherein others had failed. This was
achieved by deciphering how the cells were able to interact such
that the scientists were able to refine the systems for controlling the
immune system of the body.
The checkpoint inhibitors are known to not work for every individual
out there. These have been approved only for specific cancer
treatments. The checkpoint inhibitors that are available in the market
out there are currently utilized for treating neck, lung, kidney, head,
and bladder cancer.
The T-cells – a specific type of white blood cells, are sometimes known
as the warriors of the body’s immune system. They are made use of by
the body for fighting major infections. In the given immunotherapy
therapy, the T-cells are made use of for treating cancer. Dr. Allison
was successful in coming across a checkpoint referred to as CTLA-4.
Honjo found another one known as PD-1. These major discoveries
by the scientists have helped in the development of drugs that would
allow the T-cells to fight cancer effectively.
382 Two Leading Cancer Immunotherapy Researchers Receive the 2018 Nobel Prize in Medicine
Healthy Lifestyles, Nutrition, Prevention
W
hen it comes to talking about nutrition and the overall
prevention of major diseases, the term “antioxidants” cannot
be avoided. Antioxidants are substances that are responsible
for protecting the cells in the body from the damage caused by
the free radicals. This damage could occur due to certain factors
including smoking, chemicals, pollution, radiation, and a byproduct
of the normal metabolism process. Some of the significant dietary
antioxidants that can be included in a healthy lifestyle include
vitamin A, selenium, vitamins C & E, carotenoids, along with several
phytochemicals including quercetin, lycopene, and lutein.
One can come across the antioxidants in many natural sources of
food items. For instance, there are large amounts of antioxidants in
fruits, nuts, vegetables, whole grains, and so more. There is no surprise
T
he FDA recently approved the use of Libtayo (cemiplimab-
rwlc), an intravenous drug designed for patients with metastatic
cutaneous squamous cell carcinoma (CSCC) or locally advanced
CSCC who are not eligible for curative surgery or curative radiation.
Just in the United States, there are more than 700.000 new cases
discovered each year, making CSCC the second most common human
cancer and accounting for about 20% of all diagnosis. People who
are constantly exposed to ultraviolet radiation from the Sun or other
sources develop ulcers or hard lumps with scaly tops. Most of the
time, surgical resection is enough, but for approximately 5% of
patients who develop an advanced form, no treatment is effective.
T
he idea of using the patient’s own antibodies to treat HER2-
positive cancers is not new, but only now have scientists come
close to making it a reality.
It all started in 2008, when Jay Berzofsky, M.D., Ph.D., chief of the
Vaccine Branch at the NCI’s Center for Cancer Research presented
his paper detailing a serum able to eradicated large breast tumors
and lung metastases in mice. The concept was simple – harvest blood
from the subject, genetically modify dendritic cells to produce parts
of the HER2 protein, inject them back and hope they would trigger
an immune response against the cancer.
Fast forward to 2018, Dr. Berzofsky reports positive results in his
clinical trials at the CRI-CIMT-EATI-AACR International Cancer
Personalized Vaccine Could Become New Norm for Treating HER2-Positive Tumors 387
Immunotherapy Conference in New York. Out of the 11 participant
members that received the highest doses, six showed clinical
benefits. One patient suffering from ovarian cancer displayed a
complete response that lasted 89 weeks, one patient with a case of
gastroesophageal cancer had a partial response that lasted 16 weeks
and the last four (two cases of colon cancer, one prostate cancer, and
one with ovarian cancer) had stable disease.
Personalized-Vaccine-Could-Become-New-Norm-for-Treating-HER2-
Positive-Tumors
As he describes it, “immunotherapy marshals the exquisite specificity
of the immune system to destroy cancer, and some types may have
potentially fewer side effects than traditional chemotherapy”.
Dendritic cells are an important part of the immune system because
they can train T cells to attack cancer even when it has spread beyond
the original tumor site.
“We are using a vaccine approach to generate an immune response
to HER2, which is found at high levels on and drives the growth of
several types of cancer, including breast, ovarian, lung, colorectal, and
gastroesophageal cancers”, added Dr. Berzofsky in the press release.
Clinical trials are moving forward and the next objective is to
combine two immune-boosting therapies that will hopefully increase
effectiveness.
388 Personalized Vaccine Could Become New Norm for Treating HER2-Positive Tumors
Cancer Breakthroughs, Kidney Cancer
I
t all started with a car accident that, ironically enough, might
have saved his life. Two and a half years later, Thomas Bland is
completely recovered and cancer-free – a living testimony of how
effective biologic therapy can be.
About three years ago, on his way to work, another driver slammed
into his car. Thomas had to be airlifted to VCU Medical Center, where
he went through extensive testing. As he remembers it: “they did a CT
scan to assess the damage, and that’s when they found the tumor”.
After recovering from the injuries sustained in the accident, doctors
removed his left kidney and adrenal gland. The biopsy revealed
that he was, in fact, suffering from sarcomatoid kidney cancer, a
particularly aggressive form of malignancy. Because of how fast the
First Case of Complete Immunotherapy Response for Kidney Cancer Patient 389
malignancy spreads through the body, this diagnosis usually means a
life expectancy of less than 12 months.
Three months after the surgery, the news was bad – the cancer had
returned and was spreading to his right lung and right hip bone.
Four months of grueling standard cancer treatment followed, with no
effect. The disease was actually advancing towards his right adrenal
gland, surrounding bones and causing nodules on his scalp. Time was
running out for Thomas.
This is when his doctor, Asit Paul, M.D., Ph.D., convinced him to try
an experimental new drug called Nivolumab (also known as Opdivo).
The treatment was so recent that at the time there was “no data
supporting the use of nivolumab in patients like Mr. Bland”.
Part of a new wave of immunotherapy medication, Nivolumab is a
checkpoint inhibitor that blocks certain proteins used by the cancer
cells to hide from antibodies and evade destruction. Every two weeks,
Thomas was administered Opdivo intravenously. Within a month, the
tumors on the scalp started shrinking and after a few months, scans
showed no spots of cancer anywhere in his body.
“I didn’t even have any side effects, at least nothing like I experienced
with chemo”, admitted Mr. Bland. He went on to say “I really want
to thank Dr. Paul, nurse practitioner Gwen Parker, my other nurses,
and the rest of the staff at Massey Cancer Center. They saved my life”.
390 First Case of Complete Immunotherapy Response for Kidney Cancer Patient
Breaking Cancer Research, Breast Cancer
I
t might sound strange, but cancers are actually unique to every
individual. Just like fingerprints, they appear to be similar, though,
on closer inspection, they differ widely.
In 2006, at the age of 46, Teresa McKeown was diagnosed with
breast cancer. She followed the standard treatment and overcame the
malignancy. 11 years later though, it came back in full force, with
what is called triple-negative disease, more aggressive and harder to
treat. Nothing worked this time. It quickly spread to her intestine,
making it difficult to eat and causing her peritoneal cavity to fill with
liquid. Now Teresa had lost all hope and began writing goodbye
letters to her children.
