Abirapro 250mg

Abirapro is belongs to type of anti-cancer medication that will

act by decline the androgen production in the body. Androgen
is a male hormone that canmaintance the tumor cell in prostate
glands, the main ingredient which is used as abiraterone .
Actually thisdrug is given by co administration with
prednisolone, a steroid which reduce the liability of side effects
produced by Abiraterone.

MECHANISM OF ACTION
Androgens are balance the production of malignant in prostate.
Abiraprois belongs to anti androgen drugs, thatcauses to
suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it
is involves in androgen conglomerate. Reduce the serum
testosterone level. Declined the tumor cell occurred.

SAFETY AND WARNING OF ABIRAPRO

Anyallergy, serious liver problem or pregnant in patient,
Abiraprotherapy should be stopped Avoid taking of other
medications, i.e prescription, over-the-counter, vitamins, herbal
remedies, etc be sure to inform the doctors before the
treatment. Do not take Aspirin administrated and products
containing aspirin till doctor particularly allow the drug.
PHARMACOKINETICS
Absorption:
Time to maximum plasma concentration of Abiraprotablet
takes 12 hours.
Distribution:
Maximum bound to the human plasma protein like albumin
and alpha-1 acid glycoprotein.
Metabolism:
Themain two metabolites of Abiraterone in human plasma are
Abiraterone sulphate and N-oxide Abiraterone sulphate.
Excretion:
The drug mainly excreted in 88% feces and 5% in urine Half-life
of tablet Abirapro is 12 ± 5 hours.
DRUG INTERACTION
Interaction of Abirapro with dextromethorphan will raises the
Cmax and AUC of dextromethorphan Interaction Abirapro with
strong CYP3A inhibitors or inducers , concomitant use with
caution because pharmacokinetics is not evaluated.
PREGNANCY
Pregnancy category X: while ontherapy with Abirapro tablet if
women become pregnant, immediately stop the drug and give
counseling to the women. Abirapro tablet is not recommended
for women.
STORAGE
The drug stored at 15℃ - 30℃. Keep the drug in dry place.
MISSED DOSE
If patient missed the dose ofAbirapro, that missed dose will be
skipped and follow the regular dosing schedule.
SIDE EFFECTS
Common effects Fatigue, Arthralgia, Hypertension, Nausea,
edema, Hypokalemia, Diarrhea, vomiting, Cough, headache,
Glucocorticoid deficiency,Mineral corticoid deficiency,
Hepatotoxicity, Hypertension, Decrease in ka leve
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