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VOLUME 19 NUMBER 1 FEBRUARY 2001 123
124 GRAFF N & ROBINSON
TRADITIONAL APPROACH
have additional pelvic organs ( e g , ovary, fallopian tubes) that may develop
problems. Women patients require additional vigilance from the physician in
their ED evaluation to avoid missing the diagnosis.
The physical examination is the second step in the initial evaluation of a
patient with acute abdominal pain. With palpation, the physician can confirm if
the process causing the abdominal pain is localized to one area of the abdomen.
Right upper quadrant processes include cholecystitis or hepatitis; right lower
quadrant process includes appendicitis, mittleschmertz, ovarian cyst, and ectopic
pregnancy; left lower quadrant processes may include an obstetrical problem,
such as ectopic pregnancy, or a local problem, such as diverticulitis. Auscultation
may be used by the physician to identify findings such as the absence of bowel
sounds with an ileus. If ascites are present, percussion can be used to identify
this finding.
During the initial evaluation, the emergency physician evaluates the patient
with selected stat tests such as urinalysis, complete blood count, electrolytes,
amylase, lipase, and liver enzymes. These findings may aid the physician in
forming an initial clinical impression but usually are not diagnostic. For example,
leukocytosis is consistent with acute appendicitis but is present with many other
conditions as well.
After the initial history, physical examination, and diagnostic tests, disposi-
tion decisions can be difficult on many patients. If the patient has clear evidence
of a specific disease, then a lengthy evaluation is not necessary. The patient is
admitted or released, depending on the seriousness of the disease condition and
the need for acute care hospital therapy. Many patients, however, do not have
clear evidence of the cause of their acute condition after the initial evaluation.
In these patients, the physician makes a probability of disease estimate.30At
some threshold for probability of disease, the physician discusses with the
patient his or her concern about their condition and recommends admission to
the hospital.3O When the probability of disease is lower than this threshold, the
physician reassures the patient and releases him or her.30The problem with a
traditional ED approach, limited to admission or discharge only, is that patients
must meet a higher threshold for further testing to occur. Any threshold for
admission of the ED patient to the hospital is a balance between what the
physician feels to be an appropriate diagnostic work-up and the use of limited
hospital resources, including time.
If there is a relatively high threshold for considering disease, above which
the physician admits the patient, quality of care problems arise for some patients
not meeting that threshold. If a patient falls below this threshold, the physician
reassures them and releases them. Whereas many patients with acute appendici-
tis initially present with classic symptoms (i.e., migration of pain to the right
lower quadrant, nausea, vomiting, and fever), just as many have nonspecific
These appendicitis patients often are released home with false
reassurance from the physician that they are fine, or admitted to the hospital
without their diagnosis being identified. In either case, needed surgery is de-
layed.
Appendicitis patients who are missed during the initial evaluation have few
documented signs or symptoms of appendicitis. Using Alvarados’ validated
appendicitis “MANTRELS” scoring system, Graff et alZofound these patients to
have an average appendicitis score of 2 out of 10 points. Rusnak et a13’ examined
126 GRAFF IV & ROBINSON
a series of cases where the appendicitis patient's diagnosis was missed in the
ED and the patient sued the physician. The authors found that these patients had
few clinical signs or symptoms of appendicitis at the time of their pre~entation.~~
When the initial physician misses the diagnosis of appendicitis, the patient's
outcome worsens. Brender et a17 found that the initial physician missed many
appendicitis presentations. The perforation rate was increased in those presenta-
tions initially missed by the physician (66.7% versus 39.5y0).~ Time delay from
the initial physician evaluation until surgery was greater in perforated than in
nonperforated patients (38.8 hours versus 10.5 h o ~ r s )Savrin
.~ et a138found 45%
of appendicitis patients with perforation had been evaluated by a physician and
released home with the diagnosis missed. Schere et a139found the percentage of
appendicitis patients whose diagnosis was missed by the physician was 17.6%
for patients with perforation compared with 5.3% for appendicitis patients
without perforation. Buchman et a19 found the diagnosis was missed in 27.1%
of appendicitis patients, which resulted in 4.6 days' delay before the patient was
admitted to the hospital. Cacioppo et all1 examined the changes from 1980 to
1987 as insurance payers created road blocks to patients being referred to a
surgeon for evaluation. These authors found the percentage of patients not
evaluated by a surgeon initially increased from 7.9% to 24.1%. Those patients
not referred to the surgeon by the initial physician had 3.5 days' delay before
surgery with the perforation rate increased from 26.3% to 40.5%." Traditionally,
the physician has failed to diagnose appendicitis in 10% to 27% of cases with
many patients experiencing adverse outcomes, such as perforation and abscess
formation.