In this darkest of moments, one shimmer of light appeared in the form
of a clinical trial at Moores Cancer Center at UC San Diego Health.
N
atural alternatives to current forms of cancer treatment,
especially chemotherapy and radiation, present a number of
intrinsic advantages and have been a point of focus in recent
years. Vismia baccifera might just be the perfect candidate to take
over this job.
“Right now, there is huge interest in identifying compounds derived
from plants that could be used as chemotherapeutic agents with the
capacity to prevent tumours from growing, or to treat metastasis, for
example”, explained Dr Jenifer Trepiana, member of the team from
UPV/EHU’s Faculty of Medicine and Nursing that worked on the
project.
These researchers from the University of the Basque Country
discovered that the plant, a native of the Amazonian region, produced
B
ecause of how aggressive chemotherapy or other cancer treatment
options can be on the body, patients often complain about taste
and smell abnormalities (TSA), leading to loss of appetite or even
anorexia.
The Food and Function journal presented an article exploring the
possibility of using lactoferrin, a multifunctional protein with many
bioactive properties, in order to relieve TSA effects. With nutrition
being a crucial component in the recovery process, alleviating
reported symptoms like food having “metallic flavor or aftertaste”
could significantly improve healing times and general outcome.
“By suggesting lactoferrin as a dietary supplement, we can reduce TSA
for many patients, restoring their ability to enjoy foods during a time
in which nutrition can play a key role in their recovery”, said Susan
Milk Could Restore Gustatory and Olfactory Sensations to Chemo Patients 395
Duncan, professor in the Department of Food Science and Technology
at Virginia Tech and co-author of the paper.
It might seem like a trivial issue, but having a satisfying meal not
only provides natural vitamins and minerals required for the healing
process, it also helps on a psychological level, giving cancer patients a
feeling of comfort and normalcy. Too often, in cases like these, people
suffer from poor appetite, weight loss, diminished nutrition, and even
depression.
Mrs. Duncan went on to say: “This research could help us develop
TSA-targeted biomarkers and strategies for improving quality of life
during chemotherapy. Cancer patients and their supporting family
and friends may again find comfort in enjoying a meal together”.
The trial involved cancer patients and also 12 healthy subjects. They
were administered 3 tablets per day (250 mg per tablet), for 30 days.
Results showed consistently high traces of salivary proteome and
minerals. Overall, Lactoferrin “increased the abundance (P < 0.05)
of salivary α-amylase and Zn-α-2-GP, and led to an overall increase
of expression (≥2-fold changes) of immune proteins including
immunoglobulin heavy chain, annexin A1, and proteinase inhibitor”.
Ensuring adequate patient care and high quality of life is always a
priority, especially when dealing with serious diseases like cancer
396 Milk Could Restore Gustatory and Olfactory Sensations to Chemo Patients
Bone Cancer, Leukemia Cancer
T
he journal Leukemia published not one but two articles (found
here and here) regarding a new drug that facilitates and improves
bone marrow donation and transplantation. Researchers hope to
make the operation safer and more effective for patients.
Truly a life-saving procedure, the stem cell transplant is designed to
restore the body’s blood making ability for those battling certain types
of cancer, like leukemia, or immune deficiency diseases. Even though
it presents countless risks, each year, this is the last resort for tens of
thousands of people around the world.
The team from Cincinnati Children’s Cancer and Blood Diseases
Institute identified a Cdc42 activity-specific inhibitor (CASIN) that
can help with several stages of the process. In order to assimilate
the new donor cells, hematopoietic stem cells (HSCs), existing ones
T
owards coming up with a breakthrough in the field of cancer
treatment, two Birmingham hospitals are making use of the
Herpes virus for treating brain cancer.
The herpes virus – the one which is responsible for causing cold sores,
is currently under trial for treating brain tumors. The two leading
Birmingham hospitals including the Children’s of Alabama and UAB
are the only hospitals in the world that are trying out the herpes virus
research for treating the patients with brain cancer.
Though it is quite an early stage in the given research, still it has
been revealing major results. A patient named Nick Tasoglou claimed
that in the beginning, this treatment approach sounded a bit weird
to him. Dr. Gregory Friedman in the field of Pediatric Hematology
Birmingham Hospitals Making Use of Herpes Virus for Treating Brain Cancer 399
& Oncology stated that they have learned a way of engineering the
herpes virus such that they are quite safe. As such, these viruses can
be directed and targeted for killing the cancer cells.
Dr. Friedman also claimed that this could be the future of cancer
treatment.
Once the biopsy is done towards confirming the presence of a recurring
tumor in the brain, the doctors go ahead with placing catheters directly
to the cancer tumors. After this, the catheters are externalized through
the scalp of the patient. The following day, the engineered herpes virus
is infused for over 6 hours through the catheter. After this process has
finished, the catheters are pulled out and the patient is given time to
recover.
The main advantage of this type of treatment over the conventional
radiation or chemotherapy methods is that it tends to be a one-time
treatment instead of being a continuous treatment. The study finds
that the herpes virus – G207 is safe for children having malignant
brain tumors. As many as 7 children have been treated through this
method.
