Академический Документы
Профессиональный Документы
Культура Документы
P T
Please note: The Med Ed server replacement is scheduled between 1 PM and 4 PM on Tuesday, April 2, 2019. To avoid any data
loss, please don't work on the Student Source and the Faculty Source web sites during this time.
Pathology > Basic Hematology > Red Cell Disorders > Hemolytic Anemia
Hemolytic Anemia
Increased destruction of red blood cells in the peripheral blood without evidence
of ineffective erythropoiesis is known as hemolytic anemia. Such anemias are
generally classified into either inherited or acquired types.
RBCs normally live about 120 days following bone marrow release as reticulocytes.
When the RBCs become senescent they are removed from the peripheral blood by
macrophages in the spleen and liver.
https://www.med-ed.virginia.edu/courses/path/innes/rcd/hemo.cfm 1/4
3/31/2019 Pathology Thread
Hemoglobin-haptoglobin is cleared almost immediately from the plasma by
hepatic reticuloendothelial cells.
Amino acids from the globin chains are recycled and the Fe removed from the
heme and reused.
https://www.med-ed.virginia.edu/courses/path/innes/rcd/hemo.cfm 2/4
3/31/2019 Pathology Thread
Intravascular Extravascular
Transfused normal RBCs will have a shortened survival, no different than the
short lifespan of the patient's own RBCs, if, the abnormalities are acquired and
extrinsic to the RBC. This is the case in most hemolytic anemias
https://www.med-ed.virginia.edu/courses/path/innes/rcd/hemo.cfm 3/4
3/31/2019 Pathology Thread
The RBC membrane is a phospholipid bilayer with varying amounts of membrane cholesterol. A number of transmembrane (band
3 and several glycophorins) and membrane support [actin; ankryn (band2.1); band4.1; spectrin] proteins are present.
The actin - spectrin - 4.1 complexes help maintain the structural strength and stability of the RBC membrane. The spectrin -
ankryn - band 3 complexes stabilize the phospholipid bilayer.
Department of Pathology
PO Box 800214
UVa Health System
Charlottesville, VA 22908
Tel:(434) 924-5198
https://www.med-ed.virginia.edu/courses/path/innes/rcd/hemo.cfm 4/4