When a physicians' practice is limited to admit or discharge an ED patient
with abdominal pain, usage problems also arise. Physicians admit patients to
the hospital who have a probability of disease greater than the threshold to
admit. Some of these patients do have a serious disease, but most do not. The
average rate of false positive surgery rate ranges from 20% to 30%.31*42 This
results in unnecessary surgery to avoid delays in performing surgery and re-
sulting perforation. In 1984, Berry and Malt4 summarized the first 100 years of
management of appendicitis. This included a review of 23 studies with 13,848
patients and the first 100 years of experience with appendicitis at Massachusetts
General Hospital, where the first appendectomy was perf~rmed.~ They con-
cluded that low diagnostic accuracy was necessary (high false-positive surgery
rate) to reduce the risk of perforation. They recommended a 23% false-positive
surgery rate as the ideal balance for the s ~ r g e o nThe
. ~ consequences of negative
laparotomy result in a threefold waste of hospital resources, unnecessary compli-
cations to the patient, and expense to the health care system.18 Gough et all8
found the incidence of noninflammed appendices removed was 29.6% and
was nearly twice as high in women than men. Postoperative complications
reached 6.7%.l8
the other 80% are safely released, avoiding hospitalization at 50% of the cost
and charges of admission to the hospital. With the third pathway, the physician
can be more discriminating in deciding who to commit to expensive hospitaliza-
tion without unwanted risk to patient safety.
Clinical changes over time illustrate the benefit of observation in patients
whose diagnosis is not clear after the initial ED evaluation.20Patients with
appendicitis develop more signs and symptoms during evaluation in the ED
observation unit. Judging patients by the 10 point appendicitis scoring system,
Graff et a P found that during 12 hours of observation the amount of clinical
findings in patients with appendicitis increased from 6.8 to 7.8 points. They also
found that patients without appendicitis during 12 hours of observation cleared
their clinical findings with appendicitis scores decreasing from 3.8 to 1.6.20
Formation of a probability of disease estimate from clinical findings and consid-
eration of the changes (delta) over a 12-hour period of observation (Fig. 1)
clarifies the patient's diagnosis.
In evaluating patients for appendicitis, Lewis et a124found serial examina-
tion was the best approach to minimize perforation risk while reducing delays
to diagnosis.24To identify patients with appendicitis who present with atypical
symptoms, the physician needs to decrease the threshold for extended evaluation
of abdominal pain patients. Appendicitis patients whose diagnosis is initially
missed have few signs and symptoms of appendicitis (Fig. 2). Observation is a
.-c
-8
-10 -
3 4 5 6 7 8 9 10
Figure 1. Probability of appendicitis after observation: calculation from initial and change
in appendicitis score. Bottom curve = 24%; second curve = 33%; third curve = 62%;
fourth curve = 97%; top curve = 100%. (From Graff LG, Radford MJ, Werne CW:
Probability of appendicitis before and after observation. Ann Emerg Med 20503-507,1991;
with permission.)
128 GRAFF FJ & ROBINSON
Figure 2. Amount of clinical findings of appendicitis in abdominal pain patients. First bar
= misses (patients with appendicitis whose diagnosis is missed by the initial physician);
second bar = false positives (patients without appendicitis who are taken to surgery for
suspected appendicitis; third bar = true positives (patients with appendicitis identified by
initial physician).
OBSERVATION STRATEGIES
individualized for each hospital. The indications for surgical consultation and
hospital admission include:
Developed peritoneal signs or shock
Worsening abdominal tenderness during the observation period
Persistent pain or tenderness after observation period
Focalizing tenderness
Deteriorating vital signs
Identification of a surgical pathology (such as ectopic pregnancy or small
bowel obstruction)
Worsening toxicity as defined by clinical condition, laboratory, or ancillary
testing
Worsening or continued high appendicitis (MANTELS) score
Table 1 examines the many diagnostic testing options for the abdominal
pain patient.