400 Birmingham Hospitals Making Use of Herpes Virus for Treating Brain Cancer
Categories
Bladder Cancer
Cancer Patient Fights Terminal Cancer Through Alternative
Treatments! . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106
First Treatment for Advanced Skin Cancer Approved . . . . . . . . . . . . . . . . . . 170
Olive Oil – The Amazing Elixir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
Urine Color: A Cancer Indicator . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
All-new Advanced CAR-T Treatment Might Give Hope to the
Cancer Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
Newly Identified Biomarker Could Pave the Way for
Personalized Bladder Cancer Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
Breaking Treatment Displays Promising Results in
Fighting Bladder Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349
Fish Intake Could Lead to Lower Cancer Risks! . . . . . . . . . . . . . . . . . . . . . . . 355
New Bladder Cancer Drug Shows Impressive Results . . . . . . . . . . . . . . . . . 363
FDA Greenlights First Treatment for Advanced Skin Cancer . . . . . . . . . . . . 385
Blood Cancer
New Drug Developed by Israeli Researchers That Kills Multiple
Leukemic Proteins at Once! . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
First Non-Chemotherapy Treatment for Rare Blood Cancer . . . . . . . . . . . . . 29
Categories 401
Cholesterol-Lowering Drug, Statin, Can Better Blood
Cancer Treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Cancer Blood Test Based on Protein Produced by Malarial Parasite can
Revolutionize Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Innovative Genetic Testing Service to Help Cancer Patients . . . . . . . . . . . . . 79
A Recent Ground-Breaking Study Could Minimize the Side Effects
of CAR T-Cell Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .90
New Drug Puts Cancer Cells in Permanent Suspension . . . . . . . . . . . . . . . . 142
Hundreds of Kidney, Skin and Blood Cancer Patients May Be
Cured from Breakthrough Drug . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
New FDA Approved Drug Enters Leukemia Fight . . . . . . . . . . . . . . . . . . . . . . 207
All-new Advanced CAR-T Treatment Might Give Hope to the
Cancer Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
Black Raspberries Offer Promise for Treating Cancer . . . . . . . . . . . . . . . . . 339
FDA Approved for Leukemia! – Copiktra . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
Bone Cancer
New Drug Developed by Israeli Researchers That Kills Multiple
Leukemic Proteins at Once! . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Pediatric Osteosarcoma Drug Receives Orphan Drug Designation . . . . . . . 371
New Drug Enhances the Harvest of Bone Marrow . . . . . . . . . . . . . . . . . . . . 397
Brain Cancer
New Drug Combination Could Help Curb Melanoma That
Has Spread to Brain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
New Chemical Found That Can Cause Self-Destruction in the
Brain Cancer Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Emerging Hopeful Glioblastoma Treatments. . . . . . . . . . . . . . . . . . . . . . . . . . . 51
Additional Inhibitor Could Reduce Brain Cancer Resistance
to Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Experimental Dog Treatment Could Save Human Lives. . . . . . . . . . . . . . . . . . 98
Nanoparticles, High Tech Weapons Fighting Brain Cancer. . . . . . . . . . . . . . 183
Nanoparticles can Help Battle Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . 199
Modified Poliovirus Helps Treat Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . 215
Stem Cells Could Be an Effective Drug Delivery Tool for
Brain Cancer in Children. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
402 Categories
Saving Healthy Cells in Brain Cancer Treatment, Synthetically. . . . . . . . . . 313
Head and Neck Trial with NBTXR3 Nanoparticles Shows Promise. . . . . . . . 335
Zika Virus Offers Promise for Treating Fatal Brain Cancer As Per a Study. . . . 337
Birmingham Hospitals Making Use of Herpes Virus for
Treating Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399
Categories 403
Genetic testing: Not a One-and-Done Deal. . . . . . . . . . . . . . . . . . . . . . . . . . . 164
The Immune System of the Alpaca Reveals a Potential Treatment
for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Could Wart Vaccines Really Treat Skin Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 267
Arsenic Shows Surprising Benefits in Cancer Fight . . . . . . . . . . . . . . . . . . . . 273
New Vaccine Completely Removes Cancer in Mice. . . . . . . . . . . . . . . . . . . . . 281
Combination of Molecules Found to be Effective in the
Treatment of Cancer in Mice. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
Scientists Discovered a Drug Target for Neurodegenerative
Diseases & Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
Primary Tumors Found to Inhibit Secondary Tumors. . . . . . . . . . . . . . . . . . . 299
Switchable CAR-T Cells Target Pancreatic Ductal Adenocarcinoma. . . . . . . 309
New Treatment Discovered to Fight Melanoma Better Than
Traditional Vaccine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
A Tumor Suppressor – BRCA Associated Protein. . . . . . . . . . . . . . . . . . . . . . . 323
Breaking Treatment Displays Promising Results in
Fighting Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349
Vaccine to Possibly Treat Head and Neck Cancer. . . . . . . . . . . . . . . . . . . . . . 353
Two Leading Cancer Immunotherapy Researchers Receive the 2018
Nobel Prize in Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381
Genetic Tumor Mapping Could Save Countless Lives. . . . . . . . . . . . . . . . . . . 391
404 Categories
Breakthrough FDA Designation
LOXO-292 Receives FDA Breakthrough Therapy Designation for the
Treatment of Lung & Thyroid Cancers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
FDA Approved for Leukemia! – Copiktra. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
FDA Greenlights First Treatment for Advanced Skin Cancer. . . . . . . . . . . . . 385
Breast Cancer
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Neem Oil Could Help Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Discovery of T-cells Hidden in Bone Marrow Can Help Beat
Brain Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Breast Cancer Drug Proves Promising in Phase III Clinical Trials. . . . . . . . . . 47
Apples Reduce Chance of Cancer With Up To 25% . . . . . . . . . . . . . . . . . . . . . . 53
Safe Amount of Alcohol to Drink Is Zero . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Mesothelin Targeted CAR T-Cell Therapy Shows Efficacy in
Early Stages of Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
China approves Breakthrough Therapy Drug for Breast Cancer. . . . . . . . . . 114
Supercomputer Joins Fight Against Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 128
Ways of Reducing the Risk of Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144
Protein That Inhibits Breast Cancer Suppression Finally Blocked. . . . . . . . 148
Groundbreaking Immunotherapy Leads to Complete Remission
of Breast Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
University Of Toledo Professor Working On Cutting Edge Cancer
Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152
CAR T-Cell Therapy Might Alter the Treatment of Mesothelioma. . . . . . . . . 156
New Cancer Vaccine Shows Early Promise For Patients With
Her2-Positive Cancers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
Categories 405
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Discovery Blocks Vicious Cycle of Inflammation and Tumor Growth. . . . . . 197
Study Spares Breast Cancer Patients from Unnecessary Chemotherapy . . . 203
Long-term Study Reveals Lower Cancer Incidence from
Vegetable and Fruit Diet. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
More Vitamin D May Offer Less Risk of Breast Cancer. . . . . . . . . . . . . . . . . . 239
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
When People Care There is HOPE!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Possible Male Breast Cancer Signs You Should Be Aware of . . . . . . . . . . . . 265
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
The Sweet Potato – An Unexpected Weapon against Breast Cancer?. . . . . 279
Can Match Tea Fight Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
Primary Tumors Found to Inhibit Secondary Tumors. . . . . . . . . . . . . . . . . . . 299
