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PATOLOGIA CLÍNICA ______________________________________

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BIOQUÍMICOS ______________________________________
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Ana Laura D´Amico Fam ______________________________________
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PERFIL PROTÉICO ______________________________________
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PROTEÍNA TOTAL ______________________________________
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» Albumina ______________________________________
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» Globulinas ______________________________________
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» α, β, ϒ ______________________________________
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ALBUMINA ______________________________________
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» A principal proteína produzida pelo fígado ______________________________________
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FUNÇÃO HEPÁTICA!!! ______________________________________
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60 a 80% de perda hepática - hipoalbuminemia ______________________________________
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» Carreadora ______________________________________
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» Pressão oncótica ______________________________________
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» Proteína de inflamação negativa ______________________________________
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ALBUMINA ______________________________________
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HIPOALBUMINEMIA HIPERALBUMINEMIA ______________________________________
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» Diminuição da ______________________________________
ingesta » Desidratação!!! ______________________________________
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» Diminuição da ______________________________________
absorção ______________________________________
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» Diminuição da ______________________________________
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produção ______________________________________
» Aumento das perdas ______________________________________
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GLOBULINA ______________________________________
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» α e β: ______________________________________
» Sintetizadas pelo fígado ______________________________________
» Proteínas de fase aguda da inflamação: 2 a 5 dias ______________________________________
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» ϒ: ______________________________________
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» Imunoglobulinas : ______________________________________
ANTICORPOS ______________________________________
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GLOBULINA ______________________________________
= ______________________________________
PROTEINA TOTAL ______________________________________
- ______________________________________
ALBUMINA ______________________________________
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ALBUMINA ______________________________________
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HIPOALBUMINEMIA HIPERALBUMINEMIA ______________________________________
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» Diminuição da ______________________________________
ingesta » Desidratação!!! ______________________________________
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» Diminuição da ______________________________________
absorção ______________________________________
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» Diminuição da ______________________________________
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produção ______________________________________
» Aumento das perdas ______________________________________
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GLOBULINA ______________________________________
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HIPOGLOBULINEMIA HIPERGLOBULINEMIA ______________________________________
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» RARA! » Doenças auto-imunes ______________________________________
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» Falta de colostro » Pré-parto ______________________________________
» Doença hepática » Inflamações ______________________________________
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crônica » Infecções ______________________________________
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» Imunodeficiência » Neoplasias ______________________________________
» Hemorragias ______________________________________
» Síndrome nefrótica ______________________________________
» Desnutrição ______________________________________
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FÍGADO ______________________________________
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HEPATÓCITO ______________________________________
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ALT ______________________________________
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FA GGT ______________________________________
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LESÃO / ______________________________________
NECROSE ______________________________________
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COLESTASE ______________________________________
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LESÃO HEPÁTICA/
NECROSE
» Leva ao aumento das enzimas hepáticas: Quais?
» ALT à Meia-vida: 21 dias
» AST à Meia-vida: 12 horas Muscular
» Causas: neoplasias, lipidose, colangite,
colangiohepatite, medicamentos, toxinas, sepse,
drogas, doenças infecciosas, corticóides, etc.
Diminuição das enzimas = ______________________________________
CIRROSE HEPÁTICA
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COLESTASE
» Leva ao aumento das enzimas hepáticas: Quais?
» Fosfatase Alcalina à não é hepatoespecífica.
» GGT à hepatoespecífica em felinos.
¨ Causas: neoplasias, lipidose, colangite corticosteróide,
colangiohepatite, doença biliar extrahepática
Diminuição das enzimas = ______________________________________
CIRROSE HEPÁTICA
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FUNÇÃO HEPÁTICA ______________________________________
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»Albumina Melhor ______________________________________
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»Glicose ______________________________________
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»Triglicerideos ______________________________________
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»Colesterol ______________________________________
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»Uréia ______________________________________
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»Bilirrubinas ______________________________________
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BILIRRUBINAS ______________________________________
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»Seu aumento sérico leva à ______________________________________
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ICTERÍCIA ______________________________________
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HIPERBILIRRUBINEMIA ______________________________________
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»Pré-hepática Anemia ______________________________________
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»Hepática Hipoalbuminemia ______________________________________

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»Pós-hepática Colestase ______________________________________
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