Laboratory testing, radiography, and advanced diagnostic testing account
for the majority of charges to the low-risk individual that does not require
surgery. Differentiating surgical emergencies from nonsurgical emergencies often
require additional testing that may result in one of two strategies; The wait and
see strategy narrows the diagnosis through a series of progressively more specific
tests. This ordering pattern is cost-effective but could delay care and manage-
ment. Alternatively, ordering all laboratories and studies on initial presentation
(shot-gunning) may provide information earlier but may incur additional costs
through inappropriate ordering patterns. Table 1 illustrates the limitations of
single laboratory and radiographic testing.
The most frequently ordered study for abdominal pain is the complete
blood count (CBC). Complete blood count elevations in the context of abdominal
pain imply a more serious pathology. The CBC should never be used to make a
sole diagnosis of an abdominal pathology, as nearly 11%of normal adults have
elevated white blood cell (WBC) counts and 13% have left shifts. Conversely,
elevated CBCs occur in only 42% to 90% of those patients with confirmed
appendicitis. In a prospective trial of 382 children with appendicitis, only 13
(3.9%) had a normal CBC and no left shift, resulting in a 96% ~ensitivity.~
Unfortunately, elevated CBCs are reported with almost any infectious, inflam-
matory, or traumatic condition, reducing the specificity of CBC in some reports
less to than 50%.
Other than pregnancy testing, there are few laboratory tests that clearly are
indicated for all patients. The standard electrolyte panel, consisting of serum
sodium, chloride, potassium, blood urea nitrogen, and creatinine are rarely
helpful in the work-up of abdominal pain except to monitor the patient's
hydration status. Urinalysis is indicated in the evaluation of most patients with
abdominal pain but has limited use, except in the diagnosis of urinary tract
infections (UTI) in patients with urinary tract symptoms. It can be false positive
in up to 30% of appendicitis cases.4oBorrero6 noted that 24 of 134 (17.9%) of
symptomatic abdominal aortic aneurysms presenting to EDs were misdiagnosed
as nephrolithiasis. In this trial, 12 of the 14 patients with diagnostic delays
resulted from intravenous pyelograms testing6Furthermore, in a trial by Pomper
et a1,3* gross hematuria was found to be a significant cause of the delay in
arriving to the diagnosis of appendicitis.
Plain films routinely ordered for all presenting abdominal patients are
another example of an ordering practice that may no longer be necessary.'2,36
Abdominal radiographs are rarely helpful as an initial test for abdominal pain
except where bowel obstruction, foreign body, or perforated viscous is an imme-
diate concern. Even in these presentations, CT provides more information with
Table 1. DIAGNOSTIC STUDIES FOR COMMON ABDOMINAL PRESENTATIONS
Common Testing CBC Lytes UA Xray UIS CT Scan
Abdominal aortic aneurysm A A Y Y Angiogr
Appendicitis Y A Y Y C-reacti
Biliary tract disease A A Y' Y HIDA s
Bowel obstruction, perforation A A Y* Y Y
Cholecystitis A A Y' Y
Diverticulitis A A Y Y Barium
Ectopic pregnancy A A Y' HCG, pr
Gastroenteritis Y Y A Fecal le
Hernia A Physical
Intestinal infarction/ischemia A A A Y Angiogr
Ovarian torsion Y A Y Doppler
Pancreatitis A A Y Y Lipase*,
Pelvic inflammatory disease Y A A ESR, CR
Pyelonephritis Y Y
Renal colic A Y Y A Y Helical
Testicular torsion Y Y Doppler,
134 GRAFF rV & ROBINSON
little additional cost than a complete abdominal series. Using similar inclusion
criteria as noted previously, Rothrock et aP6reported a 48% reduction in unneces-
sary radiographs without missing any major disease. Campbell et all2reviewed
5080 patients with abdominal pain and reported that if the patient presented
with suspected appendicitis, UTI, or nonspecific abdominal pain, the radio-
graphs were not likely to be helpful and may, in fact, cloud the diagnosis.
Results from this trial support the conclusion that radiographs without clear
indication add little to the diagnosis and may actually delay the management of
abdominal pain.12
Observation of selected emergency department abdominal pain patients is
imperative. Early appropriate laboratories and radiographic testing combined
with observation can reduce cost and resource without jeopardizing safety. An
advantage of observation pathways is that the physician has the opportunity to
narrow his or her diagnosis by observation and is not obligated to shot-gun the
patient at presentation. The patient with mild diffuse abdominal pain may
develop focal findings in the right lower quadrant, improve, or even be found
to have other pathology clarified by serial evaluations.
SUMMARY
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