Discovery of New Metal-Based Inhibitor May Improve Treatments
for Triple-Negative Breast Cancer (TNBC). . . . . . . . . . . . . . . . . . . . . . . . . . . . .317
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Benefits of Flax Seed Could Include Cancer Prevention. . . . . . . . . . . . . . . . 357
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Genetic Tumor Mapping Could Save Countless Lives. . . . . . . . . . . . . . . . . . . 391
406 Categories
Cancer
Magic Bullet Technique Effectively Targets Only Cancer Cells. . . . . . . . . . . . 23
China’s Med-Tech Benefits the World with its Non-Invasive
Treatment for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
Breaking – Cancer Research Finds Malaria Protein As a Method of
Diagnosing Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Cancer-Targeted Immunotherapy for Offering Protection Against
Metastases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
Cancer Should Not Have to Be a Death Sentence!. . . . . . . . . . . . . . . . . . . . . . 92
Cancer May be Prevented by Maintain Body pH Level. . . . . . . . . . . . . . . . . . . 94
Health Risks for Occasional Smokers Considerably Higher than
Previously Believed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
Clubbed Nails May Indicate Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104
Hyperbaric Oxygen Treatment Has Surprising Results On
Cancer Survivor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .112
Cell-to-Cell Communication Opens Way for Better Cancer Treatment. . . . 116
Garlic, the Ultimate Panacea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
Special Genes Discovered in Elephants That Resist Cancer. . . . . . . . . . . . . 138
Chinese Tree Bark Compound Shows Anticancer Properties. . . . . . . . . . . . 146
FDA Extends Age Limit for HPV Vaccine to Include Adults
between 27 And 45. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Cancer Cells Engineered to Trigger a Death Switch in
Other Cancer Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Cancer Treatment by Targeting Telomeres & Telomerase. . . . . . . . . . . . . . . 209
Modified Poliovirus Helps Treat Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . 215
Olive Oil – The Amazing Elixir. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
XTANDI Treatment for Prostate Cancer Gets FDA Approval. . . . . . . . . . . . . . 221
All-new Advanced CAR-T Treatment Might Give Hope to the
Cancer Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
A Light-Emitting Wireless Implant to Kill Cancer . . . . . . . . . . . . . . . . . . . . . . 237
Kidney Cancer Cure via Protein Targeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
Categories 407
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
New Cancer Treatment: Molecularly Targeted Therapy. . . . . . . . . . . . . . . . . 271
Arsenic Shows Surprising Benefits in Cancer Fight . . . . . . . . . . . . . . . . . . . . 273
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Grapes May Help in Stopping the Growth of Cancer Cells. . . . . . . . . . . . . . . 345
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Amazonian Plant Could Have Miraculous Anticancer Properties. . . . . . . . . 393
Cancer Breakthroughs
New Breakthrough Treatment Discovered for Bowel Cancer . . . . . . . . . . . . . . 1
Researchers at Queen’s University Belfast Succeeded in Creating
a Ray of Hope for Bowel Cancer Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
China approves Breakthrough Therapy Drug for Breast Cancer. . . . . . . . . . 114
Array BioPharma Receives FDA Breakthrough Therapy Designation
for BRAFTOVI in Combination Drugs for Colorectal Cancer. . . . . . . . . . . . . . 120
The Immune System of the Alpaca Reveals a Potential Treatment
for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Hundreds of Kidney, Skin and Blood Cancer Patients
May Be Cured from Breakthrough Drug. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Delta-tocotrienol Inhibitors Might Reduce Risk of
Tumor Invasion and Metastasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
“Promising” Treatment Trial Gives New Hope for the
Deadliest Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
Revolution in Melanoma Treatment for Patients. . . . . . . . . . . . . . . . . . . . . . 249
New Peptide Drug Targets Liver Cancer from Within. . . . . . . . . . . . . . . . . . . 257
Oral Bacteria – a Breakthrough Passage in Weight Loss,
Cancer Treatment, and Overall Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
FDA Issues Breakthrough Therapy Designation for LENVIMA. . . . . . . . . . . . 263
New Cancer Treatment: Molecularly Targeted Therapy. . . . . . . . . . . . . . . . . 271
First Case of Complete Immunotherapy Response for
Kidney Cancer Patient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
408 Categories
Cancer Cures
P53 Gene Suppression Inhibits Colorectal Cancer Growth. . . . . . . . . . . . . . . . 7
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Cure for Acute Leukemia Within Reach - First Time in 40 Years. . . . . . . . . . . 86
Hyperbaric Oxygen Treatment Has Surprising Results On
Cancer Survivor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .112
Cell-to-Cell Communication Opens Way for Better Cancer T
reatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116
Studies Suggest Aspirin Keeps Colorectal Cancer Away . . . . . . . . . . . . . . . . 130
Innovative Therapy to Cut Radiation Sessions for Prostate Cancer . . . . . . 134
Treatments Ensuring Quality of Life for Lung Cancer Patients! . . . . . . . . . . 136
Special Genes Discovered in Elephants That Resist Cancer. . . . . . . . . . . . . 138
A Major Vulnerability of Childhood Leukemia Discovered!. . . . . . . . . . . . . . 140
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Taming Pediatric Leukemia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Nanoparticles, High Tech Weapons Fighting Brain Cancer. . . . . . . . . . . . . . 183
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Cancer Cells Engineered to Trigger a Death Switch in
Other Cancer Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Delta-tocotrienol Inhibitors Might Reduce Risk of
Tumor Invasion and Metastasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
Cancer Treatment by Targeting Telomeres & Telomerase. . . . . . . . . . . . . . . 209
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Turmeric Can Cure Stomach Cancer: According to JNU Study. . . . . . . . . . . . 213
Modified Poliovirus Helps Treat Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . 215
“Promising” Treatment Trial Gives New Hope for the
Deadliest Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
New Study Could “Pause & Reverse” Lung Cancer. . . . . . . . . . . . . . . . . . . . . 243
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Revolution in Melanoma Treatment for Patients. . . . . . . . . . . . . . . . . . . . . . 249
Categories 409
Merck’s Keytruda on Its Way to Dealing with Head &
Neck Cancer Case. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253
Arsenic Shows Surprising Benefits in Cancer Fight . . . . . . . . . . . . . . . . . . . . 273
Grapes May Help in Stopping the Growth of Cancer Cells. . . . . . . . . . . . . . . 345
Birmingham Hospitals Making Use of Herpes Virus for
Treating Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399
Cancer Technology
P53 Gene Suppression Inhibits Colorectal Cancer Growth. . . . . . . . . . . . . . . . 7
Magic Bullet Technique Effectively Targets Only Cancer Cells. . . . . . . . . . . . 23
Can Artificial Intelligence Combat Pancreatic Cancer? . . . . . . . . . . . . . . . . . . 35
Emerging Hopeful Glioblastoma Treatments. . . . . . . . . . . . . . . . . . . . . . . . . . . 51
Hyperbaric Oxygen Treatment Has Surprising Results On
Cancer Survivor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .112
Supercomputer Joins Fight Against Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 128
Innovative Therapy to Cut Radiation Sessions for Prostate Cancer . . . . . . 134
Special Genes Discovered in Elephants That Resist Cancer. . . . . . . . . . . . . 138
A Major Vulnerability of Childhood Leukemia Discovered!. . . . . . . . . . . . . . 140
Surgeons at Pennsylvania “Light Up” Tumors for Boosting
the Chances of Mesothelioma Survival . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
Nanoparticles, High Tech Weapons Fighting Brain Cancer. . . . . . . . . . . . . . 183
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Discovery Blocks Vicious Cycle of Inflammation and
Tumor Growth. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Nanoparticles can Help Battle Brain Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . 199
Delta-tocotrienol Inhibitors Might Reduce Risk of
Tumor Invasion and Metastasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
New FDA Approved Drug Enters Leukemia Fight. . . . . . . . . . . . . . . . . . . . . . . 207
All-new Advanced CAR-T Treatment Might Give Hope to the
Cancer Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
“Promising” Treatment Trial Gives New Hope for the
Deadliest Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
A Light-Emitting Wireless Implant to Kill Cancer . . . . . . . . . . . . . . . . . . . . . . 237
Revolution in Melanoma Treatment for Patients. . . . . . . . . . . . . . . . . . . . . . 249
410 Categories
Merck’s Keytruda on Its Way to Dealing with Head &
Neck Cancer Case. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253
New Cancer Treatment: Molecularly Targeted Therapy. . . . . . . . . . . . . . . . . 271
Arsenic Shows Surprising Benefits in Cancer Fight . . . . . . . . . . . . . . . . . . . . 273
Cutting Edge Radiotherapy Machine Introduced in the U.K. . . . . . . . . . . . . 351
Birmingham Hospitals Making Use of Herpes Virus for
Treating Brain Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .399
Cervical Cancer
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Head and Neck Trial with NBTXR3 Nanoparticles Shows Promise . . . . . . . 335
How can Blueberries Help in Killing Cancer Cells? . . . . . . . . . . . . . . . . . . . . 361
New Vaccine to Possibly Treat Incurable HPV-Related Cancers . . . . . . . . . 367
Colorectal Cancer
New Breakthrough Treatment Discovered for Bowel Cancer . . . . . . . . . . . . . . 1
New Drug Developed by Israeli Researchers That Kills Multiple
Leukemic Proteins at Once!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Researchers at Queen’s University Belfast Succeeded in Creating
a Ray of Hope for Bowel Cancer Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
P53 Gene Suppression Inhibits Colorectal Cancer Growth. . . . . . . . . . . . . . . . 7
Large Colorectal Lesions Removed Without Surgery with the Help of
High-Tech Robotic Systems. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Immunotherapy – A New Form of Lung Cancer Treatment!. . . . . . . . . . . . . . . 31
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Apples Reduce Chance of Cancer With Up To 25% . . . . . . . . . . . . . . . . . . . . . . 53
Prevent Colon Cancer with These Six Foods . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Array BioPharma Receives FDA Breakthrough Therapy Designation
for BRAFTOVI in Combination Drugs for Colorectal Cancer. . . . . . . . . . . . . . 120
Categories 411
Kale and Broccoli Could Prevent Colon Cancer. . . . . . . . . . . . . . . . . . . . . . . . 126
Studies Suggest Aspirin Keeps Colorectal Cancer Away . . . . . . . . . . . . . . . . 130
Photodynamic Theory Beats Lung Cancer!. . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
The Immune System of the Alpaca Reveals a Potential Treatment
for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Prevent Ovarian Cancer with Aspirin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
A Light-Emitting Wireless Implant to Kill Cancer . . . . . . . . . . . . . . . . . . . . . . 237
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Could E. Coli Treatment Cure Crohn’s Disease?. . . . . . . . . . . . . . . . . . . . . . . . 319
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Endometrial Cancer
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Researchers Explore Gene Therapy to Treat Endometrial Cancer. . . . . . . . . 55
FDA Issues Breakthrough Therapy Designation for LENVIMA. . . . . . . . . . . . 263
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Esophagus Cancer
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Immunotherapy – A New Form of Lung Cancer Treatment!. . . . . . . . . . . . . . . 31
412 Categories
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
A Light-Emitting Wireless Implant to Kill Cancer . . . . . . . . . . . . . . . . . . . . . . 237
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Discovery of New Metal-Based Inhibitor May Improve Treatments
for Triple-Negative Breast Cancer (TNBC). . . . . . . . . . . . . . . . . . . . . . . . . . . . .317
Could E. Coli Treatment Cure Crohn’s Disease?. . . . . . . . . . . . . . . . . . . . . . . . 319
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Treatment Might Help in Reducing the Risk of Esophageal
Adenocarcinoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
Head and Neck Trial with NBTXR3 Nanoparticles Shows Promise. . . . . . . . 335
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Categories 413
New Vaccine to Possibly Treat Incurable HPV-Related Cancers. . . . . . . . . . 367
FDA Greenlights First Treatment for Advanced Skin Cancer. . . . . . . . . . . . . 385
Healthy Lifestyles
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Novel Blood Tests Help in Predicting Risks & Survival of
Kidney Cancer 5 Years Before Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Apples Reduce Chance of Cancer With Up To 25% . . . . . . . . . . . . . . . . . . . . . . 53
Safe Amount of Alcohol to Drink Is Zero . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
New Five Minute Procedure to Help With Enlarged Prostate. . . . . . . . . . . . . 61
Why You Should Start Drinking Chamomile Tea Today . . . . . . . . . . . . . . . . . . 63
Prevent Colon Cancer with These Six Foods . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Beating Cancer by Discovering the Benefits of Beetroot. . . . . . . . . . . . . . . . . 81
Benefits of Having Carrots Everyday. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
Cancer May be Prevented by Maintain Body pH Level. . . . . . . . . . . . . . . . . . . 94
Health Risks for Occasional Smokers Considerably Higher than
Previously Believed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
Avoiding Getting Tattoos Lowers Cancer Risk. . . . . . . . . . . . . . . . . . . . . . . . . 108
Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein. . . . . . 118
Garlic, the Ultimate Panacea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
Kale and Broccoli Could Prevent Colon Cancer. . . . . . . . . . . . . . . . . . . . . . . . 126
Treatments Ensuring Quality of Life for Lung Cancer Patients! . . . . . . . . . . 136
Ways of Reducing the Risk of Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144
Drinking More Water can Help in Reducing Bladder Infections
in Women. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Long-term Study Reveals Lower Cancer Incidence from
Vegetable and Fruit Diet. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
More Vitamin D May Offer Less Risk of Breast Cancer. . . . . . . . . . . . . . . . . . 239
414 Categories
Oral Bacteria – a Breakthrough Passage in Weight Loss,
Cancer Treatment, and Overall Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
How Your Diet Feeds Pancreatic Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
The Sweet Potato – An Unexpected Weapon against Breast Cancer?. . . . . 279
Early Age Drinking May Lead To Aggressive Prostate
Cancer Later In Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
Can Match Tea Fight Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
Dietary Tips that May Help to Stave Off Cancer –
What Do You Have to Lose? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
The Incredible Benefits of Coconut Oil. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291
Red Meat May Not be as Bad as We Have Been Told – You decide!. . . . . . . 297
Top Ways to Give Your Brain a Boost. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305
Eating Broccoli While Pregnant Could Help in
Preventing Breast Cancer in Child. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
The Numerous Health Benefits of Brazil Nuts. . . . . . . . . . . . . . . . . . . . . . . . . 329
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Grapes May Help in Stopping the Growth of Cancer Cells. . . . . . . . . . . . . . . 345
Top Medicinal & Health Properties of Cayenne Pepper . . . . . . . . . . . . . . . . 347
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Benefits of Flax Seed Could Include Cancer Prevention. . . . . . . . . . . . . . . . 357
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
How can Blueberries Help in Killing Cancer Cells?. . . . . . . . . . . . . . . . . . . . . 361
Benefits of Antioxidants for the Overall Health. . . . . . . . . . . . . . . . . . . . . . . 383
Milk Could Restore Gustatory and Olfactory Sensations to
Chemo Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
Hope Stories
Cancer Survivor, A Record Breaker Cyclist, Sets Upon a
New Challenge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Categories 415
Carol Neufeld’s, A Cancer Fighter, Inspirational Story. . . . . . . . . . . . . . . . . . 110
Photodynamic Theory Beats Lung Cancer!. . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
4 Little Girls Who Beat Cancer Reunite at Hospital for Touching Photo. . . . . 154
All-new Advanced CAR-T Treatment Might Give Hope to the
Cancer Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
When People Care There is HOPE!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Cancer Cannot Take Away Who You Are!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
New Bladder Cancer Drug Shows Impressive Results. . . . . . . . . . . . . . . . . . 363
Kevin Schwartzel saved the Life of Johnny Sawyer Dyer. . . . . . . . . . . . . . . . 379
Kidney Cancer
Novel Blood Tests Help in Predicting Risks & Survival of
Kidney Cancer 5 Years Before Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
New Drug Combination Could Help Curb Melanoma That
Has Spread to Brain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein. . . . . . 118
Photodynamic Theory Beats Lung Cancer!. . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
First Treatment for Advanced Skin Cancer Approved. . . . . . . . . . . . . . . . . . . 170
Hundreds of Kidney, Skin and Blood Cancer Patients
May Be Cured from Breakthrough Drug. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Urine Color: A Cancer Indicator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Kidney Cancer Cure via Protein Targeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
Metabolic Differences in Kidney Tumors Could Help
Better Treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
First Case of Complete Immunotherapy Response for
Kidney Cancer Patient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
Leukemia Cancer
New Drug Developed by Israeli Researchers That Kills Multiple
Leukemic Proteins at Once!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Cholesterol-Lowering Drug, Statin, Can Better Blood
Cancer Treatments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Cure for Acute Leukemia Within Reach - First Time in 40 Years. . . . . . . . . . . 86
416 Categories
A Major Vulnerability of Childhood Leukemia Discovered!. . . . . . . . . . . . . . 140
4 Little Girls Who Beat Cancer Reunite at Hospital for Touching Photo. . . . . 154
Taming Pediatric Leukemia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
New FDA Approved Drug Enters Leukemia Fight. . . . . . . . . . . . . . . . . . . . . . . 207
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Arsenic Shows Surprising Benefits in Cancer Fight . . . . . . . . . . . . . . . . . . . . 273
New Treatment for Hairy Cell Leukemia Approved By the FDA. . . . . . . . . . . 325
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
FDA Approved for Leukemia! – Copiktra. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
Kevin Schwartzel saved the Life of Johnny Sawyer Dyer. . . . . . . . . . . . . . . . 379
New Drug Enhances the Harvest of Bone Marrow . . . . . . . . . . . . . . . . . . . . . 397
Liver Cancer
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Cancer Blood Test Based on Protein Produced by Malarial Parasite can
Revolutionize Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Cell Immunotherapy Provides Potential Cure for Advanced
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Supercomputer Joins Fight Against Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 128
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
New Peptide Drug Targets Liver Cancer from Within. . . . . . . . . . . . . . . . . . . 257
New Drug Can Help in Fighting Liver Cancer with Fewer Side Effects. . . . . 327
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Lung Cancer
LOXO-292 Receives FDA Breakthrough Therapy Designation for the
Treatment of Lung & Thyroid Cancers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
A New Drug Combination Shrinks Tumors in
Chemotherapy-Resistant Lung and Ovarian Cancer . . . . . . . . . . . . . . . . . . . . 25
New Drug Combination Could Help Curb Melanoma That
Has Spread to Brain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Immunotherapy – A New Form of Lung Cancer Treatment!. . . . . . . . . . . . . . . 31
Categories 417
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Discovery of T-cells Hidden in Bone Marrow Can Help Beat
Brain Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Apples Reduce Chance of Cancer With Up To 25% . . . . . . . . . . . . . . . . . . . . . . 53
Nivolumab Receives FDA Accelerated Approval for Treating Small
Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Cancer Blood Test Based on Protein Produced by Malarial Parasite can
Revolutionize Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Mesothelin Targeted CAR T-Cell Therapy Shows Efficacy in
Early Stages of Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Cancer Should Not Have to Be a Death Sentence!. . . . . . . . . . . . . . . . . . . . . . 92
Cell Immunotherapy Provides Potential Cure for Advanced
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Health Risks for Occasional Smokers Considerably Higher than
Previously Believed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
Clubbed Nails May Indicate Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104
Cancer Patient Fights Terminal Cancer Through Alternative
Treatments! . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106
Photodynamic Theory Beats Lung Cancer!. . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
Treatments Ensuring Quality of Life for Lung Cancer Patients! . . . . . . . . . . 136
4 Little Girls Who Beat Cancer Reunite at Hospital for Touching Photo. . . . . 154
CAR T-Cell Therapy Might Alter the Treatment of Mesothelioma. . . . . . . . . 156
New Cancer Vaccine Shows Early Promise For Patients With
Her2-Positive Cancers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
First Treatment for Advanced Skin Cancer Approved. . . . . . . . . . . . . . . . . . . 170
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Hundreds of Kidney, Skin and Blood Cancer Patients
May Be Cured from Breakthrough Drug. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Delta-tocotrienol Inhibitors Might Reduce Risk of
Tumor Invasion and Metastasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Olive Oil – The Amazing Elixir. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
418 Categories
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
A Light-Emitting Wireless Implant to Kill Cancer . . . . . . . . . . . . . . . . . . . . . . 237
New Study Could “Pause & Reverse” Lung Cancer. . . . . . . . . . . . . . . . . . . . . 243
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Discovery of New Metal-Based Inhibitor May Improve Treatments
for Triple-Negative Breast Cancer (TNBC). . . . . . . . . . . . . . . . . . . . . . . . . . . . .317
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Imfinzi Can Help To Fight Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Lymphoma Cancer
When People Care There is HOPE!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
This Week in Oncology News. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Japan Approves New Treatment for Advanced Hodgkin’s Lymphoma. . . . . 365
Melanoma
New Drug Developed by Israeli Researchers That Kills Multiple
Leukemic Proteins at Once!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Melanoma Cancer
New Drug Combo to Lead Fight Against Melanoma. . . . . . . . . . . . . . . . . . . . . 19
New Drug Combination Could Help Curb Melanoma That
Has Spread to Brain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Immunotherapy – A New Form of Lung Cancer Treatment!. . . . . . . . . . . . . . . 31
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Discovery of T-cells Hidden in Bone Marrow Can Help Beat
Brain Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Simple Blood Test Can Reveal Skin Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96
First Treatment for Advanced Skin Cancer Approved. . . . . . . . . . . . . . . . . . . 170
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Categories 419
Revolution in Melanoma Treatment for Patients. . . . . . . . . . . . . . . . . . . . . . 249
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Could Wart Vaccines Really Treat Skin Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 267
New Vaccine Completely Removes Cancer in Mice. . . . . . . . . . . . . . . . . . . . . 281
FR900359, Discovered from Plants to Reduces Tumor Growth
in Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
New Treatment Discovered to Fight Melanoma Better Than
Traditional Vaccine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
FDA Greenlights First Treatment for Advanced Skin Cancer. . . . . . . . . . . . . 385
Mesothelioma Cancer
New Treatment to Prevent Pleural Mesothelioma Recurrence. . . . . . . . . . . . 57
Mesothelin Targeted CAR T-Cell Therapy Shows Efficacy in
Early Stages of Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Supercomputer Joins Fight Against Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 128
CAR T-Cell Therapy Might Alter the Treatment of Mesothelioma. . . . . . . . . 156
Surgeons at Pennsylvania “Light Up” Tumors for Boosting the Chances
of Mesothelioma Survival. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
A Tumor Suppressor – BRCA Associated Protein. . . . . . . . . . . . . . . . . . . . . . . 323
Nutrition
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Beating Cancer by Discovering the Benefits of Beetroot. . . . . . . . . . . . . . . . . 81
Cure for Acute Leukemia Within Reach - First Time in 40 Years. . . . . . . . . . . 86
Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein. . . . . . 118
Know About the Too Good-to-be-True Health Benefits of Turmeric. . . . . . 122
Garlic, the Ultimate Panacea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
420 Categories
Kale and Broccoli Could Prevent Colon Cancer. . . . . . . . . . . . . . . . . . . . . . . . 126
Ways of Reducing the Risk of Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Long-term Study Reveals Lower Cancer Incidence from
Vegetable and Fruit Diet. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Turmeric Can Cure Stomach Cancer: According to JNU Study. . . . . . . . . . . . 213
Olive Oil – The Amazing Elixir. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
How To Minimize The Risks Of Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . 219
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
More Vitamin D May Offer Less Risk of Breast Cancer. . . . . . . . . . . . . . . . . . 239
How Your Diet Feeds Pancreatic Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
The Sweet Potato – An Unexpected Weapon against Breast Cancer?. . . . . 279
Can Match Tea Fight Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
Dietary Tips that May Help to Stave Off Cancer –
What Do You Have to Lose? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
The Incredible Benefits of Coconut Oil. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291
Red Meat May Not be as Bad as We Have Been Told – You decide!. . . . . . . 297
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
The Numerous Health Benefits of Brazil Nuts. . . . . . . . . . . . . . . . . . . . . . . . . 329
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Top Health Benefits of Cinnamon. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343
Grapes May Help in Stopping the Growth of Cancer Cells. . . . . . . . . . . . . . . 345
Top Medicinal & Health Properties of Cayenne Pepper . . . . . . . . . . . . . . . . 347
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Benefits of Flax Seed Could Include Cancer Prevention. . . . . . . . . . . . . . . . 357
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
How can Blueberries Help in Killing Cancer Cells?. . . . . . . . . . . . . . . . . . . . . 361
Categories 421
Benefits of Antioxidants for the Overall Health. . . . . . . . . . . . . . . . . . . . . . . 383
Milk Could Restore Gustatory and Olfactory Sensations to
Chemo Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
Others
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Ovarian Cancer
A New Drug Combination Shrinks Tumors in
Chemotherapy-Resistant Lung and Ovarian Cancer . . . . . . . . . . . . . . . . . . . . 25
Researchers Explore Gene Therapy to Treat Endometrial Cancer. . . . . . . . . 55
Mesothelin Targeted CAR T-Cell Therapy Shows Efficacy in
Early Stages of Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Cancer Should Not Have to Be a Death Sentence!. . . . . . . . . . . . . . . . . . . . . . 92
Carol Neufeld’s, A Cancer Fighter, Inspirational Story. . . . . . . . . . . . . . . . . . 110
The Immune System of the Alpaca Reveals a Potential Treatment
for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166
Prostate Cancer, Ovarian Cancer, Sarcomas and
More Cancer Types Now Linked to Lynch Syndrome . . . . . . . . . . . . . . . . . . . 193
Prevent Ovarian Cancer with Aspirin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
FDA Issues Breakthrough Therapy Designation for LENVIMA. . . . . . . . . . . . 263
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
The Prognostic Importance of Antigen 45 (CT45) in Extending Life
of an Ovarian Cancer Patient. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 373
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
422 Categories
Pancreatic Cancer
Can Artificial Intelligence Combat Pancreatic Cancer? . . . . . . . . . . . . . . . . . . 35
Cancer Blood Test Based on Protein Produced by Malarial Parasite can
Revolutionize Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Mesothelin Targeted CAR T-Cell Therapy Shows Efficacy in
Early Stages of Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Cell Immunotherapy Provides Potential Cure for Advanced
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Chinese Tree Bark Compound Shows Anticancer Properties. . . . . . . . . . . . 146
‘Death Cap’ Mushroom Could Aid in Cancer Fight. . . . . . . . . . . . . . . . . . . . . . 162
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Top Do’s & Don’ts for Pancreatic Cancer Treatment. . . . . . . . . . . . . . . . . . . . 181
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
How To Minimize The Risks Of Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . 219
“Promising” Treatment Trial Gives New Hope for the
Deadliest Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229
Vaccination for Hepatitis B Might Help in Preventing
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
How Your Diet Feeds Pancreatic Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Switchable CAR-T Cells Target Pancreatic Ductal Adenocarcinoma. . . . . . . 309
Could E. Coli Treatment Cure Crohn’s Disease?. . . . . . . . . . . . . . . . . . . . . . . . 319
Top Medicinal & Health Properties of Cayenne Pepper . . . . . . . . . . . . . . . . 347
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Fighting Pancreatic Cancer! There is HOPE!. . . . . . . . . . . . . . . . . . . . . . . . . . . 375
Prevention
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Novel Blood Tests Help in Predicting Risks & Survival of
Kidney Cancer 5 Years Before Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Green Tea – More Benefits with Each Sip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Neem Oil Could Help Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Categories 423
Apples Reduce Chance of Cancer With Up To 25% . . . . . . . . . . . . . . . . . . . . . . 53
Why You Should Start Drinking Chamomile Tea Today . . . . . . . . . . . . . . . . . . 63
Prevent Colon Cancer with These Six Foods . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Beating Cancer by Discovering the Benefits of Beetroot. . . . . . . . . . . . . . . . . 81
Benefits of Having Carrots Everyday. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
Cancer May be Prevented by Maintain Body pH Level . . . . . . . . . . . . . . . . . . 94
Health Risks for Occasional Smokers Considerably Higher than
Previously Believed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
Avoiding Getting Tattoos Lowers Cancer Risk. . . . . . . . . . . . . . . . . . . . . . . . . 108
Cell-to-Cell Communication Opens Way for Better Cancer Treatment. . . . 116
Lesser Risk of Kidney Cancer with more Vitamin D Binding Protein. . . . . . 118
Array BioPharma Receives FDA Breakthrough Therapy Designation
for BRAFTOVI in Combination Drugs for Colorectal Cancer. . . . . . . . . . . . . . 120
1Know About the Too Good-to-be-True Health Benefits of Turmeric . . . . 122
Garlic, the Ultimate Panacea , Kale and Broccoli Could Prevent
Colon Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126
Prevent Ovarian Cancer with Aspirin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
Vaccination for Hepatitis B Might Help in Preventing
Pancreatic Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
More Vitamin D May Offer Less Risk of Breast Cancer. . . . . . . . . . . . . . . . . . 239
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Oral Bacteria – a Breakthrough Passage in Weight Loss,
Cancer Treatment, and Overall Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
The Sweet Potato – An Unexpected Weapon against Breast Cancer?. . . . . 279
Early Age Drinking May Lead To Aggressive Prostate
Cancer Later In Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
Can Match Tea Fight Cancer?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
Dietary Tips that May Help to Stave Off Cancer –
What Do You Have to Lose? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
The Incredible Benefits of Coconut Oil. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291
Eating Broccoli While Pregnant Could Help in
Preventing Breast Cancer in Child. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307
424 Categories
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
The Numerous Health Benefits of Brazil Nuts. . . . . . . . . . . . . . . . . . . . . . . . . 329
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
Grapes May Help in Stopping the Growth of Cancer Cells. . . . . . . . . . . . . . . 345
Top Medicinal & Health Properties of Cayenne Pepper . . . . . . . . . . . . . . . . 347
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Benefits of Flax Seed Could Include Cancer Prevention. . . . . . . . . . . . . . . . 357
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
How can Blueberries Help in Killing Cancer Cells?. . . . . . . . . . . . . . . . . . . . . 361
Benefits of Antioxidants for the Overall Health. . . . . . . . . . . . . . . . . . . . . . . 383
Milk Could Restore Gustatory and Olfactory Sensations to
Chemo Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
Prostate
How can Blueberries Help in Killing Cancer Cells?. . . . . . . . . . . . . . . . . . . . . 361
Prostate Cancer
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Neem Oil Could Help Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
New Five Minute Procedure to Help With Enlarged Prostate. . . . . . . . . . . . . 61
Adelaide Researchers Looking for Better Treatment for
Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Innovative Therapy to Cut Radiation Sessions for Prostate Cancer . . . . . . 134
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Connection to Healthy Diets Imply Lower Risks of Cancer. . . . . . . . . . . . . . 175
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Prostate Cancer, Ovarian Cancer, Sarcomas and
More Cancer Types Now Linked to Lynch Syndrome . . . . . . . . . . . . . . . . . . . 193
Hundreds of Kidney, Skin and Blood Cancer Patients
May Be Cured from Breakthrough Drug. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
XTANDI Treatment for Prostate Cancer Gets FDA Approval. . . . . . . . . . . . . . 221
Categories 425
Urine Color: A Cancer Indicator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Blood Tests can Help in Predicting the Treatment for
Patients with Prostate Cancer: Study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Walnuts May be Able to Prevent Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Early Age Drinking May Lead To Aggressive Prostate
Cancer Later In Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
Junk Food Can Lead To Cancer According To Study . . . . . . . . . . . . . . . . . . . . 333
Cutting Edge Radiotherapy Machine Introduced in the U.K.. . . . . . . . . . . . . 351
Benefits of Flax Seed Could Include Cancer Prevention. . . . . . . . . . . . . . . . 357
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Personalized Vaccine Could Become New Norm for
Treating HER2-Positive Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Skin Cancer
New Drug Combo to Lead Fight Against Melanoma. . . . . . . . . . . . . . . . . . . . . 19
New Drug Combination Could Help Curb Melanoma That
Has Spread to Brain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Immunotherapy – A New Form of Lung Cancer Treatment!. . . . . . . . . . . . . . . 31
Discovery of T-cells Hidden in Bone Marrow Can Help Beat
Brain Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Simple Blood Test Can Reveal Skin Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96
First Treatment for Advanced Skin Cancer Approved. . . . . . . . . . . . . . . . . . . 170
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Australia Working on Breakthrough Blood Test for
Detecting Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
HPV Vaccine Removes Dozens of Tumors from Patient
With Advanced Skin Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
Hundreds of Kidney, Skin and Blood Cancer Patients
May Be Cured from Breakthrough Drug. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
426 Categories
Can Pomegranate Juice Keep Cancer Away? . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Revolution in Melanoma Treatment for Patients. . . . . . . . . . . . . . . . . . . . . . 249
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Could Wart Vaccines Really Treat Skin Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 267
Guava Leaves May Keep Cancer at Bay!. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
New Vaccine Completely Removes Cancer in Mice. . . . . . . . . . . . . . . . . . . . . 281
New Treatment Discovered to Fight Melanoma Better Than
Traditional Vaccine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
Black Raspberries Offer Promise for Treating Cancer. . . . . . . . . . . . . . . . . . 339
New Bladder Cancer Drug Shows Impressive Results. . . . . . . . . . . . . . . . . . 363
FDA Greenlights First Treatment for Advanced Skin Cancer. . . . . . . . . . . . . 385
Stomach Cancer
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
How Could Genes be Helpful in Curing Cancer?. . . . . . . . . . . . . . . . . . . . . . . . 33
Hyperbaric Oxygen Treatment Has Surprising Results On
Cancer Survivor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .112
Garlic, the Ultimate Panacea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Turmeric Can Cure Stomach Cancer: According to JNU Study. . . . . . . . . . . . 213
Olive Oil – The Amazing Elixir. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
New Initiative Could Prove Life-saving for Indians Suffering
from Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Asian Mushrooms Show Potential for Cancer Treatment . . . . . . . . . . . . . . . 255
Role of Ginger & Its Constituents in the Treatment of
Gastrointestinal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Pancreatic, Gastric and Various Cancers May Help with Prevention
from Citrus Fruit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Testicular Cancer
FDA Extends Age Limit for HPV Vaccine to Include Adults
between 27 and 45. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158
Categories 427
Throat Cancer
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Thyroid Cancer
LOXO-292 Receives FDA Breakthrough Therapy Designation for the
Treatment of Lung & Thyroid Cancers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Why You Should Start Drinking Chamomile Tea Today . . . . . . . . . . . . . . . . . . 63
Discovery Blocks Vicious Cycle of Inflammation and Tumor Growth. . . . . . 197
LOXO-101 Receives Breakthrough Therapy Designation from FDA and
Is Ready to Fight Solid Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
The Numerous Health Benefits of Brazil Nuts. . . . . . . . . . . . . . . . . . . . . . . . . 329
Fish Intake Could Lead to Lower Cancer Risks!. . . . . . . . . . . . . . . . . . . . . . . . 355
Uterine Cancer
Why Should Cruciferous Vegetables be on Your Plate Every day?. . . . . . . . . 15
Immunotherapy – A New Form of Lung Cancer Treatment!. . . . . . . . . . . . . . . 31
Drinking More Water can Help in Reducing Bladder Infections
in Women. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160
PARP Inhibitors May Bring New Hope to Patients With
Small Cell Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Lycopene, the Hidden Treasure from Inside Tomatoes. . . . . . . . . . . . . . . . . 187
Urine Color: A Cancer Indicator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
428 Categories